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ONTOLOGY REPORT - ANNOTATIONS

Term:midbrain-hindbrain boundary development
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Accession:GO:0030917 term browser browse the term
Definition:The process whose specific outcome is the progression of the midbrain-hindbrain boundary over time, from its formation to the mature structure. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages.
Synonyms:exact_synonym: MHB development;   isthmic organizer development;   isthmomesencephalic boundary development;   isthmus development;   midbrain-hindbrain orgainizer development

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midbrain-hindbrain boundary development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G En1 engrailed homeobox 1 acts_upstream_of_or_within ISO (PMID:15607945) MGI PMID:15607945 NCBI chrNW_004955459:10,839,581...10,844,198 JBrowse link
G Fgf8 fibroblast growth factor 8 acts_upstream_of_or_within ISO (PMID:17601531) MGI PMID:17601531 NCBI chrNW_004955485:8,517,412...8,521,732
Ensembl chrNW_004955485:8,517,412...8,521,770 		JBrowse link
G Gbx2 gastrulation brain homeobox 2 acts_upstream_of_or_within ISO (PMID:16651541) MGI PMID:16651541 NCBI chrNW_004955453:538,066...541,415
Ensembl chrNW_004955453:538,280...540,306 		JBrowse link
G Lrp6 LDL receptor related protein 6 acts_upstream_of_or_within ISO (PMID:11029008), (PMID:19795512) MGI PMID:11029008 PMID:19795512 NCBI chrNW_004955413:9,080,901...9,237,644
Ensembl chrNW_004955413:9,080,914...9,237,650 		JBrowse link
G Wnt1 Wnt family member 1 acts_upstream_of_or_within ISO (PMID:2205396) MGI PMID:2205396 NCBI chrNW_004955500:7,797,063...7,811,142
Ensembl chrNW_004955500:7,797,060...7,811,167 		JBrowse link
midbrain-hindbrain boundary initiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ssbp3 single stranded DNA binding protein 3 involved_in ISO (MGI:3578570|PMID:15857913) UniProt PMID:15857913 MGI:3578570 NCBI chrNW_004955464:4,901,150...5,049,341
Ensembl chrNW_004955464:4,901,151...5,047,656 		JBrowse link
midbrain-hindbrain boundary maturation during brain development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Wnt1 Wnt family member 1 acts_upstream_of_or_within ISO (PMID:8555108) MGI PMID:8555108 NCBI chrNW_004955500:7,797,063...7,811,142
Ensembl chrNW_004955500:7,797,060...7,811,167 		JBrowse link
midbrain-hindbrain boundary morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gbx2 gastrulation brain homeobox 2 acts_upstream_of_or_within ISO (PMID:16651541) MGI PMID:16651541 NCBI chrNW_004955453:538,066...541,415
Ensembl chrNW_004955453:538,280...540,306 		JBrowse link
G Hes1 hes family bHLH transcription factor 1 acts_upstream_of_or_within ISO (PMID:11500373) MGI PMID:11500373 NCBI chrNW_004955420:14,565,921...14,568,447
Ensembl chrNW_004955420:14,564,283...14,568,447 		JBrowse link
G Hes3 hes family bHLH transcription factor 3 acts_upstream_of_or_within ISO (PMID:11522634) MGI PMID:11522634 NCBI chrNW_004955486:6,272,757...6,273,721
Ensembl chrNW_004955486:6,272,757...6,273,721 		JBrowse link
G Kdm2b lysine demethylase 2B involved_in ISO (MGI:4949568|PMID:21220025) BHF-UCL PMID:21220025 MGI:4949568 NCBI chrNW_004955482:6,774,021...6,885,113
Ensembl chrNW_004955482:6,774,059...6,887,171 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12346
    developmental process 5853
      anatomical structure development 5540
        midbrain-hindbrain boundary development 9
          midbrain-hindbrain boundary initiation 1
          midbrain-hindbrain boundary maturation + 1
          midbrain-hindbrain boundary morphogenesis + 4
Path 2
Term Annotations click to browse term
  biological_process 12346
    developmental process 5853
      anatomical structure development 5540
        multicellular organism development 4550
          embryo development 1224
            embryo development ending in birth or egg hatching 821
              chordate embryonic development 805
                neural tube development 192
                  neural tube patterning 44
                    rostrocaudal neural tube patterning 14
                      midbrain-hindbrain boundary development 9
                        midbrain-hindbrain boundary initiation 1
                        midbrain-hindbrain boundary maturation + 1
                        midbrain-hindbrain boundary morphogenesis + 4
paths to the root