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ONTOLOGY REPORT - ANNOTATIONS


Term:granulocyte differentiation
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Accession:GO:0030851 term browser browse the term
Definition:The process in which a myeloid precursor cell acquires the specialized features of a granulocyte. Granulocytes are a class of leukocytes characterized by the presence of granules in their cytoplasm. These cells are active in allergic immune reactions such as arthritic inflammation and rashes. This class includes basophils, eosinophils and neutrophils.
Synonyms:exact_synonym: granulocyte cell differentiation


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granulocyte differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ap3b1 adaptor related protein complex 3 subunit beta 1 acts_upstream_of_or_within ISO (MGI:5587889|PMID:23748140) MGI PMID:23748140 MGI:5587889 NCBI chrNW_004955425:22,792,616...23,051,509
Ensembl chrNW_004955425:22,792,616...23,051,737
JBrowse link
G Cbfa2t3 CBFA2/RUNX1 partner transcriptional co-repressor 3 acts_upstream_of_or_within ISO (PMID:15231665) MGI PMID:15231665 NCBI chrNW_004955541:2,724,369...2,777,540
Ensembl chrNW_004955541:2,724,312...2,777,592
JBrowse link
G Cebpa CCAAT enhancer binding protein alpha involved_in ISO (MGI:2152476|PMID:11672531)
(MGI:3513695|PMID:15589173)
UniProt PMID:11672531 PMID:15589173 MGI:2152476 MGI:3513695 NCBI chrNW_004955468:3,046,544...3,049,217
Ensembl chrNW_004955468:3,047,931...3,049,080
JBrowse link
G Cebpe CCAAT enhancer binding protein epsilon involved_in ISO (PMID:10359588) UniProt PMID:10359588 NCBI chrNW_004955409:37,186,282...37,187,914
Ensembl chrNW_004955409:37,186,039...37,187,921
JBrowse link
G Cited2 Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2 acts_upstream_of_or_within ISO (MGI:3847632|PMID:17644732) MGI PMID:17644732 MGI:3847632 NCBI chrNW_004955436:20,370,950...20,372,677
Ensembl chrNW_004955436:20,370,950...20,372,677
JBrowse link
G Kdm1a lysine demethylase 1A involved_in ISO (MGI:5284774|PMID:17707228) UniProt PMID:17707228 MGI:5284774 NCBI chrNW_004955452:3,044,042...3,104,650
Ensembl chrNW_004955452:3,044,264...3,104,418
JBrowse link
G L3mbtl3 L3MBTL histone methyl-lysine binding protein 3 acts_upstream_of_or_within ISO (MGI:3578583|PMID:15889154) MGI PMID:15889154 MGI:3578583 NCBI chrNW_004955436:10,900,521...11,014,259
Ensembl chrNW_004955436:10,920,075...11,013,520
JBrowse link
G LOC102023780 aromatase ISO RGD PMID:18401763 RGD:4784626 NCBI chrNW_004955409:3,198,622...3,313,072
Ensembl chrNW_004955409:3,266,233...3,313,142
JBrowse link
G Nkap NFKB activating protein acts_upstream_of_or_within ISO (MGI:4838711|PMID:20610818) MGI PMID:20610818 MGI:4838711 NCBI chrNW_004955534:106,122...119,508
Ensembl chrNW_004955534:106,122...119,344
JBrowse link
G Sp3 Sp3 transcription factor acts_upstream_of_or_within ISO (MGI:2670314|PMID:12676787) MGI PMID:12676787 MGI:2670314 NCBI chrNW_004955449:1,347,781...1,404,368 JBrowse link
G Spi1 Spi-1 proto-oncogene acts_upstream_of_or_within ISO (MGI:2179579|PMID:11980719) MGI PMID:11980719 MGI:2179579 NCBI chrNW_004955422:873,735...886,560
Ensembl chrNW_004955422:873,735...886,560
JBrowse link
G Srp54 signal recognition particle 54 involved_in ISO (PMID:28972538) UniProt PMID:28972538 NCBI chrNW_004955409:25,977,226...26,016,351
Ensembl chrNW_004955409:25,977,226...26,016,351
JBrowse link
G Zfpm1 zinc finger protein, FOG family member 1 acts_upstream_of_or_within ISO (MGI:4420713|PMID:20010697) MGI PMID:20010697 MGI:4420713 NCBI chrNW_004955541:2,461,690...2,495,614 JBrowse link
basophil differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gata1 GATA binding protein 1 involved_in ISO (PMID:7678994) BHF-UCL PMID:7678994 NCBI chrNW_004955543:334,581...342,042
Ensembl chrNW_004955543:334,061...342,061
JBrowse link
G Tal1 TAL bHLH transcription factor 1, erythroid differentiation factor involved_in ISO (PMID:7678994) BHF-UCL PMID:7678994 NCBI chrNW_004955464:11,304,611...11,317,420
Ensembl chrNW_004955464:11,310,628...11,315,924
JBrowse link
eosinophil differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gata1 GATA binding protein 1 involved_in ISO (PMID:8507862) BHF-UCL PMID:8507862 NCBI chrNW_004955543:334,581...342,042
Ensembl chrNW_004955543:334,061...342,061
