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ONTOLOGY REPORT - ANNOTATIONS

Term:endoplasmic reticulum unfolded protein response
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Accession:GO:0030968 term browser browse the term
Definition:The series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) or other ER-related stress; results in changes in the regulation of transcription and translation.
Comment:Note that this term should not be confused with 'response to unfolded protein ; GO:0006986', which refers to any response to the presence of unfolded proteins anywhere in the cell or in multicellular organism. Also see 'ER-associated protein catabolic process ; GO:0030433'.
Synonyms:exact_synonym: ER unfolded protein response;   erUPR
 related_synonym: SREBP-mediated signalling pathway


show annotations for term's descendants           Sort by:
 
endoplasmic reticulum unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Amfr autocrine motility factor receptor involved_in ISO
IBA		 (PMID:17157811)
PMID:21873635		 RGD PMID:17157811 PMID:21873635 RGD:13792537 NCBI chr19:10,996,705...11,032,260
Ensembl chr19:10,996,099...11,032,247 		JBrowse link
G Atf3 activating transcription factor 3 involved_in ISO (MGI:3722921|PMID:14729979) RGD PMID:14729979 MGI:3722921 NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631 		JBrowse link
G Atf4 activating transcription factor 4 involved_in ISS
ISO		 GO_REF:0000024
(MGI:5496937|PMID:23624402)		 UniProt
RGD		 PMID:23624402 GO_REF:0000024 MGI:5496937 NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446 		JBrowse link
G Atf6 activating transcription factor 6 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177 		JBrowse link
G Atf6b activating transcription factor 6 beta involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr20:4,090,921...4,098,920
Ensembl chr20:4,090,921...4,098,894 		JBrowse link
G Bhlha15 basic helix-loop-helix family, member a15 involved_in ISS
ISO		 GO_REF:0000024
(MGI:5607242|PMID:17612490)		 UniProt
RGD		 PMID:17612490 GO_REF:0000024 MGI:5607242 NCBI chr12:10,420,465...10,424,641
Ensembl chr12:10,420,467...10,424,713 		JBrowse link
G Casp12 caspase 12 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(MGI:1858648|PMID:10882126)		 Ensembl
RGD		 PMID:10882126 GO_REF:0000107 MGI:1858648 NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037 		JBrowse link
G Ccnd1 cyclin D1 acts_upstream_of_or_within ISO (MGI:3620306|PMID:16176978) RGD PMID:16176978 MGI:3620306 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Cdk5rap3 CDK5 regulatory subunit associated protein 3 involved_in ISO
IEA
ISS		 (PMID:23152784)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:23152784 GO_REF:0000024 GO_REF:0000107 NCBI chr10:81,894,393...81,903,581
Ensembl chr10:81,894,393...81,903,590 		JBrowse link
G Creb3l1 cAMP responsive element binding protein 3-like 1 involved_in ISS
ISO		 GO_REF:0000024
(MGI:4438316|PMID:19767743)		 UniProt
RGD		 PMID:19767743 GO_REF:0000024 MGI:4438316 NCBI chr 3:77,952,589...77,993,513
Ensembl chr 3:77,952,540...77,993,456 		JBrowse link
G Creb3l2 cAMP responsive element binding protein 3-like 2 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 4:65,907,570...66,112,078
Ensembl chr 4:65,907,655...66,023,763 		JBrowse link
G Creb3l3 cAMP responsive element binding protein 3-like 3 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 7:8,622,614...8,631,053
