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Term:spectrin binding
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Accession:GO:0030507 term browser browse the term
Definition:Interacting selectively and non-covalently with spectrin, a protein that is the major constituent of the erythrocyte cytoskeletal network. It associates with band 4.1 (see band protein) and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. It is composed of nonhomologous chains, alpha and beta, which aggregate side-to-side in an antiparallel fashion to form dimers, tetramers, and higher polymers.

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spectrin binding term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADD1 adducin 1 IEA
(PMID:21873635) Ensembl
PMID:21873635 GO_REF:0000107 NCBI chr 8:1,627,146...1,710,653
Ensembl chr 8:1,627,177...1,710,661
JBrowse link
G ADD2 adducin 2 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 3:71,729,882...71,845,761
Ensembl chr 3:71,730,002...71,840,862
JBrowse link
G ADD3 adducin 3 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr14:120,451,421...120,583,725
Ensembl chr14:120,451,573...120,583,723
JBrowse link
G ANK1 ankyrin 1 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr17:10,752,258...10,985,129
Ensembl chr17:10,763,876...10,985,191
JBrowse link
G ANK2 ankyrin 2 ISO (PMID:15262991) BHF-UCL PMID:15262991 NCBI chr 8:109,306,793...109,661,970 JBrowse link
G ANK3 ankyrin 3 ISO PMID:17620337 BHF-UCL PMID:17620337 RGD:8693373 NCBI chr14:63,416,154...63,809,220 JBrowse link
G CAMSAP1 calmodulin regulated spectrin associated protein 1 IEA Ensembl
GO_REF:0000002, GO_REF:0000107
G CAMSAP2 calmodulin regulated spectrin associated protein family member 2 IEA InterPro GO_REF:0000002 NCBI chr10:23,275,302...23,360,167
Ensembl chr10:23,275,321...23,360,168
JBrowse link
G CAMSAP3 calmodulin regulated spectrin associated protein family member 3 IEA InterPro GO_REF:0000002 NCBI chr 2:71,531,607...71,547,413
Ensembl chr 2:71,531,607...71,547,419
JBrowse link
G DCTN2 dynactin subunit 2 IEA Ensembl GO_REF:0000107 NCBI chr 5:22,799,286...22,814,358
Ensembl chr 5:22,799,286...22,814,364
JBrowse link
G DMTN dematin actin binding protein IEA Ensembl GO_REF:0000107 NCBI chr14:6,315,643...6,346,722
Ensembl chr14:6,321,870...6,346,870
JBrowse link
G DYNC1I1 dynein cytoplasmic 1 intermediate chain 1 IEA Ensembl GO_REF:0000107 NCBI chr 9:75,414,663...75,760,527
Ensembl chr 9:75,336,441...75,760,523
JBrowse link
G EPB41 erythrocyte membrane protein band 4.1 ISO PMID:23704327 MGI PMID:23704327 RGD:8553853 NCBI chr 6:85,842,538...86,029,522
Ensembl chr 6:85,842,605...86,029,522
JBrowse link
G EPB41L2 erythrocyte membrane protein band 4.1 like 2 IEA Ensembl GO_REF:0000107 NCBI chr 1:32,418,210...32,630,643
Ensembl chr 1:32,418,217...32,630,643
JBrowse link
G GNB1 G protein subunit beta 1 ISO PMID:23704327 MGI PMID:23704327 RGD:8553853 NCBI chr 6:63,867,155...63,957,514
Ensembl chr 6:63,867,155...63,924,535
JBrowse link
G GNB3 G protein subunit beta 3 ISO PMID:23704327 MGI PMID:23704327 RGD:8553853 NCBI chr 5:63,863,656...63,871,352
Ensembl chr 5:63,863,661...63,870,433
JBrowse link
G KIF3A kinesin family member 3A ISO (PMID:23704327) MGI PMID:23704327 NCBI chr 2:134,932,339...135,069,408
Ensembl chr 2:134,932,615...135,069,351
JBrowse link
G MYO10 myosin X IEA Ensembl GO_REF:0000107 NCBI chr16:5,907,111...6,145,485
Ensembl chr16:5,907,116...6,145,442
JBrowse link
G MYO7A myosin VIIA IEA Ensembl GO_REF:0000107 NCBI chr 9:11,251,187...11,337,618
Ensembl chr 9:11,249,075...11,666,296
JBrowse link
G PDE6G phosphodiesterase 6G ISO PMID:23704327 MGI PMID:23704327 RGD:8553853 NCBI chr12:1,235,886...1,239,808 JBrowse link
G PTPRC protein tyrosine phosphatase receptor type C IEA Ensembl GO_REF:0000107 NCBI chr10:21,482,984...21,601,627
Ensembl chr10:21,466,373...21,764,560
JBrowse link
G PTPRN protein tyrosine phosphatase receptor type N IEA Ensembl GO_REF:0000107 NCBI chr15:121,329,284...121,349,228
Ensembl chr15:121,329,288...121,349,276
JBrowse link
G RHO rhodopsin ISO PMID:23704327 MGI PMID:23704327 RGD:8553853 NCBI chr13:68,908,578...68,913,651
Ensembl chr13:68,908,578...68,913,651
JBrowse link
G SAG S-antigen visual arrestin ISO PMID:23704327 MGI PMID:23704327 RGD:8553853 NCBI chr15:133,704,975...133,741,844
Ensembl chr15:133,691,886...133,741,798
JBrowse link
G SLC26A5 solute carrier family 26 member 5 IEA Ensembl GO_REF:0000107 NCBI chr 9:103,382,558...103,420,054
Ensembl chr 9:103,378,776...103,453,730
JBrowse link
G SPTAN1 spectrin alpha, non-erythrocytic 1 ISO PMID:23704327
MGI PMID:18796539, PMID:23704327 MGI:MGI:3821785, RGD:8553853 NCBI chr 1:268,936,120...269,002,261
Ensembl chr 1:268,936,025...269,002,261
JBrowse link
G SPTBN4 spectrin beta, non-erythrocytic 4 IEA Ensembl GO_REF:0000107 NCBI chr 6:48,729,839...48,812,799
Ensembl chr 6:48,729,750...48,812,796
JBrowse link
G SPTBN5 spectrin beta, non-erythrocytic 5 IEA Ensembl GO_REF:0000107 NCBI chr 1:129,461,598...129,514,380
Ensembl chr 1:129,463,674...129,511,568
JBrowse link
G STX4 syntaxin 4 ISO RGD PMID:16870704 RGD:2306291 NCBI chr 3:17,422,266...17,431,377
Ensembl chr 3:17,416,842...17,431,053
JBrowse link
G UNC13A unc-13 homolog A ISO RGD PMID:9704016 RGD:70020 NCBI chr 2:60,057,926...60,130,015 JBrowse link
G USH1C USH1 protein network component harmonin IEA Ensembl GO_REF:0000107 NCBI chr 2:41,593,793...41,646,777
Ensembl chr 2:41,593,802...41,647,411
JBrowse link
G USH1G USH1 protein network component sans IEA Ensembl GO_REF:0000107 NCBI chr12:6,333,640...6,341,083
Ensembl chr12:6,334,279...6,339,692
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 17442
    binding 15351
      protein-containing complex binding 1453
        spectrin binding 32
Path 2
Term Annotations click to browse term
  molecular_function 17442
    binding 15351
      protein binding 13764
        cytoskeletal protein binding 953
          spectrin binding 32
paths to the root


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.