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ONTOLOGY REPORT - ANNOTATIONS


Term:regulation of ossification
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Accession:GO:0030278 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance.
Synonyms:exact_synonym: regulation of bone biosynthesis;   regulation of bone formation


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regulation of ossification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acvr1 activin A receptor type 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624732:7,929,997...8,004,235
Ensembl chrNW_004624732:7,929,583...8,005,072
JBrowse link
G Ccdc134 coiled-coil domain containing 134 involved_in ISO (PMID:32181939) UniProt PMID:32181939 NCBI chrNW_004624752:6,872,192...6,885,435
Ensembl chrNW_004624752:6,871,911...6,885,396
JBrowse link
G Creb3l1 cAMP responsive element binding protein 3 like 1 acts_upstream_of_or_within ISO (PMID:19767743) MGI PMID:19767743 NCBI chrNW_004624767:2,215,850...2,247,470
Ensembl chrNW_004624767:2,215,558...2,247,509
JBrowse link
G Csf1 colony stimulating factor 1 acts_upstream_of_or_within ISO (PMID:12865350) MGI PMID:12865350 NCBI chrNW_004624772:5,663,374...5,705,965
Ensembl chrNW_004624772:5,663,070...5,707,753
JBrowse link
G Dhrs3 dehydrogenase/reductase 3 acts_upstream_of_or_within ISO (PMID:24005908) MGI PMID:24005908 NCBI chrNW_004624818:557,399...590,872
Ensembl chrNW_004624818:557,409...590,872
JBrowse link
G Egr2 early growth response 2 acts_upstream_of_or_within ISO (PMID:8565822) MGI PMID:8565822 NCBI chrNW_004624791:953,009...959,656
Ensembl chrNW_004624791:955,161...959,791
JBrowse link
G Esrra estrogen related receptor alpha ISO RGD PMID:12193582 RGD:625668 NCBI chrNW_004624767:21,999,932...22,007,582
Ensembl chrNW_004624767:21,999,932...22,009,485
JBrowse link
G Fgfr3 fibroblast growth factor receptor 3 acts_upstream_of_or_within ISO (PMID:20053668) MGI PMID:20053668 NCBI chrNW_004624755:25,633,690...25,647,361
Ensembl chrNW_004624755:25,635,165...25,646,932
JBrowse link
G Intu inturned planar cell polarity protein acts_upstream_of_or_within ISO (PMID:25774014) MGI PMID:25774014 NCBI chrNW_004624777:8,585,777...8,674,887
Ensembl chrNW_004624777:8,596,178...8,675,295
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 acts_upstream_of_or_within ISO (PMID:20053668) MGI PMID:20053668 NCBI chrNW_004624747:1,296,062...1,389,674
Ensembl chrNW_004624747:1,296,221...1,389,757
JBrowse link
G Mapk14 mitogen-activated protein kinase 14 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:20053668) Ensembl
MGI
PMID:20053668 GO_REF:0000107 NCBI chrNW_004624754:21,528,121...21,598,064
Ensembl chrNW_004624754:21,527,333...21,597,733
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 acts_upstream_of_or_within ISO (PMID:20053668) MGI PMID:20053668 NCBI chrNW_004624782:13,150,824...13,158,327
Ensembl chrNW_004624782:13,152,039...13,159,113
JBrowse link
G P3h1 prolyl 3-hydroxylase 1 acts_upstream_of_or_within ISO (PMID:20363744) MGI PMID:20363744 NCBI chrNW_004624892:1,988,309...2,003,285
Ensembl chrNW_004624892:1,988,096...2,003,319
JBrowse link
G Pbx1 PBX homeobox 1 acts_upstream_of_or_within ISO (PMID:11566859) MGI PMID:11566859 NCBI chrNW_004624826:2,944,272...3,250,957
Ensembl chrNW_004624826:2,945,004...3,215,110
JBrowse link
G Prl prolactin ISO RGD PMID:17218965 RGD:1642577 NCBI chrNW_004624756:4,585,542...4,593,285 JBrowse link
G Ptger4 prostaglandin E receptor 4 acts_upstream_of_or_within ISO (PMID:10749873) MGI PMID:10749873 NCBI chrNW_004624759:14,243,887...14,259,090
Ensembl chrNW_004624759:14,244,899...14,258,445
JBrowse link
G Rsad2 radical S-adenosyl methionine domain containing 2 ISO RGD PMID:10698968 RGD:631877 NCBI chrNW_004624846:3,395,536...3,408,616
Ensembl chrNW_004624846:3,395,406...3,408,626
JBrowse link
G Runx2 RUNX family transcription factor 2 acts_upstream_of_or_within ISO (PMID:10213384) MGI PMID:10213384 NCBI chrNW_004624754:14,601,574...14,868,469
Ensembl chrNW_004624754:14,679,974...14,867,729
JBrowse link
G Sfrp1 secreted frizzled related protein 1 ISO RGD PMID:15677765 RGD:1580305 NCBI chrNW_004624780:2,133,105...2,172,301
Ensembl chrNW_004624780:2,132,960...2,174,508
JBrowse link
G Six2 SIX homeobox 2 involved_in ISO (PMID:20515681) UniProt PMID:20515681 NCBI chrNW_004624738:26,442,935...26,447,100
Ensembl chrNW_004624738:26,442,965...26,446,942
