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ONTOLOGY REPORT - ANNOTATIONS


Term:granulocyte differentiation
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Accession:GO:0030851 term browser browse the term
Definition:The process in which a myeloid precursor cell acquires the specialized features of a granulocyte. Granulocytes are a class of leukocytes characterized by the presence of granules in their cytoplasm. These cells are active in allergic immune reactions such as arthritic inflammation and rashes. This class includes basophils, eosinophils and neutrophils.
Synonyms:exact_synonym: granulocyte cell differentiation



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granulocyte differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AP3B1 adaptor related protein complex 3 subunit beta 1 acts_upstream_of_or_within ISO (MGI:5587889|PMID:23748140) MGI PMID:23748140 MGI:5587889 NCBI chr 3:28,481,974...28,748,095
Ensembl chr 3:28,481,038...28,751,258
JBrowse link
G CBFA2T3 CBFA2/RUNX1 partner transcriptional co-repressor 3 acts_upstream_of_or_within ISO (PMID:15231665) MGI PMID:15231665 NCBI chr 5:64,432,291...64,518,905
Ensembl chr 5:64,431,843...64,519,528
JBrowse link
G CEBPA CCAAT enhancer binding protein alpha involved_in ISO (MGI:3513695|PMID:15589173)
(MGI:2152476|PMID:11672531)
UniProt PMID:11672531 PMID:15589173 MGI:2152476 MGI:3513695 NCBI chr 1:118,846,252...118,851,045 JBrowse link
G CEBPE CCAAT enhancer binding protein epsilon involved_in ISO (PMID:10359588) UniProt PMID:10359588 NCBI chr 8:3,423,046...3,425,595
Ensembl chr 8:3,423,040...3,425,217
JBrowse link
G CITED2 Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2 acts_upstream_of_or_within ISO (MGI:3847632|PMID:17644732) MGI PMID:17644732 MGI:3847632 NCBI chr 1:31,522,911...31,525,342
Ensembl chr 1:31,523,799...31,524,995
JBrowse link
G CYP19A1 cytochrome P450 family 19 subfamily A member 1 ISO RGD PMID:18401763 RGD:4784626 NCBI chr30:16,954,020...17,056,728
Ensembl chr30:16,957,215...16,988,353
JBrowse link
G KDM1A lysine demethylase 1A involved_in ISO (MGI:5284774|PMID:17707228) UniProt PMID:17707228 MGI:5284774 NCBI chr 2:76,313,742...76,375,716
Ensembl chr 2:76,156,434...76,375,632
JBrowse link
G L3MBTL3 L3MBTL histone methyl-lysine binding protein 3 acts_upstream_of_or_within ISO (MGI:3578583|PMID:15889154) MGI PMID:15889154 MGI:3578583 NCBI chr 1:68,538,014...68,655,173
Ensembl chr 1:68,540,051...68,654,414
JBrowse link
G NKAP NFKB activating protein acts_upstream_of_or_within ISO (MGI:4838711|PMID:20610818) MGI PMID:20610818 MGI:4838711 NCBI chr  X:91,922,326...91,956,566
Ensembl chr  X:91,923,550...91,956,414
JBrowse link
G SP3 Sp3 transcription factor acts_upstream_of_or_within ISO (MGI:2670314|PMID:12676787) MGI PMID:12676787 MGI:2670314 NCBI chr36:18,023,750...18,086,995
Ensembl chr36:18,024,627...18,077,587
JBrowse link
G SPI1 Spi-1 proto-oncogene acts_upstream_of_or_within ISO (MGI:2179579|PMID:11980719) MGI PMID:11980719 MGI:2179579 NCBI chr18:42,253,849...42,269,497
Ensembl chr18:42,253,811...42,269,727
JBrowse link
G SRP54 signal recognition particle 54 involved_in ISS UniProt GO_REF:0000024 NCBI chr 8:13,800,275...13,837,799
Ensembl chr 8:13,677,760...13,837,722
JBrowse link
