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ONTOLOGY REPORT - ANNOTATIONS


Term:replisome
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Accession:GO:0030894 term browser browse the term
Definition:A multi-component enzymatic machine at the replication fork which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins.
Synonyms:related_synonym: DNA synthesome complex;   RC complex;   replication-competent complex
 xref: Wikipedia:Replisome


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replisome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Donson DNA replication fork stabilization factor DONSON ISO (PMID:28191891) RGD PMID:28191891 NCBI chr11:31,834,608...31,847,751
Ensembl chr11:31,837,839...31,847,490
JBrowse link
alpha DNA polymerase:primase complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pola1 DNA polymerase alpha 1, catalytic subunit IDA
ISO
IBA
ISS
IEA
IC
(MGI:1203906|PMID:9584195)
(PMID:2175912), (PMID:22465957)
PMID:21873635
GO_REF:0000024
GO_REF:0000107
RGD
UniProt
Ensembl
PMID:2175912, PMID:9584195, PMID:22465957, PMID:7670930, PMID:21873635, PMID:7503737 GO_REF:0000024, GO_REF:0000107, MGI:1203906, RGD:1580605, RGD:13792537, RGD:2307013 NCBI chr  X:62,382,604...62,698,830
Ensembl chr  X:62,382,608...62,698,830
JBrowse link
G Pola2 DNA polymerase alpha 2, accessory subunit TAS
ISO
IBA
IEA
IC
(MGI:1203906|PMID:9584195)
(PMID:22465957)
PMID:21873635
GO_REF:0000107
RGD
Ensembl
PMID:9584195, PMID:22465957, PMID:11536367, PMID:21873635, PMID:7503737 GO_REF:0000107, MGI:1203906, RGD:633584, RGD:13792537, RGD:2307013 NCBI chr 1:221,297,417...221,321,601
Ensembl chr 1:221,273,538...221,321,570
JBrowse link
G Prim1 DNA primase subunit 1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 7:2,435,524...2,451,169
Ensembl chr 7:2,435,553...2,451,165
JBrowse link
G Prim2 DNA primase subunit 2 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 9:38,535,435...38,745,058
Ensembl chr 9:38,536,920...38,745,099
JBrowse link
delta DNA polymerase complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pold1 DNA polymerase delta 1, catalytic subunit IC
ISO
IEA
IBA
IDA
(MGI:6383350|PMID:11595739)
GO_REF:0000107
(PMID:11595739), (PMID:22465957)
PMID:21873635
RGD
Ensembl
PMID:11595739, PMID:22465957, PMID:7503737, PMID:21873635, PMID:10541966 GO_REF:0000107, MGI:6383350, RGD:2307013, RGD:13792537, RGD:729526 NCBI chr 1:100,538,066...100,554,105
Ensembl chr 1:100,537,900...100,554,488
JBrowse link
G Pold2 DNA polymerase delta 2, accessory subunit IC
ISO
IBA
IDA
(MGI:6383350|PMID:11595739)
(PMID:11595739), (PMID:22465957)
PMID:21873635
RGD PMID:11595739, PMID:22465957, PMID:7503737, PMID:21873635, PMID:10541966 MGI:6383350, RGD:2307013, RGD:13792537, RGD:729526 NCBI chr14:86,111,416...86,117,578
Ensembl chr14:86,111,294...86,117,578
JBrowse link
G Pold3 DNA polymerase delta 3, accessory subunit IC
IBA
ISO
PMID:21873635
(PMID:11595739), (PMID:22465957)
(MGI:6383350|PMID:11595739)
RGD PMID:11595739, PMID:22465957, PMID:7503737, PMID:21873635 MGI:6383350, RGD:2307013, RGD:13792537 NCBI chr 1:165,085,142...165,122,385
Ensembl chr 1:165,083,622...165,123,455
JBrowse link
G Pold4 DNA polymerase delta 4, accessory subunit IC
IBA
PMID:21873635 RGD
GO_Central
PMID:7503737, PMID:21873635 RGD:2307013, RGD:13792537 NCBI chr 1:219,480,841...219,483,244
Ensembl chr 1:219,481,575...219,483,241
JBrowse link
DNA replication factor A complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AC095390.1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 Ensembl chr12:51,965,417...51,965,779 JBrowse link
G Bcas2 BCAS2, pre-mRNA processing factor colocalizes_with ISO (PMID:24332808) RGD PMID:24332808 NCBI chr 2:205,662,633...205,670,514
Ensembl chr 2:205,662,588...205,670,511
JBrowse link
G Cdc5l cell division cycle 5-like colocalizes_with ISO
