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ONTOLOGY REPORT - ANNOTATIONS

Term:endoplasmic reticulum unfolded protein response
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Accession:GO:0030968 term browser browse the term
Definition:The series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) or other ER-related stress; results in changes in the regulation of transcription and translation.
Comment:Note that this term should not be confused with 'response to unfolded protein ; GO:0006986', which refers to any response to the presence of unfolded proteins anywhere in the cell or in multicellular organism.
Synonyms:exact_synonym: ER unfolded protein response;   erUPR
 related_synonym: SREBP-mediated signalling pathway


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endoplasmic reticulum unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AMFR autocrine motility factor receptor involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 6:29,366,812...29,417,800
Ensembl chr 6:29,366,936...29,413,697 		JBrowse link
G ATF3 activating transcription factor 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:130,772,259...130,829,678
Ensembl chr 9:130,772,262...130,785,506 		JBrowse link
G ATF4 activating transcription factor 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:8,742,964...8,745,752
Ensembl chr 5:8,742,967...8,745,368 		JBrowse link
G ATF6 activating transcription factor 6 involved_in IBA
IEA		 GO_Central
TreeGrafter		 GO_REF:0000033 GO_REF:0000118 NCBI chr 4:88,591,279...88,806,156
Ensembl chr 4:88,591,288...88,805,304 		JBrowse link
G ATF6B activating transcription factor 6 beta involved_in IEA
IBA		 TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000118 NCBI chr 7:24,153,551...24,171,743
Ensembl chr 7:24,161,061...24,171,709 		JBrowse link
G BHLHA15 basic helix-loop-helix family member a15 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:5,410,467...5,414,074
Ensembl chr 3:5,410,518...5,414,072 		JBrowse link
G CCND1 cyclin D1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16176978) Ensembl
MGI		 PMID:16176978 GO_REF:0000107 NCBI chr 2:3,621,242...3,633,380
Ensembl chr 2:3,621,246...3,633,296 		JBrowse link
G CDK5RAP3 CDK5 regulatory subunit associated protein 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:24,224,262...24,234,468
Ensembl chr12:24,224,263...24,234,467 		JBrowse link
G CREB3 cAMP responsive element binding protein 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:236,450,573...236,456,381
Ensembl chr 1:236,450,573...236,456,375 		JBrowse link
G CREB3L1 cAMP responsive element binding protein 3 like 1 involved_in ISO (MGI:4438316|PMID:19767743) UniProt PMID:19767743 MGI:4438316 NCBI chr 2:16,186,206...16,220,948
Ensembl chr 2:16,186,206...16,220,940 		JBrowse link
G DDIT3 DNA damage inducible transcript 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:30188326)
(PMID:15601821)		 Ensembl
MGI		 PMID:15601821 PMID:30188326 GO_REF:0000107 NCBI chr 5:22,785,441...22,789,867
Ensembl chr 5:22,785,445...22,789,829 		JBrowse link
G DERL1 derlin 1 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 4:16,310,407...16,341,405
Ensembl chr 4:16,310,314...16,341,433 		JBrowse link
G DERL2 derlin 2 involved_in IEA
IBA		 Ensembl
TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr12:51,508,138...51,524,799
Ensembl chr12:51,507,996...51,524,793 		JBrowse link
G DERL3 derlin 3 involved_in IEA
IBA		 Ensembl
TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr14:49,871,077...49,875,022
Ensembl chr14:49,871,218...49,877,672 		JBrowse link
G EIF2AK2 eukaryotic translation initiation factor 2 alpha kinase 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15542627) Ensembl
MGI		 PMID:15542627 GO_REF:0000107 NCBI chr 3:103,041,029...103,096,741
Ensembl chr 3:103,041,221...103,096,738 		JBrowse link
G EIF2AK3 eukaryotic translation initiation factor 2 alpha kinase 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10882126), (PMID:11430819), (PMID:15542627), (PMID:15911877), (PMID:16176978)
(PMID:14517290), (PMID:9930704)		 Ensembl
MGI		 PMID:9930704 PMID:10882126 PMID:11430819 PMID:14517290 PMID:15542627 More... GO_REF:0000107 NCBI chr 3:57,423,894...57,506,247
Ensembl chr 3:57,423,943...57,506,245 		JBrowse link
G EIF2AK4 eukaryotic translation initiation factor 2 alpha kinase 4 acts_upstream_of_or_within ISO (PMID:16176978) MGI PMID:16176978 NCBI chr 1:131,244,818...131,355,240
