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ONTOLOGY REPORT - ANNOTATIONS

Term:negative regulation of ossification
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Accession:GO:0030279 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance.
Synonyms:exact_synonym: down regulation of ossification;   downregulation of ossification;   negative regulation of bone biosynthesis;   negative regulation of bone formation
 narrow_synonym: inhibition of ossification


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negative regulation of ossification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb2 adrenoceptor beta 2 IMP RGD PMID:16177600 RGD:1598747 NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512 		JBrowse link
G Bcl2 BCL2, apoptosis regulator acts_upstream_of_or_within ISO (MGI:85084|PMID:9008714) RGD PMID:9008714 MGI:85084 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Calca calcitonin-related polypeptide alpha acts_upstream_of_or_within ISO MGI:3527257 (MGI:3653805|PMID:15537449)
MGI:3527257 (MGI:2447255|PMID:12488435)		 RGD PMID:12488435 PMID:15537449 MGI:2447255 MGI:3653805 NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105 		JBrowse link
G Calcr calcitonin receptor involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:3038975 (MGI:3037515|PMID:14970190)		 Ensembl
RGD		 PMID:14970190 GO_REF:0000107 MGI:3037515 NCBI chr 4:31,661,270...31,736,392
Ensembl chr 4:31,661,273...31,736,392 		JBrowse link
G Chsy1 chondroitin sulfate synthase 1 involved_in ISO (PMID:21129727) RGD PMID:21129727 NCBI chr 1:119,689,626...119,750,711
Ensembl chr 1:119,686,350...119,750,601 		JBrowse link
G Cyp27b1 cytochrome P450, family 27, subfamily b, polypeptide 1 IMP RGD PMID:32231239 RGD:32716373 NCBI chr 7:62,869,340...62,876,242
Ensembl chr 7:62,871,297...62,876,241 		JBrowse link
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 involved_in IMP
ISO		 (MGI:3803396|PMID:18505822) RGD PMID:18505822 PMID:21773994 MGI:3803396, RGD:6907379 NCBI chr 1:228,381,521...228,385,202
Ensembl chr 1:228,381,521...228,385,202 		JBrowse link
G Enpp1 ectonucleotide pyrophosphatase/phosphodiesterase 1 acts_upstream_of_or_within ISO MGI:1857079 (MGI:1270097|PMID:9662402) RGD PMID:9662402 MGI:1270097 NCBI chr 1:20,698,746...20,763,741
Ensembl chr 1:20,698,764...20,763,715 		JBrowse link
G Gfra4 GDNF family receptor alpha 4 acts_upstream_of_or_within ISO MGI:3625130 (MGI:3623870|PMID:16497798) RGD PMID:16497798 MGI:3623870 NCBI chr 3:118,254,937...118,262,252
Ensembl chr 3:118,255,402...118,258,329 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha involved_in ISO (MGI:5300390|PMID:22081627) RGD PMID:22081627 MGI:5300390 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Kremen1 kringle containing transmembrane protein 1 involved_in IEA
ISO		 GO_REF:0000107
(MGI:3803396|PMID:18505822)		 Ensembl
RGD		 PMID:18505822 GO_REF:0000107 MGI:3803396 NCBI chr14:80,081,870...80,147,489
Ensembl chr14:80,084,403...80,147,516 		JBrowse link
G Kremen2 kringle containing transmembrane protein 2 involved_in ISO (MGI:3803396|PMID:18505822) RGD PMID:18505822 MGI:3803396 NCBI chr10:12,763,345...12,767,854
Ensembl chr10:12,763,397...12,767,854 		JBrowse link