JBrowse link
G Tent5a terminal nucleotidyltransferase 5A involved_in ISO (PMID:26803617) UniProt PMID:26803617 NCBI chrNW_004624799:12,829,562...12,836,850
Ensembl chrNW_004624799:12,829,528...12,834,511
JBrowse link
negative regulation of bone mineralization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahsg alpha 2-HS glycoprotein involved_in ISO (PMID:12556469) RGD
UniProt
PMID:8702833 PMID:12556469 RGD:1626074 NCBI chrNW_004624730:70,149,461...70,156,058
Ensembl chrNW_004624730:70,149,850...70,156,039
JBrowse link
G Bcor BCL6 corepressor involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624762:15,338,331...15,465,683
Ensembl chrNW_004624762:15,420,596...15,465,873
JBrowse link
G Ecm1 extracellular matrix protein 1 involved_in ISO (PMID:11165938) UniProt PMID:11165938 NCBI chrNW_004624772:18,234,537...18,239,896
Ensembl chrNW_004624772:18,233,727...18,240,601
JBrowse link
G Enpp1 ectonucleotide pyrophosphatase/phosphodiesterase 1 involved_in ISO (PMID:22510396), (PMID:25479107), (PMID:30111653) UniProt PMID:22510396 PMID:25479107 PMID:30111653 NCBI chrNW_004624753:5,918,005...5,983,480
Ensembl chrNW_004624753:5,917,689...5,982,308
JBrowse link
G Fgf23 fibroblast growth factor 23 involved_in ISO (PMID:18282132) UniProt PMID:18282132 NCBI chrNW_004624860:1,478,712...1,486,808
Ensembl chrNW_004624860:1,479,303...1,486,323
JBrowse link
G Gata1 GATA binding protein 1 acts_upstream_of_or_within ISO (PMID:15005853) MGI PMID:15005853 NCBI chrNW_004624893:595,948...602,980
Ensembl chrNW_004624893:595,967...602,979
JBrowse link
G Grem1 gremlin 1, DAN family BMP antagonist involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624804:1,606,182...1,620,932
Ensembl chrNW_004624804:1,608,757...1,620,938
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:17181398) Ensembl
MGI
PMID:17181398 GO_REF:0000107 NCBI chrNW_004624734:39,414,458...39,471,705
Ensembl chrNW_004624734:39,411,824...39,471,705
JBrowse link
G LOC101724812 C-C chemokine receptor type 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624730:74,822,848...74,828,614
Ensembl chrNW_004624730:74,826,659...74,827,726
JBrowse link
G Ltbp3 latent transforming growth factor beta binding protein 3 acts_upstream_of_or_within ISO (PMID:11790802) MGI PMID:11790802 NCBI chrNW_004624767:20,845,949...20,861,169
Ensembl chrNW_004624767:20,845,949...20,860,673
JBrowse link
G Mepe matrix extracellular phosphoglycoprotein acts_upstream_of_or_within ISO (PMID:22766095)
(PMID:12421822), (PMID:15843468)
MGI PMID:12421822 PMID:15843468 PMID:22766095 NCBI chrNW_004624872:4,345,045...4,358,456 JBrowse link
G Nfe2 nuclear factor, erythroid 2 acts_upstream_of_or_within ISO (PMID:15005853) MGI PMID:15005853 NCBI chrNW_004624904:2,324,186...2,332,204
Ensembl chrNW_004624904:2,322,758...2,332,194
JBrowse link
G Ptk2b protein tyrosine kinase 2 beta involved_in ISO (PMID:17537919) UniProt PMID:17537919 NCBI chrNW_004624758:22,065,448...22,182,604
Ensembl chrNW_004624758:22,124,836...22,182,605
JBrowse link
G Sox9 SRY-box transcription factor 9 acts_upstream_of_or_within ISO (PMID:11371614) MGI PMID:11371614 NCBI chrNW_004624801:2,296,353...2,300,853
Ensembl chrNW_004624801:2,296,168...2,301,596
JBrowse link
G Srgn serglycin involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624754:3,379,651...3,412,175
Ensembl chrNW_004624754:3,401,480...3,411,488
JBrowse link
G Trpm4 transient receptor potential cation channel subfamily M member 4 ISO RGD PMID:23081848 RGD:10003033 NCBI chrNW_004624832:4,902,335...4,937,806
Ensembl chrNW_004624832:4,902,659...4,936,926
JBrowse link
negative regulation of bone mineralization involved in bone maturation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Grem1 gremlin 1, DAN family BMP antagonist involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624804:1,606,182...1,620,932
Ensembl chrNW_004624804:1,608,757...1,620,938
JBrowse link
G Pth parathyroid hormone involved_in ISO PMID:11604398 CAFA PMID:11604398 RGD:12793028 NCBI chrNW_004624766:5,489,857...5,492,777
Ensembl chrNW_004624766:5,489,800...5,492,871
JBrowse link
G Rflna refilin A acts_upstream_of_or_within ISO (PMID:24436304) MGI PMID:24436304 NCBI chrNW_004624747:23,766,756...23,775,238
Ensembl chrNW_004624747:23,766,856...23,774,397
JBrowse link
G Rflnb refilin B acts_upstream_of_or_within ISO (PMID:24436304) MGI PMID:24436304 NCBI chrNW_004624786:3,793,266...3,801,894
