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ONTOLOGY REPORT - ANNOTATIONS


Term:granulocyte differentiation
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Accession:GO:0030851 term browser browse the term
Definition:The process in which a myeloid precursor cell acquires the specialized features of a granulocyte. Granulocytes are a class of leukocytes characterized by the presence of granules in their cytoplasm. These cells are active in allergic immune reactions such as arthritic inflammation and rashes. This class includes basophils, eosinophils and neutrophils.
Synonyms:exact_synonym: granulocyte cell differentiation



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granulocyte differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AP3B1 adaptor related protein complex 3 subunit beta 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:5587889|PMID:23748140) Ensembl
MGI
PMID:23748140 GO_REF:0000107 MGI:5587889 NCBI chr 2:86,875,922...87,142,722
Ensembl chr 2:86,873,081...87,142,744
JBrowse link
G CBFA2T3 CBFA2/RUNX1 partner transcriptional co-repressor 3 acts_upstream_of_or_within
involved_in
ISO
IEA
(PMID:15231665) MGI
Ensembl
PMID:15231665 GO_REF:0000107 NCBI chr 6:779,164...854,449
Ensembl chr 6:778,967...852,821
JBrowse link
G CEBPA CCAAT enhancer binding protein alpha involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:43,083,200...43,085,884
Ensembl chr 6:43,083,203...43,085,836
JBrowse link
G CEBPE CCAAT enhancer binding protein epsilon involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:75,926,652...75,929,949
Ensembl chr 7:75,927,662...75,929,771
JBrowse link
G CITED2 Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3847632|PMID:17644732) Ensembl
MGI
PMID:17644732 GO_REF:0000107 MGI:3847632 NCBI chr 1:25,155,652...25,158,517
Ensembl chr 1:25,155,664...25,160,279
JBrowse link
G CYP19A2 cytochrome P450 19A2 ISO RGD PMID:18401763 RGD:4784626 NCBI chr 1:120,652,172...120,695,899
Ensembl chr 1:120,367,667...120,695,899
JBrowse link
G HSD3B1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 ISO RGD PMID:18401763 RGD:4784626 NCBI chr 4:101,565,229...101,574,110 JBrowse link
G KDM1A lysine demethylase 1A involved_in ISO (MGI:5284774|PMID:17707228) UniProt PMID:17707228 MGI:5284774 NCBI chr 6:80,903,407...80,971,875
Ensembl chr 6:80,903,496...80,971,595
JBrowse link
G L3MBTL3 L3MBTL histone methyl-lysine binding protein 3 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3578583|PMID:15889154) Ensembl
MGI
PMID:15889154 GO_REF:0000107 MGI:3578583 NCBI chr 1:33,198,295...33,319,477
Ensembl chr 1:33,198,301...33,319,367
JBrowse link
G NKAP NFKB activating protein acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:4838711|PMID:20610818) MGI
Ensembl
PMID:20610818 GO_REF:0000107 MGI:4838711 NCBI chr  X:98,233,504...98,276,839
Ensembl chr  X:98,227,659...98,276,812
JBrowse link
G SP3 Sp3 transcription factor involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:2670314|PMID:12676787) Ensembl
MGI
PMID:12676787 GO_REF:0000107 MGI:2670314 NCBI chr15:79,935,986...79,990,139
Ensembl chr15:79,935,994...80,025,850
JBrowse link
G SPI1 Spi-1 proto-oncogene involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:2179579|PMID:11980719) Ensembl
MGI
PMID:11980719 GO_REF:0000107 MGI:2179579 NCBI chr 2:15,227,850...15,245,679
Ensembl chr 2:15,227,829...15,245,667
JBrowse link
G SRP54 signal recognition particle 54 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:64,829,625...64,877,574
Ensembl chr 7:64,828,874...64,877,193
JBrowse link
G ZFPM1 zinc finger protein, FOG family member 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:4420713|PMID:20010697) Ensembl
MGI
PMID:20010697 GO_REF:0000107 MGI:4420713 NCBI chr 6:1,091,158...1,153,972
Ensembl chr 6:1,091,259...1,108,717
JBrowse link
basophil differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GATA1 GATA binding protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:42,898,431...42,905,939
Ensembl chr  X:42,898,442...42,905,976
JBrowse link
G TAL1 TAL bHLH transcription factor 1, erythroid differentiation factor involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:164,282,242...164,297,636
Ensembl chr 6:164,281,737...164,297,637
JBrowse link
eosinophil differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GATA1 GATA binding protein 1 involved_in ISO (PMID:8507862) BHF-UCL PMID:8507862 NCBI chr  X:42,898,431...42,905,939
