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ONTOLOGY REPORT - ANNOTATIONS

Term:negative regulation of BMP signaling pathway
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Accession:GO:0030514 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of the BMP signaling pathway.
Synonyms:exact_synonym: down regulation of BMP signaling pathway;   downregulation of BMP signaling pathway;   negative regulation of BMP signalling pathway;   negative regulation of bone morphogenetic protein signaling pathway;   negative regulation of bone morphogenetic protein signalling pathway
 narrow_synonym: inhibition of BMP signaling pathway;   negative regulation of decapentaplegic receptor signaling pathway;   negative regulation of decapentaplegic receptor signalling pathway;   negative regulation of decapentaplegic signaling pathway
 related_synonym: negative regulation of BMP receptor signaling pathway
 alt_id: GO:0090099

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negative regulation of BMP signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase acts_upstream_of_or_within ISO (PMID:22729085) MGI PMID:22729085 NCBI chrNW_004955513:652,048...799,182
Ensembl chrNW_004955513:653,252...799,239 		JBrowse link
G Bambi BMP and activin membrane bound inhibitor acts_upstream_of_or_within ISO (PMID:21743293) ARUK-UCL PMID:21743293 NCBI chrNW_004955429:21,024,396...21,025,890
Ensembl chrNW_004955429:21,024,374...21,025,890 		JBrowse link
G Cav1 caveolin 1 involved_in ISO (PMID:15657086) BHF-UCL PMID:15657086 NCBI chrNW_004955432:22,258,262...22,292,403
Ensembl chrNW_004955432:22,258,250...22,292,403 		JBrowse link
G Cer1 cerberus 1, DAN family BMP antagonist acts_upstream_of_or_within ISO (PMID:9431803), (PMID:9501024) MGI PMID:9431803 PMID:9501024 NCBI chrNW_004955434:17,738,281...17,740,823
Ensembl chrNW_004955434:17,734,495...17,740,823 		JBrowse link
G Chrd chordin involved_in
acts_upstream_of_or_within		 ISO (PMID:11472837)
(PMID:15381701)
(PMID:15780974), (PMID:19850029)		 BHF-UCL
MGI		 PMID:11472837 PMID:15381701 PMID:15780974 PMID:19850029 NCBI chrNW_004955420:23,111,690...23,120,038
Ensembl chrNW_004955420:23,112,093...23,120,036 		JBrowse link
G Chrdl1 chordin like 1 involved_in
acts_upstream_of_or_within		 ISO (PMID:11401399)
(PMID:23676271)		 MGI PMID:11401399 PMID:23676271 NCBI chrNW_004955490:5,108,308...5,218,679
Ensembl chrNW_004955490:5,108,308...5,257,445 		JBrowse link
G Chrdl2 chordin like 2 acts_upstream_of_or_within ISO (PMID:14660436) MGI PMID:14660436 NCBI chrNW_004955414:16,986,199...17,018,166
Ensembl chrNW_004955414:16,986,233...17,018,225 		JBrowse link
G Crim1 cysteine rich transmembrane BMP regulator 1 acts_upstream_of_or_within ISO (PMID:21743293) ARUK-UCL PMID:21743293 NCBI chrNW_004955441:4,275,411...4,420,537
Ensembl chrNW_004955441:4,274,611...4,420,537 		JBrowse link
G Ctdspl2 CTD small phosphatase like 2 acts_upstream_of_or_within ISO (PMID:25100727) MGI PMID:25100727 NCBI chrNW_004955416:10,970,487...11,046,179
Ensembl chrNW_004955416:10,970,492...11,046,179 		JBrowse link
G Dand5 DAN domain BMP antagonist family member 5 involved_in ISO (MGI:3055649|PMID:15466485) BHF-UCL PMID:15466485 MGI:3055649 NCBI chrNW_004955415:32,012,637...32,015,965
Ensembl chrNW_004955415:32,012,637...32,015,965 		JBrowse link
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 acts_upstream_of_or_within ISO (PMID:19850029) MGI PMID:19850029 NCBI chrNW_004955425:7,353,964...7,357,599 JBrowse link
G Dlx1 distal-less homeobox 1 involved_in ISO (PMID:14671321) UniProt PMID:14671321 NCBI chrNW_004955449:2,920,705...2,924,667
Ensembl chrNW_004955449:2,920,478...2,924,667 		JBrowse link
G Fstl3 follistatin like 3 involved_in
