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ONTOLOGY REPORT - ANNOTATIONS


Term:myofibril assembly
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Accession:GO:0030239 term browser browse the term
Definition:Formation of myofibrils, the repeating units of striated muscle.


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myofibril assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Capn3 calpain 3 acts_upstream_of_or_within ISO (MGI:3046122|PMID:15138196) MGI PMID:15138196 MGI:3046122 NCBI chrNW_004936471:5,667,839...5,711,822 JBrowse link
G Klhl41 kelch like family member 41 involved_in ISO (MGI:5486546|PMID:18178185) UniProt PMID:18178185 MGI:5486546 NCBI chrNW_004936509:47,298...62,608 JBrowse link
G Myh10 myosin heavy chain 10 acts_upstream_of_or_within ISO (MGI:1354135|PMID:10712438) MGI PMID:10712438 MGI:1354135 NCBI chrNW_004936595:1,697,283...1,832,571 JBrowse link
G Neurl2 neuralized E3 ubiquitin protein ligase 2 acts_upstream_of_or_within ISO (MGI:3042352|PMID:14960280) MGI PMID:14960280 MGI:3042352 NCBI chrNW_004936514:7,136,797...7,141,377 JBrowse link
G Tmod1 tropomodulin 1 acts_upstream_of_or_within ISO (MGI:2683807|PMID:14657235) MGI PMID:14657235 MGI:2683807 NCBI chrNW_004936524:6,347,089...6,403,996 JBrowse link
cardiac muscle thin filament assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nebl nebulette involved_in ISO (PMID:11822876), (PMID:18823973) UniProt PMID:11822876 PMID:18823973 NCBI chrNW_004936520:6,658,555...6,992,643 JBrowse link
cardiac myofibril assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Actc1 actin alpha cardiac muscle 1 acts_upstream_of_or_within ISO (MGI:87509|PMID:9114002) MGI PMID:9114002 MGI:87509 NCBI chrNW_004936673:1,092,700...1,098,256 JBrowse link
G Csrp3 cysteine and glycine rich protein 3 involved_in ISO (MGI:2447926|PMID:12507422) BHF-UCL PMID:12507422 MGI:2447926 NCBI chrNW_004936654:271,067...313,251 JBrowse link
G Fhod3 formin homology 2 domain containing 3 acts_upstream_of_or_within ISO (MGI:5436289|PMID:23213483) MGI PMID:23213483 MGI:5436289 NCBI chrNW_004936517:8,614,384...9,044,894 JBrowse link
G LOC101966001 titin-cap involved_in ISO (PMID:9817758) BHF-UCL PMID:9817758 NCBI chrNW_004936490:14,856,433...14,857,692 JBrowse link
G Myh10 myosin heavy chain 10 acts_upstream_of_or_within ISO (MGI:1099556|PMID:9356462) MGI PMID:9356462 MGI:1099556 NCBI chrNW_004936595:1,697,283...1,832,571 JBrowse link
G Myl2 myosin light chain 2 acts_upstream_of_or_within ISO (MGI:1194431|PMID:9422794) MGI PMID:9422794 MGI:1194431 NCBI chrNW_004936558:3,746,227...3,753,576 JBrowse link
G Mylk3 myosin light chain kinase 3 involved_in ISO PMID:17885681 BHF-UCL PMID:17885681 RGD:8554371 NCBI chrNW_004936475:89,717...137,866 JBrowse link
G Pdgfra platelet derived growth factor receptor alpha involved_in ISO (MGI:1931346|PMID:11239463) UniProt PMID:11239463 MGI:1931346 NCBI chrNW_004936482:16,804,129...16,853,539 JBrowse link
G Pdgfrb platelet derived growth factor receptor beta involved_in ISO (MGI:1931346|PMID:11239463) UniProt PMID:11239463 MGI:1931346 NCBI chrNW_004936504:4,762,251...4,799,789 JBrowse link
