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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of epithelial cell differentiation
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Accession:GO:0030857 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of epithelial cell differentiation.
Synonyms:exact_synonym: down regulation of epithelial cell differentiation;   downregulation of epithelial cell differentiation
 narrow_synonym: inhibition of epithelial cell differentiation


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negative regulation of epithelial cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cav1 caveolin 1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:2180364 (MGI:3703676|PMID:12388746)
Ensembl
RGD
PMID:12388746 GO_REF:0000107 MGI:3703676 NCBI chr 4:44,597,123...44,630,206
Ensembl chr 4:44,597,123...44,630,200
JBrowse link
G Ccnd1 cyclin D1 involved_in ISO MGI:88039 (MGI:3054506|PMID:15314168) RGD PMID:15314168 MGI:3054506 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Dll1 delta like canonical Notch ligand 1 involved_in ISS
ISO
GO_REF:0000024
(MGI:5296438|PMID:21915337)
UniProt
RGD
PMID:21915337 GO_REF:0000024 MGI:5296438 NCBI chr 1:57,318,621...57,326,732
Ensembl chr 1:57,318,708...57,327,379
JBrowse link
G Ifng interferon gamma involved_in IDA PMID:20624457 BHF-UCL PMID:20624457 RGD:8554478 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Nkx6-3 NK6 homeobox 3 acts_upstream_of_or_within ISO MGI:3795186 (MGI:3795066|PMID:18347062) RGD PMID:18347062 MGI:3795066 NCBI chr16:73,665,269...73,670,482
Ensembl chr16:73,665,269...73,670,482
JBrowse link
G Osr1 odd-skipped related transcription factor 1 involved_in ISS
ISO
GO_REF:0000024
(MGI:3697513|PMID:16790474)
UniProt
RGD
PMID:16790474 GO_REF:0000024 MGI:3697513 NCBI chr 6:35,314,431...35,321,458
Ensembl chr 6:35,314,444...35,321,667
JBrowse link
G Smo smoothened, frizzled class receptor involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:1934268|MGI:2445832 (MGI:3696007|PMID:17199044)
Ensembl
RGD
PMID:17199044 GO_REF:0000107 MGI:3696007 NCBI chr 4:57,019,941...57,041,779
Ensembl chr 4:57,019,941...57,042,770
JBrowse link
G Sox9 SRY-box transcription factor 9 acts_upstream_of_or_within ISO MGI:2385468 (MGI:5523405|PMID:24058167) RGD PMID:24058167 MGI:5523405 NCBI chr10:101,288,528...101,294,030
Ensembl chr10:101,288,489...101,293,379
JBrowse link
G Tbx3 T-box transcription factor 3 acts_upstream_of_or_within ISO MGI:3769504 (MGI:3788969|PMID:18356246) RGD PMID:18356246 MGI:3788969 NCBI chr12:42,479,518...42,494,588
Ensembl chr12:42,480,560...42,492,526
JBrowse link
G Yap1 Yes1 associated transcriptional regulator acts_upstream_of_or_within ISO (MGI:3818355|PMID:17980593) RGD PMID:17980593 MGI:3818355 NCBI chr 8:6,133,014...6,204,240
Ensembl chr 8:6,135,493...6,203,579
JBrowse link
G Zeb1 zinc finger E-box binding homeobox 1 acts_upstream_of_or_within ISO (MGI:3773108|PMID:18192284) RGD PMID:18192284 MGI:3773108 NCBI chr17:54,656,627...54,714,920
Ensembl chr17:54,658,463...54,714,914
JBrowse link
inhibition of neuroepithelial cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nodal nodal growth differentiation factor acts_upstream_of_or_within ISO MGI:2180793 (MGI:3640721|PMID:16678814) RGD PMID:16678814 MGI:3640721 NCBI chr20:31,035,729...31,044,096
Ensembl chr20:31,035,729...31,044,096
JBrowse link
