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ONTOLOGY REPORT - ANNOTATIONS


Term:cortical actin cytoskeleton
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Accession:GO:0030864 term browser browse the term
Definition:The portion of the actin cytoskeleton, comprising filamentous actin and associated proteins, that lies just beneath the plasma membrane.


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cortical actin cytoskeleton term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Actn1 actinin alpha 1 located_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936495:12,124,489...12,217,223
Ensembl chrNW_004936495:12,124,443...12,217,242
JBrowse link
G Actn2 actinin alpha 2 located_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936484:16,186,844...16,248,394
Ensembl chrNW_004936484:16,186,642...16,248,400
JBrowse link
G Actn3 actinin alpha 3 located_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936599:3,033,854...3,046,364
Ensembl chrNW_004936599:3,029,202...3,046,385
JBrowse link
G Actn4 actinin alpha 4 located_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936801:1,333,077...1,402,885
Ensembl chrNW_004936801:1,333,077...1,404,054
JBrowse link
G Akap13 A-kinase anchoring protein 13 located_in ISO (PMID:11546812) UniProt PMID:11546812 NCBI chrNW_004936483:11,661,862...11,977,292 JBrowse link
G Cap1 cyclase associated actin cytoskeleton regulatory protein 1 located_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936474:21,854,454...21,881,622
Ensembl chrNW_004936474:21,854,330...21,881,622
JBrowse link
G Cdh1 cadherin 1 located_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936475:18,990,529...19,065,954
Ensembl chrNW_004936475:18,990,474...19,067,203
JBrowse link
G Cdh2 cadherin 2 located_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936550:6,885,484...7,067,001
Ensembl chrNW_004936550:6,886,706...6,945,056
JBrowse link
G Cfl1 cofilin 1 located_in ISO (PMID:15004221), (PMID:15548599) MGI PMID:15004221 PMID:15548599 NCBI chrNW_004936599:3,678,724...3,682,314
Ensembl chrNW_004936599:3,677,804...3,682,307
JBrowse link
G Cldn5 claudin 5 located_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936619:3,455,508...3,457,053
Ensembl chrNW_004936619:3,456,166...3,456,822
JBrowse link
G Coro1a coronin 1A located_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936501:12,338,542...12,344,236
Ensembl chrNW_004936501:12,338,542...12,344,265
JBrowse link
G Cotl1 coactosin like F-actin binding protein 1 located_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936641:3,422,734...3,458,830
Ensembl chrNW_004936641:3,423,144...3,455,432
JBrowse link
G Cttn cortactin located_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936599:481,234...503,857
Ensembl chrNW_004936599:481,243...501,743
JBrowse link
G Dbn1 drebrin 1 located_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936597:1,735,589...1,751,628
Ensembl chrNW_004936597:1,735,380...1,747,569
JBrowse link
G Dbnl drebrin like located_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936478:19,007,630...19,021,068
Ensembl chrNW_004936478:19,007,672...19,020,361
JBrowse link
G Dlc1 DLC1 Rho GTPase activating protein located_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936573:2,493,051...2,658,396
Ensembl chrNW_004936573:2,492,875...2,658,714
JBrowse link
G Dst dystonin located_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936476:4,344,673...4,772,892
Ensembl chrNW_004936476:4,344,716...4,771,878
JBrowse link
G Dstn destrin, actin depolymerizing factor located_in ISO (PMID:15548599) MGI PMID:15548599 NCBI chrNW_004936485:2,504,492...2,537,507
Ensembl chrNW_004936485:2,504,234...2,538,203
JBrowse link
G Eef1a1 eukaryotic translation elongation factor 1 alpha 1 located_in ISO (PMID:19158340) UniProt PMID:19158340 NCBI chrNW_004936859:740,620...744,534
Ensembl chrNW_004936859:740,615...744,262