G Srf serum response factor acts_upstream_of_or_within ISO (MGI:3513738|PMID:15569937) MGI PMID:15569937 MGI:3513738 NCBI chrNW_004936476:16,779,941...16,789,499 JBrowse link
G Ttn titin involved_in
acts_upstream_of_or_within
ISO (PMID:11846417), (PMID:9817758)
(MGI:3653555|PMID:16702235)
BHF-UCL
MGI
PMID:9817758 PMID:11846417 PMID:16702235 MGI:3653555 NCBI chrNW_004936509:7,733,426...7,999,503 JBrowse link
negative regulation of cardiac myofibril assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Smad4 SMAD family member 4 involved_in ISO (MGI:3689643|PMID:16151019) BHF-UCL PMID:16151019 MGI:3689643 NCBI chrNW_004936497:12,242,869...12,278,012 JBrowse link
negative regulation of sarcomere organization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cav3 caveolin 3 involved_in ISO (PMID:12847114) BHF-UCL PMID:12847114 NCBI chrNW_004936602:4,264,896...4,278,160 JBrowse link
G Mfn2 mitofusin 2 ISO RGD PMID:24777478 RGD:13204833 NCBI chrNW_004936474:767,754...795,258 JBrowse link
positive regulation of sarcomere organization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp10 bone morphogenetic protein 10 involved_in ISO (PMID:17921333) BHF-UCL PMID:17921333 NCBI chrNW_004936491:13,180,086...13,186,004 JBrowse link
G Edn1 endothelin 1 involved_in ISO (PMID:12847114) BHF-UCL PMID:12847114 NCBI chrNW_004936534:885,489...892,292 JBrowse link
G Ep300 E1A binding protein p300 ISO RGD PMID:12724418 RGD:2312280 NCBI chrNW_004936492:696,982...778,132 JBrowse link
G Mylk3 myosin light chain kinase 3 involved_in ISO PMID:17885681 BHF-UCL PMID:17885681 RGD:8554371 NCBI chrNW_004936475:89,717...137,866 JBrowse link
G Prox1 prospero homeobox 1 involved_in ISO (MGI:3830437|PMID:19091769) BHF-UCL PMID:19091769 MGI:3830437 NCBI chrNW_004936628:4,185,712...4,240,680 JBrowse link
regulation of sarcomere organization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akap13 A-kinase anchoring protein 13 involved_in ISO (MGI:5308772|PMID:20139090) UniProt PMID:20139090 MGI:5308772 NCBI chrNW_004936483:11,661,862...11,977,292 JBrowse link
G Ankrd23 ankyrin repeat domain 23 acts_upstream_of_or_within ISO (MGI:3760007|PMID:17392382) MGI PMID:17392382 MGI:3760007 NCBI chrNW_004936744:776,030...781,710 JBrowse link
G Hdac2 histone deacetylase 2 acts_upstream_of_or_within ISO (MGI:3711360|PMID:17322895) MGI PMID:17322895 MGI:3711360 NCBI chrNW_004936679:2,448,676...2,474,641 JBrowse link
G Mef2c myocyte enhancer factor 2C acts_upstream_of_or_within ISO (MGI:3768576|PMID:17875930) MGI PMID:17875930 MGI:3768576 NCBI chrNW_004936469:7,060,480...7,225,497 JBrowse link
sarcomere organization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Actg1 actin gamma 1 acts_upstream_of_or_within ISO (MGI:3053481|PMID:15194427) MGI PMID:15194427 MGI:3053481 NCBI chrNW_004936594:5,170,711...5,173,251 JBrowse link
G Actn2 actinin alpha 2 involved_in ISO (PMID:25433700) UniProt PMID:25433700 NCBI chrNW_004936484:16,186,844...16,248,394 JBrowse link
G Bmp10 bone morphogenetic protein 10 involved_in ISO PMID:17921333 BHF-UCL PMID:17921333 RGD:2302083 NCBI chrNW_004936491:13,180,086...13,186,004 JBrowse link