negative regulation of blood vessel endothelial cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Foxj2 forkhead box J2 involved_in ISO (PMID:24792364) RGD PMID:24792364 NCBI chr 4:155,653,446...155,679,815
Ensembl chr 4:155,653,718...155,679,793
JBrowse link
negative regulation of endothelial cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acvrl1 activin A receptor like type 1 involved_in ISO (MGI:4830635|PMID:20406889) RGD PMID:20406889 MGI:4830635 NCBI chr 7:142,769,942...142,787,336
Ensembl chr 7:142,776,252...142,787,335
JBrowse link
G Id1 inhibitor of DNA binding 1, HLH protein IMP RGD PMID:20830586 RGD:9686141 NCBI chr 3:148,214,623...148,216,715
Ensembl chr 3:148,215,540...148,216,718
JBrowse link
G Jag1 jagged canonical Notch ligand 1 involved_in IEA
ISO
GO_REF:0000107
(MGI:5661129|PMID:25535084)
Ensembl
RGD
PMID:25535084 GO_REF:0000107 MGI:5661129 NCBI chr 3:130,079,361...130,114,781
Ensembl chr 3:130,079,361...130,114,770
JBrowse link
G Notch4 notch receptor 4 involved_in ISO (MGI:1934537|PMID:11344305) RGD PMID:11344305 MGI:1934537 NCBI chr20:4,329,794...4,353,868
Ensembl chr20:4,329,811...4,353,785
JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 IMP RGD PMID:17450384 RGD:2302022 NCBI chr 5:63,056,071...63,119,635
Ensembl chr 5:63,050,758...63,119,635
JBrowse link
G Vhl von Hippel-Lindau tumor suppressor acts_upstream_of_or_within ISO MGI:2136645|MGI:3608931 (MGI:5618205|PMID:25186293) RGD PMID:25186293 MGI:5618205 NCBI chr 4:145,580,869...145,587,835
Ensembl chr 4:145,580,799...145,587,845
JBrowse link
G Xdh xanthine dehydrogenase involved_in IEA
ISO
GO_REF:0000107
(PMID:18386220)
Ensembl
RGD
PMID:18386220 GO_REF:0000107 NCBI chr 6:25,149,570...25,211,273
Ensembl chr 6:25,149,235...25,211,494
JBrowse link
G Zeb1 zinc finger E-box binding homeobox 1 involved_in IEA
ISO
GO_REF:0000107
(PMID:23765923)
Ensembl
RGD
PMID:23765923 GO_REF:0000107 NCBI chr17:54,656,627...54,714,920
Ensembl chr17:54,658,463...54,714,914
JBrowse link
negative regulation of epidermal cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dll1 delta like canonical Notch ligand 1 involved_in ISS
ISO
GO_REF:0000024
(MGI:3793982|PMID:17960184)
UniProt
RGD
PMID:17960184 GO_REF:0000024 MGI:3793982 NCBI chr 1:57,318,621...57,326,732
Ensembl chr 1:57,318,708...57,327,379
JBrowse link
G Ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit acts_upstream_of_or_within ISO MGI:2661097 (MGI:3846264|PMID:19303854) RGD PMID:19303854 MGI:3846264 NCBI chr 4:77,284,404...77,347,011
Ensembl chr 4:77,284,404...77,347,011
JBrowse link
G Gdf3 growth differentiation factor 3 involved_in ISO (PMID:18823971) RGD PMID:18823971 NCBI chr 4:155,417,667...155,422,014
Ensembl chr 4:155,417,004...155,421,998
JBrowse link
negative regulation of epithelial cell differentiation involved in kidney development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mmp9 matrix metallopeptidase 9 involved_in IEA
ISO
GO_REF:0000107
(MGI:6270954|PMID:24503540)
Ensembl
RGD
PMID:24503540 GO_REF:0000107 MGI:6270954 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
negative regulation of establishment of endothelial barrier term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G S1pr3 sphingosine-1-phosphate receptor 3 involved_in ISO (PMID:24851274) RGD PMID:24851274 NCBI chr17:13,799,383...13,812,877
Ensembl chr17:13,799,383...13,812,704
JBrowse link
G Vegfa vascular endothelial growth factor A involved_in ISO (PMID:20048167) RGD PMID:20048167 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
