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ONTOLOGY REPORT - ANNOTATIONS


Term:granulocyte differentiation
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Accession:GO:0030851 term browser browse the term
Definition:The process in which a myeloid precursor cell acquires the specialized features of a granulocyte. Granulocytes are a class of leukocytes characterized by the presence of granules in their cytoplasm. These cells are active in allergic immune reactions such as arthritic inflammation and rashes. This class includes basophils, eosinophils and neutrophils.
Synonyms:exact_synonym: granulocyte cell differentiation



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granulocyte differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AP3B1 adaptor related protein complex 3 subunit beta 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:5587889|PMID:23748140) Ensembl
MGI
PMID:23748140 GO_REF:0000107 MGI:5587889 NCBI chr 5:78,000,522...78,294,704
Ensembl chr 5:78,002,326...78,294,698
JBrowse link
G CBFA2T3 CBFA2/RUNX1 partner transcriptional co-repressor 3 acts_upstream_of_or_within IDA (PMID:15231665) MGI PMID:15231665 NCBI chr16:88,874,858...88,977,207
Ensembl chr16:88,874,858...88,977,207
JBrowse link
G CEBPA CCAAT enhancer binding protein alpha involved_in ISS UniProt GO_REF:0000024 NCBI chr19:33,299,934...33,302,564
Ensembl chr19:33,299,934...33,302,534
JBrowse link
G CEBPE CCAAT enhancer binding protein epsilon involved_in IMP (PMID:10359588) UniProt PMID:10359588 NCBI chr14:23,117,306...23,119,255
Ensembl chr14:23,117,306...23,119,255
JBrowse link
G CITED2 Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3847632|PMID:17644732) Ensembl
MGI
PMID:17644732 GO_REF:0000107 MGI:3847632 NCBI chr 6:139,371,807...139,374,648
Ensembl chr 6:139,371,807...139,374,648
JBrowse link
G CSF3 colony stimulating factor 3 involved_in NAS (PMID:15664994) UniProt PMID:15664994 NCBI chr17:40,015,440...40,017,813
Ensembl chr17:40,015,361...40,017,813
JBrowse link
G CYP19A1 cytochrome P450 family 19 subfamily A member 1 ISO RGD PMID:18401763 RGD:4784626 NCBI chr15:51,208,057...51,338,596
Ensembl chr15:51,208,057...51,338,601
JBrowse link
G HSD3B1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 ISO RGD PMID:18401763 RGD:4784626 NCBI chr 1:119,507,203...119,515,058
Ensembl chr 1:119,507,198...119,515,054
JBrowse link
G KDM1A lysine demethylase 1A involved_in ISO (MGI:5284774|PMID:17707228) UniProt PMID:17707228 MGI:5284774 NCBI chr 1:23,019,443...23,083,691
Ensembl chr 1:23,019,443...23,083,689
JBrowse link
G L3MBTL3 L3MBTL histone methyl-lysine binding protein 3 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3578583|PMID:15889154) Ensembl
MGI
PMID:15889154 GO_REF:0000107 MGI:3578583 NCBI chr 6:130,018,581...130,141,440
Ensembl chr 6:130,013,699...130,141,449
JBrowse link
G NKAP NFKB activating protein acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:4838711|PMID:20610818) MGI
Ensembl
PMID:20610818 GO_REF:0000107 MGI:4838711 NCBI chr  X:119,920,672...119,943,751
Ensembl chr  X:119,920,672...119,943,751
JBrowse link
G SP3 Sp3 transcription factor involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:2670314|PMID:12676787) Ensembl
MGI
PMID:12676787 GO_REF:0000107 MGI:2670314 NCBI chr 2:173,900,775...173,965,702
Ensembl chr 2:173,880,850...173,965,373
JBrowse link
G SPI1 Spi-1 proto-oncogene acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:2179579|PMID:11980719) MGI
Ensembl
PMID:11980719 GO_REF:0000107 MGI:2179579 NCBI chr11:47,354,859...47,395,640