Ensembl chr 1:131,245,466...131,355,226 		JBrowse link
G ERLEC1 endoplasmic reticulum lectin 1 involved_in IEA InterPro
UniProt		 GO_REF:0000002 GO_REF:0000104 NCBI chr 3:87,362,166...87,389,814
Ensembl chr 3:87,355,904...87,389,814 		JBrowse link
G ERMP1 endoplasmic reticulum metallopeptidase 1 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:27566589) FlyBase
Ensembl		 PMID:27566589 GO_REF:0000107 NCBI chr 1:216,312,827...216,382,063
Ensembl chr 1:216,312,615...216,396,296 		JBrowse link
G ERN1 endoplasmic reticulum to nucleus signaling 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10882126), (PMID:11430819), (PMID:15601821) Ensembl
MGI
InterPro		 PMID:10882126 PMID:11430819 PMID:15601821 GO_REF:0000002 GO_REF:0000107 NCBI chr12:14,881,913...14,963,290
Ensembl chr12:14,881,923...14,963,284 		JBrowse link
G ERN2 endoplasmic reticulum to nucleus signaling 2 involved_in IEA InterPro GO_REF:0000002 NCBI chr 3:22,510,067...22,537,872
Ensembl chr 3:22,510,558...22,537,868 		JBrowse link
G ERO1A endoplasmic reticulum oxidoreductase 1 alpha involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15601821) Ensembl
MGI		 PMID:15601821 GO_REF:0000107 NCBI chr 1:182,268,651...182,318,147
Ensembl chr 1:182,265,261...182,318,195 		JBrowse link
G FGF21 fibroblast growth factor 21 ISO RGD PMID:23123503 RGD:10401883 NCBI chr 6:54,082,653...54,084,532
Ensembl chr 6:54,080,739...54,084,601 		JBrowse link
G HERPUD1 homocysteine inducible ER protein with ubiquitin like domain 1 acts_upstream_of_or_within
involved_in		 ISO
IBA
IEA		 (PMID:10922362) RGD
MGI
GO_Central
TreeGrafter
Ensembl		 PMID:10922362 PMID:15102845 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 RGD:1304324 NCBI chr 6:18,901,171...18,913,427
Ensembl chr 6:18,901,297...18,913,424 		JBrowse link
G HERPUD2 HERPUD family member 2 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr18:38,284,520...38,326,323
Ensembl chr18:38,284,520...38,326,311 		JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 involved_in IEA
IBA		 Ensembl
GO_Central
TreeGrafter		 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,894 		JBrowse link
G HYOU1 hypoxia up-regulated 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 9:46,264,929...46,277,056
Ensembl chr 9:46,264,933...46,276,995 		JBrowse link
G IFNB1 interferon beta 1 ISO RGD PMID:18412159 RGD:401854236 NCBI chr 1:201,850,935...201,851,495
Ensembl chr 1:201,850,935...201,851,495 		JBrowse link
G IFNG interferon gamma acts_upstream_of_or_within ISO (PMID:15911877) MGI PMID:15911877 NCBI chr 5:32,477,906...32,482,670
Ensembl chr 5:32,477,906...32,482,670 		JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:14517290) Ensembl
MGI		 PMID:14517290 GO_REF:0000107 NCBI chr15:82,967,485...83,146,185
Ensembl chr15:82,973,656...83,146,183 		JBrowse link
G OS9 OS9 endoplasmic reticulum lectin involved_in IEA InterPro
UniProt		 GO_REF:0000002 GO_REF:0000104 NCBI chr 5:22,957,903...23,004,464
Ensembl chr 5:22,957,875...23,004,458 		JBrowse link
G PARP16 poly(ADP-ribose) polymerase family member 16 involved_in IEA
IBA		 Ensembl
GO_Central
TreeGrafter		 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr 1:163,292,778...163,320,047
Ensembl chr 1:163,292,784...163,320,021 		JBrowse link
G PARP8 poly(ADP-ribose) polymerase family member 8 involved_in IBA
IEA		 GO_Central
TreeGrafter		 GO_REF:0000033 GO_REF:0000118 NCBI chr16:30,304,800...30,486,416
Ensembl chr16:30,305,738...30,486,414 		JBrowse link
G PKM pyruvate kinase M1/2 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 7:60,971,807...61,032,780
Ensembl chr 7:60,975,667...61,004,316
Ensembl chr 7:60,975,667...61,004,316 		JBrowse link
G PPP1R15A protein phosphatase 1 regulatory subunit 15A acts_upstream_of_or_within ISO (PMID:15601821) RGD
MGI		 PMID:15601821 PMID:18266951 PMID:22154936 RGD:9999171 RGD:9999413 NCBI chr 6:54,172,038...54,175,461
Ensembl chr 6:54,172,050...54,175,463 		JBrowse link
G PTPN1 protein tyrosine phosphatase non-receptor type 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:52,017,100...52,086,747
Ensembl chr17:52,017,130...52,086,736 		JBrowse link
G QRICH1 glutamine rich 1 involved_in ISO (PMID:33384352) UniProt PMID:33384352 NCBI chr13:31,663,812...31,714,523
Ensembl chr13:31,658,642...31,714,455 		JBrowse link
G RHBDD2 rhomboid domain containing 2 involved_in IEA
IBA		 TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000118 NCBI chr 3:10,299,201...10,329,638
