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ONTOLOGY REPORT - ANNOTATIONS

Term:endoplasmic reticulum unfolded protein response
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Accession:GO:0030968 term browser browse the term
Definition:The series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) or other ER-related stress; results in changes in the regulation of transcription and translation.
Comment:Note that this term should not be confused with 'response to unfolded protein ; GO:0006986', which refers to any response to the presence of unfolded proteins anywhere in the cell or in multicellular organism.
Synonyms:exact_synonym: ER unfolded protein response;   erUPR
 related_synonym: SREBP-mediated signalling pathway


show annotations for term's descendants           Sort by:
endoplasmic reticulum unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AMFR autocrine motility factor receptor involved_in IMP
IEA
IBA		 (PMID:17157811) UniProt
TreeGrafter
GO_Central		 PMID:17157811 GO_REF:0000033 GO_REF:0000118 NCBI chr16:56,361,452...56,425,545
Ensembl chr16:56,361,452...56,425,545 		JBrowse link
G ATF3 activating transcription factor 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:212,565,407...212,620,777
Ensembl chr 1:212,565,334...212,620,777 		JBrowse link
G ATF4 activating transcription factor 4 involved_in IEA
ISS		 Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr22:39,520,559...39,522,686
Ensembl chr22:39,519,695...39,522,683 		JBrowse link
G ATF6 activating transcription factor 6 involved_in TAS
IEA
IBA		 (PMID:19816510) BHF-UCL
TreeGrafter
GO_Central		 PMID:19816510 GO_REF:0000033 GO_REF:0000118 NCBI chr 1:161,766,320...161,964,070
Ensembl chr 1:161,766,298...161,977,574 		JBrowse link
G ATF6B activating transcription factor 6 beta involved_in IEA
IBA		 TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000118 NCBI chr 6:32,115,264...32,128,246
Ensembl chr 6:32,115,264...32,128,253 		JBrowse link
G BHLHA15 basic helix-loop-helix family member a15 involved_in IEA
ISS		 Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr 7:98,211,439...98,215,457
Ensembl chr 7:98,211,439...98,215,457 		JBrowse link
G CASP12 caspase 12 (gene/pseudogene) acts_upstream_of_or_within ISO (PMID:10882126) MGI PMID:10882126 NCBI chr11:104,883,286...104,898,460
Ensembl chr11:104,885,718...104,898,670 		JBrowse link
G CCND1 cyclin D1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16176978) Ensembl
MGI		 PMID:16176978 GO_REF:0000107 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474 		JBrowse link
G CDK5RAP3 CDK5 regulatory subunit associated protein 3 involved_in IMP (PMID:23152784) UniProt PMID:23152784 NCBI chr17:47,967,904...47,981,781
Ensembl chr17:47,967,810...47,981,781 		JBrowse link
G CREB3 cAMP responsive element binding protein 3 involved_in IDA (PMID:16940180), (PMID:18391022) ParkinsonsUK-UCL PMID:16940180 PMID:18391022 NCBI chr 9:35,732,666...35,736,999
Ensembl chr 9:35,732,598...35,736,999 		JBrowse link
G CREB3L1 cAMP responsive element binding protein 3 like 1 involved_in ISS UniProt GO_REF:0000024 NCBI chr11:46,277,662...46,321,409
Ensembl chr11:46,277,662...46,321,409 		JBrowse link
G CTH cystathionine gamma-lyase involved_in TAS (PMID:22169477) UniProt PMID:22169477 NCBI chr 1:70,411,268...70,439,851
Ensembl chr 1:70,411,218...70,439,851 		JBrowse link
G DDIT3 DNA damage inducible transcript 3 involved_in
acts_upstream_of_or_within		 ISS
ISO
IEA		 (PMID:30188326)
(PMID:15601821)		 UniProt
MGI
Ensembl		 PMID:15601821 PMID:30188326 GO_REF:0000024 GO_REF:0000107 NCBI chr12:57,516,588...57,520,517
Ensembl chr12:57,516,588...57,521,737 		JBrowse link
G DERL1 derlin 1 involved_in IDA