Ensembl chr  X:42,898,442...42,905,976
JBrowse link
G IL25 interleukin 25 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:2388222|PMID:12077275) Ensembl
MGI
PMID:12077275 GO_REF:0000107 MGI:2388222 NCBI chr 7:75,710,453...75,717,688
Ensembl chr 7:75,710,996...75,721,826
JBrowse link
eosinophil fate commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GATA1 GATA binding protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:42,898,431...42,905,939
Ensembl chr  X:42,898,442...42,905,976
JBrowse link
G GATA2 GATA binding protein 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:71,981,139...71,997,626
Ensembl chr13:71,984,063...71,997,622
JBrowse link
negative regulation of granulocyte differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADIPOQ adiponectin, C1Q and collagen domain containing involved_in ISS
IEA
UniProt
Ensembl
GO_REF:0000024 GO_REF:0000107 NCBI chr13:124,633,906...124,646,237
Ensembl chr13:124,633,684...124,646,648
JBrowse link
G C1QC complement C1q C chain involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:80,592,591...80,597,464
Ensembl chr 6:80,592,478...80,597,459
JBrowse link
G CEACAM1 CEA cell adhesion molecule 1 involved_in ISO (MGI:4837548|PMID:21029969) UniProt PMID:21029969 MGI:4837548 NCBI chr 6:49,437,308...49,460,614 JBrowse link
G CUL4A cullin 4A involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3691926|PMID:12393421) Ensembl
MGI
PMID:12393421 GO_REF:0000107 MGI:3691926 NCBI chr11:78,557,030...78,588,964
Ensembl chr11:78,557,070...78,589,194
JBrowse link
G INPP5D inositol polyphosphate-5-phosphatase D acts_upstream_of_or_within ISO (MGI:1266928|PMID:9620849) MGI PMID:9620849 MGI:1266928 NCBI chr15:133,501,067...133,626,647
Ensembl chr15:133,501,092...133,626,647
JBrowse link
G PRDM16 PR/SET domain 16 involved_in ISO (PMID:12816872) UniProt PMID:12816872 NCBI chr 6:64,704,181...65,012,580
Ensembl chr 6:64,704,468...65,012,575
JBrowse link
G RARA retinoic acid receptor alpha involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:22,047,449...22,085,759
Ensembl chr12:22,047,442...22,085,674
JBrowse link
G RUNX1 RUNX family transcription factor 1 involved_in ISO (PMID:9199349) UniProt PMID:9199349 NCBI chr13:198,371,835...198,635,648
Ensembl chr13:198,371,835...198,638,189
JBrowse link
G ZBTB46 zinc finger and BTB domain containing 46 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:5320487|PMID:22615127) Ensembl
MGI
PMID:22615127 GO_REF:0000107 MGI:5320487 NCBI chr17:62,659,779...62,715,221
Ensembl chr17:62,659,784...62,709,239
JBrowse link
negative regulation of neutrophil differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G INPP5D inositol polyphosphate-5-phosphatase D involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:1266928|PMID:9620849) Ensembl
MGI
PMID:9620849 GO_REF:0000107 MGI:1266928 NCBI chr15:133,501,067...133,626,647
Ensembl chr15:133,501,092...133,626,647
JBrowse link
G TRIB1 tribbles pseudokinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:14,289,739...14,298,119
Ensembl chr 4:14,289,739...14,298,075
JBrowse link
neutrophil differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CSF2 colony stimulating factor 2 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3842881|PMID:19109256) Ensembl
MGI
PMID:19109256 GO_REF:0000107 MGI:3842881 NCBI chr 2:134,354,724...134,357,155
Ensembl chr 2:134,354,724...134,357,155
JBrowse link
G DHRS7B dehydrogenase/reductase 7B involved_in ISO (MGI:5630041|PMID:25565205) MGI PMID:25565205 MGI:5630041 NCBI chr12:61,320,665...61,347,542
Ensembl chr12:61,318,454...61,352,985
JBrowse link
G FASN fatty acid synthase involved_in ISO (MGI:5630041|PMID:25565205) MGI PMID:25565205 MGI:5630041 NCBI chr12:922,405...937,560
Ensembl chr12:920,507...937,559
JBrowse link
G IL17C interleukin 17C acts_upstream_of_or_within ISO (MGI:2388222|PMID:12077275) MGI PMID:12077275 MGI:2388222 NCBI chr 6:1,023,330...1,025,173
Ensembl chr 6:1,019,790...1,025,123
JBrowse link
G JAGN1 jagunal homolog 1 involved_in
NOT|involved_in
ISO (PMID:25129144)
(MGI:5604054|PMID:25129145)
UniProt PMID:25129144 PMID:25129145 MGI:5604054 NCBI chr13:66,154,855...66,158,329 JBrowse link
G LBR lamin B receptor involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:13,389,896...13,416,831
Ensembl chr10:13,386,946...13,416,759
JBrowse link
G LEF1 lymphoid enhancer binding factor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:113,824,511...113,944,078