Ensembl chr 3:10,299,209...10,309,622 		JBrowse link
G SELENOS selenoprotein S involved_in IBA
IEA		 GO_Central
TreeGrafter		 GO_REF:0000033 GO_REF:0000118 NCBI chr 1:139,829,002...139,836,923
Ensembl chr 1:139,828,791...139,836,914 		JBrowse link
G SERP1 stress associated endoplasmic reticulum protein 1 involved_in
acts_upstream_of_or_within		 IEA
ISO
IBA		 (PMID:16415102) Ensembl
MGI
GO_Central
TreeGrafter		 PMID:16415102 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr13:90,756,845...90,761,400
Ensembl chr13:90,756,855...90,761,560 		JBrowse link
G SERP2 stress associated endoplasmic reticulum protein family member 2 involved_in IEA
IBA		 TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000118 NCBI chr11:22,672,235...22,700,895
Ensembl chr11:22,672,240...22,700,675 		JBrowse link
G STC2 stanniocalcin 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15485913) Ensembl
MGI		 PMID:15485913 GO_REF:0000107 NCBI chr16:50,989,676...51,001,412
Ensembl chr16:50,989,433...51,004,481 		JBrowse link
G STUB1 STIP1 homology and U-box containing protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:41,092,514...41,095,181
Ensembl chr 3:41,092,449...41,095,136 		JBrowse link
G TBL2 transducin beta like 2 involved_in IEA
IBA		 Ensembl
GO_Central
TreeGrafter		 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr 3:10,850,347...10,892,441
Ensembl chr 3:10,876,973...10,892,404 		JBrowse link
G TMTC4 transmembrane O-mannosyltransferase targeting cadherins 4 involved_in
acts_upstream_of_or_within		 IEA
ISO
IBA		 (PMID:30188326) Ensembl
MGI
TreeGrafter
GO_Central		 PMID:30188326 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr11:69,361,219...69,442,769
Ensembl chr11:69,361,229...69,443,039 		JBrowse link
G VAPB VAMP associated protein B and C involved_in IEA
ISS		 Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr17:58,594,749...58,644,925
Ensembl chr17:58,594,749...58,644,914 		JBrowse link
G WFS1 wolframin ER transmembrane glycoprotein involved_in IEA
IBA		 TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000118 NCBI chr 8:4,362,678...4,405,185
Ensembl chr 8:4,362,680...4,385,273 		JBrowse link
G XBP1 X-box binding protein 1 involved_in ISO (MGI:5605954|PMID:14559994)
(PMID:25239945)
(MGI:5573106|PMID:24753614), (MGI:5607242|PMID:17612490), (MGI:5607243|PMID:16332684)		 RGD
ParkinsonsUK-UCL
UniProt		 PMID:14559994 PMID:15171721 PMID:16332684 PMID:17612490 PMID:24753614 More... MGI:5573106 MGI:5605954 MGI:5607242 MGI:5607243 RGD:1304536 NCBI chr14:46,011,239...46,016,526
Ensembl chr14:46,008,377...46,016,526 		JBrowse link
G YOD1 YOD1 deubiquitinase involved_in IEA
IBA		 Ensembl
GO_Central
TreeGrafter		 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr 9:67,672,640...67,681,889
Ensembl chr 9:67,672,651...67,681,826 		JBrowse link
IRE1-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DNAJC10 DnaJ heat shock protein family (Hsp40) member C10 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr15:88,198,751...88,256,396
Ensembl chr15:88,198,794...88,259,002 		JBrowse link
G ERN1 endoplasmic reticulum to nucleus signaling 1 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr12:14,881,913...14,963,290
Ensembl chr12:14,881,923...14,963,284 		JBrowse link
G ERN2 endoplasmic reticulum to nucleus signaling 2 involved_in IEA
IBA		 TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000118 NCBI chr 3:22,510,067...22,537,872
Ensembl chr 3:22,510,558...22,537,868 		JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 involved_in ISO (PMID:24508390) WB PMID:24508390 NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,894 		JBrowse link
G PARP16 poly(ADP-ribose) polymerase family member 16 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:163,292,778...163,320,047
Ensembl chr 1:163,292,784...163,320,021 		JBrowse link
G PTPN1 protein tyrosine phosphatase non-receptor type 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:52,017,100...52,086,747
Ensembl chr17:52,017,130...52,086,736 		JBrowse link
G VAPB VAMP associated protein B and C involved_in IEA
ISS		 Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr17:58,594,749...58,644,925
Ensembl chr17:58,594,749...58,644,914 		JBrowse link
negative regulation of ATF6-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATF6B activating transcription factor 6 beta involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:24,153,551...24,171,743
