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ONTOLOGY REPORT - ANNOTATIONS

Term:hyaluronan biosynthetic process
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Accession:GO:0030213 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine.
Synonyms:exact_synonym: hyaluronan anabolism;   hyaluronan biosynthesis;   hyaluronan formation;   hyaluronan synthesis


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hyaluronan biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCC5 ATP binding cassette subfamily C member 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr34:16,856,624...16,947,844
Ensembl chr34:16,856,633...16,946,422 		JBrowse link
G CCND3 cyclin D3 ISO RGD PMID:19276076 RGD:2316018 NCBI chr12:10,593,786...10,688,304
Ensembl chr12:10,594,712...10,600,891 		JBrowse link
G HAS1 hyaluronan synthase 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10617644) TreeGrafter
MGI		 PMID:10617644 GO_REF:0000118 NCBI chr 1:105,376,091...105,386,043
Ensembl chr 1:105,376,536...105,385,134 		JBrowse link
G HAS2 hyaluronan synthase 2 involved_in IEA Ensembl
TreeGrafter
UniProt		 GO_REF:0000041 GO_REF:0000107 GO_REF:0000118 NCBI chr13:20,310,946...20,342,647
Ensembl chr13:20,309,872...20,341,636 		JBrowse link
G HAS3 hyaluronan synthase 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:9060470) Ensembl
MGI
TreeGrafter		 PMID:9060470 GO_REF:0000107 GO_REF:0000118 NCBI chr 5:80,520,261...80,530,769
Ensembl chr 5:80,520,261...80,529,434 		JBrowse link
G HYAL1 hyaluronidase 1 involved_in ISO (PMID:21829529) UniProt PMID:21829529 NCBI chr20:39,035,924...39,040,443
Ensembl chr20:39,038,514...39,040,368 		JBrowse link
G IL1B interleukin 1 beta involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:37,019,329...37,033,388
Ensembl chr17:37,019,329...37,024,458 		JBrowse link
negative regulation of hyaluronan biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AP2A1 adaptor related protein complex 2 subunit alpha 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:106,752,326...106,784,803
Ensembl chr 1:106,751,800...106,784,663 		JBrowse link
G B9D2 B9 domain containing 2 involved_in ISO (PMID:17324121) UniProt PMID:17324121 NCBI chr 1:112,621,832...112,627,726
Ensembl chr 1:112,621,633...112,643,885 		JBrowse link
G CLTC clathrin heavy chain involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:34,116,344...34,183,023
Ensembl chr 9:34,116,634...34,182,719 		JBrowse link
G SMPD3 sphingomyelin phosphodiesterase 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:22383528) Ensembl
MGI		 PMID:22383528 GO_REF:0000107 NCBI chr 5:81,089,657...81,172,173
Ensembl chr 5:81,142,888...81,172,189 		JBrowse link
G TGFB1 transforming growth factor beta 1 involved_in ISS
IEA		 AgBase
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:112,629,476...112,643,885
Ensembl chr 1:112,621,633...112,643,885 		JBrowse link
positive regulation of hyaluronan biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EGF epidermal growth factor involved_in IEA Ensembl GO_REF:0000107 NCBI chr32:30,073,541...30,166,904
Ensembl chr32:30,073,950...30,166,295 		JBrowse link
G HAS2 hyaluronan synthase 2 ISO RGD PMID:12186949 PMID:17080198 RGD:9588629 RGD:9588632 NCBI chr13:20,310,946...20,342,647
Ensembl chr13:20,309,872...20,341,636 		JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr32:23,948,598...24,040,704
Ensembl chr32:23,942,954...24,040,703 		JBrowse link
G PDGFB platelet derived growth factor subunit B involved_in ISS
IEA		 UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr10:25,798,877...25,819,422
Ensembl chr10:25,798,938...25,817,746 		JBrowse link
G PTGER4 prostaglandin E receptor 4 ISO RGD PMID:17080198 RGD:9588632 NCBI chr 4:68,663,362...68,676,241
Ensembl chr 4:68,663,364...68,676,358 		JBrowse link
regulation of hyaluronan biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SMPD3 sphingomyelin phosphodiesterase 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:22383528) Ensembl
MGI		 PMID:22383528 GO_REF:0000107 NCBI chr 5:81,089,657...81,172,173
Ensembl chr 5:81,142,888...81,172,189 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17917
    metabolic process 10998
      organic substance metabolic process 10554
        macromolecule metabolic process 8924
          aminoglycan metabolic process 116
            aminoglycan biosynthetic process 69
              glycosaminoglycan biosynthetic process 63
                hyaluronan biosynthetic process 16
                  negative regulation of hyaluronan biosynthetic process 5
                  positive regulation of hyaluronan biosynthetic process 5
                  regulation of hyaluronan biosynthetic process + 10
Path 2
Term Annotations click to browse term
  biological_process 17917
    metabolic process 10998
      organic substance metabolic process 10554
        carbohydrate derivative metabolic process 1131
          aminoglycan metabolic process 116
            glycosaminoglycan metabolic process 105
              mucopolysaccharide metabolic process 86
                hyaluronan metabolic process 40
                  hyaluronan biosynthetic process 16
                    negative regulation of hyaluronan biosynthetic process 5
                    positive regulation of hyaluronan biosynthetic process 5
                    regulation of hyaluronan biosynthetic process + 10
paths to the root