JBrowse link
G Flot1 flotillin 1 located_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936837:387,012...401,076
Ensembl chrNW_004936837:380,288...401,071
JBrowse link
G Flot2 flotillin 2 located_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936538:5,071,546...5,090,287
Ensembl chrNW_004936538:5,071,546...5,090,313
JBrowse link
G Gsn gelsolin located_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936487:9,749,755...9,802,787
Ensembl chrNW_004936487:9,764,944...9,802,841
JBrowse link
G Gys2 glycogen synthase 2 located_in ISO PMID:9003423 UniProt PMID:9003423 RGD:8553883 NCBI chrNW_004936548:5,256,185...5,309,758
Ensembl chrNW_004936548:5,256,437...5,309,758
JBrowse link
G Hcls1 hematopoietic cell-specific Lyn substrate 1 located_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936536:8,065,489...8,084,777
Ensembl chrNW_004936536:8,065,464...8,083,923
JBrowse link
G Iqgap1 IQ motif containing GTPase activating protein 1 located_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936483:16,489,127...16,594,712
Ensembl chrNW_004936483:16,489,133...16,594,783
JBrowse link
G Lancl2 LanC like glutathione S-transferase 2 located_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936678:217,272...268,780
Ensembl chrNW_004936678:219,991...265,627
JBrowse link
G Lasp1 LIM and SH3 protein 1 located_in ISO PMID:10806114 UniProt PMID:10806114 RGD:8553950 NCBI chrNW_004936490:14,267,185...14,296,114
Ensembl chrNW_004936490:14,263,973...14,298,951
JBrowse link
G Llgl1 LLGL scribble cell polarity complex component 1 located_in IEA Ensembl
TreeGrafter
GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936741:1,770,797...1,784,716
Ensembl chrNW_004936741:1,770,620...1,788,356
JBrowse link
G Llgl2 LLGL scribble cell polarity complex component 2 located_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936594:754,140...792,493
Ensembl chrNW_004936594:765,310...792,155
JBrowse link
G LOC101973720 rap guanine nucleotide exchange factor 3 located_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936512:5,636,197...5,659,606
Ensembl chrNW_004936512:5,636,758...5,659,300
Ensembl chrNW_004936512:5,636,758...5,659,300
JBrowse link
G Med28 mediator complex subunit 28 located_in ISO (PMID:15467741) MGI PMID:15467741 NCBI chrNW_004936477:10,586,436...10,592,366 JBrowse link
G Misp mitotic spindle positioning located_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936588:290,620...294,058
Ensembl chrNW_004936588:290,662...294,248
JBrowse link
G Mlph melanophilin located_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936525:776,102...821,067
Ensembl chrNW_004936525:775,955...821,085
JBrowse link
G Mobp myelin associated oligodendrocyte basic protein located_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936473:28,663,986...28,709,394
Ensembl chrNW_004936473:28,689,242...28,697,772
JBrowse link
G Mtss2 MTSS I-BAR domain containing 2 located_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936475:22,948,608...22,967,489
Ensembl chrNW_004936475:22,950,793...22,967,467
JBrowse link
G Myadm myeloid associated differentiation marker located_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936994:78,989...83,536
Ensembl chrNW_004936994:80,439...83,536
JBrowse link
G Myo1a myosin IA located_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936646:1,238,630...1,258,491
Ensembl chrNW_004936646:1,238,865...1,258,040
JBrowse link
G Myo1f myosin IF located_in ISO (PMID:17023661) MGI PMID:17023661 NCBI chrNW_004936588:5,299,977...5,331,065
Ensembl chrNW_004936588:5,302,018...5,336,345
JBrowse link
G Myrip myosin VIIA and Rab interacting protein located_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936473:28,921,837...29,252,737
Ensembl chrNW_004936473:28,982,604...29,252,745
JBrowse link
G Myzap myocardial zonula adherens protein located_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936471:18,853,797...18,940,362