Ensembl chrNW_004624786:3,793,302...3,801,630
JBrowse link
negative regulation of ossification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acvr1b activin A receptor type 1B involved_in ISO (PMID:22155034) UniProt PMID:22155034 NCBI chrNW_004624816:331,695...374,187
Ensembl chrNW_004624816:331,695...374,193
JBrowse link
G Adrb2 adrenoceptor beta 2 ISO RGD PMID:16177600 RGD:1598747 NCBI chrNW_004624774:8,211,723...8,215,962
Ensembl chrNW_004624774:8,211,984...8,213,240
JBrowse link
G Bcl2 BCL2 apoptosis regulator involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:9008714) Ensembl
MGI
PMID:9008714 GO_REF:0000107 NCBI chrNW_004624792:8,854,345...9,032,727
Ensembl chrNW_004624792:8,859,522...9,031,344
JBrowse link
G Bmp3 bone morphogenetic protein 3 involved_in ISO (PMID:15269709) UniProt PMID:15269709 NCBI chrNW_004624757:9,952,847...9,980,259
Ensembl chrNW_004624757:9,956,293...9,980,234
JBrowse link
G Calca calcitonin related polypeptide alpha acts_upstream_of_or_within
involved_in
ISO
IEA
(PMID:12488435) MGI
Ensembl
PMID:12488435 GO_REF:0000107 NCBI chrNW_004624766:6,764,388...6,771,396
Ensembl chrNW_004624766:6,766,185...6,768,173
JBrowse link
G Calcr calcitonin receptor acts_upstream_of_or_within ISO (PMID:14970190) MGI PMID:14970190 NCBI chrNW_004624813:233,117...357,507
Ensembl chrNW_004624813:233,042...357,396
JBrowse link
G Chsy1 chondroitin sulfate synthase 1 involved_in ISO (PMID:21129727) UniProt PMID:21129727 NCBI chrNW_004624768:3,567,770...3,628,360 JBrowse link
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 involved_in ISO
IEA
RGD
Ensembl
PMID:21773994 GO_REF:0000107 RGD:6907379 NCBI chrNW_004624791:11,313,139...11,316,998
Ensembl chrNW_004624791:11,313,142...11,315,982
JBrowse link
G Enpp1 ectonucleotide pyrophosphatase/phosphodiesterase 1 acts_upstream_of_or_within ISO (PMID:9662402) MGI PMID:9662402 NCBI chrNW_004624753:5,918,005...5,983,480
Ensembl chrNW_004624753:5,917,689...5,982,308
JBrowse link
G Gfra4 GDNF family receptor alpha 4 acts_upstream_of_or_within ISO (PMID:16497798) MGI PMID:16497798 NCBI chrNW_004624741:4,752,376...4,757,642
Ensembl chrNW_004624741:4,753,792...4,757,642
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624734:39,414,458...39,471,705
Ensembl chrNW_004624734:39,411,824...39,471,705
JBrowse link
G Kremen1 kringle containing transmembrane protein 1 involved_in ISO (PMID:18505822) UniProt PMID:18505822 NCBI chrNW_004624747:5,377,996...5,449,203
Ensembl chrNW_004624747:5,377,996...5,445,504
JBrowse link
G Kremen2 kringle containing transmembrane protein 2 involved_in ISO (PMID:18505822) UniProt PMID:18505822 NCBI chrNW_004624824:702,648...711,615
Ensembl chrNW_004624824:707,798...711,643
JBrowse link
G LOC101700851 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial ISO RGD PMID:32231239 RGD:32716373 NCBI chrNW_004624802:10,176,865...10,181,725
Ensembl chrNW_004624802:10,176,919...10,181,657
JBrowse link
G Lrp4 LDL receptor related protein 4 involved_in ISO (PMID:21471202) UniProt PMID:21471202 NCBI chrNW_004624767:1,708,866...1,757,629 JBrowse link
G Mdk midkine involved_in ISO (PMID:20200993) UniProt PMID:20200993 NCBI chrNW_004624767:2,171,096...2,173,436
Ensembl chrNW_004624767:2,171,096...2,173,512
JBrowse link
G Mef2c myocyte enhancer factor 2C involved_in ISO (PMID:17696759) UniProt PMID:17696759 NCBI chrNW_004624743:8,072,871...8,235,174
Ensembl chrNW_004624743:8,072,673...8,235,252
JBrowse link
G Mkx mohawk homeobox ISO RGD PMID:27370800 RGD:40924660 NCBI chrNW_004624805:6,060,131...6,122,305
Ensembl chrNW_004624805:6,061,635...6,121,926
JBrowse link
G Notch1 notch receptor 1 involved_in ISO (PMID:21493891) BHF-UCL PMID:21493891 NCBI chrNW_004624760:1,636,331...1,676,398
Ensembl chrNW_004624760:1,634,702...1,676,531
JBrowse link
G P2ry2 purinergic receptor P2Y2 ISO RGD PMID:12210747 RGD:729594 NCBI chrNW_004624817:3,706,017...3,721,045
Ensembl chrNW_004624817:3,706,017...3,719,649
JBrowse link
G Ptk2b protein tyrosine kinase 2 beta ISO RGD PMID:17537919 RGD:1642610 NCBI chrNW_004624758:22,065,448...22,182,604
Ensembl chrNW_004624758:22,124,836...22,182,605
JBrowse link
G Rbpj recombination signal binding protein for immunoglobulin kappa J region involved_in ISO (PMID:21493891) BHF-UCL PMID:21493891 NCBI chrNW_004624755:6,176,497...6,298,034
Ensembl chrNW_004624755:6,176,497...6,298,225