Ensembl chr11:47,354,860...47,378,547
JBrowse link
G SRP54 signal recognition particle 54 involved_in IMP (PMID:28972538) UniProt PMID:28972538 NCBI chr14:34,982,981...35,029,567
Ensembl chr14:34,981,957...35,029,686
JBrowse link
G ZFPM1 zinc finger protein, FOG family member 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:4420713|PMID:20010697) Ensembl
MGI
PMID:20010697 GO_REF:0000107 MGI:4420713 NCBI chr16:88,451,782...88,537,031
Ensembl chr16:88,453,280...88,537,031
JBrowse link
basophil differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GATA1 GATA binding protein 1 involved_in IEP
IEA
(PMID:7678994) BHF-UCL
InterPro
PMID:7678994 GO_REF:0000002 NCBI chr  X:48,786,590...48,794,311
Ensembl chr  X:48,786,562...48,794,311
JBrowse link
G TAL1 TAL bHLH transcription factor 1, erythroid differentiation factor involved_in IEP (PMID:7678994) BHF-UCL PMID:7678994 NCBI chr 1:47,216,290...47,232,389
Ensembl chr 1:47,216,290...47,232,220
JBrowse link
eosinophil differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GATA1 GATA binding protein 1 involved_in IEA
IEP
(PMID:8507862) InterPro
BHF-UCL
PMID:8507862 GO_REF:0000002 NCBI chr  X:48,786,590...48,794,311
Ensembl chr  X:48,786,562...48,794,311
JBrowse link
G IL25 interleukin 25 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:2388222|PMID:12077275) Ensembl
MGI
PMID:12077275 GO_REF:0000107 MGI:2388222 NCBI chr14:23,372,809...23,376,403
Ensembl chr14:23,372,809...23,376,403
JBrowse link
eosinophil fate commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GATA1 GATA binding protein 1 involved_in IDA (PMID:12045236) BHF-UCL PMID:12045236 NCBI chr  X:48,786,590...48,794,311
Ensembl chr  X:48,786,562...48,794,311
JBrowse link
G GATA2 GATA binding protein 2 involved_in IDA (PMID:12045236) BHF-UCL PMID:12045236 NCBI chr 3:128,479,422...128,493,201
Ensembl chr 3:128,479,427...128,493,201
JBrowse link
negative regulation of granulocyte differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADIPOQ adiponectin, C1Q and collagen domain containing involved_in IDA (PMID:10961870) BHF-UCL PMID:10961870 NCBI chr 3:186,842,710...186,858,463
Ensembl chr 3:186,842,704...186,858,463
JBrowse link
G C1QC complement C1q C chain involved_in IDA (PMID:10961870) BHF-UCL PMID:10961870 NCBI chr 1:22,643,633...22,648,108
Ensembl chr 1:22,643,633...22,648,110
JBrowse link
G CEACAM1 CEA cell adhesion molecule 1 involved_in ISS UniProt GO_REF:0000024 NCBI chr19:42,507,306...42,528,482
Ensembl chr19:42,507,304...42,561,234
JBrowse link
G CUL4A cullin 4A involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3691926|PMID:12393421) Ensembl
MGI
PMID:12393421 GO_REF:0000107 MGI:3691926 NCBI chr13:113,208,193...113,267,108
Ensembl chr13:113,208,193...113,267,108
JBrowse link
G INPP5D inositol polyphosphate-5-phosphatase D acts_upstream_of_or_within ISO (MGI:1266928|PMID:9620849) MGI PMID:9620849 MGI:1266928 NCBI chr 2:233,060,342...233,207,903
Ensembl chr 2:233,059,967...233,207,903
JBrowse link
G PRDM16 PR/SET domain 16 involved_in IDA (PMID:12816872) UniProt PMID:12816872 NCBI chr 1:3,069,203...3,438,621
Ensembl chr 1:3,069,168...3,438,621
JBrowse link
G RARA retinoic acid receptor alpha involved_in IDA (PMID:19917671) UniProt PMID:19917671 NCBI chr17:40,309,180...40,357,643
Ensembl chr17:40,309,180...40,357,643
JBrowse link
G RUNX1 RUNX family transcription factor 1 involved_in IMP (PMID:9199349) UniProt PMID:9199349 NCBI chr21:34,787,801...35,049,334
Ensembl chr21:34,787,801...36,004,667