Ensembl chr 7:8,622,614...8,631,048 		JBrowse link
G Creb3l4 cAMP responsive element binding protein 3-like 4 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 2:175,690,340...175,696,084
Ensembl chr 2:175,690,335...175,695,932 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 involved_in
acts_upstream_of_or_within		 ISS
ISO
IEA		 GO_REF:0000024
MGI:2654034|MGI:5441015 (MGI:3525819|PMID:15601821), (MGI:6270315|PMID:30188326)
(MGI:5496937|PMID:23624402)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:15601821 PMID:23624402 PMID:30188326 GO_REF:0000024 GO_REF:0000107 MGI:3525819 MGI:5496937 MGI:6270315 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Derl1 derlin 1 involved_in ISO
IBA		 (PMID:15215856)
PMID:21873635		 RGD PMID:15215856 PMID:21873635 RGD:13792537 NCBI chr 7:89,404,413...89,427,095
Ensembl chr 7:89,404,417...89,427,145 		JBrowse link
G Derl2 derlin 2 involved_in IBA
ISO		 PMID:21873635
(PMID:16449189)		 RGD PMID:16449189 PMID:21873635 RGD:13792537 NCBI chr10:55,727,764...55,739,462
Ensembl chr10:55,727,643...55,739,518 		JBrowse link
G Derl3 derlin 3 involved_in ISO
IBA		 (PMID:16449189)
PMID:21873635		 RGD PMID:16449189 PMID:21873635 RGD:13792537 NCBI chr20:12,754,490...12,768,454
Ensembl chr20:12,763,543...12,767,027 		JBrowse link
G Eif2ak2 eukaryotic translation initiation factor 2-alpha kinase 2 acts_upstream_of_or_within ISO (MGI:3511630|PMID:15542627) RGD PMID:15542627 MGI:3511630 NCBI chr 6:16,189,000...16,224,972
Ensembl chr 6:16,188,979...16,224,971 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 involved_in
acts_upstream_of_or_within		 ISS
ISO		 GO_REF:0000024
MGI:2177666 (MGI:1333015|PMID:9930704), (MGI:1858648|PMID:10882126), (MGI:2136067|PMID:11430819), (MGI:2677605|PMID:14517290), (MGI:3511630|PMID:15542627), (MGI:3583403|PMID:15911877), (MGI:3620306|PMID:16176978)
(PMID:10677345), (PMID:11907036), (PMID:22169477)		 UniProt
RGD		 PMID:9930704 PMID:10677345 PMID:10882126 PMID:11430819 PMID:11907036 More... GO_REF:0000024 MGI:1333015 MGI:1858648 MGI:2136067 MGI:2677605 MGI:3511630 MGI:3583403 MGI:3620306 NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911 		JBrowse link
G Eif2ak4 eukaryotic translation initiation factor 2 alpha kinase 4 acts_upstream_of_or_within ISO MGI:2387965 (MGI:3620306|PMID:16176978) RGD PMID:16176978 MGI:3620306 NCBI chr 3:105,356,261...105,441,630
Ensembl chr 3:105,356,261...105,441,630 		JBrowse link
G Erlec1 endoplasmic reticulum lectin 1 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr14:104,655,745...104,693,508
Ensembl chr14:104,655,673...104,693,480 		JBrowse link
G Ermp1 endoplasmic reticulum metallopeptidase 1 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:27566589)
GO_REF:0000107		 RGD
Ensembl		 PMID:27566589 GO_REF:0000107 NCBI chr 1:227,383,992...227,422,120
Ensembl chr 1:227,387,920...227,436,909 		JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 acts_upstream_of_or_within ISO (MGI:1858648|PMID:10882126), (MGI:2136067|PMID:11430819), (MGI:3525819|PMID:15601821) RGD PMID:10882126 PMID:11430819 PMID:15601821 MGI:1858648 MGI:2136067 MGI:3525819 NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029 		JBrowse link
G Ero1a endoplasmic reticulum oxidoreductase 1 alpha acts_upstream_of_or_within ISO (MGI:3525819|PMID:15601821) RGD PMID:15601821 MGI:3525819 NCBI chr15:18,495,037...18,530,440
Ensembl chr15:18,492,945...18,530,478 		JBrowse link