JBrowse link
G Sfrp1 secreted frizzled related protein 1 involved_in
acts_upstream_of_or_within
ISO (PMID:15677765)
(PMID:19254787)
UniProt
MGI
PMID:15677765 PMID:19254787 NCBI chrNW_004624780:2,133,105...2,172,301
Ensembl chrNW_004624780:2,132,960...2,174,508
JBrowse link
G Smad2 SMAD family member 2 involved_in ISO (PMID:22155034) UniProt PMID:22155034 NCBI chrNW_004624778:11,380,656...11,460,566
Ensembl chrNW_004624778:11,384,769...11,501,078
JBrowse link
G Smad3 SMAD family member 3 involved_in ISO (PMID:22155034) UniProt PMID:22155034 NCBI chrNW_004624781:5,795,652...5,890,047
Ensembl chrNW_004624781:5,795,652...5,890,371
JBrowse link
G Smad6 SMAD family member 6 involved_in ISO (PMID:10655064) BHF-UCL PMID:10655064 NCBI chrNW_004624781:6,043,183...6,108,959
Ensembl chrNW_004624781:6,042,904...6,107,860
JBrowse link
G Smad7 SMAD family member 7 involved_in ISO (PMID:29503843) CACAO PMID:29503843 NCBI chrNW_004624778:12,415,364...12,444,882
Ensembl chrNW_004624778:12,415,282...12,444,835
JBrowse link
G Smurf1 SMAD specific E3 ubiquitin protein ligase 1 acts_upstream_of_or_within ISO (PMID:15820682) MGI PMID:15820682 NCBI chrNW_004624740:32,480,138...32,615,436
Ensembl chrNW_004624740:32,483,092...32,615,260
JBrowse link
G Sost sclerostin acts_upstream_of_or_within ISO (PMID:23918385) MGI PMID:23918385 NCBI chrNW_004624795:1,006,811...1,009,437
Ensembl chrNW_004624795:1,006,813...1,008,685
JBrowse link
G Sox9 SRY-box transcription factor 9 involved_in ISO (PMID:20056916)
(PMID:29503843)
UniProt
CACAO
PMID:20056916 PMID:29503843 NCBI chrNW_004624801:2,296,353...2,300,853
Ensembl chrNW_004624801:2,296,168...2,301,596
JBrowse link
G Tgfb1 transforming growth factor beta 1 acts_upstream_of_or_within ISO (PMID:15820682) MGI PMID:15820682 NCBI chrNW_004624907:162,567...175,696
Ensembl chrNW_004624907:161,569...176,605
JBrowse link
G Tmem53 transmembrane protein 53 involved_in ISO (PMID:33824347) UniProt PMID:33824347 NCBI chrNW_004624906:528,595...579,894
Ensembl chrNW_004624906:544,485...580,001
JBrowse link
G Tph1 tryptophan hydroxylase 1 ISO RGD PMID:20139991 RGD:5686362 NCBI chrNW_004624766:9,629,951...9,687,772
Ensembl chrNW_004624766:9,629,849...9,668,393
JBrowse link
G Vdr vitamin D receptor ISO RGD PMID:32231239 RGD:32716373 NCBI chrNW_004624816:4,314,146...4,423,946
Ensembl chrNW_004624816:4,365,961...4,424,514
JBrowse link
positive regulation of bone mineralization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acvr1 activin A receptor type 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624732:7,929,997...8,004,235
Ensembl chrNW_004624732:7,929,583...8,005,072
JBrowse link
G Acvr2a activin A receptor type 2A involved_in ISO (PMID:18436533) BHF-UCL PMID:18436533 NCBI chrNW_004624866:539,967...619,575
Ensembl chrNW_004624866:539,894...620,302
JBrowse link
G Acvr2b activin A receptor type 2B involved_in ISO (PMID:18436533) BHF-UCL PMID:18436533 NCBI chrNW_004624731:2,557,993...2,600,250
Ensembl chrNW_004624731:2,566,063...2,600,035
JBrowse link
G Adgrv1 adhesion G protein-coupled receptor V1 involved_in ISO (PMID:22419726) UniProt PMID:22419726 NCBI chrNW_004624743:9,849,070...10,292,392 JBrowse link
G Adrb2 adrenoceptor beta 2 acts_upstream_of_or_within ISO (PMID:15724149) MGI PMID:15724149 NCBI chrNW_004624774:8,211,723...8,215,962
Ensembl chrNW_004624774:8,211,984...8,213,240
JBrowse link
G Alox5 arachidonate 5-lipoxygenase involved_in ISO (PMID:24906289) UniProt PMID:24906289 NCBI chrNW_004624966:168,244...220,430
Ensembl chrNW_004624966:168,250...220,522
JBrowse link
G Ano6 anoctamin 6 involved_in ISO (PMID:25589784) UniProt PMID:25589784 NCBI chrNW_004624816:6,896,176...7,077,758
Ensembl chrNW_004624816:6,894,413...7,077,883
JBrowse link
G Atp2b1 ATPase plasma membrane Ca2+ transporting 1 involved_in ISO (PMID:26392310) UniProt PMID:26392310 NCBI chrNW_004624750:16,990,288...17,103,279 JBrowse link
G Atraid all-trans retinoic acid induced differentiation factor involved_in ISO (PMID:21723284) UniProt PMID:21723284 NCBI chrNW_004624738:9,311,746...9,318,099
Ensembl chrNW_004624738:9,311,836...9,317,861
JBrowse link
G Bmp2 bone morphogenetic protein 2 involved_in ISO (PMID:18436533), (PMID:20576608)
(PMID:20675382)
BHF-UCL PMID:18436533 PMID:20576608 PMID:20675382 NCBI chrNW_004624741:7,706,205...7,717,677
Ensembl chrNW_004624741:7,706,236...7,719,484