G ZFPM1 zinc finger protein, FOG family member 1 acts_upstream_of_or_within ISO (MGI:4420713|PMID:20010697) MGI PMID:20010697 MGI:4420713 NCBI chr 5:64,812,353...64,863,278 JBrowse link
basophil differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GATA1 GATA binding protein 1 involved_in ISO (PMID:7678994) BHF-UCL PMID:7678994 NCBI chr  X:41,991,321...41,998,319
Ensembl chr  X:41,971,582...41,998,303
JBrowse link
G TAL1 TAL bHLH transcription factor 1, erythroid differentiation factor involved_in ISO (PMID:7678994) BHF-UCL PMID:7678994 NCBI chr15:13,446,752...13,462,038
Ensembl chr15:13,449,481...13,462,047
JBrowse link
eosinophil differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GATA1 GATA binding protein 1 involved_in ISO (PMID:8507862) BHF-UCL PMID:8507862 NCBI chr  X:41,991,321...41,998,319
Ensembl chr  X:41,971,582...41,998,303
JBrowse link
G IL25 interleukin 25 acts_upstream_of_or_within ISO (MGI:2388222|PMID:12077275) MGI PMID:12077275 MGI:2388222 NCBI chr 8:3,621,268...3,624,689
Ensembl chr 8:3,618,161...3,624,043
JBrowse link
eosinophil fate commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GATA1 GATA binding protein 1 involved_in ISO (PMID:12045236) BHF-UCL PMID:12045236 NCBI chr  X:41,991,321...41,998,319
Ensembl chr  X:41,971,582...41,998,303
JBrowse link
G GATA2 GATA binding protein 2 involved_in ISO (PMID:12045236) BHF-UCL PMID:12045236 NCBI chr20:2,472,251...2,488,380
Ensembl chr20:2,473,912...2,480,991
JBrowse link
negative regulation of granulocyte differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADIPOQ adiponectin, C1Q and collagen domain containing involved_in ISO (PMID:10961870) BHF-UCL PMID:10961870 NCBI chr34:19,398,310...19,410,519
Ensembl chr34:19,354,825...19,409,844
JBrowse link
G C1QC complement C1q C chain involved_in ISO (PMID:10961870) BHF-UCL PMID:10961870 NCBI chr 2:76,660,039...76,664,602
Ensembl chr 2:76,660,035...76,664,577
JBrowse link
G CEACAM1 CEA cell adhesion molecule 1 involved_in ISO (MGI:4837548|PMID:21029969) UniProt PMID:21029969 MGI:4837548 NCBI chr 1:111,902,429...111,919,191
Ensembl chr 1:111,745,413...111,917,830
JBrowse link
G CUL4A cullin 4A involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3691926|PMID:12393421) Ensembl
MGI
PMID:12393421 GO_REF:0000107 MGI:3691926 NCBI chr22:60,624,215...60,667,844
Ensembl chr22:60,624,241...60,666,616
JBrowse link
G INPP5D inositol polyphosphate-5-phosphatase D acts_upstream_of_or_within ISO (MGI:1266928|PMID:9620849) MGI PMID:9620849 MGI:1266928 NCBI chr25:44,612,146...44,731,347
Ensembl chr25:44,611,523...44,730,200
JBrowse link
G PRDM16 PR/SET domain 16 involved_in ISO (PMID:12816872) UniProt PMID:12816872 NCBI chr 5:57,805,951...58,018,817
Ensembl chr 5:57,730,370...58,017,976
JBrowse link
G RARA retinoic acid receptor alpha involved_in ISO (PMID:19917671) UniProt PMID:19917671 NCBI chr 9:22,254,803...22,298,614
Ensembl chr 9:22,254,806...22,289,459
JBrowse link
G RUNX1 RUNX family transcription factor 1 involved_in ISO (PMID:9199349) UniProt PMID:9199349 NCBI chr31:30,170,859...30,420,344
Ensembl chr31:30,170,605...30,420,839
JBrowse link
G ZBTB46 zinc finger and BTB domain containing 46 acts_upstream_of_or_within ISO (MGI:5320487|PMID:22615127) MGI PMID:22615127 MGI:5320487 NCBI chr24:47,290,696...47,329,342
Ensembl chr24:47,292,684...47,329,570
JBrowse link