Ensembl chr 7:24,161,061...24,171,709 		JBrowse link
G WFS1 wolframin ER transmembrane glycoprotein involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:4,362,678...4,405,185
Ensembl chr 8:4,362,680...4,385,273 		JBrowse link
negative regulation of endoplasmic reticulum unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CREBRF CREB3 regulatory factor involved_in ISO (PMID:18391022) UniProt PMID:18391022 NCBI chr16:51,146,015...51,210,806
Ensembl chr16:51,150,560...51,226,212 		JBrowse link
G MIR199A-1 microRNA mir-199a-1 acts_upstream_of ISO (PMID:24299514) BHF-UCL PMID:24299514 NCBI chr 9:114,533,783...114,533,858
Ensembl chr 9:114,533,777...114,533,880 		JBrowse link
G MIR199A-2 microRNA mir-199a-2 acts_upstream_of ISO (PMID:24299514) BHF-UCL PMID:24299514 NCBI chr 2:69,558,051...69,558,130
Ensembl chr 2:69,558,050...69,558,131 		JBrowse link
G XBP1 X-box binding protein 1 involved_in ISO (PMID:25239945) UniProt PMID:25239945 NCBI chr14:46,011,239...46,016,526
Ensembl chr14:46,008,377...46,016,526 		JBrowse link
negative regulation of IRE1-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BFAR bifunctional apoptosis regulator involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:28,572,789...28,612,659
Ensembl chr 3:28,573,393...28,612,217 		JBrowse link
G DDRGK1 DDRGK domain containing 1 involved_in IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr17:32,479,981...32,491,401
Ensembl chr17:32,479,977...32,491,396 		JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 involved_in ISS UniProt GO_REF:0000024 NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,894 		JBrowse link
G PDIA6 protein disulfide isomerase family A member 6 involved_in ISO (PMID:24508390) WB PMID:24508390 NCBI chr 3:125,752,079...125,774,225
Ensembl chr 3:125,751,978...125,776,077 		JBrowse link
G UFL1 UFM1 specific ligase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:63,638,589...63,698,931
Ensembl chr 1:63,638,596...63,700,476 		JBrowse link
negative regulation of PERK-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA7 ATP binding cassette subfamily A member 7 involved_in ISO (MGI:5774886|PMID:27030769) ARUK-UCL PMID:27030769 MGI:5774886 NCBI chr 2:77,357,161...77,375,349
Ensembl chr 2:77,357,218...77,375,180 		JBrowse link
G NCK1 NCK adaptor protein 1 involved_in IEA
IBA		 Ensembl
TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr13:77,863,655...77,940,944
Ensembl chr13:77,863,701...77,945,468 		JBrowse link
G NCK2 NCK adaptor protein 2 involved_in IEA
IBA		 Ensembl
TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr 3:49,063,813...49,222,274
Ensembl chr 3:49,063,991...49,198,664 		JBrowse link
G PTPN1 protein tyrosine phosphatase non-receptor type 1 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr17:52,017,100...52,086,747
Ensembl chr17:52,017,130...52,086,736 		JBrowse link
PERK-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATF4 activating transcription factor 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:8,742,964...8,745,752
Ensembl chr 5:8,742,967...8,745,368 		JBrowse link
G EIF2AK3 eukaryotic translation initiation factor 2 alpha kinase 3 involved_in ISO (MGI:3722921|PMID:14729979), (MGI:6467680|PMID:17707796) UniProt PMID:14729979 PMID:17707796 MGI:3722921 MGI:6467680 NCBI chr 3:57,423,894...57,506,247
Ensembl chr 3:57,423,943...57,506,245 		JBrowse link
G EIF2S1 eukaryotic translation initiation factor 2 subunit alpha involved_in IEA
ISS		 Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr 7:91,085,025...91,109,835
Ensembl chr 7:91,085,335...91,109,827 		JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:82,967,485...83,146,185
Ensembl chr15:82,973,656...83,146,183 		JBrowse link
G QRICH1 glutamine rich 1 involved_in ISO (PMID:33384352) UniProt PMID:33384352 NCBI chr13:31,663,812...31,714,523
Ensembl chr13:31,658,642...31,714,455 		JBrowse link
G RPAP2 RNA polymerase II associated protein 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:124,691,655...124,773,914
Ensembl chr 4:124,690,317...124,773,887 		JBrowse link
G TMED2 transmembrane p24 trafficking protein 2 acts_upstream_of_or_within ISO (PMID:28797121) MGI PMID:28797121 NCBI chr14:29,390,903...29,400,454
Ensembl chr14:29,390,335...29,400,440 		JBrowse link
positive regulation of ATF6-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATF6 activating transcription factor 6 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:88,591,279...88,806,156