JBrowse link
G ZBTB46 zinc finger and BTB domain containing 46 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:5320487|PMID:22615127) Ensembl
MGI
PMID:22615127 GO_REF:0000107 MGI:5320487 NCBI chr20:63,743,670...63,832,332
Ensembl chr20:63,743,668...63,832,038
JBrowse link
negative regulation of neutrophil differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G INPP5D inositol polyphosphate-5-phosphatase D involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:1266928|PMID:9620849) Ensembl
MGI
PMID:9620849 GO_REF:0000107 MGI:1266928 NCBI chr 2:233,060,342...233,207,903
Ensembl chr 2:233,059,967...233,207,903
JBrowse link
G TRIB1 tribbles pseudokinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:125,430,290...125,438,403
Ensembl chr 8:125,430,358...125,438,403
JBrowse link
neutrophil differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CSF2 colony stimulating factor 2 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3842881|PMID:19109256) Ensembl
MGI
PMID:19109256 GO_REF:0000107 MGI:3842881 NCBI chr 5:132,073,789...132,076,170
Ensembl chr 5:132,073,789...132,076,170
JBrowse link
G DHRS7B dehydrogenase/reductase 7B involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:21,123,368...21,191,445
Ensembl chr17:21,123,364...21,193,265
JBrowse link
G FASN fatty acid synthase involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:82,078,338...82,098,303
Ensembl chr17:82,078,338...82,098,294
JBrowse link
G IL17C interleukin 17C acts_upstream_of_or_within ISO (MGI:2388222|PMID:12077275) MGI PMID:12077275 MGI:2388222 NCBI chr16:88,638,572...88,640,468
Ensembl chr16:88,638,572...88,640,468
JBrowse link
G JAGN1 jagunal homolog 1 involved_in
NOT|involved_in
IMP
ISO
(PMID:25129144)
(MGI:5604054|PMID:25129145)
UniProt
UniProt
PMID:25129144 PMID:25129145 MGI:5604054 NCBI chr 3:9,890,610...9,894,349
Ensembl chr 3:9,890,574...9,894,349
JBrowse link
G LBR lamin B receptor involved_in ISS UniProt GO_REF:0000024 NCBI chr 1:225,401,502...225,428,821
Ensembl chr 1:225,401,502...225,428,925
JBrowse link
G LEF1 lymphoid enhancer binding factor 1 involved_in IMP (PMID:17063141) UniProt PMID:17063141 NCBI chr 4:108,047,548...108,168,932
Ensembl chr 4:108,047,545...108,168,956
JBrowse link
positive regulation of eosinophil differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IL5 interleukin 5 involved_in IEA
ISO
Ensembl
RGD
PMID:10529595 PMID:10727846 GO_REF:0000107 RGD:2303509 RGD:2303750 NCBI chr 5:132,539,194...132,556,864
Ensembl chr 5:132,541,445...132,556,838
JBrowse link
G TRIB1 tribbles pseudokinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:125,430,290...125,438,403
Ensembl chr 8:125,430,358...125,438,403
JBrowse link
positive regulation of granulocyte differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EVI2B ecotropic viral integration site 2B involved_in IMP
ISS
(PMID:28186500) UniProt PMID:28186500 GO_REF:0000024 NCBI chr17:31,303,770...31,314,149
Ensembl chr17:31,303,770...31,314,105
JBrowse link
G GFI1B growth factor independent 1B transcriptional repressor involved_in ISO (MGI:5284774|PMID:17707228) UniProt PMID:17707228 MGI:5284774 NCBI chr 9:132,945,531...132,991,697
Ensembl chr 9:132,944,000...132,991,687
JBrowse link
G HAX1 HCLS1 associated protein X-1 involved_in IMP (PMID:23001182) BHF-UCL PMID:23001182 NCBI chr 1:154,272,629...154,275,875
Ensembl chr 1:154,272,589...154,275,875
JBrowse link
G HCLS1 hematopoietic cell-specific Lyn substrate 1 involved_in IMP (PMID:23001182) BHF-UCL PMID:23001182 NCBI chr 3:121,631,399...121,660,903