JBrowse link
G Bmp4 bone morphogenetic protein 4 involved_in
acts_upstream_of_or_within
ISO (PMID:14749725), (PMID:18436533) RGD
UniProt
MGI
PMID:14749725 PMID:15352071 PMID:18436533 RGD:9068399 NCBI chrNW_004624731:15,262,480...15,269,196
Ensembl chrNW_004624731:15,263,274...15,269,743
JBrowse link
G Bmp6 bone morphogenetic protein 6 involved_in ISO (PMID:18436533) BHF-UCL PMID:18436533 NCBI chrNW_004624756:17,742,822...17,894,931
Ensembl chrNW_004624756:17,743,834...17,894,753
JBrowse link
G Bmp7 bone morphogenetic protein 7 involved_in ISO (PMID:18436533) BHF-UCL PMID:18436533 NCBI chrNW_004624741:23,658,214...23,743,227
Ensembl chrNW_004624741:23,658,004...23,737,742
JBrowse link
G Bmpr1a bone morphogenetic protein receptor type 1A involved_in ISO (PMID:18436533) BHF-UCL PMID:18436533 NCBI chrNW_004624841:218,642...304,744
Ensembl chrNW_004624841:219,133...265,397
JBrowse link
G Bmpr1b bone morphogenetic protein receptor type 1B involved_in ISO (PMID:18436533) BHF-UCL PMID:18436533 NCBI chrNW_004624757:22,697,639...23,142,209
Ensembl chrNW_004624757:22,955,666...23,142,499
JBrowse link
G Bmpr2 bone morphogenetic protein receptor type 2 involved_in ISO (PMID:18436533) BHF-UCL PMID:18436533 NCBI chrNW_004624765:13,849,689...13,950,839
Ensembl chrNW_004624765:13,857,062...13,947,683
JBrowse link
G Ccn1 cellular communication network factor 1 involved_in ISO (PMID:20675382) BHF-UCL PMID:20675382 NCBI chrNW_004624742:11,882,815...11,885,686
Ensembl chrNW_004624742:11,882,907...11,885,667
JBrowse link
G Cd276 CD276 molecule acts_upstream_of_or_within ISO (PMID:15317945) MGI PMID:15317945 NCBI chrNW_004624781:691,348...703,202 JBrowse link
G Csf1r colony stimulating factor 1 receptor ISO RGD PMID:18434589 RGD:151665814 NCBI chrNW_004624774:9,363,156...9,391,939
Ensembl chrNW_004624774:9,363,908...9,391,986
JBrowse link
G Fam20c FAM20C golgi associated secretory pathway kinase involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:17369251), (PMID:22615579) Ensembl
MGI
PMID:17369251 PMID:22615579 GO_REF:0000107 NCBI chrNW_004624740:25,984,642...26,032,089
Ensembl chrNW_004624740:25,984,091...26,032,649
JBrowse link
G Fbn2 fibrillin 2 involved_in ISO (PMID:20855508) BHF-UCL PMID:20855508 NCBI chrNW_004624774:12,863,446...13,116,929
Ensembl chrNW_004624774:12,863,446...13,116,545
JBrowse link
G Fgfr3 fibroblast growth factor receptor 3 acts_upstream_of_or_within ISO (PMID:20053668) MGI PMID:20053668 NCBI chrNW_004624755:25,633,690...25,647,361
Ensembl chrNW_004624755:25,635,165...25,646,932
JBrowse link
G Fzd9 frizzled class receptor 9 involved_in ISO (PMID:21402791) UniProt PMID:21402791 NCBI chrNW_004624740:14,323,445...14,325,616
Ensembl chrNW_004624740:14,323,817...14,325,601
JBrowse link
G Gpm6b glycoprotein M6B involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624882:220,267...374,912
Ensembl chrNW_004624882:220,362...374,912
JBrowse link
G Isg15 ISG15 ubiquitin like modifier involved_in ISO (PMID:21402791) UniProt PMID:21402791 NCBI chrNW_004624818:8,510,657...8,511,749 JBrowse link
G Kl klotho involved_in ISO (PMID:12110410) UniProt PMID:12110410 NCBI chrNW_004624915:95,155...110,834 JBrowse link
G Mef2c myocyte enhancer factor 2C involved_in ISO (PMID:21652706) UniProt PMID:21652706 NCBI chrNW_004624743:8,072,871...8,235,174
Ensembl chrNW_004624743:8,072,673...8,235,252
JBrowse link
G Nell1 neural EGFL like 1 involved_in ISO (PMID:21723284) UniProt PMID:21723284 NCBI chrNW_004624766:11,921,570...12,734,032
Ensembl chrNW_004624766:11,921,650...12,737,576
JBrowse link
G Osr1 odd-skipped related transcription factor 1 involved_in ISO (PMID:21262216) BHF-UCL PMID:21262216 NCBI chrNW_004624738:2,136,228...2,559,092
Ensembl chrNW_004624738:2,136,151...2,138,441
JBrowse link
G Osr2 odd-skipped related transciption factor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624763:6,035,923...6,043,682
Ensembl chrNW_004624763:6,035,953...6,043,437
JBrowse link
G P2rx7 purinergic receptor P2X 7 acts_upstream_of_or_within ISO (PMID:12677010), (PMID:18519738) MGI PMID:12677010 PMID:18519738 NCBI chrNW_004624747:21,725,813...21,768,123
Ensembl chrNW_004624747:21,725,395...21,759,453
JBrowse link
G Pkdcc protein kinase domain containing, cytoplasmic involved_in ISO (PMID:19097194) UniProt PMID:19097194 NCBI chrNW_004624738:23,759,382...23,768,743
Ensembl chrNW_004624738:23,759,398...23,771,639