G Capn3 calpain 3 acts_upstream_of_or_within ISO (MGI:3046122|PMID:15138196) MGI PMID:15138196 MGI:3046122 NCBI chrNW_004936471:5,667,839...5,711,822 JBrowse link
G Casq1 calsequestrin 1 involved_in ISO (MGI:5306707|PMID:22049211) UniProt PMID:22049211 MGI:5306707 NCBI chrNW_004936740:430,367...442,468 JBrowse link
G Casq2 calsequestrin 2 involved_in ISO (MGI:4453101|PMID:19920148) UniProt PMID:19920148 MGI:4453101 NCBI chrNW_004936627:1,001,681...1,069,377 JBrowse link
G Cfl2 cofilin 2 acts_upstream_of_or_within ISO (MGI:5316079|PMID:22343409) MGI PMID:22343409 MGI:5316079 NCBI chrNW_004936494:8,946,442...8,948,320 JBrowse link
G Fhod3 formin homology 2 domain containing 3 acts_upstream_of_or_within ISO (MGI:4422153|PMID:19706596) MGI PMID:19706596 MGI:4422153 RGD:8554207 NCBI chrNW_004936517:8,614,384...9,044,894 JBrowse link
G Foxp1 forkhead box P1 acts_upstream_of_or_within ISO (MGI:4829405|PMID:20713518) MGI PMID:20713518 MGI:4829405 NCBI chrNW_004936603:2,631,781...3,146,104 JBrowse link
G Itgb1 integrin subunit beta 1 acts_upstream_of_or_within ISO (MGI:84974|PMID:9004034) MGI PMID:9004034 MGI:84974 NCBI chrNW_004936574:1,465,981...1,495,717 JBrowse link
G Krt19 keratin 19 involved_in ISO (PMID:16000376) UniProt PMID:16000376 NCBI chrNW_004936490:16,440,723...16,444,679 JBrowse link
G Krt8 keratin 8 involved_in ISO PMID:15247274 UniProt PMID:15247274 RGD:1600063 NCBI chrNW_004936512:10,247,049...10,254,748 JBrowse link
G Ldb3 LIM domain binding 3 acts_upstream_of_or_within ISO (MGI:2153618|PMID:11696561) MGI PMID:11696561 MGI:2153618 NCBI chrNW_004936804:196,592...259,168 JBrowse link
G Lmod2 leiomodin 2 involved_in ISO (PMID:18403713)
(MGI:5787841|PMID:27274810)
UniProt PMID:18403713 PMID:27274810 MGI:5787841 RGD:11344939 NCBI chrNW_004936605:1,829,187...1,838,385 JBrowse link
G LOC101957084 plectin involved_in ISO (MGI:5567855|PMID:24487589) MGI PMID:24487589 MGI:5567855 NCBI chrNW_004936470:8,194,124...8,252,139 JBrowse link
G LOC101966001 titin-cap involved_in ISO (PMID:9817758) BHF-UCL PMID:9817758 NCBI chrNW_004936490:14,856,433...14,857,692 JBrowse link
G Mybpc3 myosin binding protein C3 acts_upstream_of_or_within ISO (MGI:3616388|PMID:16380103)
(MGI:3695637|PMID:17075052), (MGI:3696622|PMID:16224063)
MGI PMID:16224063 PMID:16380103 PMID:17075052 MGI:3616388 MGI:3695637 MGI:3696622 NCBI chrNW_004936562:1,871,194...1,890,092 JBrowse link
G Mylk3 myosin light chain kinase 3 involved_in ISO PMID:18202317
(MGI:3841874|PMID:18202317)
BHF-UCL PMID:18202317 MGI:3841874 RGD:8554765 NCBI chrNW_004936475:89,717...137,866 JBrowse link
G Myom2 myomesin 2 involved_in ISO (PMID:33033063) FlyBase PMID:33033063 NCBI chrNW_004936615:1,153,056...1,223,239 JBrowse link
G Myoz1 myozenin 1 involved_in ISO (MGI:3831256|PMID:18846255) BHF-UCL PMID:18846255 MGI:3831256 NCBI chrNW_004936521:5,420,553...5,428,470 JBrowse link
G Myoz2 myozenin 2 involved_in ISO (MGI:3513659|PMID:15543153) BHF-UCL PMID:15543153 MGI:3513659 NCBI chrNW_004936869:244,599...284,228 JBrowse link
G Mypn myopalladin involved_in ISO (PMID:11309420) BHF-UCL PMID:11309420 NCBI chrNW_004936521:10,050,638...10,142,395 JBrowse link