G Lrp4 LDL receptor related protein 4 involved_in ISO (PMID:21471202) RGD PMID:21471202 NCBI chr 3:77,429,600...77,483,593
Ensembl chr 3:77,429,798...77,483,593 		JBrowse link
G Mdk midkine involved_in ISS
ISO		 GO_REF:0000024
(MGI:5780844|PMID:20200993)		 UniProt
RGD		 PMID:20200993 GO_REF:0000024 MGI:5780844 NCBI chr 3:77,901,156...77,903,997
Ensembl chr 3:77,901,158...77,903,130 		JBrowse link
G Mef2c myocyte enhancer factor 2C involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:17696759)		 UniProt
Ensembl
RGD		 PMID:17696759 GO_REF:0000024 GO_REF:0000107 NCBI chr 2:13,973,299...14,136,065
Ensembl chr 2:13,993,438...14,132,880 		JBrowse link
G Mir222 microRNA 222 IMP RGD PMID:31691506 RGD:151893486 NCBI chr  X:3,428,904...3,429,006
Ensembl chr  X:3,428,904...3,429,006 		JBrowse link
G Mkx mohawk homeobox IMP RGD PMID:27370800 RGD:40924660 NCBI chr17:55,077,073...55,156,877
Ensembl chr17:55,077,540...55,156,124 		JBrowse link
G Notch1 notch receptor 1 involved_in ISO (MGI:5437413|PMID:21493891) RGD PMID:21493891 MGI:5437413 NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531 		JBrowse link
G P2ry2 purinergic receptor P2Y2 IDA RGD PMID:12210747 RGD:729594 NCBI chr 1:155,352,050...155,367,423
Ensembl chr 1:155,351,165...155,367,632 		JBrowse link
G Ptk2b protein tyrosine kinase 2 beta IMP RGD PMID:17537919 RGD:1642610 NCBI chr15:40,360,722...40,481,235
Ensembl chr15:40,360,723...40,481,282 		JBrowse link
G Rbpj recombination signal binding protein for immunoglobulin kappa J region involved_in ISO (MGI:5437413|PMID:21493891) RGD PMID:21493891 MGI:5437413 NCBI chr14:57,338,493...57,523,330
Ensembl chr14:57,338,507...57,523,353 		JBrowse link
G Sfrp1 secreted frizzled-related protein 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(PMID:15677765), (PMID:19254787)
(MGI:3850611|PMID:19254787)		 Ensembl
RGD		 PMID:15677765 PMID:19254787 GO_REF:0000107 MGI:3850611 NCBI chr16:68,575,763...68,613,905
Ensembl chr16:68,575,763...68,614,286 		JBrowse link
G Smad6 SMAD family member 6 involved_in ISO (MGI:1352979|PMID:10655064) RGD PMID:10655064 MGI:1352979 NCBI chr 8:64,450,114...64,519,673
Ensembl chr 8:64,450,114...64,519,763 		JBrowse link
G Smad7 SMAD family member 7 involved_in IEA
ISO		 GO_REF:0000107
(MGI:6377914|PMID:29503843)		 Ensembl
RGD		 PMID:29503843 GO_REF:0000107 MGI:6377914 NCBI chr18:68,988,429...69,016,774
Ensembl chr18:68,988,429...69,016,765 		JBrowse link
G Smurf1 SMAD specific E3 ubiquitin protein ligase 1 acts_upstream_of_or_within ISO MGI:3576775 (MGI:3575204|PMID:15820682) RGD PMID:15820682 MGI:3575204 NCBI chr12:9,635,009...9,726,520
Ensembl chr12:9,635,025...9,726,519 		JBrowse link
G Sost sclerostin acts_upstream_of_or_within ISO MGI:5544793 (MGI:5509072|PMID:23918385) RGD PMID:23918385 MGI:5509072 NCBI chr10:86,912,517...86,915,561
Ensembl chr10:86,911,517...86,915,561 		JBrowse link
G Sox9 SRY-box transcription factor 9 involved_in ISS
ISO		 GO_REF:0000024
(PMID:29503843)
(MGI:4947506|PMID:20056916)		 UniProt
RGD		 PMID:20056916 PMID:29503843 GO_REF:0000024 MGI:4947506 NCBI chr10:97,806,485...97,811,994
