Send us a Message



 Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) RatMine GViewer (Genome Viewer) Overgo Probe Designer ACP Haplotyper VCMap
Aging & Age-Related Disease Cancer Cardiovascular Disease COVID-19 Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models PhenoMiner (Quantitative Phenotypes) Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

ONTOLOGY REPORT - ANNOTATIONS

Term:negative regulation of ossification
go back to main search page
Accession:GO:0030279 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance.
Synonyms:exact_synonym: down regulation of ossification;   downregulation of ossification;   negative regulation of bone biosynthesis;   negative regulation of bone formation
 narrow_synonym: inhibition of ossification


show annotations for term's descendants           Sort by:
 
negative regulation of ossification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb2 adrenoceptor beta 2 IMP RGD PMID:16177600 RGD:1598747 NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512 		JBrowse link
G Bcl2 BCL2, apoptosis regulator involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(MGI:85084|PMID:9008714)		 Ensembl
RGD		 PMID:9008714 GO_REF:0000107 MGI:85084 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Calca calcitonin-related polypeptide alpha acts_upstream_of_or_within ISO MGI:3527257 (MGI:3653805|PMID:15537449)
MGI:3527257 (MGI:2447255|PMID:12488435)		 RGD PMID:12488435 PMID:15537449 MGI:2447255 MGI:3653805 NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105 		JBrowse link
G Calcr calcitonin receptor involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:3038975 (MGI:3037515|PMID:14970190)		 Ensembl
RGD		 PMID:14970190 GO_REF:0000107 MGI:3037515 NCBI chr 4:31,661,270...31,736,392
Ensembl chr 4:31,661,273...31,736,392 		JBrowse link
G Chsy1 chondroitin sulfate synthase 1 involved_in ISO (PMID:21129727) RGD PMID:21129727 NCBI chr 1:119,689,626...119,750,711
Ensembl chr 1:119,686,350...119,750,601 		JBrowse link
G Cyp27b1 cytochrome P450, family 27, subfamily b, polypeptide 1 IMP RGD PMID:32231239 RGD:32716373 NCBI chr 7:62,869,340...62,876,242
Ensembl chr 7:62,871,297...62,876,241 		JBrowse link
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 involved_in IMP
ISO		 (MGI:3803396|PMID:18505822) RGD PMID:18505822 PMID:21773994 MGI:3803396, RGD:6907379 NCBI chr 1:228,381,521...228,385,202
Ensembl chr 1:228,381,521...228,385,202 		JBrowse link
G Enpp1 ectonucleotide pyrophosphatase/phosphodiesterase 1 acts_upstream_of_or_within ISO MGI:1857079 (MGI:1270097|PMID:9662402) RGD PMID:9662402 MGI:1270097 NCBI chr 1:20,698,746...20,763,741
Ensembl chr 1:20,698,764...20,763,715 		JBrowse link
G Gfra4 GDNF family receptor alpha 4 acts_upstream_of_or_within ISO MGI:3625130 (MGI:3623870|PMID:16497798) RGD PMID:16497798 MGI:3623870 NCBI chr 3:118,254,937...118,262,252
Ensembl chr 3:118,255,402...118,258,329 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha involved_in ISO (MGI:5300390|PMID:22081627) RGD PMID:22081627 MGI:5300390 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Kremen1 kringle containing transmembrane protein 1 involved_in IEA
ISO		 GO_REF:0000107
(MGI:3803396|PMID:18505822)		 Ensembl