Ensembl chrNW_004936471:18,853,923...18,939,507
JBrowse link
G Nf2 NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor located_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936657:3,536,212...3,622,999
Ensembl chrNW_004936657:3,536,141...3,623,821
JBrowse link
G Pdlim2 PDZ and LIM domain 2 located_in ISO RGD PMID:15505042 RGD:1359754 NCBI chrNW_004936555:6,318,813...6,331,556
Ensembl chrNW_004936555:6,318,762...6,331,575
JBrowse link
G Pjvk pejvakin located_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936509:7,670,557...7,677,480
Ensembl chrNW_004936509:7,670,325...7,677,581
JBrowse link
G Plekhh2 pleckstrin homology, MyTH4 and FERM domain containing H2 located_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936508:8,153,367...8,268,760
Ensembl chrNW_004936508:8,153,122...8,268,779
JBrowse link
G Ppp1r9a protein phosphatase 1 regulatory subunit 9A located_in ISO (PMID:15996550) MGI PMID:15996550 NCBI chrNW_004936585:4,981,555...5,277,185 JBrowse link
G Ppp1r9b protein phosphatase 1 regulatory subunit 9B located_in ISO (PMID:15996550) MGI PMID:15996550 NCBI chrNW_004936490:11,497,389...11,514,191 JBrowse link
G Rdx radixin located_in ISO (MGI:5645204|PMID:21047789) UniProt PMID:21047789 MGI:5645204 RGD:10054076 NCBI chrNW_004936612:3,992,542...4,060,598
Ensembl chrNW_004936612:3,992,542...4,040,315
JBrowse link
G Scnn1a sodium channel epithelial 1 subunit alpha ISO RGD PMID:16356937 RGD:1624121 NCBI chrNW_004936709:1,377,852...1,403,398
Ensembl chrNW_004936709:1,377,831...1,403,833
JBrowse link
G Shroom1 shroom family member 1 located_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936647:2,371,673...2,385,037
Ensembl chrNW_004936647:2,371,612...2,385,045
JBrowse link
G Shroom2 shroom family member 2 located_in IEA Ensembl
TreeGrafter
GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936644:42,620...127,481
Ensembl chrNW_004936644:42,581...127,531
JBrowse link
G Shroom3 shroom family member 3 located_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936676:533,654...703,549
Ensembl chrNW_004936676:409,926...703,839
JBrowse link
G Shroom4 shroom family member 4 located_in ISO (MGI:3690292|PMID:16684770) HGNC-UCL PMID:16684770 MGI:3690292 NCBI chrNW_004936721:2,068,731...2,166,537 JBrowse link
G Slc2a1 solute carrier family 2 member 1 located_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936474:24,205,878...24,236,611
Ensembl chrNW_004936474:24,206,644...24,236,713
JBrowse link
G Spta1 spectrin alpha, erythrocytic 1 located_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936740:1,686,218...1,759,083
Ensembl chrNW_004936740:1,686,218...1,759,078
JBrowse link
G Sptan1 spectrin alpha, non-erythrocytic 1 located_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936487:16,071,043...16,142,662
Ensembl chrNW_004936487:16,070,996...16,142,662
JBrowse link
G Sptb spectrin beta, erythrocytic located_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936495:8,415,950...8,540,590
Ensembl chrNW_004936495:8,415,912...8,486,039
JBrowse link
G Sptbn1 spectrin beta, non-erythrocytic 1 located_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936491:920,830...1,108,374
Ensembl chrNW_004936491:956,986...1,108,640
JBrowse link
G Sptbn2 spectrin beta, non-erythrocytic 2 located_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936599:2,890,404...2,928,502
Ensembl chrNW_004936599:2,890,817...2,928,499
JBrowse link
G Sptbn4 spectrin beta, non-erythrocytic 4 located_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936661:2,831,132...2,903,619
Ensembl chrNW_004936661:2,827,572...2,903,655
JBrowse link
G Trpv4 transient receptor potential cation channel subfamily V member 4 located_in ISO PMID:20657843 BHF-UCL PMID:20657843 RGD:8553293 NCBI chrNW_004936769:1,424,526...1,447,547
Ensembl chrNW_004936769:1,424,549...1,447,516
JBrowse link