IEA
IBA		 (PMID:15215856) UniProt
TreeGrafter
GO_Central		 PMID:15215856 GO_REF:0000033 GO_REF:0000118 NCBI chr 8:123,013,170...123,042,302
Ensembl chr 8:123,013,170...123,042,302 		JBrowse link
G DERL2 derlin 2 involved_in IDA
IBA
IEA		 (PMID:16449189) UniProt
GO_Central
TreeGrafter		 PMID:16449189 GO_REF:0000033 GO_REF:0000118 NCBI chr17:5,471,254...5,486,817
Ensembl chr17:5,471,254...5,486,811 		JBrowse link
G DERL3 derlin 3 involved_in IDA
IEA
IBA		 (PMID:16449189) UniProt
TreeGrafter
GO_Central		 PMID:16449189 GO_REF:0000033 GO_REF:0000118 NCBI chr22:23,834,503...23,839,006
Ensembl chr22:23,834,503...23,839,128 		JBrowse link
G EIF2AK2 eukaryotic translation initiation factor 2 alpha kinase 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15542627) Ensembl
MGI		 PMID:15542627 GO_REF:0000107 NCBI chr 2:37,099,210...37,156,980
Ensembl chr 2:37,099,210...37,157,522 		JBrowse link
G EIF2AK3 eukaryotic translation initiation factor 2 alpha kinase 3 involved_in
acts_upstream_of_or_within		 IDA
ISO
TAS		 (PMID:10677345), (PMID:11907036), (PMID:22169477)
(PMID:10882126), (PMID:11430819), (PMID:15542627), (PMID:15911877), (PMID:16176978)
(PMID:14517290), (PMID:9930704)
(PMID:19816510)		 UniProt
MGI
BHF-UCL		 PMID:9930704 PMID:10677345 PMID:10882126 PMID:11430819 PMID:11907036 More... NCBI chr 2:88,556,741...88,628,145
Ensembl chr 2:88,556,741...88,691,518 		JBrowse link
G EIF2AK4 eukaryotic translation initiation factor 2 alpha kinase 4 acts_upstream_of_or_within ISO (PMID:16176978) MGI PMID:16176978 NCBI chr15:39,934,115...40,035,591
Ensembl chr15:39,934,115...40,035,591 		JBrowse link
G ERLEC1 endoplasmic reticulum lectin 1 involved_in IEA InterPro
UniProt		 GO_REF:0000002 GO_REF:0000104 NCBI chr 2:53,787,044...53,818,796
Ensembl chr 2:53,787,009...53,833,038 		JBrowse link
G ERMP1 endoplasmic reticulum metallopeptidase 1 acts_upstream_of_or_within IMP (PMID:27566589) FlyBase PMID:27566589 NCBI chr 9:5,784,572...5,867,091
Ensembl chr 9:5,749,832...5,879,537 		JBrowse link
G ERN1 endoplasmic reticulum to nucleus signaling 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10882126), (PMID:11430819), (PMID:15601821) Ensembl
MGI
InterPro		 PMID:10882126 PMID:11430819 PMID:15601821 GO_REF:0000002 GO_REF:0000107 NCBI chr17:64,039,142...64,130,144
Ensembl chr17:64,039,080...64,130,819 		JBrowse link
G ERN2 endoplasmic reticulum to nucleus signaling 2 involved_in IEA InterPro GO_REF:0000002 NCBI chr16:23,690,310...23,713,222
Ensembl chr16:23,690,310...23,713,226 		JBrowse link
G ERO1A endoplasmic reticulum oxidoreductase 1 alpha involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15601821) Ensembl
MGI		 PMID:15601821 GO_REF:0000107 NCBI chr14:52,639,915...52,695,558
Ensembl chr14:52,639,915...52,695,900 		JBrowse link
G FGF21 fibroblast growth factor 21 involved_in ISO
IEA		 RGD
Ensembl		 PMID:23123503 GO_REF:0000107 RGD:10401883 NCBI chr19:48,755,524...48,758,330
Ensembl chr19:48,755,524...48,758,333 		JBrowse link
G HERPUD1 homocysteine inducible ER protein with ubiquitin like domain 1 acts_upstream_of_or_within
involved_in		 ISO
IEA
IBA		 (PMID:10922362) RGD
MGI
TreeGrafter
GO_Central
Ensembl		 PMID:10922362 PMID:15102845 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 RGD:1304324 NCBI chr16:56,932,142...56,944,864
Ensembl chr16:56,932,142...56,944,864 		JBrowse link
G HERPUD2 HERPUD family member 2 involved_in IBA
IEA		 GO_Central
TreeGrafter		 GO_REF:0000033 GO_REF:0000118 NCBI chr 7:35,632,659...35,695,135
Ensembl chr 7:35,632,659...35,697,459 		JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 involved_in IEA
IBA
TAS		 (PMID:19816510) Ensembl
GO_Central
TreeGrafter