G Fgf21 fibroblast growth factor 21 IEP RGD PMID:23123503 RGD:10401883 NCBI chr 1:96,083,495...96,084,738
Ensembl chr 1:96,083,441...96,090,454 		JBrowse link
G Herpud1 homocysteine inducible ER protein with ubiquitin like domain 1 acts_upstream_of_or_within
involved_in		 IMP
ISO
IBA		 (MGI:1913176|PMID:10922362)
PMID:21873635		 RGD PMID:10922362 PMID:15102845 PMID:21873635 MGI:1913176, RGD:1304324, RGD:13792537 NCBI chr19:10,598,411...10,609,002
Ensembl chr19:10,598,417...10,618,424 		JBrowse link
G Herpud2 HERPUD family member 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:23,573,374...23,617,874
Ensembl chr 8:23,573,379...23,617,874 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 involved_in IBA
ISO		 PMID:21873635
(MGI:4437543|PMID:19816510)		 RGD PMID:19816510 PMID:21873635 MGI:4437543, RGD:13792537 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Ifng interferon gamma acts_upstream_of_or_within ISO (MGI:3583403|PMID:15911877) RGD PMID:15911877 MGI:3583403 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 acts_upstream_of_or_within ISO (MGI:2677605|PMID:14517290) RGD PMID:14517290 MGI:2677605 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Os9 OS9, endoplasmic reticulum lectin involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 7:62,915,498...62,957,591
Ensembl chr 7:62,915,515...62,943,745 		JBrowse link
G Parp16 poly (ADP-ribose) polymerase family, member 16 involved_in ISO
IBA		 (PMID:23103912)
PMID:21873635		 RGD PMID:23103912 PMID:21873635 RGD:13792537 NCBI chr 8:65,731,152...65,749,438
Ensembl chr 8:65,727,706...65,749,433 		JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A acts_upstream_of_or_within IEP
ISO		 MGI:2652765 (MGI:3525819|PMID:15601821) RGD PMID:15601821 PMID:22154936 PMID:18266951 MGI:3525819, RGD:9999171, RGD:9999413 NCBI chr 1:96,000,053...96,003,128
Ensembl chr 1:96,000,058...96,003,171 		JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 involved_in ISO
ISS		 (PMID:22169477)
GO_REF:0000024		 RGD
UniProt		 PMID:22169477 GO_REF:0000024 NCBI chr 3:156,638,811...156,687,503
Ensembl chr 3:156,638,769...156,687,504 		JBrowse link
G Qrich1 glutamine-rich 1 involved_in ISO (PMID:33384352) RGD PMID:33384352 NCBI chr 8:109,216,900...109,256,472
Ensembl chr 8:109,217,376...109,261,359 		JBrowse link
G Selenos selenoprotein S involved_in ISO
IEA
IBA		 (PMID:15215856)
GO_REF:0000107
PMID:21873635		 RGD
Ensembl		 PMID:15215856 PMID:21873635 GO_REF:0000107, RGD:13792537 NCBI chr 1:119,659,779...119,669,546
Ensembl chr 1:119,659,751...119,669,833 		JBrowse link
G Serp1 stress-associated endoplasmic reticulum protein 1 involved_in
acts_upstream_of_or_within		 IBA
ISO		 PMID:21873635
MGI:3652355 (MGI:3619104|PMID:16415102)		 RGD PMID:16415102 PMID:21873635 MGI:3619104, RGD:13792537 NCBI chr 2:142,757,254...142,761,243
Ensembl chr 2:142,757,270...142,761,116 		JBrowse link
G Serp2 stress-associated endoplasmic reticulum protein family member 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr15:51,879,884...51,903,965
Ensembl chr15:51,879,877...51,904,785 		JBrowse link
G Stc2 stanniocalcin 2 acts_upstream_of_or_within ISO (MGI:3511371|PMID:15485913) RGD PMID:15485913 MGI:3511371 NCBI chr10:16,251,046...16,260,815
Ensembl chr10:16,250,853...16,262,973 		JBrowse link
G Stub1 STIP1 homology and U-box containing protein 1 involved_in ISO (MGI:5582182|PMID:12150907) RGD PMID:12150907 MGI:5582182 NCBI chr10:14,850,765...14,853,046
Ensembl chr10:14,850,765...14,853,046 		JBrowse link