ISS
(PMID:24332808)
GO_REF:0000024
RGD
UniProt
PMID:24332808 GO_REF:0000024 NCBI chr 9:17,949,764...17,988,514
Ensembl chr 9:17,949,764...17,988,509
JBrowse link
G Ercc5 ERCC excision repair 5, endonuclease colocalizes_with ISO (PMID:7700386) RGD PMID:7700386 NCBI chr 9:50,928,847...50,970,962
Ensembl chr 9:50,925,619...50,970,955
JBrowse link
G Helb DNA helicase B colocalizes_with ISO (PMID:26774285) RGD PMID:26774285 NCBI chr 7:64,860,641...64,888,146
Ensembl chr 7:64,860,666...64,887,448
JBrowse link
G LOC100362927 replication protein A3-like IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr12:51,965,390...51,965,816 JBrowse link
G Plrg1 pleiotropic regulator 1 colocalizes_with ISO
IBA
ISS
(PMID:24332808)
PMID:21873635
GO_REF:0000024
RGD
UniProt
PMID:24332808, PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr 2:182,040,338...182,056,669
Ensembl chr 2:182,040,318...182,056,673
JBrowse link
G Prpf19 pre-mRNA processing factor 19 colocalizes_with ISO
ISS
(PMID:24332808)
GO_REF:0000024
RGD
UniProt
PMID:24332808 GO_REF:0000024 NCBI chr 1:226,947,065...226,958,147
Ensembl chr 1:226,947,105...226,958,144
JBrowse link
G Rpa1 replication protein A1 IDA
IBA
ISO
PMID:21873635
UniProtKB:P15927 (PMID:11927569), (PMID:16135809), (PMID:27723717), (PMID:27723720)
RGD PMID:11927569, PMID:16135809, PMID:27723717, PMID:27723720, PMID:8463251, PMID:21873635, PMID:7503737 RGD:2307012, RGD:13792537, RGD:2307013 NCBI chr10:62,140,419...62,191,518
Ensembl chr10:62,140,419...62,191,512
JBrowse link
G Rpa2 replication protein A2 IDA
IBA
ISO
PMID:21873635
UniProtKB:P27694 (PMID:11927569), (PMID:16135809), (PMID:2406247), (PMID:27723717), (PMID:27723720)
RGD PMID:2406247, PMID:11927569, PMID:16135809, PMID:27723717, PMID:27723720, PMID:8463251, PMID:21873635, PMID:7503737 RGD:2307012, RGD:13792537, RGD:2307013 NCBI chr 5:150,957,041...150,967,597
Ensembl chr 5:150,957,001...150,968,269
JBrowse link
G Rpa3 replication protein A3 IDA
IBA
ISO
PMID:21873635
(PMID:11927569)
RGD PMID:11927569, PMID:7503737, PMID:21873635 RGD:2307013, RGD:13792537 NCBI chr 4:34,279,320...34,282,351
Ensembl chr 4:34,279,320...34,282,351
JBrowse link
G Smarcal1 Swi/SNF related matrix associated, actin dependent regulator of chromatin, subfamily a-like 1 colocalizes_with ISS
IBA
ISO
GO_REF:0000024
PMID:21873635
(PMID:19793862), (PMID:19793863)
UniProt
RGD
PMID:19793862, PMID:19793863, PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr 9:79,943,775...79,990,230
Ensembl chr 9:79,944,132...79,990,229
JBrowse link
G Tonsl tonsoku-like, DNA repair protein colocalizes_with ISO
ISS
(PMID:21055983)
GO_REF:0000024
RGD
UniProt
PMID:21055983 GO_REF:0000024 NCBI chr 7:117,688,397...117,703,139
Ensembl chr 7:117,688,397...117,703,094
JBrowse link
G Xpa XPA, DNA damage recognition and repair factor colocalizes_with ISO (PMID:7700386) RGD PMID:7700386 NCBI chr 5:61,749,767...61,793,641
Ensembl chr 5:61,749,767...61,792,928
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 20602
    cellular anatomical entity 20292
      replication fork 73
        replisome 23
          cytoplasmic replisome + 0
          nuclear replisome + 22
          primosome complex + 0
          replication inhibiting complex + 0
Path 2
Term Annotations click to browse term
  cellular_component 20602
    cellular anatomical entity 20292
      intracellular anatomical structure 14638
        intracellular organelle 12405
          intracellular non-membrane-bounded organelle 5177
            chromosome 1421
              replication fork 73
                replisome 23
                  cytoplasmic replisome + 0
                  nuclear replisome + 22
                  primosome complex + 0
                  replication inhibiting complex + 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.