G Neurl2 neuralized E3 ubiquitin protein ligase 2 acts_upstream_of_or_within ISO (MGI:3042352|PMID:14960280) MGI PMID:14960280 MGI:3042352 NCBI chrNW_004936514:7,136,797...7,141,377 JBrowse link
G Nkx2-5 NK2 homeobox 5 acts_upstream_of_or_within ISO (MGI:4829405|PMID:20713518) MGI PMID:20713518 MGI:4829405 NCBI chrNW_004936609:2,406,004...2,408,980 JBrowse link
G Prkar1a protein kinase cAMP-dependent type I regulatory subunit alpha acts_upstream_of_or_within ISO (MGI:3821563|PMID:18316483) MGI PMID:18316483 MGI:3821563 NCBI chrNW_004936541:7,845,876...7,863,677 JBrowse link
G Six4 SIX homeobox 4 involved_in ISO (MGI:5298278|PMID:21884692) UniProt PMID:21884692 MGI:5298278 NCBI chrNW_004936495:4,887,718...4,900,198 JBrowse link
G Srf serum response factor acts_upstream_of_or_within ISO (MGI:3513738|PMID:15569937) MGI PMID:15569937 MGI:3513738 NCBI chrNW_004936476:16,779,941...16,789,499 JBrowse link
G Synpo2l synaptopodin 2 like involved_in ISO (MGI:6102963|PMID:29206857) BHF-UCL PMID:29206857 MGI:6102963 NCBI chrNW_004936521:5,407,767...5,418,368 JBrowse link
G Tnnt2 troponin T2, cardiac type acts_upstream_of_or_within ISO (MGI:1342889|PMID:10449439) MGI PMID:10449439 MGI:1342889 NCBI chrNW_004936567:3,052,167...3,069,077 JBrowse link
G Tpm1 tropomyosin 1 involved_in ISO (PMID:11273725) BHF-UCL PMID:11273725 NCBI chrNW_004936471:23,643,645...23,670,775 JBrowse link
G Ttn titin acts_upstream_of_or_within
involved_in
ISO (MGI:3653555|PMID:16702235)
(MGI:3760201|PMID:17360664)
(PMID:11846417), (PMID:9817758)
RGD
MGI
BHF-UCL
PMID:9817758 PMID:11034912 PMID:11846417 PMID:16702235 PMID:17360664 MGI:3653555 MGI:3760201 RGD:634444 NCBI chrNW_004936509:7,733,426...7,999,503 JBrowse link
G Wdr1 WD repeat domain 1 acts_upstream_of_or_within ISO (MGI:5574550|PMID:24840128) MGI PMID:24840128 MGI:5574550 NCBI chrNW_004936477:16,643,142...16,682,450 JBrowse link
G Xirp1 xin actin binding repeat containing 1 acts_upstream_of_or_within ISO (MGI:3775114|PMID:17766470) MGI PMID:17766470 MGI:3775114 NCBI chrNW_004936473:28,434,910...28,444,146 JBrowse link
sarcomerogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC101966001 titin-cap involved_in ISO (PMID:9817758) BHF-UCL PMID:9817758 NCBI chrNW_004936490:14,856,433...14,857,692 JBrowse link
G Mylk3 myosin light chain kinase 3 involved_in ISO PMID:17885681 BHF-UCL PMID:17885681 RGD:8554371 NCBI chrNW_004936475:89,717...137,866 JBrowse link
G Ttn titin involved_in ISO (PMID:9817758) BHF-UCL PMID:9817758 NCBI chrNW_004936509:7,733,426...7,999,503 JBrowse link
skeletal muscle myosin thick filament assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC101966001 titin-cap involved_in ISO (PMID:9817758) BHF-UCL PMID:9817758 NCBI chrNW_004936490:14,856,433...14,857,692 JBrowse link
G Tmod1 tropomodulin 1 NOT|acts_upstream_of_or_within ISO (MGI:2683807|PMID:14657235) MGI PMID:14657235 MGI:2683807 NCBI chrNW_004936524:6,347,089...6,403,996 JBrowse link
G Ttn titin involved_in ISO (PMID:9817758) BHF-UCL PMID:9817758 NCBI chrNW_004936509:7,733,426...7,999,503 JBrowse link
skeletal muscle thin filament assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta1 actin alpha 1, skeletal muscle involved_in ISO (PMID:11333380) UniProt PMID:11333380 NCBI chrNW_004936484:20,236,320...20,239,385 JBrowse link
