Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

ONTOLOGY REPORT - ANNOTATIONS


Term:granulocyte differentiation
go back to main search page
Accession:GO:0030851 term browser browse the term
Definition:The process in which a myeloid precursor cell acquires the specialized features of a granulocyte. Granulocytes are a class of leukocytes characterized by the presence of granules in their cytoplasm. These cells are active in allergic immune reactions such as arthritic inflammation and rashes. This class includes basophils, eosinophils and neutrophils.
Synonyms:exact_synonym: granulocyte cell differentiation



show annotations for term's descendants           Sort by:
 
granulocyte differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ap3b1 adaptor related protein complex 3 subunit beta 1 acts_upstream_of_or_within ISO (MGI:5587889|PMID:23748140) RGD PMID:23748140 MGI:5587889 NCBI chr 2:25,600,069...25,800,937
Ensembl chr 2:25,600,040...25,800,935
JBrowse link
G Cbfa2t3 CBFA2/RUNX1 partner transcriptional co-repressor 3 acts_upstream_of_or_within ISO (PMID:15231665) RGD PMID:15231665 NCBI chr19:50,679,897...50,750,028
Ensembl chr19:50,680,729...50,749,610
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha involved_in IEA
ISO
ISS
GO_REF:0000107
(MGI:2152476|PMID:11672531), (MGI:3513695|PMID:15589173)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:11672531 PMID:15589173 GO_REF:0000024 GO_REF:0000107 MGI:2152476 MGI:3513695 NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412
JBrowse link
G Cebpe CCAAT/enhancer binding protein epsilon involved_in ISO (PMID:10359588) RGD PMID:10359588 NCBI chr15:28,169,885...28,171,283
Ensembl chr15:28,169,704...28,171,814
JBrowse link
G Cited2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 acts_upstream_of_or_within ISO MGI:2385355 (MGI:3847632|PMID:17644732) RGD PMID:17644732 MGI:3847632 NCBI chr 1:12,312,426...12,314,869
Ensembl chr 1:12,312,160...12,314,897
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 IEP RGD PMID:18401763 RGD:4784626 NCBI chr 8:54,553,165...54,580,758
Ensembl chr 8:54,553,165...54,580,758
JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 IEP RGD PMID:18401763 RGD:4784626 NCBI chr 2:186,169,864...186,175,984
Ensembl chr 2:186,169,863...186,175,999
JBrowse link
G Kdm1a lysine demethylase 1A involved_in ISO (MGI:5284774|PMID:17707228) RGD PMID:17707228 MGI:5284774 NCBI chr 5:148,782,976...148,838,319
Ensembl chr 5:148,782,976...148,838,319
JBrowse link
G L3mbtl3 L3MBTL histone methyl-lysine binding protein 3 acts_upstream_of_or_within ISO MGI:3579468 (MGI:3578583|PMID:15889154) RGD PMID:15889154 MGI:3578583 NCBI chr 1:18,988,763...19,089,247
Ensembl chr 1:18,990,618...19,089,263
JBrowse link
G Nkap NFKB activating protein involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:2176073|MGI:4839023 (MGI:4838711|PMID:20610818)
Ensembl
RGD
PMID:20610818 GO_REF:0000107 MGI:4838711 NCBI chr  X:116,373,031...116,392,677
Ensembl chr  X:116,372,839...116,394,945
JBrowse link
G Sp3 Sp3 transcription factor acts_upstream_of_or_within ISO MGI:2182438 (MGI:2670314|PMID:12676787) RGD PMID:12676787 MGI:2670314 NCBI chr 3:57,811,855...57,857,150
Ensembl chr 3:57,812,075...57,860,342
JBrowse link
G Spi1 Spi-1 proto-oncogene acts_upstream_of_or_within ISO (MGI:2179579|PMID:11980719) RGD PMID:11980719 MGI:2179579 NCBI chr 3:77,059,744...77,093,730
Ensembl chr 3:77,073,012...77,092,393
JBrowse link
G Srp54a signal recognition particle 54A involved_in ISS