G Tbl2 transducin (beta)-like 2 involved_in ISO (PMID:25393282) RGD PMID:25393282 NCBI chr12:21,517,600...21,532,114
Ensembl chr12:21,520,682...21,531,896 		JBrowse link
G Tmtc4 transmembrane O-mannosyltransferase targeting cadherins 4 acts_upstream_of_or_within ISO MGI:5008116 (MGI:6270315|PMID:30188326) RGD PMID:30188326 MGI:6270315 NCBI chr15:100,000,157...100,056,573
Ensembl chr15:100,000,152...100,056,543 		JBrowse link
G Vapb VAMP associated protein B and C involved_in ISO
ISS		 (PMID:16891305)
GO_REF:0000024		 RGD
UniProt		 PMID:16891305 GO_REF:0000024 NCBI chr 3:162,536,090...162,578,738
Ensembl chr 3:162,535,905...162,573,763 		JBrowse link
G Wfs1 wolframin ER transmembrane glycoprotein involved_in IBA
ISO		 PMID:21873635
(MGI:3629256|PMID:16571599), (MGI:4999711|PMID:19911006)		 RGD PMID:16571599 PMID:19911006 PMID:21873635 MGI:3629256 MGI:4999711, RGD:13792537 NCBI chr14:73,810,478...73,834,993
Ensembl chr14:73,810,404...73,835,602 		JBrowse link
G Xbp1 X-box binding protein 1 involved_in IDA
ISO		 (MGI:5573106|PMID:24753614), (MGI:5607242|PMID:17612490) RGD PMID:17612490 PMID:24753614 PMID:15171721 MGI:5573106 MGI:5607242, RGD:1304536 NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693 		JBrowse link
G Yod1 YOD1 deubiquitinase involved_in ISO
IBA
ISS		 (PMID:19818707)
PMID:21873635
GO_REF:0000024		 RGD
UniProt		 PMID:19818707 PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr13:42,175,313...42,177,030
Ensembl chr13:42,174,820...42,177,205 		JBrowse link
IRE1-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ern1 endoplasmic reticulum to nucleus signaling 1 involved_in ISO
IBA		 (PMID:11779465), (PMID:19328063), (PMID:28128204), (PMID:29198525), (PMID:9637683)
PMID:21873635
(MGI:5571560|PMID:24508390), (MGI:6114871|PMID:25164867)		 RGD PMID:9637683 PMID:11779465 PMID:19328063 PMID:24508390 PMID:25164867 More... MGI:5571560 MGI:6114871, RGD:13792537 NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029 		JBrowse link
G Ern2 endoplasmic reticulum to nucleus signaling 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:176,726,454...176,743,289
Ensembl chr 1:176,726,454...176,743,289 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 involved_in ISO (MGI:5571560|PMID:24508390) RGD PMID:24508390 MGI:5571560 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Parp16 poly (ADP-ribose) polymerase family, member 16 involved_in ISO
IEA		 (PMID:23103912)
GO_REF:0000107		 RGD
Ensembl		 PMID:23103912 GO_REF:0000107 NCBI chr 8:65,731,152...65,749,438
Ensembl chr 8:65,727,706...65,749,433 		JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 involved_in ISO (MGI:5616322|PMID:15465829) RGD PMID:15465829 MGI:5616322 NCBI chr 3:156,638,811...156,687,503
Ensembl chr 3:156,638,769...156,687,504 		JBrowse link
G Vapb VAMP associated protein B and C involved_in ISO
ISS		 (PMID:20940299)
GO_REF:0000024		 RGD
UniProt		 PMID:20940299 GO_REF:0000024 NCBI chr 3:162,536,090...162,578,738
Ensembl chr 3:162,535,905...162,573,763 		JBrowse link
negative regulation of ATF6-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf6b activating transcription factor 6 beta involved_in ISO (PMID:9837962) RGD PMID:9837962 NCBI chr20:4,090,921...4,098,920
Ensembl chr20:4,090,921...4,098,894 		JBrowse link
G Wfs1 wolframin ER transmembrane glycoprotein involved_in IGI
ISO		 PMID:20160352
(PMID:20160352)		 RGD PMID:20160352 PMID:20160352 RGD:10047363 NCBI chr14:73,810,478...73,834,993