negative regulation of neutrophil differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G INPP5D inositol polyphosphate-5-phosphatase D acts_upstream_of_or_within ISO (MGI:1266928|PMID:9620849) MGI PMID:9620849 MGI:1266928 NCBI chr25:44,612,146...44,731,347
Ensembl chr25:44,611,523...44,730,200
JBrowse link
G TRIB1 tribbles pseudokinase 1 involved_in ISO (MGI:5488531|PMID:23515163) CACAO PMID:23515163 MGI:5488531 NCBI chr13:23,337,788...23,346,304
Ensembl chr13:23,337,788...23,346,304
JBrowse link
neutrophil differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CSF2 colony stimulating factor 2 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3842881|PMID:19109256) Ensembl
MGI
PMID:19109256 GO_REF:0000107 MGI:3842881 NCBI chr11:20,342,880...20,346,959
Ensembl chr11:20,344,648...20,346,959
JBrowse link
G DHRS7B dehydrogenase/reductase 7B involved_in ISO (MGI:5630041|PMID:25565205) MGI PMID:25565205 MGI:5630041 NCBI chr 5:42,603,027...42,666,446
Ensembl chr 5:42,603,078...42,665,673
JBrowse link
G FASN fatty acid synthase involved_in ISO (MGI:5630041|PMID:25565205) MGI PMID:25565205 MGI:5630041 NCBI chr 9:233,105...249,573
Ensembl chr 9:232,963...249,092
JBrowse link
G IL17C interleukin 17C acts_upstream_of_or_within ISO (MGI:2388222|PMID:12077275) MGI PMID:12077275 MGI:2388222 NCBI chr 5:64,702,668...64,703,694
Ensembl chr 5:64,702,730...64,703,984
JBrowse link
G JAGN1 jagunal homolog 1 involved_in
NOT|involved_in
IEA
ISO
(MGI:5604054|PMID:25129145) Ensembl
UniProt
PMID:25129145 GO_REF:0000107 MGI:5604054 NCBI chr20:8,372,981...8,376,089
Ensembl chr20:8,373,316...8,376,085
JBrowse link
G LBR lamin B receptor involved_in ISO (MGI:5308142|PMID:22140257) UniProt PMID:22140257 MGI:5308142 NCBI chr 7:39,289,517...39,309,026
Ensembl chr 7:39,288,147...39,307,606
JBrowse link
G LEF1 lymphoid enhancer binding factor 1 involved_in ISO (PMID:17063141) UniProt PMID:17063141 NCBI chr32:28,516,002...28,633,759
Ensembl chr32:28,517,108...28,634,019
JBrowse link
positive regulation of eosinophil differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IL5 interleukin 5 ISO RGD PMID:10529595 PMID:10727846 RGD:2303509 RGD:2303750 NCBI chr11:20,825,469...20,827,269
Ensembl chr11:20,825,469...20,827,269
JBrowse link
G TRIB1 tribbles pseudokinase 1 involved_in ISO (MGI:5488531|PMID:23515163) CACAO PMID:23515163 MGI:5488531 NCBI chr13:23,337,788...23,346,304
Ensembl chr13:23,337,788...23,346,304
JBrowse link
positive regulation of granulocyte differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EVI2B ecotropic viral integration site 2B involved_in ISO (PMID:28186500) UniProt PMID:28186500 NCBI chr 9:41,526,232...41,538,453
Ensembl chr 9:41,535,738...41,537,108
JBrowse link
G GFI1B growth factor independent 1B transcriptional repressor involved_in ISO (MGI:5284774|PMID:17707228) UniProt PMID:17707228 MGI:5284774 NCBI chr 9:51,380,697...51,394,679
Ensembl chr 9:51,380,696...51,392,812
JBrowse link
G HAX1 HCLS1 associated protein X-1 involved_in ISO (PMID:23001182) BHF-UCL PMID:23001182 NCBI chr 7:42,969,711...42,972,783
Ensembl chr 7:42,969,713...42,972,710
JBrowse link
G HCLS1 hematopoietic cell-specific Lyn substrate 1 involved_in ISO (PMID:23001182)
(MGI:5448611|PMID:23001182)
BHF-UCL PMID:23001182 MGI:5448611 NCBI chr33:24,901,023...24,925,710
Ensembl chr33:24,901,287...24,922,923
JBrowse link