acts_upstream_of_or_within		 ISO (PMID:17878677)
(PMID:11010968)		 UniProt
MGI		 PMID:11010968 PMID:17878677 NCBI chrNW_004955495:7,077,424...7,082,768
Ensembl chrNW_004955495:7,078,427...7,082,717 		JBrowse link
G Gdf3 growth differentiation factor 3 involved_in ISO (PMID:18823971) UniProt PMID:18823971 NCBI chrNW_004955413:6,493,734...6,516,315 JBrowse link
G Grem1 gremlin 1, DAN family BMP antagonist involved_in
acts_upstream_of_or_within		 ISO (PMID:16816361), (PMID:27036124)
(PMID:17522159)
(PMID:15539560)		 UniProt
MGI
BHF-UCL		 PMID:15539560 PMID:16816361 PMID:17522159 PMID:27036124 NCBI chrNW_004955416:1,812,725...1,825,528
Ensembl chrNW_004955416:1,812,676...1,826,271 		JBrowse link
G Grem2 gremlin 2, DAN family BMP antagonist involved_in ISO (MGI:5507937|PMID:23063586) UniProt PMID:23063586 MGI:5507937 NCBI chrNW_004955406:11,245,960...11,343,677
Ensembl chrNW_004955406:11,245,960...11,343,677 		JBrowse link
G Hipk2 homeodomain interacting protein kinase 2 involved_in ISO (PMID:12874272) UniProt PMID:12874272 NCBI chrNW_004955494:3,365,826...3,554,735
Ensembl chrNW_004955494:3,393,049...3,554,844 		JBrowse link
G Hjv hemojuvelin BMP co-receptor acts_upstream_of_or_within ISO (PMID:20065295) MGI PMID:20065295 NCBI chrNW_004955568:80,386...84,707
Ensembl chrNW_004955568:80,444...84,834 		JBrowse link
G Htra1 HtrA serine peptidase 1 acts_upstream_of_or_within ISO (PMID:14973287) MGI PMID:14973287 NCBI chrNW_004955477:761,127...808,396
Ensembl chrNW_004955477:761,127...808,994 		JBrowse link
G Htra3 HtrA serine peptidase 3 involved_in ISO (MGI:3046453|PMID:15206957) UniProt PMID:15206957 MGI:3046453 NCBI chrNW_004955514:2,716,448...2,740,590
Ensembl chrNW_004955514:2,717,290...2,737,288 		JBrowse link
G Lrp2 LDL receptor related protein 2 involved_in ISO (MGI:5908338|PMID:20460439) UniProt PMID:20460439 MGI:5908338 NCBI chrNW_004955449:5,155,109...5,314,886
Ensembl chrNW_004955449:5,160,946...5,314,948 		JBrowse link
G Nanog Nanog homeobox acts_upstream_of_or_within ISO (PMID:16801560) MGI PMID:16801560 NCBI chrNW_004955413:6,561,323...6,565,770 JBrowse link
G Nbl1 NBL1, DAN family BMP antagonist involved_in
acts_upstream_of_or_within		 ISO (PMID:23063586)
(PMID:23676271)
(PMID:25561725)		 UniProt
MGI		 PMID:23063586 PMID:23676271 PMID:25561725 NCBI chrNW_004955452:316,867...319,883
Ensembl chrNW_004955452:308,573...319,989 		JBrowse link
G Nog noggin involved_in
acts_upstream_of_or_within		 ISO (PMID:10780858), (PMID:15539560), (PMID:8752214)
(PMID:19852960)
(MGI:3715084|PMID:17400546), (PMID:17360443)
(PMID:15110716), (PMID:15975920), (PMID:18462699), (PMID:19850029)
(PMID:16712836)
(MGI:3783944|PMID:17218603)		 BHF-UCL
MGI		 PMID:8752214 PMID:10780858 PMID:15110716 PMID:15539560 PMID:15975920 More... MGI:3715084 MGI:3783944 NCBI chrNW_004955451:6,192,368...6,193,766
Ensembl chrNW_004955451:6,193,042...6,193,740 		JBrowse link
G Notch1 notch receptor 1 involved_in ISO (MGI:4412151|PMID:19695258) BHF-UCL PMID:19695258 MGI:4412151 NCBI chrNW_004955513:4,225,939...4,264,875
Ensembl chrNW_004955513:4,225,956...4,263,259 		JBrowse link
G Pparg peroxisome proliferator activated receptor gamma acts_upstream_of_or_within ISO (PMID:21743293) ARUK-UCL PMID:21743293 NCBI chrNW_004955429:14,814,690...14,936,869
Ensembl chrNW_004955429:14,873,908...14,937,387 		JBrowse link
G Ppm1a protein phosphatase, Mg2+/Mn2+ dependent 1A acts_upstream_of_or_within ISO (PMID:25100727) MGI PMID:25100727 NCBI chrNW_004955466:9,315,227...9,331,213
Ensembl chrNW_004955466:9,315,227...9,362,028 		JBrowse link
G Sfrp1 secreted frizzled related protein 1 acts_upstream_of_or_within ISO (PMID:19850029) MGI PMID:19850029 NCBI chrNW_004955536:1,663,721...1,702,678
Ensembl chrNW_004955536:1,663,344...1,703,514 		JBrowse link