BHF-UCL		 PMID:19816510 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr 9:125,234,853...125,241,343
Ensembl chr 9:125,234,853...125,241,382 		JBrowse link
G HYOU1 hypoxia up-regulated 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr11:119,044,188...119,057,205
Ensembl chr11:119,044,188...119,057,227 		JBrowse link
G IFNB1 interferon beta 1 ISO RGD PMID:18412159 RGD:401854236 NCBI chr 9:21,077,104...21,077,942
Ensembl chr 9:21,077,104...21,077,942 		JBrowse link
G IFNG interferon gamma acts_upstream_of_or_within ISO (PMID:15911877) MGI PMID:15911877 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740 		JBrowse link
G MBTPS1 membrane bound transcription factor peptidase, site 1 involved_in TAS Reactome Reactome:R-HSA-381119 Reactome:R-HSA-8874177 NCBI chr16:84,053,763...84,116,942
Ensembl chr16:84,053,761...84,116,942 		JBrowse link
G MBTPS2 membrane bound transcription factor peptidase, site 2 involved_in TAS Reactome Reactome:R-HSA-381119 Reactome:R-HSA-8874177 NCBI chr  X:21,839,617...21,885,423
Ensembl chr  X:21,839,617...21,885,423 		JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 involved_in
acts_upstream_of_or_within		 IEA
ISO
ISS		 (PMID:14517290) Ensembl
MGI
ParkinsonsUK-UCL		 PMID:14517290 GO_REF:0000024 GO_REF:0000107 NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,218,667...177,392,756 		JBrowse link
G OS9 OS9 endoplasmic reticulum lectin involved_in IEA InterPro
UniProt		 GO_REF:0000002 GO_REF:0000104 NCBI chr12:57,694,132...57,721,557
Ensembl chr12:57,693,841...57,728,342 		JBrowse link
G PARP16 poly(ADP-ribose) polymerase family member 16 involved_in IMP
IBA
IEA		 (PMID:23103912) UniProt
GO_Central
TreeGrafter		 PMID:23103912 GO_REF:0000033 GO_REF:0000118 NCBI chr15:65,230,917...65,286,883
Ensembl chr15:65,234,460...65,300,618 		JBrowse link
G PARP6 poly(ADP-ribose) polymerase family member 6 involved_in IEA
IBA		 TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000118 NCBI chr15:72,241,181...72,272,554
Ensembl chr15:72,241,181...72,272,999 		JBrowse link
G PARP8 poly(ADP-ribose) polymerase family member 8 involved_in IEA
IBA		 TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000118 NCBI chr 5:50,665,931...50,846,519
Ensembl chr 5:50,665,899...50,846,519 		JBrowse link
G PPP1R15A protein phosphatase 1 regulatory subunit 15A acts_upstream_of_or_within ISO (PMID:15601821) RGD
MGI		 PMID:15601821 PMID:18266951 PMID:22154936 RGD:9999171 RGD:9999413 NCBI chr19:48,872,421...48,876,058
Ensembl chr19:48,872,212...48,876,059 		JBrowse link
G PTPN1 protein tyrosine phosphatase non-receptor type 1 involved_in IDA (PMID:22169477) UniProt PMID:22169477 NCBI chr20:50,510,383...50,585,241
Ensembl chr20:50,510,321...50,585,241 		JBrowse link
G QRICH1 glutamine rich 1 involved_in IMP (PMID:33384352) UniProt PMID:33384352 NCBI chr 3:49,029,707...49,094,373
Ensembl chr 3:49,029,707...49,094,363 		JBrowse link
G RHBDD2 rhomboid domain containing 2 involved_in IBA
IEA		 GO_Central
TreeGrafter		 GO_REF:0000033 GO_REF:0000118 NCBI chr 7:75,879,034...75,888,926
Ensembl chr 7:75,842,602...75,888,926 		JBrowse link
G SELENOS selenoprotein S involved_in IDA
IEA
IBA		 (PMID:15215856) UniProt
TreeGrafter
GO_Central		 PMID:15215856 GO_REF:0000033 GO_REF:0000118 NCBI chr15:101,270,809...101,277,485
Ensembl chr15:101,270,817...101,277,500 		JBrowse link
G SERP1 stress associated endoplasmic reticulum protein 1 involved_in
acts_upstream_of_or_within		 IEA
ISO
IBA		 (PMID:16415102) Ensembl
MGI
TreeGrafter
GO_Central		 PMID:16415102 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr 3:150,541,998...150,546,496
Ensembl chr 3:150,541,998...150,603,228 		JBrowse link
G SERP2 stress associated endoplasmic reticulum protein family member 2 involved_in IBA