ISO
GO_REF:0000024
(PMID:28972538)
UniProt
RGD
PMID:28972538 GO_REF:0000024 NCBI chr 6:72,587,582...72,645,154
Ensembl chr 6:72,587,605...72,625,189
JBrowse link
G Zfpm1 zinc finger protein, multitype 1 acts_upstream_of_or_within ISO MGI:2176182|MGI:4421436 (MGI:4420713|PMID:20010697) RGD PMID:20010697 MGI:4420713 NCBI chr19:50,334,352...50,391,029
Ensembl chr19:50,334,682...50,390,591
JBrowse link
basophil differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gata1 GATA binding protein 1 involved_in ISO (PMID:7678994) RGD PMID:7678994 NCBI chr  X:14,529,706...14,537,530
Ensembl chr  X:14,529,702...14,537,530
JBrowse link
G Tal1 TAL bHLH transcription factor 1, erythroid differentiation factor involved_in ISO (PMID:7678994) RGD PMID:7678994 NCBI chr 5:128,586,776...128,600,976
Ensembl chr 5:128,587,701...128,600,976
JBrowse link
eosinophil differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gata1 GATA binding protein 1 involved_in ISO (PMID:8507862) RGD PMID:8507862 NCBI chr  X:14,529,706...14,537,530
Ensembl chr  X:14,529,702...14,537,530
JBrowse link
G Il25 interleukin 25 acts_upstream_of_or_within ISO (MGI:2388222|PMID:12077275) RGD PMID:12077275 MGI:2388222 NCBI chr15:28,408,842...28,411,676
Ensembl chr15:28,408,842...28,411,893
JBrowse link
eosinophil fate commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gata1 GATA binding protein 1 involved_in ISO (PMID:12045236) RGD PMID:12045236 NCBI chr  X:14,529,706...14,537,530
Ensembl chr  X:14,529,702...14,537,530
JBrowse link
G Gata2 GATA binding protein 2 involved_in ISO (PMID:12045236) RGD PMID:12045236 NCBI chr 4:120,654,205...120,667,763
Ensembl chr 4:120,658,986...120,667,761
JBrowse link
negative regulation of granulocyte differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing involved_in ISO
ISS
(PMID:10961870)
GO_REF:0000024
RGD
UniProt
PMID:10961870 GO_REF:0000024 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
JBrowse link
G C1qc complement C1q C chain involved_in ISO
IEA
(PMID:10961870)
GO_REF:0000107
RGD
Ensembl
PMID:10961870 GO_REF:0000107 NCBI chr 5:149,127,424...149,130,732
Ensembl chr 5:149,127,415...149,131,017
JBrowse link
G Ceacam1 CEA cell adhesion molecule 1 involved_in ISS
ISO
GO_REF:0000024
(MGI:4837548|PMID:21029969)
UniProt
RGD
PMID:21029969 GO_REF:0000024 MGI:4837548 NCBI chr 1:81,043,595...81,060,050
Ensembl chr 1:81,043,595...81,059,992
JBrowse link
G Cul4a cullin 4A acts_upstream_of_or_within ISO (MGI:3691926|PMID:12393421) RGD PMID:12393421 MGI:3691926 NCBI chr16:76,385,298...76,422,316
Ensembl chr16:76,384,546...76,422,330
JBrowse link
G Inpp5d inositol polyphosphate-5-phosphatase D acts_upstream_of_or_within ISO MGI:2386884 (MGI:1266928|PMID:9620849) RGD PMID:9620849 MGI:1266928 NCBI chr 9:88,287,680...88,392,748
Ensembl chr 9:88,287,677...88,392,746
JBrowse link
G Prdm16 PR/SET domain 16 involved_in ISO (PMID:12816872) RGD PMID:12816872 NCBI chr 5:164,879,864...165,203,986
Ensembl chr 5:164,880,587...165,203,601
JBrowse link
G Rara retinoic acid receptor, alpha involved_in ISO (PMID:19917671) RGD PMID:19917671 NCBI chr10:83,883,490...83,928,932
Ensembl chr10:83,893,384...83,928,142
JBrowse link
G Runx1 RUNX family transcription factor 1 involved_in ISO (PMID:9199349) RGD PMID:9199349 NCBI chr11:31,839,880...32,074,427
Ensembl chr11:31,843,764...32,074,542
JBrowse link
G Zbtb46 zinc finger and BTB domain containing 46 acts_upstream_of_or_within ISO MGI:5320483 (MGI:5320487|PMID:22615127) RGD PMID:22615127 MGI:5320487 NCBI chr 3:168,497,294...168,567,799