G Sfrp2 secreted frizzled related protein 2 acts_upstream_of_or_within ISO (PMID:19850029) MGI PMID:19850029 NCBI chrNW_004955471:8,103,937...8,112,596
Ensembl chrNW_004955471:8,103,783...8,112,321 		JBrowse link
G Ski SKI proto-oncogene involved_in
acts_upstream_of_or_within		 ISO (PMID:14699069)
(PMID:21937600)
(PMID:17054724)		 UniProt
MGI		 PMID:14699069 PMID:17054724 PMID:21937600 NCBI chrNW_004955486:8,857,693...8,921,821
Ensembl chrNW_004955486:8,857,693...8,921,821 		JBrowse link
G Skor1 SKI family transcriptional corepressor 1 involved_in ISO (PMID:17292623) UniProt PMID:17292623 NCBI chrNW_004955450:8,184,843...8,195,626
Ensembl chrNW_004955450:8,185,523...8,193,777 		JBrowse link
G Skor2 SKI family transcriptional corepressor 2 acts_upstream_of_or_within ISO (PMID:21937600) MGI PMID:21937600 NCBI chrNW_004955402:32,577,189...32,618,611
Ensembl chrNW_004955402:32,582,575...32,618,436 		JBrowse link
G Smad6 SMAD family member 6 involved_in ISO (PMID:22275001), (PMID:30848080)
(PMID:33667543), (PMID:9436979)		 UniProt PMID:9436979 PMID:22275001 PMID:30848080 PMID:33667543 NCBI chrNW_004955450:9,005,332...9,070,790 JBrowse link
G Smad7 SMAD family member 7 involved_in
acts_upstream_of_or_within		 ISO (PMID:17438144)
(PMID:19850029)		 BHF-UCL
MGI		 PMID:17438144 PMID:19850029 NCBI chrNW_004955402:34,028,184...34,058,949
Ensembl chrNW_004955402:34,028,063...34,058,291 		JBrowse link
G Smurf1 SMAD specific E3 ubiquitin protein ligase 1 involved_in ISO (PMID:27214554) BHF-UCL PMID:27214554 NCBI chrNW_004955460:14,774,545...14,860,783
Ensembl chrNW_004955460:14,774,545...14,802,879 		JBrowse link
G Sorl1 sortilin related receptor 1 involved_in ISO (MGI:5704270|PMID:26584636) UniProt PMID:26584636 MGI:5704270 NCBI chrNW_004955412:22,421,984...22,576,179
Ensembl chrNW_004955412:22,421,984...22,576,179 		JBrowse link
G Sost sclerostin acts_upstream_of_or_within ISO (PMID:14633986)
(PMID:17002572)		 MGI PMID:14633986 PMID:17002572 NCBI chrNW_004955451:17,054,939...17,058,027
Ensembl chrNW_004955451:17,054,939...17,058,027 		JBrowse link
G Sostdc1 sclerostin domain containing 1 involved_in
acts_upstream_of_or_within		 ISO (PMID:15020244)
(PMID:16179481)
(PMID:14623234), (PMID:16179481)		 UniProt
MGI		 PMID:14623234 PMID:15020244 PMID:16179481 NCBI chrNW_004955410:19,657,805...19,662,121
Ensembl chrNW_004955410:19,657,029...19,662,131 		JBrowse link
G Spart spartin acts_upstream_of_or_within ISO (PMID:22619377) MGI PMID:22619377 NCBI chrNW_004955431:9,758,159...9,786,468
Ensembl chrNW_004955431:9,758,053...9,786,644 		JBrowse link
G Tcf7l2 transcription factor 7 like 2 acts_upstream_of_or_within ISO (PMID:17919533) MGI PMID:17919533 NCBI chrNW_004955431:18,020,309...18,207,926
Ensembl chrNW_004955431:18,020,409...18,209,134 		JBrowse link
G Tmem53 transmembrane protein 53 involved_in ISO (PMID:33824347)
(MGI:6713651|PMID:33824347)		 UniProt PMID:33824347 MGI:6713651 NCBI chrNW_004955464:13,552,963...13,577,528
Ensembl chrNW_004955464:13,552,922...13,577,528 		JBrowse link
G Tmprss6 transmembrane serine protease 6 acts_upstream_of_or_within ISO (PMID:19751239) MGI PMID:19751239 NCBI chrNW_004955413:23,579,946...23,615,277
Ensembl chrNW_004955413:23,580,530...23,612,276 		JBrowse link
G Tnfaip6 TNF alpha induced protein 6 involved_in ISO (PMID:16771708) UniProt PMID:16771708 NCBI chrNW_004955440:16,915,952...16,944,375
Ensembl chrNW_004955440:16,916,055...16,944,190 		JBrowse link
G Tob1 transducer of ERBB2, 1 acts_upstream_of_or_within ISO (PMID:11163184) MGI PMID:11163184 NCBI chrNW_004955451:10,950,270...10,963,183 JBrowse link
G Trim33 tripartite motif containing 33 involved_in ISO (PMID:19135894) UniProt PMID:19135894 NCBI chrNW_004955435:17,631,596...17,750,261