IEA		 GO_Central
TreeGrafter		 GO_REF:0000033 GO_REF:0000118 NCBI chr13:44,373,647...44,397,714
Ensembl chr13:44,373,665...44,397,714 		JBrowse link
G STC2 stanniocalcin 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15485913) Ensembl
MGI		 PMID:15485913 GO_REF:0000107 NCBI chr 5:173,314,723...173,328,414
Ensembl chr 5:173,314,723...173,328,447 		JBrowse link
G STUB1 STIP1 homology and U-box containing protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:680,410...682,801
Ensembl chr16:680,224...682,870 		JBrowse link
G TBL2 transducin beta like 2 involved_in IMP
IBA
IEA		 (PMID:25393282) ParkinsonsUK-UCL
GO_Central
TreeGrafter		 PMID:25393282 GO_REF:0000033 GO_REF:0000118 NCBI chr 7:73,567,537...73,578,579
Ensembl chr 7:73,567,537...73,578,791 		JBrowse link
G TMTC4 transmembrane O-mannosyltransferase targeting cadherins 4 involved_in
acts_upstream_of_or_within		 IEA
ISO
IBA		 (PMID:30188326) Ensembl
MGI
GO_Central
TreeGrafter		 PMID:30188326 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr13:100,603,625...100,675,075
Ensembl chr13:100,603,625...100,675,093 		JBrowse link
G VAPB VAMP associated protein B and C involved_in IMP (PMID:16891305) UniProt PMID:16891305 NCBI chr20:58,389,229...58,451,101
Ensembl chr20:58,389,229...58,451,101 		JBrowse link
G VCP valosin containing protein involved_in TAS (PMID:15215856) UniProt PMID:15215856 NCBI chr 9:35,056,064...35,072,625
Ensembl chr 9:35,053,928...35,072,668 		JBrowse link
G WFS1 wolframin ER transmembrane glycoprotein involved_in IEA
IBA		 Ensembl
TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr 4:6,269,850...6,303,265
Ensembl chr 4:6,269,849...6,303,265 		JBrowse link
G XBP1 X-box binding protein 1 involved_in ISO
IDA
ISS		 (PMID:25239945) RGD
UniProt		 PMID:15171721 PMID:25239945 GO_REF:0000024 RGD:1304536 NCBI chr22:28,794,560...28,800,569
Ensembl chr22:28,794,555...28,800,597 		JBrowse link
G YOD1 YOD1 deubiquitinase involved_in IMP
IBA
IEA		 (PMID:19818707) UniProt
GO_Central
TreeGrafter		 PMID:19818707 GO_REF:0000033 GO_REF:0000118 NCBI chr 1:207,043,849...207,053,116
Ensembl chr 1:207,043,849...207,052,980 		JBrowse link
ATF6-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATF6 activating transcription factor 6 involved_in TAS
NAS		 (PMID:22013210)
(PMID:32046286)		 ParkinsonsUK-UCL
ComplexPortal		 PMID:22013210 PMID:32046286 NCBI chr 1:161,766,320...161,964,070
Ensembl chr 1:161,766,298...161,977,574 		JBrowse link
G ATF6B activating transcription factor 6 beta involved_in TAS
NAS		 (PMID:22013210)
(PMID:32046286)		 ParkinsonsUK-UCL
ComplexPortal		 PMID:22013210 PMID:32046286 NCBI chr 6:32,115,264...32,128,246
Ensembl chr 6:32,115,264...32,128,253 		JBrowse link
G CREBZF CREB/ATF bZIP transcription factor involved_in NAS (PMID:32046286) ComplexPortal PMID:32046286 NCBI chr11:85,657,990...85,682,863
Ensembl chr11:85,657,742...85,682,908 		JBrowse link
G DDIT3 DNA damage inducible transcript 3 involved_in TAS (PMID:22934019) ParkinsonsUK-UCL PMID:22934019 NCBI chr12:57,516,588...57,520,517
Ensembl chr12:57,516,588...57,521,737 		JBrowse link
G MBTPS1 membrane bound transcription factor peptidase, site 1 involved_in TAS (PMID:22934019) ParkinsonsUK-UCL PMID:22934019 Reactome:R-HSA-381033 NCBI chr16:84,053,763...84,116,942
Ensembl chr16:84,053,761...84,116,942 		JBrowse link
G MBTPS2 membrane bound transcription factor peptidase, site 2 involved_in TAS (PMID:22934019) Reactome PMID:22934019 Reactome:R-HSA-381033 NCBI chr  X:21,839,617...21,885,423
Ensembl chr  X:21,839,617...21,885,423 		JBrowse link
G XBP1 X-box binding protein 1 involved_in NAS (PMID:32046286) ComplexPortal PMID:32046286 NCBI chr22:28,794,560...28,800,569