negative regulation of establishment of Sertoli cell barrier term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il1a interleukin 1 alpha IDA RGD PMID:18057314 RGD:10046056 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
negative regulation of hepatocyte differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Frzb frizzled-related protein acts_upstream_of_or_within ISO (MGI:4356222|PMID:19562671) RGD PMID:19562671 MGI:4356222 NCBI chr 3:67,635,604...67,668,772
Ensembl chr 3:67,635,607...67,668,772
JBrowse link
negative regulation of inner ear auditory receptor cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dll1 delta like canonical Notch ligand 1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:1932522|MGI:3044907 (MGI:3621102|PMID:16495313)
Ensembl
RGD
PMID:16495313 GO_REF:0000107 MGI:3621102 NCBI chr 1:57,318,621...57,326,732
Ensembl chr 1:57,318,708...57,327,379
JBrowse link
G Hes1 hes family bHLH transcription factor 1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:104876|MGI:1341800|MGI:2149672 (MGI:1889857|PMID:11023859), (MGI:2136156|PMID:11425898), (MGI:4949990|PMID:21300049)
Ensembl
RGD
PMID:11023859 PMID:11425898 PMID:21300049 GO_REF:0000107 MGI:1889857 MGI:2136156 MGI:4949990 NCBI chr11:74,312,837...74,315,249
Ensembl chr11:74,312,806...74,315,248
JBrowse link
G Hes5 hes family bHLH transcription factor 5 acts_upstream_of_or_within ISO MGI:104853|MGI:1341800|MGI:2149674 (MGI:2136156|PMID:11425898), (MGI:4949990|PMID:21300049) RGD PMID:11425898 PMID:21300049 MGI:2136156 MGI:4949990 NCBI chr 5:172,364,421...172,365,188
Ensembl chr 5:172,364,421...172,365,188
JBrowse link
G Notch1 notch receptor 1 acts_upstream_of_or_within ISO MGI:3044585 (MGI:5617067|PMID:25535395) RGD PMID:25535395 MGI:5617067 NCBI chr 3:3,905,562...3,951,015
Ensembl chr 3:3,905,453...3,951,025
JBrowse link
negative regulation of keratinocyte differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Grhl2 grainyhead-like transcription factor 2 involved_in ISO (PMID:23254293) RGD PMID:23254293 NCBI chr 7:76,058,623...76,197,360
Ensembl chr 7:76,059,386...76,197,856
JBrowse link
G Hoxa7 homeobox A7 involved_in ISO (PMID:11435435) RGD PMID:11435435 NCBI chr 4:82,184,299...82,187,890
Ensembl chr 4:82,183,196...82,186,190
JBrowse link
G Msx2 msh homeobox 2 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:1926381 (MGI:4868690|PMID:19769717)
Ensembl
RGD
PMID:19769717 GO_REF:0000107 MGI:4868690 NCBI chr17:11,683,862...11,689,527
Ensembl chr17:11,683,862...11,689,527
JBrowse link
G Ovol2 ovo-like zinc finger 2 involved_in ISO (PMID:19700410) RGD PMID:19700410 NCBI chr 3:138,433,990...138,464,511
Ensembl chr 3:138,433,990...138,462,063
JBrowse link
G Reg3a regenerating islet-derived 3 alpha involved_in ISS
ISO
IEA
GO_REF:0000024
(MGI:5488867|PMID:22727489)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:22727489 GO_REF:0000024 GO_REF:0000107 MGI:5488867 NCBI chr 4:109,477,893...109,480,659
Ensembl chr 4:109,477,920...109,480,659
JBrowse link
G Reg3g regenerating family member 3 gamma involved_in ISS
ISO
GO_REF:0000024
(MGI:5488867|PMID:22727489)
UniProt
RGD
PMID:22727489 GO_REF:0000024 MGI:5488867 NCBI chr 4:109,529,679...109,532,234
Ensembl chr 4:109,529,679...109,532,234
JBrowse link
G Srsf6 serine and arginine rich splicing factor 6 involved_in ISS
ISO
GO_REF:0000024
(PMID:24440982)
UniProt
RGD
PMID:24440982 GO_REF:0000024 NCBI chr 3:159,305,345...159,310,668
Ensembl chr 3:159,305,345...159,310,668
JBrowse link