Ensembl chr 3:168,499,583...168,568,782
JBrowse link
negative regulation of neutrophil differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Inpp5d inositol polyphosphate-5-phosphatase D involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:2386884 (MGI:1266928|PMID:9620849)
Ensembl
RGD
PMID:9620849 GO_REF:0000107 MGI:1266928 NCBI chr 9:88,287,680...88,392,748
Ensembl chr 9:88,287,677...88,392,746
JBrowse link
G Trib1 tribbles pseudokinase 1 involved_in ISO (MGI:5488531|PMID:23515163) RGD PMID:23515163 MGI:5488531 NCBI chr 7:91,206,579...91,213,126
Ensembl chr 7:91,206,579...91,214,731
JBrowse link
neutrophil differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Csf2 colony stimulating factor 2 acts_upstream_of_or_within ISO (MGI:3842881|PMID:19109256) RGD PMID:19109256 MGI:3842881 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199
JBrowse link
G Dhrs7b dehydrogenase/reductase 7B involved_in ISO MGI:5749209 (MGI:5630041|PMID:25565205) RGD PMID:25565205 MGI:5630041 NCBI chr10:45,504,344...45,537,094
Ensembl chr10:45,504,426...45,537,076
JBrowse link
G Fasn fatty acid synthase involved_in ISO MGI:3765070 (MGI:5630041|PMID:25565205) RGD PMID:25565205 MGI:5630041 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
JBrowse link
G Il17c interleukin 17C acts_upstream_of_or_within ISO (MGI:2388222|PMID:12077275) RGD PMID:12077275 MGI:2388222 NCBI chr19:50,484,890...50,486,169
Ensembl chr19:50,484,890...50,486,169
JBrowse link
G Jagn1 jagunal homolog 1 involved_in
NOT|involved_in
ISO
ISS
(PMID:25129144)
(MGI:5604054|PMID:25129145)
GO_REF:0000024
RGD
UniProt
PMID:25129144 PMID:25129145 GO_REF:0000024 MGI:5604054 NCBI chr 4:146,591,577...146,596,287
Ensembl chr 4:146,591,510...146,596,288
JBrowse link
G Lbr lamin B receptor involved_in ISS
ISO
GO_REF:0000024
(MGI:5308142|PMID:22140257)
UniProt
RGD
PMID:22140257 GO_REF:0000024 MGI:5308142 NCBI chr13:93,539,360...93,564,065 JBrowse link
G Lef1 lymphoid enhancer binding factor 1 involved_in IEA
ISO
GO_REF:0000107
(PMID:17063141)
Ensembl
RGD
PMID:17063141 GO_REF:0000107 NCBI chr 2:219,666,549...219,779,815
Ensembl chr 2:219,666,592...219,779,794
JBrowse link
positive regulation of eosinophil differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il5 interleukin 5 IDA RGD PMID:10727846 PMID:10529595 RGD:2303509, RGD:2303750 NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213
JBrowse link
G Trib1 tribbles pseudokinase 1 involved_in ISO (MGI:5488531|PMID:23515163) RGD PMID:23515163 MGI:5488531 NCBI chr 7:91,206,579...91,213,126
Ensembl chr 7:91,206,579...91,214,731
JBrowse link
positive regulation of granulocyte differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Evi2b ecotropic viral integration site 2B involved_in ISO (PMID:28186500) RGD PMID:28186500 NCBI chr10:64,472,693...64,474,311
Ensembl chr10:64,471,505...64,481,560
JBrowse link
G Gfi1b growth factor independent 1B transcriptional repressor involved_in ISO (MGI:5284774|PMID:17707228) RGD PMID:17707228 MGI:5284774 NCBI chr 3:11,940,232...11,952,989
Ensembl chr 3:11,940,233...11,952,942
JBrowse link
G Hax1 HCLS1 associated protein X-1 involved_in ISO
IEA
(PMID:23001182)
GO_REF:0000107
RGD
Ensembl
PMID:23001182 GO_REF:0000107 NCBI chr 2:175,434,242...175,437,926
Ensembl chr 2:175,434,238...175,437,714
JBrowse link
G Hcls1 hematopoietic cell specific Lyn substrate 1 involved_in ISO (PMID:23001182)
(MGI:5448611|PMID:23001182)
RGD PMID:23001182 MGI:5448611 NCBI chr11:63,817,482...63,840,943