Ensembl chr22:28,794,555...28,800,597 		JBrowse link
IRE1-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DNAJC10 DnaJ heat shock protein family (Hsp40) member C10 involved_in IBA
IEA		 GO_Central
TreeGrafter		 GO_REF:0000033 GO_REF:0000118 NCBI chr 2:182,716,257...182,794,464
Ensembl chr 2:182,716,255...182,794,464 		JBrowse link
G ERN1 endoplasmic reticulum to nucleus signaling 1 involved_in IDA
IBA
IEA
IMP		 (PMID:11779465), (PMID:19328063), (PMID:29198525), (PMID:9637683)
(PMID:28128204)		 WB
GO_Central
TreeGrafter
Ensembl
UniProt		 PMID:9637683 PMID:11779465 PMID:19328063 PMID:28128204 PMID:29198525 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr17:64,039,142...64,130,144
Ensembl chr17:64,039,080...64,130,819 		JBrowse link
G ERN2 endoplasmic reticulum to nucleus signaling 2 involved_in IEA
IBA		 TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000118 NCBI chr16:23,690,310...23,713,222
Ensembl chr16:23,690,310...23,713,226 		JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 involved_in ISO (PMID:24508390) WB PMID:24508390 NCBI chr 9:125,234,853...125,241,343
Ensembl chr 9:125,234,853...125,241,382 		JBrowse link
G PARP16 poly(ADP-ribose) polymerase family member 16 involved_in IMP (PMID:23103912) UniProt PMID:23103912 NCBI chr15:65,230,917...65,286,883
Ensembl chr15:65,234,460...65,300,618 		JBrowse link
G PTPN1 protein tyrosine phosphatase non-receptor type 1 involved_in IEA
ISS		 Ensembl
ARUK-UCL		 GO_REF:0000024 GO_REF:0000107 NCBI chr20:50,510,383...50,585,241
Ensembl chr20:50,510,321...50,585,241 		JBrowse link
G VAPB VAMP associated protein B and C involved_in IDA (PMID:20940299) UniProt PMID:20940299 NCBI chr20:58,389,229...58,451,101
Ensembl chr20:58,389,229...58,451,101 		JBrowse link
G XBP1 X-box binding protein 1 involved_in TAS (PMID:22013210), (PMID:22934019) ParkinsonsUK-UCL PMID:22013210 PMID:22934019 NCBI chr22:28,794,560...28,800,569
Ensembl chr22:28,794,555...28,800,597 		JBrowse link
negative regulation of ATF6-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATF6B activating transcription factor 6 beta involved_in IDA (PMID:9837962) UniProt PMID:9837962 NCBI chr 6:32,115,264...32,128,246
Ensembl chr 6:32,115,264...32,128,253 		JBrowse link
G WFS1 wolframin ER transmembrane glycoprotein involved_in IEA
IDA		 (PMID:20160352) Ensembl
ParkinsonsUK-UCL		 PMID:20160352 GO_REF:0000107 NCBI chr 4:6,269,850...6,303,265
Ensembl chr 4:6,269,849...6,303,265 		JBrowse link
negative regulation of endoplasmic reticulum unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CREBRF CREB3 regulatory factor involved_in IDA (PMID:18391022) UniProt PMID:18391022 NCBI chr 5:173,056,352...173,139,284
Ensembl chr 5:173,056,352...173,139,284 		JBrowse link
G MIR199A1 microRNA 199a-1 acts_upstream_of IDA (PMID:24299514) BHF-UCL PMID:24299514 NCBI chr19:10,817,426...10,817,496
Ensembl chr19:10,817,426...10,817,496 		JBrowse link
G MIR199A2 microRNA 199a-2 acts_upstream_of IDA (PMID:24299514) BHF-UCL PMID:24299514 NCBI chr 1:172,144,535...172,144,644
Ensembl chr 1:172,144,535...172,144,644 		JBrowse link
G RACK1 receptor for activated C kinase 1 involved_in TAS (PMID:22013210) ParkinsonsUK-UCL PMID:22013210 NCBI chr 5:181,236,897...181,243,906
Ensembl chr 5:181,236,897...181,248,096 		JBrowse link
G XBP1 X-box binding protein 1 involved_in IDA (PMID:25239945) UniProt PMID:25239945 NCBI chr22:28,794,560...28,800,569
Ensembl chr22:28,794,555...28,800,597 		JBrowse link
negative regulation of IRE1-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BFAR bifunctional apoptosis regulator involved_in IMP (PMID:21068390) ParkinsonsUK-UCL PMID:21068390 NCBI chr16:14,632,951...14,669,236