G Utrn utrophin ISO RGD PMID:10760950 RGD:1580541 NCBI chrNW_004936625:1,490,327...1,999,428
Ensembl chrNW_004936625:1,489,696...1,894,813
JBrowse link
G Wdr1 WD repeat domain 1 located_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936477:16,643,142...16,682,450
Ensembl chrNW_004936477:16,629,856...16,682,450
JBrowse link
actin cap term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Actr2 actin related protein 2 located_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936491:9,980,228...10,021,417
Ensembl chrNW_004936491:9,979,427...10,022,043
JBrowse link
G Cald1 caldesmon 1 located_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936579:868,681...1,046,198
Ensembl chrNW_004936579:868,500...1,046,257
JBrowse link
G Gsn gelsolin located_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936487:9,749,755...9,802,787
Ensembl chrNW_004936487:9,764,944...9,802,841
JBrowse link
G Wasl WASP like actin nucleation promoting factor located_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936605:1,741,832...1,816,694
Ensembl chrNW_004936605:1,742,776...1,816,690
JBrowse link
actomyosin contractile ring term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anln anillin actin binding protein located_in IEA Ensembl
TreeGrafter
GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936478:11,873,676...11,934,425
Ensembl chrNW_004936478:11,880,103...11,933,247
JBrowse link
G LOC120884505 myosin-2-like located_in IEA Ensembl GO_REF:0000107
G Maea macrophage erythroblast attacher, E3 ubiquitin ligase located_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936477:21,959,465...21,996,395
Ensembl chrNW_004936477:21,959,465...21,996,937
JBrowse link
G Myh2 myosin heavy chain 2 located_in ISO (PMID:15548599) MGI PMID:15548599 NCBI chrNW_004936595:3,391,179...3,398,610 JBrowse link
G Myh9 myosin heavy chain 9 located_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936492:4,384,215...4,466,229
Ensembl chrNW_004936492:4,384,215...4,466,262
JBrowse link
G Pstpip1 proline-serine-threonine phosphatase interacting protein 1 located_in ISO (PMID:9265651) MGI PMID:9265651 NCBI chrNW_004936471:35,272,263...35,294,942
Ensembl chrNW_004936471:35,272,137...35,313,154
JBrowse link
G Rtkn rhotekin located_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936556:650,303...665,324
Ensembl chrNW_004936556:650,303...665,324
JBrowse link
cuticular plate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Calb1 calbindin 1 ISO RGD PMID:16120789 RGD:7175527 NCBI chrNW_004936544:3,858,344...3,881,985
Ensembl chrNW_004936544:3,858,344...3,882,106
JBrowse link
G Calb2 calbindin 2 ISO RGD PMID:16120789 RGD:7175527 NCBI chrNW_004936475:22,344,416...22,372,015
Ensembl chrNW_004936475:22,341,822...22,372,609
JBrowse link
G Cib2 calcium and integrin binding family member 2 located_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936471:36,859,018...36,879,170
Ensembl chrNW_004936471:36,859,018...36,878,878
JBrowse link
G Fchsd1 FCH and double SH3 domains 1 located_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936504:12,516,226...12,526,306
Ensembl chrNW_004936504:12,516,226...12,526,306
JBrowse link
G Kncn kinocilin located_in IEA Ensembl
TreeGrafter
GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936474:27,559,270...27,562,193
Ensembl chrNW_004936474:27,559,270...27,562,193
JBrowse link
G Myo1e myosin IE ISO RGD PMID:12486594 RGD:1298992 NCBI chrNW_004936471:20,244,424...20,435,604
Ensembl chrNW_004936471:20,244,397...20,435,648
JBrowse link
G Pvalb parvalbumin ISO RGD PMID:16120789 RGD:7175527 NCBI chrNW_004936492:4,048,459...4,064,024
Ensembl chrNW_004936492:4,048,470...4,064,019
JBrowse link
G Snx9 sorting nexin 9 located_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936489:9,736,255...9,804,841
Ensembl chrNW_004936489:9,736,242...9,804,874
JBrowse link