Ensembl chr11:63,817,476...63,841,014
JBrowse link
G Lef1 lymphoid enhancer binding factor 1 involved_in ISO
IEA
(PMID:19620402), (PMID:23001182)
GO_REF:0000107
RGD
Ensembl
PMID:19620402 PMID:23001182 GO_REF:0000107 NCBI chr 2:219,666,549...219,779,815
Ensembl chr 2:219,666,592...219,779,794
JBrowse link
G Mir223 microRNA 223 acts_upstream_of_or_within ISO MGI:3811186 (MGI:3811177|PMID:18278031) RGD PMID:18278031 MGI:3811177 NCBI chr  X:61,141,887...61,141,996
Ensembl chr  X:61,141,887...61,141,996
JBrowse link
G Runx1 RUNX family transcription factor 1 involved_in ISO
ISS
(PMID:9199349)
GO_REF:0000024
RGD
UniProt
PMID:9199349 GO_REF:0000024 NCBI chr11:31,839,880...32,074,427
Ensembl chr11:31,843,764...32,074,542
JBrowse link
G Tesc tescalcin involved_in ISO (PMID:20060826) RGD PMID:20060826 NCBI chr12:38,521,839...38,555,665
Ensembl chr12:38,521,861...38,555,824
JBrowse link
positive regulation of neutrophil differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Evi2b ecotropic viral integration site 2B involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:64,472,693...64,474,311
Ensembl chr10:64,471,505...64,481,560
JBrowse link
G Ikzf1 IKAROS family zinc finger 1 acts_upstream_of_or_within ISO MGI:2667175 (MGI:2654310|PMID:12406904) RGD PMID:12406904 MGI:2654310 NCBI chr14:86,255,065...86,340,839
Ensembl chr14:86,255,065...86,342,416
JBrowse link
regulation of granulocyte differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rara retinoic acid receptor, alpha acts_upstream_of_or_within ISO MGI:1857622 (MGI:1931374|PMID:11222375) RGD PMID:11222375 MGI:1931374 NCBI chr10:83,883,490...83,928,932
Ensembl chr10:83,893,384...83,928,142
JBrowse link
G Rbp1 retinol binding protein 1 acts_upstream_of_or_within ISO MGI:2181412 (MGI:1931374|PMID:11222375) RGD PMID:11222375 MGI:1931374 NCBI chr 8:99,025,218...99,046,740
Ensembl chr 8:99,025,206...99,046,743
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19497
    developmental process 6889
      cellular developmental process 4543
        cell differentiation 4448
          leukocyte differentiation 617
            myeloid leukocyte differentiation 238
              granulocyte differentiation 44
                basophil differentiation + 2
                eosinophil differentiation + 5
                negative regulation of granulocyte differentiation + 10
                neutrophil differentiation + 11
                positive regulation of granulocyte differentiation + 11
                regulation of granulocyte differentiation + 20
Path 2
Term Annotations click to browse term
  biological_process 19497
    developmental process 6889
      anatomical structure development 6306
        multicellular organism development 5727
          system development 5373
            immune system development 1105
              hematopoietic or lymphoid organ development 1038
                hemopoiesis 986
                  myeloid cell differentiation 443
                    myeloid leukocyte differentiation 238
                      granulocyte differentiation 44
                        basophil differentiation + 2
                        eosinophil differentiation + 5
                        negative regulation of granulocyte differentiation + 10
                        neutrophil differentiation + 11
                        positive regulation of granulocyte differentiation + 11
                        regulation of granulocyte differentiation + 20
paths to the root