Ensembl chr16:14,632,931...14,669,236 		JBrowse link
G DDRGK1 DDRGK domain containing 1 involved_in IDA
IBA
IEA		 (PMID:28128204), (PMID:32160526) UniProt
GO_Central
Ensembl		 PMID:28128204 PMID:32160526 GO_REF:0000033 GO_REF:0000107 NCBI chr20:3,190,350...3,204,682
Ensembl chr20:3,190,350...3,204,685 		JBrowse link
G DNAJB9 DnaJ heat shock protein family (Hsp40) member B9 involved_in ISS UniProt GO_REF:0000024 NCBI chr 7:108,569,874...108,574,850
Ensembl chr 7:108,569,867...108,574,850 		JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 involved_in ISS UniProt GO_REF:0000024 NCBI chr 9:125,234,853...125,241,343
Ensembl chr 9:125,234,853...125,241,382 		JBrowse link
G PDIA6 protein disulfide isomerase family A member 6 involved_in ISO (PMID:24508390) WB PMID:24508390 NCBI chr 2:10,783,391...10,837,712
Ensembl chr 2:10,783,391...10,837,977 		JBrowse link
G UFL1 UFM1 specific ligase 1 involved_in IDA (PMID:32160526) UniProt PMID:32160526 NCBI chr 6:96,521,806...96,555,276
Ensembl chr 6:96,521,595...96,555,276 		JBrowse link
negative regulation of PERK-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA7 ATP binding cassette subfamily A member 7 involved_in ISS ARUK-UCL GO_REF:0000024 NCBI chr19:1,040,107...1,065,572
Ensembl chr19:1,039,997...1,065,572 		JBrowse link
G NCK1 NCK adaptor protein 1 involved_in IDA
IBA
IEA		 (PMID:14676213) ParkinsonsUK-UCL
GO_Central
TreeGrafter
Ensembl		 PMID:14676213 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr 3:136,862,208...136,951,606
Ensembl chr 3:136,862,208...136,951,606 		JBrowse link
G NCK2 NCK adaptor protein 2 involved_in IEA
IBA		 Ensembl
TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr 2:105,744,453...105,894,272
Ensembl chr 2:105,744,912...105,894,274 		JBrowse link
G PPP1R15A protein phosphatase 1 regulatory subunit 15A involved_in TAS (PMID:22013210) ParkinsonsUK-UCL PMID:22013210 NCBI chr19:48,872,421...48,876,058
Ensembl chr19:48,872,212...48,876,059 		JBrowse link
G PPP1R15B protein phosphatase 1 regulatory subunit 15B involved_in TAS (PMID:22013210) ParkinsonsUK-UCL PMID:22013210 NCBI chr 1:204,395,826...204,411,817
Ensembl chr 1:204,396,492...204,411,887 		JBrowse link
G PTPN1 protein tyrosine phosphatase non-receptor type 1 involved_in IEA
IBA
IDA		 (PMID:21216966) Ensembl
GO_Central
TreeGrafter
ParkinsonsUK-UCL		 PMID:21216966 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr20:50,510,383...50,585,241
Ensembl chr20:50,510,321...50,585,241 		JBrowse link
PERK-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATF4 activating transcription factor 4 involved_in TAS
IEA
ISS		 (PMID:22013210), (PMID:22934019) ParkinsonsUK-UCL
Ensembl
UniProt		 PMID:22013210 PMID:22934019 GO_REF:0000024 GO_REF:0000107 NCBI chr22:39,520,559...39,522,686
Ensembl chr22:39,519,695...39,522,683 		JBrowse link
G DDIT3 DNA damage inducible transcript 3 involved_in TAS (PMID:14685163), (PMID:22934019) ParkinsonsUK-UCL PMID:14685163 PMID:22934019 NCBI chr12:57,516,588...57,520,517
Ensembl chr12:57,516,588...57,521,737 		JBrowse link
G EIF2AK3 eukaryotic translation initiation factor 2 alpha kinase 3 involved_in TAS (PMID:22934019) ParkinsonsUK-UCL PMID:22934019 NCBI chr 2:88,556,741...88,628,145
Ensembl chr 2:88,556,741...88,691,518 		JBrowse link
G EIF2S1 eukaryotic translation initiation factor 2 subunit alpha involved_in NAS
IDA		 (PMID:22934019)
(PMID:33384352)		 ParkinsonsUK-UCL
UniProt		 PMID:22934019 PMID:33384352 NCBI chr14:67,360,328...67,386,516
Ensembl chr14:67,360,328...67,386,516 		JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 involved_in IEA
TAS
ISS		 (PMID:22934019) Ensembl
ParkinsonsUK-UCL		 PMID:22934019 GO_REF:0000024 GO_REF:0000107 NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,218,667...177,392,756 		JBrowse link