Ensembl chr14:73,810,404...73,835,602 		JBrowse link
negative regulation of endoplasmic reticulum unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Crebrf CREB3 regulatory factor involved_in ISO (PMID:18391022) RGD PMID:18391022 NCBI chr10:16,399,170...16,479,650
Ensembl chr10:16,404,596...16,461,999 		JBrowse link
G Xbp1 X-box binding protein 1 involved_in ISO (PMID:25239945) RGD PMID:25239945 NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693 		JBrowse link
negative regulation of IRE1-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bfar bifunctional apoptosis regulator involved_in ISO (PMID:21068390) RGD PMID:21068390 NCBI chr10:1,552,019...1,585,040
Ensembl chr10:1,552,072...1,585,038 		JBrowse link
G Ddrgk1 DDRGK domain containing 1 involved_in ISO (PMID:28128204), (PMID:32160526)
(MGI:5912977|PMID:28128204)		 RGD PMID:28128204 PMID:32160526 MGI:5912977 NCBI chr 3:117,861,916...117,882,680
Ensembl chr 3:117,861,653...117,882,680 		JBrowse link
G Dnajb9 DnaJ heat shock protein family (Hsp40) member B9 involved_in ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr 6:61,270,385...61,276,795
Ensembl chr 6:61,269,913...61,275,063 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 involved_in ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Pdia6 protein disulfide isomerase family A, member 6 involved_in ISO (MGI:5571560|PMID:24508390) RGD PMID:24508390 MGI:5571560 NCBI chr 6:40,062,980...40,080,223
Ensembl chr 6:40,062,926...40,080,613 		JBrowse link
G Ufl1 Ufm1-specific ligase 1 involved_in ISO
ISS		 (PMID:32160526)
GO_REF:0000024		 RGD
UniProt		 PMID:32160526 GO_REF:0000024 NCBI chr 5:38,962,721...38,995,134
Ensembl chr 5:38,962,171...38,995,199 		JBrowse link
negative regulation of PERK-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca7 ATP binding cassette subfamily A member 7 involved_in ISO (MGI:5774886|PMID:27030769) RGD PMID:27030769 MGI:5774886 NCBI chr 7:9,691,452...9,711,466
Ensembl chr 7:9,691,449...9,711,425 		JBrowse link
G Nck1 NCK adaptor protein 1 involved_in ISO
IBA		 (PMID:14676213)
PMID:21873635
UniProtKB:O55033 (MGI:5613478|PMID:14676213)		 RGD PMID:14676213 PMID:21873635 MGI:5613478, RGD:13792537 NCBI chr 8:101,018,610...101,079,237
Ensembl chr 8:101,018,702...101,079,300 		JBrowse link
G Nck2 NCK adaptor protein 2 involved_in ISO
IBA		 UniProtKB:Q99M51 (MGI:5613478|PMID:14676213)
PMID:21873635		 RGD PMID:14676213 PMID:21873635 MGI:5613478, RGD:13792537 NCBI chr 9:45,713,979...45,840,330
Ensembl chr 9:45,714,883...45,840,307 		JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 involved_in ISO (PMID:21216966)
(MGI:5619464|PMID:21216966)		 RGD PMID:21216966 MGI:5619464 NCBI chr 3:156,638,811...156,687,503
Ensembl chr 3:156,638,769...156,687,504 		JBrowse link
PERK-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf4 activating transcription factor 4 involved_in ISS
ISO		 GO_REF:0000024
(MGI:3722921|PMID:14729979), (MGI:3798818|PMID:12667446)		 UniProt
RGD		 PMID:12667446 PMID:14729979 GO_REF:0000024 MGI:3722921 MGI:3798818 NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 involved_in ISO (MGI:3722921|PMID:14729979), (MGI:6467680|PMID:17707796) RGD PMID:14729979 PMID:17707796 MGI:3722921 MGI:6467680 NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911 		JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha involved_in ISO
ISS		 (PMID:33384352)
GO_REF:0000024		 RGD