RGD		 PMID:18505822 GO_REF:0000107 MGI:3803396 NCBI chr14:80,081,870...80,147,489
Ensembl chr14:80,084,403...80,147,516 		JBrowse link
G Kremen2 kringle containing transmembrane protein 2 involved_in ISO (MGI:3803396|PMID:18505822) RGD PMID:18505822 MGI:3803396 NCBI chr10:12,763,345...12,767,854
Ensembl chr10:12,763,397...12,767,854 		JBrowse link
G Lrp4 LDL receptor related protein 4 involved_in ISO (PMID:21471202) RGD PMID:21471202 NCBI chr 3:77,429,600...77,483,593
Ensembl chr 3:77,429,798...77,483,593 		JBrowse link
G Mdk midkine involved_in ISS
ISO		 GO_REF:0000024
(MGI:5780844|PMID:20200993)		 UniProt
RGD		 PMID:20200993 GO_REF:0000024 MGI:5780844 NCBI chr 3:77,901,156...77,903,997
Ensembl chr 3:77,901,158...77,903,130 		JBrowse link
G Mef2c myocyte enhancer factor 2C involved_in ISO
IEA
ISS		 (PMID:17696759)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:17696759 GO_REF:0000024 GO_REF:0000107 NCBI chr 2:13,973,299...14,136,065
Ensembl chr 2:13,993,438...14,132,880 		JBrowse link
G Mkx mohawk homeobox IMP RGD PMID:27370800 RGD:40924660 NCBI chr17:55,077,073...55,156,877
Ensembl chr17:55,077,540...55,156,124 		JBrowse link
G Notch1 notch receptor 1 involved_in ISO (MGI:5437413|PMID:21493891) RGD PMID:21493891 MGI:5437413 NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531 		JBrowse link
G P2ry2 purinergic receptor P2Y2 IDA RGD PMID:12210747 RGD:729594 NCBI chr 1:155,352,050...155,367,423
Ensembl chr 1:155,351,165...155,367,632 		JBrowse link
G Ptk2b protein tyrosine kinase 2 beta IMP RGD PMID:17537919 RGD:1642610 NCBI chr15:40,360,722...40,481,235
Ensembl chr15:40,360,723...40,481,282 		JBrowse link
G Rbpj recombination signal binding protein for immunoglobulin kappa J region involved_in ISO (MGI:5437413|PMID:21493891) RGD PMID:21493891 MGI:5437413 NCBI chr14:57,338,493...57,523,330
Ensembl chr14:57,338,507...57,523,353 		JBrowse link
G Sfrp1 secreted frizzled-related protein 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(MGI:3850611|PMID:19254787)
(PMID:15677765), (PMID:19254787)		 Ensembl
RGD		 PMID:15677765 PMID:19254787 GO_REF:0000107 MGI:3850611 NCBI chr16:68,575,763...68,613,905
Ensembl chr16:68,575,763...68,614,286 		JBrowse link
G Smad6 SMAD family member 6 involved_in ISO (MGI:1352979|PMID:10655064) RGD PMID:10655064 MGI:1352979 NCBI chr 8:64,450,114...64,519,673
Ensembl chr 8:64,450,114...64,519,763 		JBrowse link
G Smad7 SMAD family member 7 involved_in IEA
ISO		 GO_REF:0000107
(MGI:6377914|PMID:29503843)		 Ensembl
RGD		 PMID:29503843 GO_REF:0000107 MGI:6377914 NCBI chr18:68,988,429...69,016,774
Ensembl chr18:68,988,429...69,016,765 		JBrowse link
G Smurf1 SMAD specific E3 ubiquitin protein ligase 1 acts_upstream_of_or_within ISO MGI:3576775 (MGI:3575204|PMID:15820682) RGD PMID:15820682 MGI:3575204 NCBI chr12:9,635,009...9,726,520
Ensembl chr12:9,635,025...9,726,519 		JBrowse link
G Sost sclerostin acts_upstream_of_or_within ISO MGI:5544793 (MGI:5509072|PMID:23918385) RGD PMID:23918385 MGI:5509072 NCBI chr10:86,912,517...86,915,561
Ensembl chr10:86,911,517...86,915,561 		JBrowse link
G Sox9 SRY-box transcription factor 9 involved_in ISO
ISS		 (PMID:29503843)
(MGI:4947506|PMID:20056916)