Ensembl chr10:97,806,485...97,811,994 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 acts_upstream_of_or_within ISO (MGI:3575204|PMID:15820682) RGD PMID:15820682 MGI:3575204 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tmem53 transmembrane protein 53 involved_in ISO (PMID:33824347)
(MGI:6713651|PMID:33824347)		 RGD PMID:33824347 MGI:6713651 NCBI chr 5:130,721,780...130,737,692
Ensembl chr 5:130,721,659...130,737,692 		JBrowse link
G Tph1 tryptophan hydroxylase 1 IMP RGD PMID:20139991 RGD:5686362 NCBI chr 1:97,157,375...97,178,415
Ensembl chr 1:97,157,409...97,178,344 		JBrowse link
G Vdr vitamin D receptor IMP RGD PMID:32231239 RGD:32716373 NCBI chr 7:128,987,981...129,037,677
Ensembl chr 7:128,987,981...129,037,677 		JBrowse link
negative regulation of bone mineralization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahsg alpha-2-HS-glycoprotein involved_in IMP
ISO
ISS		 (MGI:3687916|PMID:12556469)
GO_REF:0000024		 RGD
UniProt		 PMID:12556469 PMID:8702833 GO_REF:0000024 MGI:3687916, RGD:1626074 NCBI chr11:78,117,903...78,145,956
Ensembl chr11:78,117,918...78,145,999 		JBrowse link
G Bcor BCL6 co-repressor involved_in ISO (PMID:19578371) RGD PMID:19578371 NCBI chr  X:10,609,756...10,729,613
Ensembl chr  X:10,687,732...10,729,613 		JBrowse link
G Ccl3 C-C motif chemokine ligand 3 involved_in ISO (PMID:21403648) RGD PMID:21403648 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938 		JBrowse link
G Ccr1 C-C motif chemokine receptor 1 involved_in ISO (PMID:21403648) RGD PMID:21403648 NCBI chr 8:123,556,286...123,561,841 JBrowse link
G Ccr1l1 chemokine (C-C motif) receptor 1-like 1 involved_in IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr 8:123,589,997...123,613,767
Ensembl chr 8:123,589,621...123,612,687 		JBrowse link
G Ecm1 extracellular matrix protein 1 involved_in ISS
ISO		 GO_REF:0000024
(PMID:11165938)		 UniProt
RGD		 PMID:11165938 GO_REF:0000024 NCBI chr 2:183,287,491...183,292,729
Ensembl chr 2:183,287,322...183,292,671 		JBrowse link
G Enpp1 ectonucleotide pyrophosphatase/phosphodiesterase 1 involved_in ISO
ISS		 (MGI:5607146|PMID:25479107), (MGI:6220772|PMID:30111653), (MGI:6294341|PMID:22510396)
GO_REF:0000024		 RGD
UniProt		 PMID:22510396 PMID:25479107 PMID:30111653 GO_REF:0000024 MGI:5607146 MGI:6220772 MGI:6294341 NCBI chr 1:20,698,746...20,763,741
Ensembl chr 1:20,698,764...20,763,715 		JBrowse link
G Fgf23 fibroblast growth factor 23 involved_in ISO (PMID:18282132) RGD PMID:18282132 NCBI chr 4:159,914,393...159,922,073
Ensembl chr 4:159,914,272...159,923,821 		JBrowse link
G Gata1 GATA binding protein 1 acts_upstream_of_or_within ISO MGI:2177586 (MGI:3653541|PMID:15005853) RGD PMID:15005853 MGI:3653541 NCBI chr  X:14,529,706...14,537,530
Ensembl chr  X:14,529,702...14,537,530 		JBrowse link
G Grem1 gremlin 1, DAN family BMP antagonist involved_in ISO (PMID:15539560) RGD PMID:15539560 NCBI chr 3:100,512,317...100,524,001
Ensembl chr 3:100,512,313...100,524,082 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:1857719 (MGI:3777866|PMID:17181398)		 Ensembl
RGD		 PMID:17181398 GO_REF:0000107 MGI:3777866 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Ltbp3 latent transforming growth factor beta binding protein 3 acts_upstream_of_or_within ISO MGI:2180017 (MGI:2178869|PMID:11790802) RGD PMID:11790802 MGI:2178869 NCBI chr 1:203,029,412...203,045,975
