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ONTOLOGY REPORT - ANNOTATIONS


Term:midbrain-hindbrain boundary development
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Accession:GO:0030917 term browser browse the term
Definition:The process whose specific outcome is the progression of the midbrain-hindbrain boundary over time, from its formation to the mature structure. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages.
Synonyms:exact_synonym: MHB development;   isthmic organizer development;   isthmomesencephalic boundary development;   isthmus development;   midbrain-hindbrain orgainizer development



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midbrain-hindbrain boundary development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G En1 engrailed homeobox 1 acts_upstream_of_or_within ISO MGI:1857163 (MGI:3525936|PMID:15607945) RGD PMID:15607945 MGI:3525936 NCBI chr13:31,750,892...31,756,477
Ensembl chr13:31,751,545...31,755,943
JBrowse link
G Fgf8 fibroblast growth factor 8 acts_upstream_of_or_within ISO MGI:2150347 (MGI:3720541|PMID:17601531) RGD PMID:17601531 MGI:3720541 NCBI chr 1:244,584,477...244,590,359
Ensembl chr 1:244,584,652...244,590,359
JBrowse link
G Gbx2 gastrulation brain homeobox 2 acts_upstream_of_or_within ISO MGI:1857634 (MGI:3624192|PMID:16651541) RGD PMID:16651541 MGI:3624192 NCBI chr 9:90,509,633...90,512,212
Ensembl chr 9:90,509,633...90,512,212
JBrowse link
G Lrp6 LDL receptor related protein 6 involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
MGI:2156191 (MGI:1891551|PMID:11029008), (MGI:4413372|PMID:19795512)
RGD PMID:11029008 PMID:19795512 PMID:21873635 MGI:1891551 MGI:4413372, RGD:13792537 NCBI chr 4:167,266,581...167,400,155
Ensembl chr 4:167,270,353...167,400,497
JBrowse link
G Wnt1 Wnt family member 1 acts_upstream_of_or_within ISO MGI:1857490 (MGI:59176|PMID:2205396) RGD PMID:2205396 MGI:59176 NCBI chr 7:129,938,604...129,942,651
Ensembl chr 7:129,938,604...129,942,651
JBrowse link
midbrain-hindbrain boundary initiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ssbp3 single stranded DNA binding protein 3 involved_in IEA
ISO
GO_REF:0000107
(MGI:3578570|PMID:15857913)
Ensembl
RGD
PMID:15857913 GO_REF:0000107 MGI:3578570 NCBI chr 5:121,691,370...121,828,035
Ensembl chr 5:121,691,393...121,827,992
JBrowse link
midbrain-hindbrain boundary maturation during brain development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Wnt1 Wnt family member 1 acts_upstream_of_or_within ISO MGI:1856382 (MGI:76584|PMID:8555108) RGD PMID:8555108 MGI:76584 NCBI chr 7:129,938,604...129,942,651
Ensembl chr 7:129,938,604...129,942,651
JBrowse link
midbrain-hindbrain boundary morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gbx2 gastrulation brain homeobox 2 acts_upstream_of_or_within ISO MGI:1857634 (MGI:3624192|PMID:16651541) RGD PMID:16651541 MGI:3624192 NCBI chr 9:90,509,633...90,512,212
Ensembl chr 9:90,509,633...90,512,212
JBrowse link
G Hes1 hes family bHLH transcription factor 1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:104877 (MGI:2149154|PMID:11500373)
Ensembl
RGD
PMID:11500373 GO_REF:0000107 MGI:2149154 NCBI chr11:70,705,763...70,708,176
Ensembl chr11:70,705,764...70,708,192
JBrowse link
G Hes3 hes family bHLH transcription factor 3 acts_upstream_of_or_within ISO MGI:104853 (MGI:2149134|PMID:11522634) RGD PMID:11522634 MGI:2149134 NCBI chr 5:162,793,611...162,799,578
Ensembl chr 5:162,794,367...162,796,261
JBrowse link
G Kdm2b lysine demethylase 2B involved_in ISO (MGI:4949568|PMID:21220025) RGD PMID:21220025 MGI:4949568 NCBI chr12:33,566,530...33,701,366
Ensembl chr12:33,574,657...33,701,355
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19812
    developmental process 6948
      anatomical structure development 6361
        midbrain-hindbrain boundary development 9
          midbrain-hindbrain boundary initiation 1
          midbrain-hindbrain boundary maturation + 1
          midbrain-hindbrain boundary morphogenesis + 4
Path 2
Term Annotations click to browse term
  biological_process 19812
    developmental process 6948
      anatomical structure development 6361
        multicellular organism development 5787
          embryo development 1357
            embryo development ending in birth or egg hatching 871
              chordate embryonic development 855
                neural tube development 198
                  neural tube patterning 50
                    rostrocaudal neural tube patterning 14
                      midbrain-hindbrain boundary development 9
                        midbrain-hindbrain boundary initiation 1
                        midbrain-hindbrain boundary maturation + 1
                        midbrain-hindbrain boundary morphogenesis + 4
paths to the root