G Tp63 tumor protein p63 acts_upstream_of_or_within ISO MGI:5140823 (MGI:5310685|PMID:22274697)
MGI:97363 (MGI:3623698|PMID:16618808)
RGD PMID:16618808 PMID:22274697 MGI:3623698 MGI:5310685 NCBI chr11:78,234,853...78,456,559
Ensembl chr11:78,234,800...78,456,501
JBrowse link
negative regulation of lens fiber cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Foxe3 forkhead box E3 involved_in ISS
ISO
PMID:16199865
(MGI:1352262|PMID:10652278), (MGI:1861492|PMID:10890982), (MGI:3603877|PMID:16199865)
RGD PMID:10652278 PMID:10890982 PMID:16199865, PMID:16199865 MGI:1352262 MGI:1861492 MGI:3603877, RGD:10047273 NCBI chr 5:133,724,796...133,725,656
Ensembl chr 5:133,724,796...133,725,656
JBrowse link
G Spred1 sprouty-related, EVH1 domain containing 1 involved_in ISO (MGI:6414698|PMID:29501879) RGD PMID:29501879 MGI:6414698 NCBI chr 3:108,795,337...108,861,650
Ensembl chr 3:108,795,235...108,857,556
JBrowse link
G Spred2 sprouty-related, EVH1 domain containing 2 involved_in ISS
ISO
GO_REF:0000024
(MGI:6414698|PMID:29501879)
UniProt
RGD
PMID:29501879 GO_REF:0000024 MGI:6414698 NCBI chr14:104,268,362...104,290,206
Ensembl chr14:104,191,517...104,290,456
JBrowse link
G Spred3 sprouty-related, EVH1 domain containing 3 involved_in ISO (MGI:6414698|PMID:29501879) RGD PMID:29501879 MGI:6414698 NCBI chr 1:88,101,213...88,112,719
Ensembl chr 1:88,103,719...88,112,683
JBrowse link
G Spry1 sprouty RTK signaling antagonist 1 involved_in ISO (MGI:6414698|PMID:29501879) RGD PMID:29501879 MGI:6414698 NCBI chr 2:124,400,689...124,405,331
Ensembl chr 2:124,400,679...124,405,331
JBrowse link
G Spry2 sprouty RTK signaling antagonist 2 involved_in ISO (MGI:6414698|PMID:29501879) RGD PMID:29501879 MGI:6414698 NCBI chr15:90,172,769...90,177,823
Ensembl chr15:90,172,975...90,175,802
JBrowse link
negative regulation of lung goblet cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Foxp1 forkhead box P1 acts_upstream_of_or_within ISO MGI:1921373 (MGI:5429471|PMID:22675208) RGD PMID:22675208 MGI:5429471 NCBI chr 4:131,362,178...131,963,466
Ensembl chr 4:131,366,744...131,694,755
JBrowse link
G Foxp4 forkhead box P4 acts_upstream_of_or_within ISO MGI:1914004 (MGI:5429471|PMID:22675208) RGD PMID:22675208 MGI:5429471 NCBI chr 9:15,068,378...15,124,962
Ensembl chr 9:15,068,399...15,125,318
JBrowse link
negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cited1 Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1 involved_in IMP PMID:15843474 UniProt PMID:15843474 RGD:8554075 NCBI chr  X:72,128,996...72,133,692
Ensembl chr  X:72,128,994...72,133,692
JBrowse link
G Ctnnb1 catenin beta 1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(MGI:3714576|PMID:17537789)
Ensembl
RGD
PMID:17537789 GO_REF:0000107 MGI:3714576 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Sall1 spalt-like transcription factor 1 acts_upstream_of_or_within ISO MGI:3603818 (MGI:5563280|PMID:24550112) RGD PMID:24550112 MGI:5563280 NCBI chr19:23,387,737...23,405,025
Ensembl chr19:23,389,375...23,405,039
JBrowse link
negative regulation of nephron tubule epithelial cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Osr1 odd-skipped related transcription factor 1 involved_in ISS
ISO
GO_REF:0000024
(MGI:3697513|PMID:16790474)
UniProt
RGD
PMID:16790474 GO_REF:0000024 MGI:3697513 NCBI chr 6:35,314,431...35,321,458
Ensembl chr 6:35,314,444...35,321,667
JBrowse link
negative regulation of pancreatic A cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hes1 hes family bHLH transcription factor 1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:2149672 (MGI:1351379|PMID:10615124)