Ensembl chr 1:203,029,877...203,045,975 		JBrowse link
G Mepe matrix extracellular phosphoglycoprotein acts_upstream_of_or_within ISO MGI:2448895 (MGI:2448336|PMID:12421822), (MGI:3851320|PMID:15843468), (MGI:5431257|PMID:22766095) RGD PMID:12421822 PMID:15843468 PMID:22766095 MGI:2448336 MGI:3851320 MGI:5431257 NCBI chr14:5,420,634...5,432,186
Ensembl chr14:5,420,635...5,432,183 		JBrowse link
G Nfe2 nuclear factor, erythroid 2 acts_upstream_of_or_within ISO MGI:1857224 (MGI:3653541|PMID:15005853) RGD PMID:15005853 MGI:3653541 NCBI chr 7:134,382,758...134,395,364
Ensembl chr 7:134,382,761...134,390,108 		JBrowse link
G Ptk2b protein tyrosine kinase 2 beta involved_in ISS
ISO		 GO_REF:0000024
(MGI:3713957|PMID:17537919)		 UniProt
RGD		 PMID:17537919 GO_REF:0000024 MGI:3713957 NCBI chr15:40,360,722...40,481,235
Ensembl chr15:40,360,723...40,481,282 		JBrowse link
G Sox9 SRY-box transcription factor 9 acts_upstream_of_or_within ISO MGI:2158693 (MGI:2135696|PMID:11371614) RGD PMID:11371614 MGI:2135696 NCBI chr10:97,806,485...97,811,994
Ensembl chr10:97,806,485...97,811,994 		JBrowse link
G Srgn serglycin involved_in ISS
ISO
IBA		 GO_REF:0000024
(PMID:16870619)
PMID:21873635		 UniProt
RGD		 PMID:16870619 PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr20:30,442,810...30,479,549
Ensembl chr20:30,442,813...30,457,406 		JBrowse link
G Trpm4 transient receptor potential cation channel, subfamily M, member 4 IMP RGD PMID:23081848 RGD:10003033 NCBI chr 1:95,781,805...95,812,095
Ensembl chr 1:95,782,000...95,812,532 		JBrowse link
negative regulation of bone mineralization involved in bone maturation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Grem1 gremlin 1, DAN family BMP antagonist involved_in ISO (PMID:15539560) RGD PMID:15539560 NCBI chr 3:100,512,317...100,524,001
Ensembl chr 3:100,512,313...100,524,082 		JBrowse link
G Pth parathyroid hormone involved_in IMP PMID:11604398 CAFA PMID:11604398 RGD:12793028 NCBI chr 1:167,508,121...167,511,530
Ensembl chr 1:167,508,598...167,511,530 		JBrowse link
G Rflna refilin A acts_upstream_of_or_within
involved_in		 ISO
IBA		 MGI:1923816 (MGI:5570967|PMID:24436304)
PMID:21873635		 RGD PMID:24436304 PMID:21873635 MGI:5570967, RGD:13792537 NCBI chr12:31,633,361...31,642,317
Ensembl chr12:31,633,361...31,642,317 		JBrowse link
G Rflnb refilin B acts_upstream_of_or_within
involved_in		 ISO
IBA		 MGI:1920371 (MGI:5570967|PMID:24436304)
PMID:21873635		 RGD PMID:24436304 PMID:21873635 MGI:5570967, RGD:13792537 NCBI chr10:60,893,693...60,899,970
Ensembl chr10:60,893,713...60,899,976 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19746
    multicellular organismal process 9178
      ossification 467
        negative regulation of ossification 48
          negative regulation of bone mineralization + 21
Path 2
Term Annotations click to browse term
  biological_process 19746
    biological regulation 13447
      regulation of biological process 13040
        regulation of multicellular organismal process 3351
          regulation of ossification 144
            negative regulation of ossification 48
              negative regulation of bone mineralization + 21
paths to the root