G Actc1 actin alpha cardiac muscle 1 acts_upstream_of_or_within ISO (MGI:87509|PMID:9114002) MGI PMID:9114002 MGI:87509 NCBI chrNW_004936673:1,092,700...1,098,256 JBrowse link
G Lmod3 leiomodin 3 involved_in ISO (PMID:25250574) UniProt PMID:25250574 NCBI chrNW_004936603:1,510,330...1,520,741 JBrowse link
G LOC101966001 titin-cap involved_in ISO (PMID:9817758) BHF-UCL PMID:9817758 NCBI chrNW_004936490:14,856,433...14,857,692 JBrowse link
G Prox1 prospero homeobox 1 involved_in ISO (MGI:3830437|PMID:19091769) BHF-UCL PMID:19091769 MGI:3830437 NCBI chrNW_004936628:4,185,712...4,240,680 JBrowse link
G Ttn titin involved_in ISO (PMID:9817758) BHF-UCL PMID:9817758 NCBI chrNW_004936509:7,733,426...7,999,503 JBrowse link
skeletal myofibril assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cflar CASP8 and FADD like apoptosis regulator involved_in ISO (MGI:5707584|PMID:21364645) BHF-UCL PMID:21364645 MGI:5707584 NCBI chrNW_004936726:381,888...425,565 JBrowse link
G LOC101957084 plectin involved_in ISO (MGI:5567855|PMID:24487589) MGI PMID:24487589 MGI:5567855 NCBI chrNW_004936470:8,194,124...8,252,139 JBrowse link
ventricular cardiac myofibril assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mef2a myocyte enhancer factor 2A involved_in ISO (MGI:2429350|PMID:12379849) UniProt PMID:12379849 MGI:2429350 NCBI chrNW_004936483:3,837,891...3,982,334 JBrowse link
G Nkx2-5 NK2 homeobox 5 acts_upstream_of_or_within ISO (MGI:4355491|PMID:19546853) MGI PMID:19546853 MGI:4355491 NCBI chrNW_004936609:2,406,004...2,408,980 JBrowse link
G Prox1 prospero homeobox 1 involved_in ISO (MGI:3830437|PMID:19091769) BHF-UCL PMID:19091769 MGI:3830437 NCBI chrNW_004936628:4,185,712...4,240,680 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12164
    developmental process 5729
      anatomical structure formation involved in morphogenesis 1119
        cellular component assembly involved in morphogenesis 108
          myofibril assembly 56
            cardiac myofibril assembly + 16
            muscle thin filament assembly 0
            sarcomere organization + 42
            sarcomerogenesis 3
            skeletal myofibril assembly + 9
            striated muscle myosin thick filament assembly + 3
            striated muscle paramyosin thick filament assembly 0
Path 2
Term Annotations click to browse term
  biological_process 12164
    cellular process 11361
      cellular component organization or biogenesis 5038
        cellular component organization 4957
          organelle organization 3076
            cytoskeleton organization 1104
              actin cytoskeleton organization 557
                actomyosin structure organization 175
                  myofibril assembly 56
                    cardiac myofibril assembly + 16
                    muscle thin filament assembly 0
                    sarcomere organization + 42
                    sarcomerogenesis 3
                    skeletal myofibril assembly + 9
                    striated muscle myosin thick filament assembly + 3
                    striated muscle paramyosin thick filament assembly 0
paths to the root