Ensembl chr 8:113,824,547...113,944,078
JBrowse link
positive regulation of eosinophil differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IL5 interleukin 5 ISO RGD PMID:10529595 PMID:10727846 RGD:2303509 RGD:2303750 NCBI chr 2:134,832,143...134,846,141
Ensembl chr 2:134,832,147...134,835,212
JBrowse link
G TRIB1 tribbles pseudokinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:14,289,739...14,298,119
Ensembl chr 4:14,289,739...14,298,075
JBrowse link
positive regulation of granulocyte differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EVI2B ecotropic viral integration site 2B involved_in ISO (PMID:28186500)
(MGI:6151386|PMID:28186500)
UniProt PMID:28186500 MGI:6151386 NCBI chr12:43,553,891...43,561,759
Ensembl chr12:43,553,872...43,562,544
JBrowse link
G GFI1B growth factor independent 1B transcriptional repressor involved_in ISO (MGI:5284774|PMID:17707228) UniProt PMID:17707228 MGI:5284774 NCBI chr 1:272,701,386...272,715,551
Ensembl chr 1:272,701,927...272,715,539
JBrowse link
G HAX1 HCLS1 associated protein X-1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:95,467,629...95,470,972
Ensembl chr 4:95,467,629...95,470,288
JBrowse link
G HCLS1 hematopoietic cell-specific Lyn substrate 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:138,852,387...138,883,088
Ensembl chr13:138,855,142...138,906,351
JBrowse link
G LEF1 lymphoid enhancer binding factor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:113,824,511...113,944,078
Ensembl chr 8:113,824,547...113,944,078
JBrowse link
G RUNX1 RUNX family transcription factor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:198,371,835...198,635,648
Ensembl chr13:198,371,835...198,638,189
JBrowse link
G TESC tescalcin involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:35,381,899...35,452,215
Ensembl chr14:35,381,918...35,452,207
JBrowse link
positive regulation of neutrophil differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EVI2B ecotropic viral integration site 2B involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr12:43,553,891...43,561,759
Ensembl chr12:43,553,872...43,562,544
JBrowse link
G IKZF1 IKAROS family zinc finger 1 acts_upstream_of_or_within ISO (MGI:2654310|PMID:12406904) MGI PMID:12406904 MGI:2654310 NCBI chr 9:136,372,202...136,464,942
Ensembl chr 9:136,372,724...136,464,942
JBrowse link
regulation of granulocyte differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RARA retinoic acid receptor alpha acts_upstream_of_or_within ISO (MGI:1931374|PMID:11222375) MGI PMID:11222375 MGI:1931374 NCBI chr12:22,047,449...22,085,759
Ensembl chr12:22,047,442...22,085,674
JBrowse link
G RBP1 retinol binding protein 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:1931374|PMID:11222375) Ensembl
MGI
PMID:11222375 GO_REF:0000107 MGI:1931374 NCBI chr13:80,380,958...80,407,328
Ensembl chr13:80,380,962...80,407,458
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16675
    developmental process 6393
      cellular developmental process 4228
        cell differentiation 4140
          leukocyte differentiation 604
            myeloid leukocyte differentiation 230
              granulocyte differentiation 43
                basophil differentiation + 2
                eosinophil differentiation + 5
                negative regulation of granulocyte differentiation + 10
                neutrophil differentiation + 11
                positive regulation of granulocyte differentiation + 10
                regulation of granulocyte differentiation + 19
Path 2
Term Annotations click to browse term
  biological_process 16675
    developmental process 6393
      anatomical structure development 5907
        multicellular organism development 5373
          system development 5039
            immune system development 1057
              hematopoietic or lymphoid organ development 993
                hemopoiesis 945
                  myeloid cell differentiation 420
                    myeloid leukocyte differentiation 230
                      granulocyte differentiation 43
                        basophil differentiation + 2
                        eosinophil differentiation + 5
                        negative regulation of granulocyte differentiation + 10
                        neutrophil differentiation + 11
                        positive regulation of granulocyte differentiation + 10
                        regulation of granulocyte differentiation + 19
paths to the root