GO_REF:0000024		 RGD
UniProt		 PMID:20056916 PMID:29503843 GO_REF:0000024 MGI:4947506 NCBI chr10:97,806,485...97,811,994
Ensembl chr10:97,806,485...97,811,994 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 acts_upstream_of_or_within ISO (MGI:3575204|PMID:15820682) RGD PMID:15820682 MGI:3575204 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tph1 tryptophan hydroxylase 1 IMP RGD PMID:20139991 RGD:5686362 NCBI chr 1:97,157,375...97,178,415
Ensembl chr 1:97,157,409...97,178,344 		JBrowse link
G Vdr vitamin D receptor IMP RGD PMID:32231239 RGD:32716373 NCBI chr 7:128,987,981...129,037,677
Ensembl chr 7:128,987,981...129,037,677 		JBrowse link
negative regulation of bone mineralization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahsg alpha-2-HS-glycoprotein involved_in IMP
ISO
ISS		 (MGI:3687916|PMID:12556469)
GO_REF:0000024		 RGD
UniProt		 PMID:12556469 PMID:8702833 GO_REF:0000024 MGI:3687916, RGD:1626074 NCBI chr11:78,117,903...78,145,956 JBrowse link
G Bcor BCL6 co-repressor involved_in ISO (PMID:19578371) RGD PMID:19578371 NCBI chr  X:10,609,756...10,729,613
Ensembl chr  X:10,687,732...10,729,613 		JBrowse link
G Ccl3 C-C motif chemokine ligand 3 involved_in ISO (PMID:21403648) RGD PMID:21403648 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938 		JBrowse link
G Ccr1 C-C motif chemokine receptor 1 involved_in ISO (PMID:21403648) RGD PMID:21403648 NCBI chr 8:123,556,286...123,561,841 JBrowse link
G Ccr1l1 chemokine (C-C motif) receptor 1-like 1 involved_in IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr 8:123,589,997...123,613,767
Ensembl chr 8:123,589,621...123,612,687 		JBrowse link
G Ecm1 extracellular matrix protein 1 involved_in ISO
ISS		 (PMID:11165938)
GO_REF:0000024		 RGD
UniProt		 PMID:11165938 GO_REF:0000024 NCBI chr 2:183,287,491...183,292,729
Ensembl chr 2:183,287,322...183,292,671 		JBrowse link
G Enpp1 ectonucleotide pyrophosphatase/phosphodiesterase 1 involved_in ISS
ISO		 GO_REF:0000024
(MGI:5607146|PMID:25479107), (MGI:6220772|PMID:30111653), (MGI:6294341|PMID:22510396)		 UniProt
RGD		 PMID:22510396 PMID:25479107 PMID:30111653 GO_REF:0000024 MGI:5607146 MGI:6220772 MGI:6294341 NCBI chr 1:20,698,746...20,763,741
Ensembl chr 1:20,698,764...20,763,715 		JBrowse link
G Fgf23 fibroblast growth factor 23 involved_in ISO (PMID:18282132) RGD PMID:18282132 NCBI chr 4:159,914,393...159,922,073
Ensembl chr 4:159,914,272...159,923,821 		JBrowse link
G Gata1 GATA binding protein 1 acts_upstream_of_or_within ISO MGI:2177586 (MGI:3653541|PMID:15005853) RGD PMID:15005853 MGI:3653541 NCBI chr  X:14,529,706...14,537,530
Ensembl chr  X:14,529,702...14,537,530 		JBrowse link
G Grem1 gremlin 1, DAN family BMP antagonist involved_in ISO (PMID:15539560) RGD PMID:15539560 NCBI chr 3:100,512,317...100,524,001
Ensembl chr 3:100,512,313...100,524,082 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:1857719 (MGI:3777866|PMID:17181398)		 Ensembl
RGD		 PMID:17181398 GO_REF:0000107 MGI:3777866 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Ltbp3 latent transforming growth factor beta binding protein 3 acts_upstream_of_or_within ISO MGI:2180017 (MGI:2178869|PMID:11790802) RGD PMID:11790802 MGI:2178869 NCBI chr 1:203,029,412...203,045,975