Ensembl chrNW_004955435:17,631,602...17,750,261 		JBrowse link
G Twsg1 twisted gastrulation BMP signaling modulator 1 acts_upstream_of_or_within ISO (PMID:15780974)
(PMID:12665593)		 MGI PMID:12665593 PMID:15780974 NCBI chrNW_004955402:2,652,020...2,685,350
Ensembl chrNW_004955402:2,652,020...2,686,117 		JBrowse link
G Vwc2 von Willebrand factor C domain containing 2 involved_in ISO (MGI:3715084|PMID:17400546) HGNC-UCL PMID:17400546 MGI:3715084 NCBI chrNW_004955456:3,949,885...4,075,622
Ensembl chrNW_004955456:3,951,428...4,075,624 		JBrowse link
G Vwc2l von Willebrand factor C domain containing 2 like acts_upstream_of_or_within ISO (PMID:19852960) MGI PMID:19852960 NCBI chrNW_004955457:1,392,622...1,540,314
Ensembl chrNW_004955457:1,392,507...1,540,330 		JBrowse link
G Wnt1 Wnt family member 1 involved_in ISO (PMID:16194878) AgBase PMID:16194878 NCBI chrNW_004955500:7,797,063...7,811,142
Ensembl chrNW_004955500:7,797,060...7,811,167 		JBrowse link
G Wnt5a Wnt family member 5A acts_upstream_of_or_within ISO (PMID:18351662) MGI PMID:18351662 NCBI chrNW_004955430:5,304,817...5,325,684
Ensembl chrNW_004955430:5,304,745...5,325,684 		JBrowse link
sequestering of BMP from receptor via BMP binding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Grem2 gremlin 2, DAN family BMP antagonist involved_in ISO (MGI:5507937|PMID:23063586) UniProt PMID:23063586 MGI:5507937 NCBI chrNW_004955406:11,245,960...11,343,677
Ensembl chrNW_004955406:11,245,960...11,343,677 		JBrowse link
G Nbl1 NBL1, DAN family BMP antagonist involved_in ISO (PMID:23063586) UniProt PMID:23063586 NCBI chrNW_004955452:316,867...319,883
Ensembl chrNW_004955452:308,573...319,989 		JBrowse link
sequestering of BMP in extracellular matrix term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cer1 cerberus 1, DAN family BMP antagonist involved_in ISO (PMID:9660951)
(MGI:1858315|PMID:10748465)		 BHF-UCL PMID:9660951 PMID:10748465 MGI:1858315 NCBI chrNW_004955434:17,738,281...17,740,823
Ensembl chrNW_004955434:17,734,495...17,740,823 		JBrowse link
G Fbn1 fibrillin 1 involved_in ISO (MGI:4836762|PMID:20855508) BHF-UCL PMID:20855508 MGI:4836762 NCBI chrNW_004955409:5,281,603...5,502,547
Ensembl chrNW_004955409:5,281,603...5,504,761 		JBrowse link
G Nbl1 NBL1, DAN family BMP antagonist involved_in ISO (MGI:1203284|PMID:9660951) BHF-UCL PMID:9660951 MGI:1203284 NCBI chrNW_004955452:316,867...319,883
Ensembl chrNW_004955452:308,573...319,989 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12321
    response to stimulus 6667
      negative regulation of response to stimulus 1543
        negative regulation of cellular response to growth factor stimulus 94
          negative regulation of BMP signaling pathway 51
            sequestering of BMP from receptor via BMP binding 2
            sequestering of BMP in extracellular matrix 3
Path 2
Term Annotations click to browse term
  biological_process 12321
    biological regulation 8863
      regulation of biological process 8603
        regulation of cellular process 8187
          signal transduction 3939
            cell surface receptor signaling pathway 2174
              enzyme-linked receptor protein signaling pathway 836
                cell surface receptor protein serine/threonine kinase signaling pathway 336
                  transforming growth factor beta receptor superfamily signaling pathway 314
                    BMP signaling pathway 141
                      regulation of BMP signaling pathway 93
                        negative regulation of BMP signaling pathway 51
                          sequestering of BMP from receptor via BMP binding 2
                          sequestering of BMP in extracellular matrix 3
paths to the root