UniProt		 PMID:33384352 GO_REF:0000024 NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225 		JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 involved_in ISO (MGI:2677605|PMID:14517290) RGD PMID:14517290 MGI:2677605 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Qrich1 glutamine-rich 1 involved_in ISO (PMID:33384352) RGD PMID:33384352 NCBI chr 8:109,216,900...109,256,472
Ensembl chr 8:109,217,376...109,261,359 		JBrowse link
G Tmed2 transmembrane p24 trafficking protein 2 acts_upstream_of_or_within ISO MGI:4456438 (MGI:5914333|PMID:28797121) RGD PMID:28797121 MGI:5914333 NCBI chr12:32,052,542...32,061,596
Ensembl chr12:32,052,543...32,071,903 		JBrowse link
positive regulation of ATF6-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf6 activating transcription factor 6 involved_in ISO (PMID:9837962) RGD PMID:9837962 NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177 		JBrowse link
positive regulation of endoplasmic reticulum unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bak1 BCL2-antagonist/killer 1 involved_in ISO (PMID:16645094) RGD PMID:16645094 NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator involved_in ISO
IEA
ISS		 (PMID:16645094)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:16645094 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 involved_in ISO (PMID:16645094), (PMID:28128204) RGD PMID:16645094 PMID:28128204 NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 involved_in ISO
IEA
ISS		 (PMID:20348923)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:20348923 GO_REF:0000024 GO_REF:0000107 NCBI chr 2:32,878,942...32,963,611
Ensembl chr 2:32,882,032...32,963,631 		JBrowse link
G Xbp1 X-box binding protein 1 involved_in ISO
IEA		 (PMID:16645094)
GO_REF:0000107		 RGD
Ensembl		 PMID:16645094 GO_REF:0000107 NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693 		JBrowse link
positive regulation of IRE1-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agr2 anterior gradient 2, protein disulphide isomerase family member involved_in ISO (PMID:23220234) RGD PMID:23220234 NCBI chr 6:52,708,602...52,729,378
Ensembl chr 6:52,708,602...52,729,371 		JBrowse link
G Tmem33 transmembrane protein 33 involved_in ISO
IEA
ISS		 (PMID:26268696)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:26268696 GO_REF:0000024 GO_REF:0000107 NCBI chr14:40,888,485...40,910,715
Ensembl chr14:40,885,712...40,910,715 		JBrowse link
positive regulation of PERK-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agr2 anterior gradient 2, protein disulphide isomerase family member involved_in ISO (PMID:23220234) RGD PMID:23220234 NCBI chr 6:52,708,602...52,729,378
Ensembl chr 6:52,708,602...52,729,371 		JBrowse link
G Bok BCL2 family apoptosis regulator BOK involved_in ISS
ISO		 GO_REF:0000024
(MGI:5648772|PMID:26015568)		 UniProt
RGD		 PMID:26015568 GO_REF:0000024 MGI:5648772 NCBI chr 9:94,223,493...94,234,476
Ensembl chr 9:94,223,389...94,234,476 		JBrowse link
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 involved_in ISO (MGI:5619464|PMID:21216966) RGD PMID:21216966 MGI:5619464 NCBI chr18:61,229,012...61,294,662
Ensembl chr18:61,229,014...61,294,627 		JBrowse link
G Tmem33 transmembrane protein 33 involved_in IEA
ISS
ISO		 GO_REF:0000107
GO_REF:0000024
(PMID:26268696)		 Ensembl
UniProt
RGD		 PMID:26268696 GO_REF:0000024 GO_REF:0000107 NCBI chr14:40,888,485...40,910,715
Ensembl chr14:40,885,712...40,910,715 		JBrowse link
positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein NOT|involved_in ISO (PMID:21803450) RGD PMID:21803450 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Creb3 cAMP responsive element binding protein 3 involved_in ISO (PMID:16940180)
(PMID:16940180), (PMID:18391022)		 RGD PMID:16940180 PMID:18391022 NCBI chr 5:57,817,835...57,823,171
Ensembl chr 5:57,817,832...57,824,390 		JBrowse link
G Ep300 E1A binding protein p300 involved_in ISO (MGI:5607229|PMID:20955178) RGD PMID:20955178 MGI:5607229 NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088 		JBrowse link
G Xbp1 X-box binding protein 1 involved_in IBA
ISO
ISS		 PMID:21873635
(MGI:5605954|PMID:14559994), (MGI:5607229|PMID:20955178), (MGI:5607243|PMID:16332684)
(PMID:25239945)
GO_REF:0000024		 RGD
UniProt		 PMID:14559994 PMID:16332684 PMID:20955178 PMID:25239945 PMID:21873635 GO_REF:0000024 MGI:5605954 MGI:5607229 MGI:5607243, RGD:13792537 NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693 		JBrowse link
regulation of endoplasmic reticulum unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pigbos1 PIGB opposite strand 1 involved_in ISO
ISS		 (PMID:31653868)
GO_REF:0000024		 RGD
UniProt		 PMID:31653868 GO_REF:0000024 NCBI chr 8:73,775,732...73,780,102
Ensembl chr 8:73,775,732...73,780,102 		JBrowse link
regulation of IRE1-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cops5 COP9 signalosome subunit 5 involved_in ISO (PMID:15234121) RGD PMID:15234121 NCBI chr 5:9,192,233...9,210,498
Ensembl chr 5:9,192,100...9,210,731 		JBrowse link
G Ficd FIC domain protein adenylyltransferase involved_in ISO
ISS		 (PMID:25601083)
GO_REF:0000024		 RGD
UniProt		 PMID:25601083 GO_REF:0000024 NCBI chr12:42,889,195...42,894,090
Ensembl chr12:42,889,194...42,894,070 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19390
    cellular process 18252
      signal transduction 6859
        endoplasmic reticulum unfolded protein response 71
          ATF6-mediated unfolded protein response + 3
          IRE1-mediated unfolded protein response + 15
          PERK-mediated unfolded protein response + 14
          negative regulation of endoplasmic reticulum unfolded protein response + 14
          positive regulation of endoplasmic reticulum unfolded protein response + 10
          positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response 4
          regulation of endoplasmic reticulum unfolded protein response + 26
Path 2
Term Annotations click to browse term
  biological_process 19390
    response to stimulus 10323
      cellular response to stimulus 8715
        cellular response to chemical stimulus 3541
          cellular response to organic substance 2868
            cellular response to topologically incorrect protein 117
              cellular response to unfolded protein 97
                endoplasmic reticulum unfolded protein response 71
                  ATF6-mediated unfolded protein response + 3
                  IRE1-mediated unfolded protein response + 15
                  PERK-mediated unfolded protein response + 14
                  negative regulation of endoplasmic reticulum unfolded protein response + 14
                  positive regulation of endoplasmic reticulum unfolded protein response + 10
                  positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response 4
                  regulation of endoplasmic reticulum unfolded protein response + 26
paths to the root