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ONTOLOGY REPORT - ANNOTATIONS


Term:beta-catenin destruction complex
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Accession:GO:0030877 term browser browse the term
Definition:A cytoplasmic protein complex containing glycogen synthase kinase-3-beta (GSK-3-beta), the adenomatous polyposis coli protein (APC), and the scaffolding protein axin, among others; phosphorylates beta-catenin, targets it for degradation by the proteasome.
Comment:Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'.
Synonyms:exact_synonym: APC-Axin-1-beta-catenin complex;   Axin-APC-beta-catenin-GSK3B complex;   BDC;   beta-catenin degradation complex
 narrow_synonym: 23S APC complex
 alt_id: GO:0034742;   GO:0034747


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beta-catenin destruction complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apc APC regulator of WNT signaling pathway part_of IEA
ISS
IBA
ISO
GO_REF:0000107
GO_REF:0000024
PMID:21873635
(PMID:16188939), (PMID:8638126), (PMID:9601641)
Ensembl
UniProt
RGD
PMID:8638126 PMID:9601641 PMID:16188939, PMID:21873635 GO_REF:0000024 GO_REF:0000107, RGD:13792537 NCBI chr18:27,011,710...27,106,323
Ensembl chr18:27,047,382...27,105,531
JBrowse link
G Apc2 APC regulator of WNT signaling pathway 2 part_of IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 7:12,258,468...12,280,459
Ensembl chr 7:12,258,468...12,275,609
JBrowse link
G Axin1 axin 1 part_of IDA
ISO
PMID:10228155
(MGI:1336856|PMID:10318824)
(PMID:16188939), (PMID:19759537), (PMID:9601641)
RGD PMID:9601641 PMID:10318824 PMID:16188939 PMID:19759537, PMID:10228155 MGI:1336856, RGD:8553327
G Cacybp calcyclin binding protein part_of ISO (PMID:16085652) RGD PMID:16085652 NCBI chr13:77,948,771...77,959,089
Ensembl chr13:77,948,771...77,959,110
JBrowse link
G Csnk1a1 casein kinase 1, alpha 1 part_of ISO
IEA
ISS
(PMID:11955436)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
ParkinsonsUK-UCL
PMID:11955436 GO_REF:0000024 GO_REF:0000107 NCBI chr18:56,887,722...56,910,610
Ensembl chr18:56,887,354...56,918,345
JBrowse link
G Ctnnb1 catenin beta 1 part_of IEA
ISO
ISS
GO_REF:0000107
(MGI:1336856|PMID:10318824)
GO_REF:0000024
(PMID:16188939), (PMID:8638126)
Ensembl
RGD
UniProt
PMID:8638126 PMID:10318824 PMID:16188939 GO_REF:0000024 GO_REF:0000107 MGI:1336856 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Ctnnbip1 catenin, beta-interacting protein 1 part_of ISO
IBA
(PMID:16188939)
PMID:21873635
RGD PMID:16188939, PMID:21873635 RGD:13792537 NCBI chr 5:166,464,170...166,513,030
Ensembl chr 5:166,464,252...166,513,027
JBrowse link
G Dact1 dishevelled-binding antagonist of beta-catenin 1 colocalizes_with ISO (PMID:22470507) RGD PMID:22470507 NCBI chr 6:93,740,440...93,751,003
Ensembl chr 6:93,740,586...93,749,809
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta part_of IDA
IEA
ISO
IBA
PMID:10228155
GO_REF:0000107
(MGI:1336856|PMID:10318824)
PMID:21873635
(PMID:16188939), (PMID:8638126), (PMID:9601641)
Ensembl
RGD
PMID:8638126 PMID:9601641 PMID:10318824 PMID:16188939, PMID:10228155, PMID:21873635 GO_REF:0000107 MGI:1336856, RGD:8553327, RGD:13792537 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Siah1 siah E3 ubiquitin protein ligase 1 part_of ISS
ISO
GO_REF:0000024
(PMID:16085652)
UniProt
RGD
PMID:16085652 GO_REF:0000024 NCBI chr19:21,372,163...21,395,773
Ensembl chr19:21,372,163...21,395,767
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 20142
    protein-containing complex 6031
      beta-catenin destruction complex 10
Path 2
Term Annotations click to browse term
  cellular_component 20142
    cellular anatomical entity 19842
      intracellular anatomical structure 14431
        cytoplasm 11417
          beta-catenin destruction complex 10
paths to the root