G Spta1 spectrin alpha, erythrocytic 1 located_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936740:1,686,218...1,759,083
Ensembl chrNW_004936740:1,686,218...1,759,078
JBrowse link
G Sptan1 spectrin alpha, non-erythrocytic 1 located_in ISO (PMID:18796539) MGI PMID:18796539 NCBI chrNW_004936487:16,071,043...16,142,662
Ensembl chrNW_004936487:16,070,996...16,142,662
JBrowse link
G Sptbn1 spectrin beta, non-erythrocytic 1 located_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936491:920,830...1,108,374
Ensembl chrNW_004936491:956,986...1,108,640
JBrowse link
G Tmc2 transmembrane channel like 2 located_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936485:16,051,974...16,122,899
Ensembl chrNW_004936485:16,051,974...16,109,978
JBrowse link
spectrin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Prkcb protein kinase C beta part_of IEA Ensembl GO_REF:0000107 NCBI chrNW_004936501:8,410,273...8,729,238
Ensembl chrNW_004936501:8,437,715...8,728,716
JBrowse link
G Spta1 spectrin alpha, erythrocytic 1 part_of IEA Ensembl GO_REF:0000107 NCBI chrNW_004936740:1,686,218...1,759,083
Ensembl chrNW_004936740:1,686,218...1,759,078
JBrowse link
G Sptb spectrin beta, erythrocytic part_of IEA InterPro GO_REF:0000002 NCBI chrNW_004936495:8,415,950...8,540,590
Ensembl chrNW_004936495:8,415,912...8,486,039
JBrowse link
G Sptbn1 spectrin beta, non-erythrocytic 1 part_of IEA InterPro GO_REF:0000002 NCBI chrNW_004936491:920,830...1,108,374
Ensembl chrNW_004936491:956,986...1,108,640
JBrowse link
G Sptbn2 spectrin beta, non-erythrocytic 2 part_of IEA Ensembl
InterPro
GO_REF:0000002 GO_REF:0000107 NCBI chrNW_004936599:2,890,404...2,928,502
Ensembl chrNW_004936599:2,890,817...2,928,499
JBrowse link
G Sptbn4 spectrin beta, non-erythrocytic 4 part_of IEA InterPro
Ensembl
GO_REF:0000002 GO_REF:0000107 NCBI chrNW_004936661:2,831,132...2,903,619
Ensembl chrNW_004936661:2,827,572...2,903,655
JBrowse link
terminal web term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Actn1 actinin alpha 1 located_in ISS AgBase GO_REF:0000024 NCBI chrNW_004936495:12,124,489...12,217,223
Ensembl chrNW_004936495:12,124,443...12,217,242
JBrowse link
G Cobl cordon-bleu WH2 repeat protein located_in ISO (MGI:5621262|PMID:22114352) UniProt PMID:22114352 MGI:5621262 NCBI chrNW_004936686:621,502...872,824 JBrowse link
G Hfe homeostatic iron regulator ISO RGD PMID:16208485 RGD:1582698 NCBI chrNW_004936671:1,940,079...1,947,574
Ensembl chrNW_004936671:1,940,101...1,947,580
JBrowse link
G Krt19 keratin 19 located_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936490:16,440,723...16,444,679
Ensembl chrNW_004936490:16,440,693...16,444,791
JBrowse link
G Pls1 plastin 1 located_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936540:4,205,871...4,323,121
Ensembl chrNW_004936540:4,205,844...4,323,120
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 16802
    cellular anatomical entity 16712
      cytoplasm 10330
        cell cortex 313
          cortical cytoskeleton 121
            cortical actin cytoskeleton 86
              actin cap 4
              actin cortical patch + 0
              actomyosin contractile ring + 7
              cuticular plate 12
              macropinocytic cup cytoskeleton 0
              spectrin 6
              terminal web 5
Path 2
Term Annotations click to browse term
  cellular_component 16802
    cellular anatomical entity 16712
      organelle 12060
        non-membrane-bounded organelle 4417
          intracellular non-membrane-bounded organelle 4417
            cytoskeleton 2128
              actin cytoskeleton 512
                cortical actin cytoskeleton 86
                  actin cap 4
                  actin cortical patch + 0
                  actomyosin contractile ring + 7
                  cuticular plate 12
                  macropinocytic cup cytoskeleton 0
                  spectrin 6
                  terminal web 5
paths to the root