JBrowse link
G Pla2g4a phospholipase A2 group IVA ISO RGD PMID:10807497 RGD:1642474 NCBI chrNW_004624814:6,597,248...6,744,294
Ensembl chrNW_004624814:6,597,005...6,744,286
JBrowse link
G Pth parathyroid hormone involved_in ISO
IEA
RGD
Ensembl
PMID:15758479 PMID:22445539 GO_REF:0000107 RGD:7207452 RGD:7242906 NCBI chrNW_004624766:5,489,857...5,492,777
Ensembl chrNW_004624766:5,489,800...5,492,871
JBrowse link
G Ptn pleiotrophin involved_in ISO (PMID:19442624) UniProt PMID:19442624 NCBI chrNW_004624765:17,523,086...17,625,264
Ensembl chrNW_004624765:17,522,916...17,548,184
JBrowse link
G Slc20a2 solute carrier family 20 member 2 involved_in ISO (PMID:30721528) UniProt PMID:30721528 NCBI chrNW_004624780:725,992...833,419
Ensembl chrNW_004624780:779,900...832,137
JBrowse link
G Slc8a1 solute carrier family 8 member A1 involved_in ISO (PMID:25589784) UniProt PMID:25589784 NCBI chrNW_004624738:21,648,277...22,026,385
Ensembl chrNW_004624738:21,651,489...21,939,927
JBrowse link
G Smad3 SMAD family member 3 ISO rat gene expressed in mouse osteoblastic cell line MC3T3-E1; TGF-beta down-regulates this activity RGD PMID:12096832 RGD:727387 NCBI chrNW_004624781:5,795,652...5,890,047
Ensembl chrNW_004624781:5,795,652...5,890,371
JBrowse link
G Tent5a terminal nucleotidyltransferase 5A involved_in ISO (PMID:33882302) UniProt PMID:33882302 NCBI chrNW_004624799:12,829,562...12,836,850
Ensembl chrNW_004624799:12,829,528...12,834,511
JBrowse link
G Tfap2a transcription factor AP-2 alpha involved_in ISO (PMID:19578371) UniProt PMID:19578371 NCBI chrNW_004624756:15,413,950...15,436,037
Ensembl chrNW_004624756:15,418,260...15,436,379
JBrowse link
G Tmem119 transmembrane protein 119 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624747:11,828,292...11,834,855 JBrowse link
G Wnt10b Wnt family member 10B acts_upstream_of_or_within ISO (PMID:15728361) MGI PMID:15728361 NCBI chrNW_004624816:3,221,573...3,227,102
Ensembl chrNW_004624816:3,210,828...3,227,096
JBrowse link
G Wnt4 Wnt family member 4 involved_in ISO (PMID:17720811) BHF-UCL PMID:17720811 NCBI chrNW_004624764:6,913,027...6,934,650
Ensembl chrNW_004624764:6,921,811...6,933,392
JBrowse link
positive regulation of bone mineralization involved in bone maturation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Actn3 actinin alpha 3 involved_in ISO (PMID:21784188) UniProt PMID:21784188 NCBI chrNW_004624767:19,844,996...19,859,274
Ensembl chrNW_004624767:19,844,884...19,858,950
JBrowse link
G Asxl2 ASXL transcriptional regulator 2 acts_upstream_of_or_within ISO (PMID:21490954) MGI PMID:21490954 NCBI chrNW_004624738:7,958,610...8,100,223
Ensembl chrNW_004624738:7,603,252...8,100,369
JBrowse link
G Bmp2 bone morphogenetic protein 2 involved_in ISO (PMID:16433617) BHF-UCL PMID:16433617 NCBI chrNW_004624741:7,706,205...7,717,677
Ensembl chrNW_004624741:7,706,236...7,719,484
JBrowse link
positive regulation of ossification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adcy10 adenylate cyclase 10 ISO RGD PMID:30067871 RGD:329412472 NCBI chrNW_004624826:5,844,868...5,897,541
Ensembl chrNW_004624826:5,845,001...5,897,497
JBrowse link
G Bmp2 bone morphogenetic protein 2 acts_upstream_of_or_within ISO (PMID:15820682), (PMID:21324897)
(PMID:9213002)
MGI PMID:9213002 PMID:15820682 PMID:21324897 NCBI chrNW_004624741:7,706,205...7,717,677
Ensembl chrNW_004624741:7,706,236...7,719,484
JBrowse link
G Bmp4 bone morphogenetic protein 4 acts_upstream_of_or_within ISO (PMID:8358941)
PMID:7911662
(PMID:14749725)
RGD
MGI
PMID:7911662 PMID:8358941 PMID:14749725 PMID:17112416 RGD:1643600 RGD:632977 NCBI chrNW_004624731:15,262,480...15,269,196
Ensembl chrNW_004624731:15,263,274...15,269,743
JBrowse link
G Bmpr2 bone morphogenetic protein receptor type 2 involved_in ISO (PMID:12441304) BHF-UCL PMID:12441304 NCBI chrNW_004624765:13,849,689...13,950,839
Ensembl chrNW_004624765:13,857,062...13,947,683
JBrowse link
G Ccn3 cellular communication network factor 3 involved_in ISO (PMID:38987585) UniProt PMID:38987585 NCBI chrNW_004624763:17,573,693...17,580,884
Ensembl chrNW_004624763:17,573,718...17,580,925
JBrowse link
G Lrp6 LDL receptor related protein 6 acts_upstream_of_or_within ISO (PMID:15469977) MGI PMID:15469977 NCBI chrNW_004624752:25,605,444...25,756,573
Ensembl chrNW_004624752:25,605,302...25,751,893
JBrowse link
G Nell1 neural EGFL like 1 involved_in ISO
IEA
RGD
TreeGrafter