G LEF1 lymphoid enhancer binding factor 1 involved_in ISO (PMID:23001182)
(PMID:19620402)
BHF-UCL
UniProt
PMID:19620402 PMID:23001182 NCBI chr32:28,516,002...28,633,759
Ensembl chr32:28,517,108...28,634,019
JBrowse link
G MIR223 microRNA mir-223 acts_upstream_of_or_within ISO (MGI:3811177|PMID:18278031) MGI PMID:18278031 MGI:3811177 NCBI chr  X:50,838,131...50,838,233
Ensembl chr  X:50,838,131...50,838,233
JBrowse link
G RUNX1 RUNX family transcription factor 1 involved_in ISO (PMID:9199349) UniProt PMID:9199349 NCBI chr31:30,170,859...30,420,344
Ensembl chr31:30,170,605...30,420,839
JBrowse link
G TESC tescalcin involved_in ISO (PMID:20060826) UniProt PMID:20060826 NCBI chr26:13,645,513...13,700,521
Ensembl chr26:13,645,511...13,689,367
JBrowse link
positive regulation of neutrophil differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EVI2B ecotropic viral integration site 2B involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 9:41,526,232...41,538,453
Ensembl chr 9:41,535,738...41,537,108
JBrowse link
G IKZF1 IKAROS family zinc finger 1 acts_upstream_of_or_within ISO (MGI:2654310|PMID:12406904) MGI PMID:12406904 MGI:2654310 NCBI chr18:1,661,851...1,750,987
Ensembl chr18:1,661,690...1,770,768
JBrowse link
regulation of granulocyte differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RARA retinoic acid receptor alpha acts_upstream_of_or_within ISO (MGI:1931374|PMID:11222375) MGI PMID:11222375 MGI:1931374 NCBI chr 9:22,254,803...22,298,614
Ensembl chr 9:22,254,806...22,289,459
JBrowse link
G RBP1 retinol binding protein 1 acts_upstream_of_or_within ISO (MGI:1931374|PMID:11222375) MGI PMID:11222375 MGI:1931374 NCBI chr23:35,677,844...35,698,194
Ensembl chr23:35,679,176...35,698,363
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 13969
    developmental process 6202
      cellular developmental process 4065
        cell differentiation 3971
          leukocyte differentiation 583
            myeloid leukocyte differentiation 234
              granulocyte differentiation 43
                basophil differentiation + 2
                eosinophil differentiation + 5
                negative regulation of granulocyte differentiation + 10
                neutrophil differentiation + 11
                positive regulation of granulocyte differentiation + 11
                regulation of granulocyte differentiation + 20
Path 2
Term Annotations click to browse term
  biological_process 13969
    developmental process 6202
      anatomical structure development 5772
        multicellular organism development 5261
          system development 4930
            immune system development 1042
              hematopoietic or lymphoid organ development 978
                hemopoiesis 930
                  myeloid cell differentiation 425
                    myeloid leukocyte differentiation 234
                      granulocyte differentiation 43
                        basophil differentiation + 2
                        eosinophil differentiation + 5
                        negative regulation of granulocyte differentiation + 10
                        neutrophil differentiation + 11
                        positive regulation of granulocyte differentiation + 11
                        regulation of granulocyte differentiation + 20
paths to the root