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ONTOLOGY REPORT - ANNOTATIONS


Term:beta-catenin destruction complex
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Accession:GO:0030877 term browser browse the term
Definition:A cytoplasmic protein complex containing glycogen synthase kinase-3-beta (GSK-3-beta), the adenomatous polyposis coli protein (APC), and the scaffolding protein axin, among others; phosphorylates beta-catenin, targets it for degradation by the proteasome.
Comment:Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'.
Synonyms:exact_synonym: APC-Axin-1-beta-catenin complex;   Axin-APC-beta-catenin-GSK3B complex;   BDC;   beta-catenin degradation complex
 narrow_synonym: 23S APC complex
 alt_id: GO:0034742;   GO:0034747



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beta-catenin destruction complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apc APC regulator of WNT signaling pathway part_of IEA
ISS
IBA
ISO
GO_REF:0000107
GO_REF:0000024
PMID:21873635
(PMID:16188939), (PMID:8638126), (PMID:9601641)
Ensembl
UniProt
RGD
PMID:8638126 PMID:9601641 PMID:16188939 PMID:21873635 GO_REF:0000024 GO_REF:0000107, RGD:13792537 NCBI chr18:25,828,558...25,925,511
Ensembl chr18:25,864,222...25,922,696
JBrowse link
G Apc2 APC regulator of WNT signaling pathway 2 part_of IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 7:9,392,336...9,414,364
Ensembl chr 7:9,392,336...9,414,310
JBrowse link
G Axin1 axin 1 part_of IDA
ISO
PMID:10228155
(MGI:1336856|PMID:10318824)
(PMID:16188939), (PMID:19759537), (PMID:9601641)
RGD PMID:9601641 PMID:10318824 PMID:16188939 PMID:19759537 PMID:10228155 MGI:1336856, RGD:8553327 NCBI chr10:15,163,684...15,215,615
Ensembl chr10:15,163,684...15,215,615
JBrowse link
G Cacybp calcyclin binding protein part_of ISO
IEA
(PMID:16085652)
GO_REF:0000107
RGD
Ensembl
PMID:16085652 GO_REF:0000107 NCBI chr13:72,437,485...72,447,810
Ensembl chr13:72,437,490...72,450,177
JBrowse link
G Csnk1a1 casein kinase 1, alpha 1 part_of ISO
IEA
ISS
(PMID:11955436)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
ParkinsonsUK-UCL
PMID:11955436 GO_REF:0000024 GO_REF:0000107 NCBI chr18:55,017,049...55,050,184
Ensembl chr18:55,017,055...55,049,271
JBrowse link
G Ctnnb1 catenin beta 1 part_of IEA
ISO
ISS
GO_REF:0000107
(MGI:1336856|PMID:10318824)
GO_REF:0000024
(PMID:16188939), (PMID:8638126)
Ensembl
RGD
UniProt
PMID:8638126 PMID:10318824 PMID:16188939 GO_REF:0000024 GO_REF:0000107 MGI:1336856 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
JBrowse link
G Ctnnbip1 catenin, beta-interacting protein 1 part_of ISO
IBA
(PMID:16188939)
PMID:21873635
RGD PMID:16188939 PMID:21873635 RGD:13792537 NCBI chr 5:159,961,961...160,010,942
Ensembl chr 5:159,961,928...160,010,939
JBrowse link
G Dact1 dishevelled-binding antagonist of beta-catenin 1 colocalizes_with
part_of
ISO
IEA
(PMID:22470507)
GO_REF:0000107
RGD
Ensembl
PMID:22470507 GO_REF:0000107 NCBI chr 6:89,790,676...89,818,254
Ensembl chr 6:89,790,644...89,817,906
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta part_of IDA
IEA
ISO
IBA
PMID:10228155
GO_REF:0000107
(MGI:1336856|PMID:10318824)
PMID:21873635
(PMID:16188939), (PMID:8638126), (PMID:9601641)
Ensembl
RGD
PMID:8638126 PMID:9601641 PMID:10318824 PMID:16188939 PMID:10228155 More... GO_REF:0000107 MGI:1336856, RGD:8553327, RGD:13792537 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Siah1 siah E3 ubiquitin protein ligase 1 part_of ISS
ISO
GO_REF:0000024
(PMID:16085652)
UniProt
RGD
PMID:16085652 GO_REF:0000024 NCBI chr19:20,378,908...20,402,512
Ensembl chr19:20,378,439...20,403,808
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 19969
    protein-containing complex 6165
      beta-catenin destruction complex 10
Path 2
Term Annotations click to browse term
  cellular_component 19969
    cellular anatomical entity 19676
      intracellular anatomical structure 14364
        cytoplasm 11373
          beta-catenin destruction complex 10
paths to the root