PMID:19493425 GO_REF:0000118 RGD:2314454 NCBI chrNW_004624766:11,921,570...12,734,032
Ensembl chrNW_004624766:11,921,650...12,737,576
JBrowse link
G Nipbl NIPBL cohesin loading factor involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:19763162) Ensembl
MGI
PMID:19763162 GO_REF:0000107 NCBI chrNW_004624759:17,899,152...18,078,213
Ensembl chrNW_004624759:17,899,152...17,999,295
JBrowse link
G Oxt oxytocin/neurophysin I prepropeptide ISO RGD PMID:18257653 RGD:2304114 NCBI chrNW_004624741:4,200,594...4,201,416
Ensembl chrNW_004624741:4,200,478...4,201,580
JBrowse link
G P2rx7 purinergic receptor P2X 7 acts_upstream_of_or_within ISO (PMID:16269410), (PMID:18519738) MGI PMID:16269410 PMID:18519738 NCBI chrNW_004624747:21,725,813...21,768,123
Ensembl chrNW_004624747:21,725,395...21,759,453
JBrowse link
G Ptger4 prostaglandin E receptor 4 ISO RGD PMID:14751573 PMID:17106877 RGD:10043372 RGD:10045950 NCBI chrNW_004624759:14,243,887...14,259,090
Ensembl chrNW_004624759:14,244,899...14,258,445
JBrowse link
G Pth parathyroid hormone ISO RGD PMID:15758479 RGD:7207452 NCBI chrNW_004624766:5,489,857...5,492,777
Ensembl chrNW_004624766:5,489,800...5,492,871
JBrowse link
G Ptn pleiotrophin involved_in ISO PMID:9817766 UniProt PMID:9817766 RGD:14397563 NCBI chrNW_004624765:17,523,086...17,625,264
Ensembl chrNW_004624765:17,522,916...17,548,184
JBrowse link
G Ptpn11 protein tyrosine phosphatase non-receptor type 11 involved_in ISO (PMID:29644115) UniProt PMID:29644115 NCBI chrNW_004624747:19,721,581...19,813,639
Ensembl chrNW_004624747:19,721,468...19,813,670
JBrowse link
G Runx2 RUNX family transcription factor 2 ISO RGD PMID:11784711 RGD:1601657 NCBI chrNW_004624754:14,601,574...14,868,469
Ensembl chrNW_004624754:14,679,974...14,867,729
JBrowse link
G Scube2 signal peptide, CUB domain and EGF like domain containing 2 acts_upstream_of_or_within ISO (PMID:25639508) MGI PMID:25639508 NCBI chrNW_004624766:1,158,607...1,241,797
Ensembl chrNW_004624766:1,151,793...1,241,774
JBrowse link
G Setd2 SET domain containing 2, histone lysine methyltransferase ISO RGD PMID:30746871 RGD:151665130 NCBI chrNW_004624730:74,187,981...74,277,857
Ensembl chrNW_004624730:74,187,995...74,277,200
JBrowse link
G Sox11 SRY-box transcription factor 11 involved_in ISO (PMID:20626275)
(PMID:15254231)
UniProt PMID:15254231 PMID:20626275 NCBI chrNW_004624846:4,043,010...4,046,660
Ensembl chrNW_004624846:4,044,893...4,046,248
JBrowse link
G Tac1 tachykinin precursor 1 ISO RGD PMID:17204323 RGD:2304342 NCBI chrNW_004624813:4,542,226...4,550,378
Ensembl chrNW_004624813:4,542,011...4,550,486
JBrowse link
G Tacr1 tachykinin receptor 1 ISO RGD PMID:17204323 RGD:2304342 NCBI chrNW_004624749:28,243,667...28,455,012
Ensembl chrNW_004624749:28,243,640...28,455,086
JBrowse link
G Thrb thyroid hormone receptor beta ISO RGD PMID:15647824 RGD:1601663 NCBI chrNW_004624788:1,950,888...2,348,895
Ensembl chrNW_004624788:1,950,890...2,349,343
JBrowse link
G Tob2 transducer of ERBB2, 2 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:18358842) Ensembl
MGI
PMID:18358842 GO_REF:0000107 NCBI chrNW_004624752:7,129,464...7,190,718
Ensembl chrNW_004624752:7,129,550...7,140,668
JBrowse link
G Wnt10b Wnt family member 10B acts_upstream_of_or_within ISO (PMID:15728361)
(PMID:17708715)
(PMID:19723499)
MGI PMID:15728361 PMID:17708715 PMID:19723499 NCBI chrNW_004624816:3,221,573...3,227,102
Ensembl chrNW_004624816:3,210,828...3,227,096
JBrowse link
G Wnt5a Wnt family member 5A involved_in ISO (PMID:20032469) BHF-UCL PMID:20032469 NCBI chrNW_004624822:1,824,378...1,843,599
Ensembl chrNW_004624822:1,825,238...1,841,288
JBrowse link
G Zbtb16 zinc finger and BTB domain containing 16 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624784:9,545,529...9,726,960
Ensembl chrNW_004624784:9,546,509...9,726,960
JBrowse link
regulation of bone mineralization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ankh ANKH inorganic pyrophosphate transport regulator involved_in
acts_upstream_of_or_within
ISO (PMID:10894769), (PMID:32639996)
(PMID:10894769), (PMID:7276519)
UniProt
MGI
PMID:7276519 PMID:10894769 PMID:32639996 NCBI chrNW_004624751:11,716,369...11,847,726
Ensembl chrNW_004624751:11,716,369...11,847,758
JBrowse link
G Bglap bone gamma-carboxyglutamate protein involved_in IEA InterPro GO_REF:0000002 NCBI chrNW_004624885:1,526,625...1,528,235