Ensembl
RGD
PMID:10615124 GO_REF:0000107 MGI:1351379 NCBI chr11:74,312,837...74,315,249
Ensembl chr11:74,312,806...74,315,248
JBrowse link
G Mir7-1 microRNA 7-1 acts_upstream_of_or_within ISO (MGI:5437569|PMID:22764048) RGD PMID:22764048 MGI:5437569 NCBI chr17:6,675,016...6,675,112
Ensembl chr17:6,675,016...6,675,112
JBrowse link
negative regulation of stomach neuroendocrine cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hes1 hes family bHLH transcription factor 1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:2149672 (MGI:3804618|PMID:18173746)
Ensembl
RGD
PMID:18173746 GO_REF:0000107 MGI:3804618 NCBI chr11:74,312,837...74,315,249
Ensembl chr11:74,312,806...74,315,248
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19634
    cellular process 18481
      negative regulation of cellular process 5131
        negative regulation of cell differentiation 739
          negative regulation of epithelial cell differentiation 50
            inhibition of neuroepithelial cell differentiation + 2
            negative regulation of cumulus cell differentiation 0
            negative regulation of endothelial cell differentiation + 11
            negative regulation of epidermal cell differentiation + 14
            negative regulation of epithelial cell differentiation involved in kidney development + 5
            negative regulation of establishment of Sertoli cell barrier 1
            negative regulation of hepatocyte differentiation 1
            negative regulation of intestinal epithelial cell development 0
            negative regulation of lens fiber cell differentiation 6
            negative regulation of lung ciliated cell differentiation 0
            negative regulation of lung goblet cell differentiation 2
            negative regulation of pancreatic A cell differentiation 2
            negative regulation of polarized epithelial cell differentiation 0
Path 2
Term Annotations click to browse term
  biological_process 19634
    developmental process 6783
      anatomical structure development 6259
        tissue development 2069
          epithelium development 1271
            epithelial cell differentiation 712
              regulation of epithelial cell differentiation 161
                negative regulation of epithelial cell differentiation 50
                  inhibition of neuroepithelial cell differentiation + 2
                  negative regulation of cumulus cell differentiation 0
                  negative regulation of endothelial cell differentiation + 11
                  negative regulation of epidermal cell differentiation + 14
                  negative regulation of epithelial cell differentiation involved in kidney development + 5
                  negative regulation of establishment of Sertoli cell barrier 1
                  negative regulation of hepatocyte differentiation 1
                  negative regulation of intestinal epithelial cell development 0
                  negative regulation of lens fiber cell differentiation 6
                  negative regulation of lung ciliated cell differentiation 0
                  negative regulation of lung goblet cell differentiation 2
                  negative regulation of pancreatic A cell differentiation 2
                  negative regulation of polarized epithelial cell differentiation 0
paths to the root