G QRICH1 glutamine rich 1 involved_in IMP (PMID:33384352) UniProt PMID:33384352 NCBI chr 3:49,029,707...49,094,373
Ensembl chr 3:49,029,707...49,094,363 		JBrowse link
G RPAP2 RNA polymerase II associated protein 2 involved_in IDA (PMID:30118681) UniProt PMID:30118681 NCBI chr 1:92,299,059...92,402,056
Ensembl chr 1:92,299,059...92,402,056 		JBrowse link
G TMED2 transmembrane p24 trafficking protein 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:28797121) Ensembl
MGI		 PMID:28797121 GO_REF:0000107 NCBI chr12:123,584,552...123,598,582
Ensembl chr12:123,584,533...123,598,582 		JBrowse link
positive regulation of ATF6-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATF6 activating transcription factor 6 involved_in IDA (PMID:9837962) UniProt PMID:9837962 NCBI chr 1:161,766,320...161,964,070
Ensembl chr 1:161,766,298...161,977,574 		JBrowse link
positive regulation of endoplasmic reticulum unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BAK1 BCL2 antagonist/killer 1 involved_in IMP (PMID:16645094) UniProt PMID:16645094 NCBI chr 6:33,572,552...33,580,276
Ensembl chr 6:33,572,547...33,580,293 		JBrowse link
G BAX BCL2 associated X, apoptosis regulator involved_in IMP (PMID:16645094) UniProt PMID:16645094 NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798 		JBrowse link
G ERN1 endoplasmic reticulum to nucleus signaling 1 involved_in IMP (PMID:16645094), (PMID:28128204) UniProt PMID:16645094 PMID:28128204 NCBI chr17:64,039,142...64,130,144
Ensembl chr17:64,039,080...64,130,819 		JBrowse link
G PIK3R1 phosphoinositide-3-kinase regulatory subunit 1 involved_in IMP (PMID:20348923) UniProt PMID:20348923 NCBI chr 5:68,215,756...68,301,821
Ensembl chr 5:68,215,740...68,301,821 		JBrowse link
G XBP1 X-box binding protein 1 involved_in IMP (PMID:16645094) UniProt PMID:16645094 NCBI chr22:28,794,560...28,800,569
Ensembl chr22:28,794,555...28,800,597 		JBrowse link
positive regulation of IRE1-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGR2 anterior gradient 2, protein disulphide isomerase family member involved_in IDA (PMID:23220234) UniProt PMID:23220234 NCBI chr 7:16,791,811...16,804,999
Ensembl chr 7:16,791,811...16,833,433 		JBrowse link
G BAK1 BCL2 antagonist/killer 1 involved_in TAS (PMID:22013210) ParkinsonsUK-UCL PMID:22013210 NCBI chr 6:33,572,552...33,580,276
Ensembl chr 6:33,572,547...33,580,293 		JBrowse link
G BAX BCL2 associated X, apoptosis regulator involved_in TAS (PMID:22013210) ParkinsonsUK-UCL PMID:22013210 NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798 		JBrowse link
G BBC3 BCL2 binding component 3 involved_in TAS (PMID:22013210) ParkinsonsUK-UCL PMID:22013210 NCBI chr19:47,220,824...47,232,860
Ensembl chr19:47,220,822...47,232,766 		JBrowse link
G BCL2L11 BCL2 like 11 involved_in TAS (PMID:22013210) ParkinsonsUK-UCL PMID:22013210 NCBI chr 2:111,120,914...111,168,445
Ensembl chr 2:111,119,378...111,168,444 		JBrowse link
G DAB2IP DAB2 interacting protein involved_in TAS (PMID:22013210) ParkinsonsUK-UCL PMID:22013210 NCBI chr 9:121,567,074...121,785,530
Ensembl chr 9:121,567,057...121,785,530 		JBrowse link
G PTPN1 protein tyrosine phosphatase non-receptor type 1 involved_in TAS (PMID:22013210) ParkinsonsUK-UCL PMID:22013210 NCBI chr20:50,510,383...50,585,241
Ensembl chr20:50,510,321...50,585,241 		JBrowse link
G TMEM33 transmembrane protein 33 involved_in IDA (PMID:26268696) UniProt PMID:26268696 NCBI chr 4:41,935,137...41,960,803
Ensembl chr 4:41,935,129...41,960,803 		JBrowse link