Ensembl chr 3:121,631,399...121,660,927
JBrowse link
G LEF1 lymphoid enhancer binding factor 1 involved_in IDA
IMP
(PMID:19620402)
(PMID:23001182)
UniProt
BHF-UCL
PMID:19620402 PMID:23001182 NCBI chr 4:108,047,548...108,168,932
Ensembl chr 4:108,047,545...108,168,956
JBrowse link
G MIR223 microRNA 223 acts_upstream_of_or_within ISO (MGI:3811177|PMID:18278031) MGI PMID:18278031 MGI:3811177 NCBI chr  X:66,018,870...66,018,979
Ensembl chr  X:66,018,870...66,018,979
JBrowse link
G RUNX1 RUNX family transcription factor 1 involved_in IMP (PMID:9199349) UniProt PMID:9199349 NCBI chr21:34,787,801...35,049,334
Ensembl chr21:34,787,801...36,004,667
JBrowse link
G TESC tescalcin involved_in IDA (PMID:20060826) UniProt PMID:20060826 NCBI chr12:117,038,923...117,099,490
Ensembl chr12:117,038,923...117,099,479
JBrowse link
positive regulation of neutrophil differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EVI2B ecotropic viral integration site 2B involved_in IBA
ISS
(PMID:21873635) GO_Central
UniProt
PMID:21873635 GO_REF:0000024 NCBI chr17:31,303,770...31,314,149
Ensembl chr17:31,303,770...31,314,105
JBrowse link
G IKZF1 IKAROS family zinc finger 1 acts_upstream_of_or_within ISO (MGI:2654310|PMID:12406904) MGI PMID:12406904 MGI:2654310 NCBI chr 7:50,303,453...50,405,101
Ensembl chr 7:50,304,068...50,405,101
JBrowse link
regulation of granulocyte differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RARA retinoic acid receptor alpha acts_upstream_of_or_within ISO (MGI:1931374|PMID:11222375) MGI PMID:11222375 MGI:1931374 NCBI chr17:40,309,180...40,357,643
Ensembl chr17:40,309,180...40,357,643
JBrowse link
G RBP1 retinol binding protein 1 acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:1931374|PMID:11222375) MGI
Ensembl
PMID:11222375 GO_REF:0000107 MGI:1931374 NCBI chr 3:139,517,438...139,539,742
Ensembl chr 3:139,517,434...139,539,829
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18605
    developmental process 7311
      cellular developmental process 4877
        cell differentiation 4770
          leukocyte differentiation 657
            myeloid leukocyte differentiation 257
              granulocyte differentiation 45
                basophil differentiation + 2
                eosinophil differentiation + 5
                negative regulation of granulocyte differentiation + 10
                neutrophil differentiation + 11
                positive regulation of granulocyte differentiation + 11
                regulation of granulocyte differentiation + 20
Path 2
Term Annotations click to browse term
  biological_process 18605
    developmental process 7311
      anatomical structure development 6638
        multicellular organism development 6007
          system development 5654
            immune system development 1183
              hematopoietic or lymphoid organ development 1113
                hemopoiesis 1064
                  myeloid cell differentiation 470
                    myeloid leukocyte differentiation 257
                      granulocyte differentiation 45
                        basophil differentiation + 2
                        eosinophil differentiation + 5
                        negative regulation of granulocyte differentiation + 10
                        neutrophil differentiation + 11
                        positive regulation of granulocyte differentiation + 11
                        regulation of granulocyte differentiation + 20
paths to the root