Ensembl chrNW_004624885:1,527,538...1,528,109
JBrowse link
G Bmp2k BMP2 inducible kinase acts_upstream_of_or_within ISO (PMID:11500515) MGI PMID:11500515 NCBI chrNW_004624757:12,160,975...12,290,575
Ensembl chrNW_004624757:12,165,134...12,290,451
JBrowse link
G Comp cartilage oligomeric matrix protein acts_upstream_of_or_within ISO (PMID:21350216) MGI PMID:21350216 NCBI chrNW_004624908:1,870,975...1,877,434
Ensembl chrNW_004624908:1,871,002...1,877,369
JBrowse link
G Ddr2 discoidin domain receptor tyrosine kinase 2 involved_in ISO (PMID:20564243) UniProt PMID:20564243 NCBI chrNW_004624826:1,225,217...1,255,889
Ensembl chrNW_004624826:1,173,621...1,249,692
JBrowse link
G Ecm1 extracellular matrix protein 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:20138147) TreeGrafter
MGI
PMID:20138147 GO_REF:0000118 NCBI chrNW_004624772:18,234,537...18,239,896
Ensembl chrNW_004624772:18,233,727...18,240,601
JBrowse link
G Enpp1 ectonucleotide pyrophosphatase/phosphodiesterase 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624753:5,918,005...5,983,480
Ensembl chrNW_004624753:5,917,689...5,982,308
JBrowse link
G Fgf23 fibroblast growth factor 23 acts_upstream_of_or_within ISO (PMID:15579309) MGI PMID:15579309 NCBI chrNW_004624860:1,478,712...1,486,808
Ensembl chrNW_004624860:1,479,303...1,486,323
JBrowse link
G Gja1 gap junction protein alpha 1 acts_upstream_of_or_within ISO (PMID:21346198) MGI PMID:21346198 NCBI chrNW_004624798:9,358,996...9,364,413
Ensembl chrNW_004624798:9,359,004...9,364,313
JBrowse link
G LOC101700851 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial involved_in ISO (PMID:9415400) BHF-UCL PMID:9415400 NCBI chrNW_004624802:10,176,865...10,181,725
Ensembl chrNW_004624802:10,176,919...10,181,657
JBrowse link
G Matn1 matrilin 1 acts_upstream_of_or_within ISO (PMID:16877353) MGI PMID:16877353 NCBI chrNW_004624764:14,188,421...14,197,244
Ensembl chrNW_004624764:14,188,140...14,195,654
JBrowse link
G Mgp matrix Gla protein involved_in IEA InterPro GO_REF:0000002 NCBI chrNW_004624752:23,146,025...23,149,266
Ensembl chrNW_004624752:23,146,166...23,149,048
JBrowse link
G Nbr1 NBR1 autophagy cargo receptor involved_in ISO (PMID:20616007) BHF-UCL PMID:20616007 NCBI chrNW_004624795:1,160,588...1,185,919 JBrowse link
G Notum notum, palmitoleoyl-protein carboxylesterase acts_upstream_of_or_within ISO (PMID:30622831) MGI PMID:30622831 NCBI chrNW_004624801:10,795,603...10,802,394
Ensembl chrNW_004624801:10,791,939...10,802,463
JBrowse link
G S1pr1 sphingosine-1-phosphate receptor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624857:4,143,269...4,147,877
Ensembl chrNW_004624857:4,143,270...4,147,877
JBrowse link
G Sgms2 sphingomyelin synthase 2 involved_in ISO (PMID:30779713) UniProt PMID:30779713 NCBI chrNW_004624830:1,498,700...1,543,112
Ensembl chrNW_004624830:1,502,336...1,542,134
JBrowse link
G Suv39h1 SUV39H1 histone lysine methyltransferase acts_upstream_of_or_within ISO (PMID:23695662) MGI PMID:23695662 NCBI chrNW_004624893:499,222...512,341
Ensembl chrNW_004624893:498,973...512,443
JBrowse link
G Twist1 twist family bHLH transcription factor 1 involved_in ISO (PMID:19597909) BHF-UCL PMID:19597909 NCBI chrNW_004624739:11,352,040...11,354,019
Ensembl chrNW_004624739:11,352,141...11,352,809
JBrowse link
G Txlng taxilin gamma involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624829:1,497,646...1,544,635
Ensembl chrNW_004624829:1,497,546...1,542,025
JBrowse link
G Zmpste24 zinc metallopeptidase STE24 acts_upstream_of_or_within ISO (PMID:23695662) MGI PMID:23695662 NCBI chrNW_004624764:22,723,643...22,777,517
Ensembl chrNW_004624764:22,723,291...22,778,761
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 15114
    multicellular organismal process 7140
      ossification 427
        regulation of ossification 138
          negative regulation of ossification + 49
          positive regulation of ossification + 62
          regulation of bone mineralization + 80
Path 2
Term Annotations click to browse term
  biological_process 15114
    biological regulation 10687
      regulation of biological process 10352
        regulation of multicellular organismal process 2899
          regulation of ossification 138
            negative regulation of ossification + 49
            positive regulation of ossification + 62
            regulation of bone mineralization + 80
paths to the root