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ONTOLOGY REPORT - ANNOTATIONS

Term:midbrain-hindbrain boundary development
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Accession:GO:0030917 term browser browse the term
Definition:The process whose specific outcome is the progression of the midbrain-hindbrain boundary over time, from its formation to the mature structure. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages.
Synonyms:exact_synonym: MHB development;   isthmic organizer development;   isthmomesencephalic boundary development;   isthmus development;   midbrain-hindbrain orgainizer development


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midbrain-hindbrain boundary development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EN1 engrailed homeobox 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15607945) Ensembl
MGI		 PMID:15607945 GO_REF:0000107 NCBI chr 2:118,842,171...118,847,648
Ensembl chr 2:118,842,171...118,847,648 		JBrowse link
G FGF8 fibroblast growth factor 8 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:17601531) Ensembl
MGI		 PMID:17601531 GO_REF:0000107 NCBI chr10:101,770,109...101,780,369
Ensembl chr10:101,770,109...101,780,371 		JBrowse link
G GBX2 gastrulation brain homeobox 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16651541) Ensembl
MGI		 PMID:16651541 GO_REF:0000107 NCBI chr 2:236,161,340...236,168,386
Ensembl chr 2:236,165,236...236,168,386 		JBrowse link
G LRP6 LDL receptor related protein 6 acts_upstream_of_or_within ISO (PMID:11029008), (PMID:19795512) MGI PMID:11029008 PMID:19795512 NCBI chr12:12,116,025...12,267,044
Ensembl chr12:12,116,025...12,267,044 		JBrowse link
G WNT1 Wnt family member 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:2205396) Ensembl
MGI		 PMID:2205396 GO_REF:0000107 NCBI chr12:48,978,322...48,982,620
Ensembl chr12:48,978,322...48,982,620 		JBrowse link
midbrain-hindbrain boundary initiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SSBP3 single stranded DNA binding protein 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:54,225,432...54,413,490
Ensembl chr 1:54,225,432...54,413,479 		JBrowse link
midbrain-hindbrain boundary maturation during brain development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G WNT1 Wnt family member 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:8555108) Ensembl
MGI		 PMID:8555108 GO_REF:0000107 NCBI chr12:48,978,322...48,982,620
Ensembl chr12:48,978,322...48,982,620 		JBrowse link
midbrain-hindbrain boundary morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GBX2 gastrulation brain homeobox 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16651541) Ensembl
MGI		 PMID:16651541 GO_REF:0000107 NCBI chr 2:236,161,340...236,168,386
Ensembl chr 2:236,165,236...236,168,386 		JBrowse link
G HES1 hes family bHLH transcription factor 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:11500373) Ensembl
MGI		 PMID:11500373 GO_REF:0000107 NCBI chr 3:194,136,148...194,138,732
Ensembl chr 3:194,136,148...194,138,732 		JBrowse link
G HES3 hes family bHLH transcription factor 3 acts_upstream_of_or_within ISO (PMID:11522634) MGI PMID:11522634 NCBI chr 1:6,244,179...6,245,578
Ensembl chr 1:6,244,179...6,245,578 		JBrowse link
G KDM2B lysine demethylase 2B involved_in IEA
ISS		 Ensembl
BHF-UCL		 GO_REF:0000024 GO_REF:0000107 NCBI chr12:121,408,461...121,582,279
Ensembl chr12:121,429,096...121,581,023 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19669
    developmental process 7610
      anatomical structure development 7020
        midbrain-hindbrain boundary development 9
          midbrain-hindbrain boundary initiation 1
          midbrain-hindbrain boundary maturation + 1
          midbrain-hindbrain boundary morphogenesis + 4
Path 2
Term Annotations click to browse term
  biological_process 19669
    developmental process 7610
      anatomical structure development 7020
        multicellular organism development 5632
          embryo development 1396
            embryo development ending in birth or egg hatching 902
              chordate embryonic development 879
                neural tube development 204
                  neural tube patterning 45
                    rostrocaudal neural tube patterning 15
                      midbrain-hindbrain boundary development 9
                        midbrain-hindbrain boundary initiation 1
                        midbrain-hindbrain boundary maturation + 1
                        midbrain-hindbrain boundary morphogenesis + 4
paths to the root