positive regulation of PERK-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGR2 anterior gradient 2, protein disulphide isomerase family member involved_in IDA (PMID:23220234) UniProt PMID:23220234 NCBI chr 7:16,791,811...16,804,999
Ensembl chr 7:16,791,811...16,833,433 		JBrowse link
G BOK BCL2 family apoptosis regulator BOK involved_in ISS
IEA		 UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr 2:241,551,393...241,574,131
Ensembl chr 2:241,551,424...241,574,131 		JBrowse link
G PTPN2 protein tyrosine phosphatase non-receptor type 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:12,785,478...12,884,237
Ensembl chr18:12,785,478...12,929,643 		JBrowse link
G TMEM33 transmembrane protein 33 involved_in IDA (PMID:26268696) UniProt PMID:26268696 NCBI chr 4:41,935,137...41,960,803
Ensembl chr 4:41,935,129...41,960,803 		JBrowse link
regulation of ATF6-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HSPA5 heat shock protein family A (Hsp70) member 5 involved_in TAS (PMID:22934019) ParkinsonsUK-UCL PMID:22934019 NCBI chr 9:125,234,853...125,241,343
Ensembl chr 9:125,234,853...125,241,382 		JBrowse link
regulation of endoplasmic reticulum unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PIGBOS1 PIGB opposite strand 1 involved_in IMP (PMID:31653868) UniProt PMID:31653868 NCBI chr15:55,317,184...55,319,123
Ensembl chr15:55,317,184...55,319,161 		JBrowse link
regulation of IRE1-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G COPS5 COP9 signalosome subunit 5 involved_in IMP (PMID:15234121) ParkinsonsUK-UCL PMID:15234121 NCBI chr 8:67,043,079...67,062,133
Ensembl chr 8:67,043,079...67,083,783 		JBrowse link
G FICD FIC domain protein adenylyltransferase involved_in IDA (PMID:25601083) UniProt PMID:25601083 NCBI chr12:108,515,277...108,521,210
Ensembl chr12:108,515,277...108,525,837 		JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 involved_in TAS (PMID:22934019) ParkinsonsUK-UCL PMID:22934019 NCBI chr 9:125,234,853...125,241,343
Ensembl chr 9:125,234,853...125,241,382 		JBrowse link
regulation of PERK-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HSPA5 heat shock protein family A (Hsp70) member 5 involved_in TAS (PMID:22934019) ParkinsonsUK-UCL PMID:22934019 NCBI chr 9:125,234,853...125,241,343
Ensembl chr 9:125,234,853...125,241,382 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19770
    cellular process 18460
      signal transduction 6605
        endoplasmic reticulum unfolded protein response 85
          ATF6-mediated unfolded protein response + 9
          IRE1-mediated unfolded protein response + 22
          PERK-mediated unfolded protein response + 19
          negative regulation of endoplasmic reticulum unfolded protein response + 19
          positive regulation of endoplasmic reticulum unfolded protein response + 14
          regulation of endoplasmic reticulum unfolded protein response + 34
Path 2
Term Annotations click to browse term
  biological_process 19770
    response to stimulus 10237
      response to chemical 5157
        response to organic substance 3735
          response to topologically incorrect protein 165
            cellular response to topologically incorrect protein 116
              cellular response to unfolded protein 102
                endoplasmic reticulum unfolded protein response 85
                  ATF6-mediated unfolded protein response + 9
                  IRE1-mediated unfolded protein response + 22
                  PERK-mediated unfolded protein response + 19
                  negative regulation of endoplasmic reticulum unfolded protein response + 19
                  positive regulation of endoplasmic reticulum unfolded protein response + 14
                  regulation of endoplasmic reticulum unfolded protein response + 34
paths to the root