Ensembl chr 4:88,591,288...88,805,304 		JBrowse link
positive regulation of endoplasmic reticulum unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BAK1 BCL2 antagonist/killer 1 involved_in ISO (PMID:16645094) UniProt PMID:16645094 NCBI chr 7:29,808,849...29,815,345 JBrowse link
G BAX BCL2 associated X, apoptosis regulator involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:54,222,341...54,228,150
Ensembl chr 6:54,222,336...54,228,140 		JBrowse link
G ERN1 endoplasmic reticulum to nucleus signaling 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:14,881,913...14,963,290
Ensembl chr12:14,881,923...14,963,284 		JBrowse link
G PIK3R1 phosphoinositide-3-kinase regulatory subunit 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:46,434,757...46,523,626
Ensembl chr16:46,511,521...46,523,609 		JBrowse link
G XBP1 X-box binding protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:46,011,239...46,016,526
Ensembl chr14:46,008,377...46,016,526 		JBrowse link
positive regulation of IRE1-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGR2 anterior gradient 2, protein disulphide isomerase family member involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:86,042,070...86,053,893
Ensembl chr 9:86,041,369...86,053,857 		JBrowse link
G TMEM33 transmembrane protein 33 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:33,012,540...33,036,448
Ensembl chr 8:33,012,390...33,036,993 		JBrowse link
positive regulation of PERK-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGR2 anterior gradient 2, protein disulphide isomerase family member involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:86,042,070...86,053,893
Ensembl chr 9:86,041,369...86,053,857 		JBrowse link
G BOK BCL2 family apoptosis regulator BOK involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:140,171,134...140,184,126
Ensembl chr15:140,171,143...140,184,121 		JBrowse link
G PTPN2 protein tyrosine phosphatase non-receptor type 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:96,769,862...96,847,136
Ensembl chr 6:96,770,253...96,847,125 		JBrowse link
G TMEM33 transmembrane protein 33 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:33,012,540...33,036,448
Ensembl chr 8:33,012,390...33,036,993 		JBrowse link
regulation of endoplasmic reticulum unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PIGBOS1 PIGB opposite strand 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:116,519,834...116,522,515
Ensembl chr 1:116,522,226...116,522,390 		JBrowse link
regulation of IRE1-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G COPS5 COP9 signalosome subunit 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:67,740,528...67,758,153
Ensembl chr 4:67,739,251...67,758,150 		JBrowse link
G FICD FIC domain protein adenylyltransferase involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:42,261,505...42,269,184
Ensembl chr14:42,260,069...42,266,858 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17799
    cellular process 16838
      signal transduction 6973
        endoplasmic reticulum unfolded protein response 73
          ATF6-mediated unfolded protein response + 3
          IRE1-mediated unfolded protein response + 15
          PERK-mediated unfolded protein response + 15
          negative regulation of endoplasmic reticulum unfolded protein response + 15
          positive regulation of endoplasmic reticulum unfolded protein response + 10
          regulation of endoplasmic reticulum unfolded protein response + 27
Path 2
Term Annotations click to browse term
  biological_process 17799
    response to stimulus 10057
      response to chemical 5871
        response to organic substance 3403
          response to topologically incorrect protein 116
            cellular response to topologically incorrect protein 101
              cellular response to unfolded protein 85
                endoplasmic reticulum unfolded protein response 73
                  ATF6-mediated unfolded protein response + 3
                  IRE1-mediated unfolded protein response + 15
                  PERK-mediated unfolded protein response + 15
                  negative regulation of endoplasmic reticulum unfolded protein response + 15
                  positive regulation of endoplasmic reticulum unfolded protein response + 10
                  regulation of endoplasmic reticulum unfolded protein response + 27
paths to the root