JBrowse link
G Il25 interleukin 25 acts_upstream_of_or_within ISO (MGI:2388222|PMID:12077275) MGI PMID:12077275 MGI:2388222 NCBI chrNW_004955409:36,960,902...36,964,038
Ensembl chrNW_004955409:36,961,398...36,964,038
JBrowse link
eosinophil fate commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gata1 GATA binding protein 1 involved_in ISO (PMID:12045236) BHF-UCL PMID:12045236 NCBI chrNW_004955543:334,581...342,042
Ensembl chrNW_004955543:334,061...342,061
JBrowse link
G Gata2 GATA binding protein 2 involved_in ISO (PMID:12045236) BHF-UCL PMID:12045236 NCBI chrNW_004955429:15,326,551...15,334,774
Ensembl chrNW_004955429:15,327,113...15,336,460
JBrowse link
negative regulation of granulocyte differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing involved_in ISO (PMID:10961870) BHF-UCL PMID:10961870 NCBI chrNW_004955420:20,911,181...20,922,992
Ensembl chrNW_004955420:20,912,348...20,914,402
JBrowse link
G C1qc complement C1q C chain involved_in ISO (PMID:10961870) BHF-UCL PMID:10961870 NCBI chrNW_004955452:2,759,079...2,762,522
Ensembl chrNW_004955452:2,758,821...2,762,522
JBrowse link
G Ceacam1 CEA cell adhesion molecule 1 involved_in ISO (MGI:4837548|PMID:21029969) UniProt PMID:21029969 MGI:4837548 NCBI chrNW_004955555:426,894...446,235 JBrowse link
G Cul4a cullin 4A acts_upstream_of_or_within ISO (MGI:3691926|PMID:12393421) MGI PMID:12393421 MGI:3691926 NCBI chrNW_004955404:583,261...617,914
Ensembl chrNW_004955404:583,261...617,914
JBrowse link
G Inpp5d inositol polyphosphate-5-phosphatase D acts_upstream_of_or_within ISO (MGI:1266928|PMID:9620849) MGI PMID:9620849 MGI:1266928 NCBI chrNW_004955453:2,938,659...3,037,211
Ensembl chrNW_004955453:2,938,659...3,037,211
JBrowse link
G Prdm16 PR/SET domain 16 involved_in ISO (PMID:12816872) UniProt PMID:12816872 NCBI chrNW_004955486:8,139,848...8,327,788
Ensembl chrNW_004955486:8,137,531...8,327,977
JBrowse link
G Rara retinoic acid receptor alpha involved_in ISO (PMID:19917671) UniProt PMID:19917671 NCBI chrNW_004955451:14,876,663...14,917,134
Ensembl chrNW_004955451:14,897,726...14,917,134
JBrowse link
G Zbtb46 zinc finger and BTB domain containing 46 acts_upstream_of_or_within ISO (MGI:5320487|PMID:22615127) MGI PMID:22615127 MGI:5320487 NCBI chrNW_004955528:438,826...485,484
Ensembl chrNW_004955528:438,859...475,543
JBrowse link
negative regulation of neutrophil differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Inpp5d inositol polyphosphate-5-phosphatase D acts_upstream_of_or_within ISO (MGI:1266928|PMID:9620849) MGI PMID:9620849 MGI:1266928 NCBI chrNW_004955453:2,938,659...3,037,211
Ensembl chrNW_004955453:2,938,659...3,037,211
JBrowse link
G Trib1 tribbles pseudokinase 1 involved_in ISO (MGI:5488531|PMID:23515163) CACAO PMID:23515163 MGI:5488531 NCBI chrNW_004955461:494,003...501,928
Ensembl chrNW_004955461:494,003...501,990
JBrowse link
neutrophil differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Csf2 colony stimulating factor 2 acts_upstream_of_or_within ISO (MGI:3842881|PMID:19109256) MGI PMID:19109256 MGI:3842881 NCBI chrNW_004955408:3,452,009...3,454,255
Ensembl chrNW_004955408:3,451,965...3,454,312
JBrowse link
G Dhrs7b dehydrogenase/reductase 7B involved_in ISO (MGI:5630041|PMID:25565205) MGI PMID:25565205 MGI:5630041 NCBI chrNW_004955577:1,071,904...1,122,204
Ensembl chrNW_004955577:1,071,775...1,121,940
JBrowse link
G Fasn fatty acid synthase involved_in ISO (MGI:5630041|PMID:25565205) MGI PMID:25565205 MGI:5630041 NCBI chrNW_004955506:1,063,002...1,079,939
Ensembl chrNW_004955506:1,063,002...1,079,939
JBrowse link
G Il17c interleukin 17C acts_upstream_of_or_within ISO (MGI:2388222|PMID:12077275) MGI PMID:12077275 MGI:2388222 NCBI chrNW_004955541:2,568,941...2,570,440
Ensembl chrNW_004955541:2,568,941...2,570,440
JBrowse link
G Jagn1 jagunal homolog 1 involved_in
NOT|involved_in
ISO (PMID:25129144)
(MGI:5604054|PMID:25129145)
UniProt PMID:25129144 PMID:25129145 MGI:5604054 NCBI chrNW_004955561:1,388,592...1,392,107
Ensembl chrNW_004955561:1,388,592...1,392,107
JBrowse link
G Lbr lamin B receptor involved_in ISO (MGI:5308142|PMID:22140257) UniProt PMID:22140257 MGI:5308142 NCBI chrNW_004955520:401,733...418,279 JBrowse link
G Lef1 lymphoid enhancer binding factor 1 involved_in ISO (PMID:17063141) UniProt PMID:17063141 NCBI chrNW_004955496:1,728,840...1,827,749