Ensembl chr 1:203,029,877...203,045,975 		JBrowse link
G Mepe matrix extracellular phosphoglycoprotein acts_upstream_of_or_within ISO MGI:2448895 (MGI:2448336|PMID:12421822), (MGI:3851320|PMID:15843468), (MGI:5431257|PMID:22766095) RGD PMID:12421822 PMID:15843468 PMID:22766095 MGI:2448336 MGI:3851320 MGI:5431257 NCBI chr14:5,420,634...5,432,186
Ensembl chr14:5,420,635...5,432,183 		JBrowse link
G Nfe2 nuclear factor, erythroid 2 acts_upstream_of_or_within ISO MGI:1857224 (MGI:3653541|PMID:15005853) RGD PMID:15005853 MGI:3653541 NCBI chr 7:134,382,758...134,395,364
Ensembl chr 7:134,382,761...134,390,108 		JBrowse link
G Ptk2b protein tyrosine kinase 2 beta involved_in ISS
ISO		 GO_REF:0000024
(MGI:3713957|PMID:17537919)		 UniProt
RGD		 PMID:17537919 GO_REF:0000024 MGI:3713957 NCBI chr15:40,360,722...40,481,235
Ensembl chr15:40,360,723...40,481,282 		JBrowse link
G Sox9 SRY-box transcription factor 9 acts_upstream_of_or_within ISO MGI:2158693 (MGI:2135696|PMID:11371614) RGD PMID:11371614 MGI:2135696 NCBI chr10:97,806,485...97,811,994
Ensembl chr10:97,806,485...97,811,994 		JBrowse link
G Srgn serglycin involved_in IBA
ISS
ISO		 PMID:21873635
GO_REF:0000024
(PMID:16870619)		 UniProt
RGD		 PMID:16870619 PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr20:30,442,810...30,479,549
Ensembl chr20:30,442,813...30,457,406 		JBrowse link
G Trpm4 transient receptor potential cation channel, subfamily M, member 4 IMP RGD PMID:23081848 RGD:10003033 NCBI chr 1:95,781,805...95,812,095
Ensembl chr 1:95,782,000...95,812,532 		JBrowse link
negative regulation of bone mineralization involved in bone maturation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Grem1 gremlin 1, DAN family BMP antagonist involved_in ISO (PMID:15539560) RGD PMID:15539560 NCBI chr 3:100,512,317...100,524,001
Ensembl chr 3:100,512,313...100,524,082 		JBrowse link
G Pth parathyroid hormone involved_in IMP PMID:11604398 CAFA PMID:11604398 RGD:12793028 NCBI chr 1:167,508,121...167,511,530
Ensembl chr 1:167,508,598...167,511,530 		JBrowse link
G Rflna refilin A involved_in
acts_upstream_of_or_within		 IBA
ISO		 PMID:21873635
MGI:1923816 (MGI:5570967|PMID:24436304)		 RGD PMID:24436304 PMID:21873635 MGI:5570967, RGD:13792537 NCBI chr12:31,633,361...31,642,317
Ensembl chr12:31,633,361...31,642,317 		JBrowse link
G Rflnb refilin B involved_in
acts_upstream_of_or_within		 IBA
ISO		 PMID:21873635
MGI:1920371 (MGI:5570967|PMID:24436304)		 RGD PMID:24436304 PMID:21873635 MGI:5570967, RGD:13792537 NCBI chr10:60,893,693...60,899,970
Ensembl chr10:60,893,713...60,899,976 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19541
    multicellular organismal process 9044
      ossification 443
        negative regulation of ossification 46
          negative regulation of bone mineralization + 21
Path 2
Term Annotations click to browse term
  biological_process 19541
    biological regulation 13630
      regulation of biological process 12890
        regulation of multicellular organismal process 2971
          regulation of ossification 137
            negative regulation of ossification 46
              negative regulation of bone mineralization + 21
paths to the root