Ensembl chrNW_004955496:1,728,840...1,828,698
JBrowse link
positive regulation of eosinophil differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il5 interleukin 5 ISO RGD PMID:10529595 PMID:10727846 RGD:2303509 RGD:2303750 NCBI chrNW_004955408:3,937,128...3,951,784
Ensembl chrNW_004955408:3,937,894...3,939,358
JBrowse link
G Trib1 tribbles pseudokinase 1 involved_in ISO (MGI:5488531|PMID:23515163) CACAO PMID:23515163 MGI:5488531 NCBI chrNW_004955461:494,003...501,928
Ensembl chrNW_004955461:494,003...501,990
JBrowse link
positive regulation of granulocyte differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Evi2b ecotropic viral integration site 2B involved_in ISO (PMID:28186500) UniProt PMID:28186500 NCBI chrNW_004955481:6,332,220...6,342,374
Ensembl chrNW_004955481:6,332,714...6,334,072
JBrowse link
G Gfi1b growth factor independent 1B transcriptional repressor involved_in ISO (MGI:5284774|PMID:17707228) UniProt PMID:17707228 MGI:5284774 NCBI chrNW_004955513:2,273,267...2,281,850
Ensembl chrNW_004955513:2,277,981...2,281,515
JBrowse link
G Hax1 HCLS1 associated protein X-1 involved_in ISO (PMID:23001182) BHF-UCL PMID:23001182 NCBI chrNW_004955545:816,789...819,667 JBrowse link
G Hcls1 hematopoietic cell-specific Lyn substrate 1 involved_in ISO (PMID:23001182)
(MGI:5448611|PMID:23001182)
BHF-UCL PMID:23001182 MGI:5448611 NCBI chrNW_004955427:20,999,934...21,020,401
Ensembl chrNW_004955427:20,999,485...21,020,531
JBrowse link
G Lef1 lymphoid enhancer binding factor 1 involved_in ISO (PMID:19620402)
(PMID:23001182)
UniProt
BHF-UCL
PMID:19620402 PMID:23001182 NCBI chrNW_004955496:1,728,840...1,827,749
Ensembl chrNW_004955496:1,728,840...1,828,698
JBrowse link
G Tesc tescalcin involved_in ISO (PMID:20060826) UniProt PMID:20060826 NCBI chrNW_004955455:14,053,918...14,092,637
Ensembl chrNW_004955455:14,053,443...14,092,637
JBrowse link
positive regulation of neutrophil differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ikzf1 IKAROS family zinc finger 1 acts_upstream_of_or_within ISO (MGI:2654310|PMID:12406904) MGI PMID:12406904 MGI:2654310 NCBI chrNW_004955456:3,617,988...3,721,791
Ensembl chrNW_004955456:3,635,380...3,721,791
JBrowse link
regulation of granulocyte differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rara retinoic acid receptor alpha acts_upstream_of_or_within ISO (MGI:1931374|PMID:11222375) MGI PMID:11222375 MGI:1931374 NCBI chrNW_004955451:14,876,663...14,917,134
Ensembl chrNW_004955451:14,897,726...14,917,134
JBrowse link
G Rbp1 retinol binding protein 1 acts_upstream_of_or_within ISO (MGI:1931374|PMID:11222375) MGI PMID:11222375 MGI:1931374 NCBI chrNW_004955508:6,046,738...6,072,202
Ensembl chrNW_004955508:6,046,316...6,072,288
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12099
    developmental process 5738
      cellular developmental process 3727
        cell differentiation 3665
          leukocyte differentiation 542
            myeloid leukocyte differentiation 217
              granulocyte differentiation 41
                basophil differentiation + 2
                eosinophil differentiation + 5
                negative regulation of granulocyte differentiation + 9
                neutrophil differentiation + 10
                positive regulation of granulocyte differentiation + 9
                regulation of granulocyte differentiation + 18
Path 2
Term Annotations click to browse term
  biological_process 12099
    developmental process 5738
      anatomical structure development 5363
        multicellular organism development 4911
          system development 4608
            immune system development 956
              hematopoietic or lymphoid organ development 898
                hemopoiesis 852
                  myeloid cell differentiation 393
                    myeloid leukocyte differentiation 217
                      granulocyte differentiation 41
                        basophil differentiation + 2
                        eosinophil differentiation + 5
                        negative regulation of granulocyte differentiation + 9
                        neutrophil differentiation + 10
                        positive regulation of granulocyte differentiation + 9
                        regulation of granulocyte differentiation + 18
paths to the root