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ONTOLOGY REPORT - ANNOTATIONS

Term:hyaluronan metabolic process
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Accession:GO:0030212 term browser browse the term
Definition:The chemical reactions and pathways involving hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine.
Synonyms:exact_synonym: hyaluronan metabolism

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hyaluronan metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cemip cell migration inducing hyaluronidase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936483:19,721,256...19,799,371
Ensembl chrNW_004936483:19,724,605...19,799,361 		JBrowse link
G Has2 hyaluronan synthase 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:21246657) Ensembl
MGI		 PMID:21246657 GO_REF:0000107 NCBI chrNW_004936470:25,418,069...25,443,332
Ensembl chrNW_004936470:25,418,063...25,444,634 		JBrowse link
G Hyal1 hyaluronidase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936529:1,838,212...1,842,399
Ensembl chrNW_004936529:1,838,676...1,841,188 		JBrowse link
G Il15 interleukin 15 ISO RGD PMID:17667861 RGD:5013835 NCBI chrNW_004936535:6,344,348...6,358,803
Ensembl chrNW_004936535:6,344,395...6,350,197 		JBrowse link
G Itih1 inter-alpha-trypsin inhibitor heavy chain 1 involved_in IEA InterPro GO_REF:0000002 NCBI chrNW_004936473:3,534,071...3,548,554
Ensembl chrNW_004936473:3,533,819...3,548,411 		JBrowse link
G Itih2 inter-alpha-trypsin inhibitor heavy chain 2 involved_in IEA InterPro GO_REF:0000002 NCBI chrNW_004936484:7,064,836...7,101,872
Ensembl chrNW_004936484:7,065,406...7,101,855 		JBrowse link
G Itih3 inter-alpha-trypsin inhibitor heavy chain 3 involved_in IEA InterPro GO_REF:0000002 NCBI chrNW_004936473:3,553,210...3,568,636
Ensembl chrNW_004936473:3,553,210...3,568,636 		JBrowse link
G Itih4 inter-alpha-trypsin inhibitor heavy chain 4 involved_in IEA InterPro GO_REF:0000002 NCBI chrNW_004936473:3,573,282...3,589,345
Ensembl chrNW_004936473:3,573,384...3,589,345 		JBrowse link
G Itih5 inter-alpha-trypsin inhibitor heavy chain 5 involved_in IEA InterPro GO_REF:0000002 NCBI chrNW_004936484:7,123,022...7,207,166
Ensembl chrNW_004936484:7,122,921...7,203,002 		JBrowse link
G Itih6 inter-alpha-trypsin inhibitor heavy chain family member 6 involved_in IEA InterPro GO_REF:0000002 NCBI chrNW_004936751:1,601,650...1,630,115
Ensembl chrNW_004936751:1,601,650...1,630,115 		JBrowse link
G Tnfaip6 TNF alpha induced protein 6 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936469:26,129,339...26,145,464
Ensembl chrNW_004936469:26,129,331...26,145,422 		JBrowse link
hyaluronan biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc5 ATP binding cassette subfamily C member 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936578:5,838,044...5,916,287
Ensembl chrNW_004936578:5,837,993...5,916,274 		JBrowse link
G Ccnd3 cyclin D3 ISO RGD PMID:19276076 RGD:2316018 NCBI chrNW_004936476:17,799,754...17,886,835
Ensembl chrNW_004936476:17,879,869...17,886,827 		JBrowse link
G Has1 hyaluronan synthase 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10617644) Ensembl
MGI
TreeGrafter		 PMID:10617644 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004937026:125,622...132,141
Ensembl chrNW_004937026:125,881...135,235 		JBrowse link
G Has2 hyaluronan synthase 2 involved_in IEA UniProt
TreeGrafter
Ensembl		 GO_REF:0000041 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936470:25,418,069...25,443,332
Ensembl chrNW_004936470:25,418,063...25,444,634 		JBrowse link
G Has3 hyaluronan synthase 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:9060470) Ensembl
MGI
TreeGrafter		 PMID:9060470 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936475:19,270,788...19,282,922
Ensembl chrNW_004936475:19,270,830...19,282,907 		JBrowse link
G Hyal1 hyaluronidase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936529:1,838,212...1,842,399
Ensembl chrNW_004936529:1,838,676...1,841,188 		JBrowse link
G Il1b interleukin 1 beta involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936783:1,251,678...1,256,807
Ensembl chrNW_004936783:1,252,158...1,257,165 		JBrowse link
hyaluronan catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Afg2a AFG2 AAA ATPase homolog A involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936662:1,957,364...2,207,410
Ensembl chrNW_004936662:1,886,176...1,929,097
Ensembl chrNW_004936662:1,886,176...1,929,097 		JBrowse link
G Cd44 CD44 molecule (IN blood group) involved_in ISO (PMID:17170110)
(PMID:26528478)		 UniProt
MGI		 PMID:17170110 PMID:26528478 NCBI chrNW_004936533:2,949,026...3,033,166 JBrowse link
G Cemip cell migration inducing hyaluronidase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936483:19,721,256...19,799,371
Ensembl chrNW_004936483:19,724,605...19,799,361 		JBrowse link
G Cemip2 cell migration inducing hyaluronidase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936503:7,750,353...7,826,408
Ensembl chrNW_004936503:7,750,352...7,825,554 		JBrowse link
G Gusb glucuronidase beta involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936543:7,721,273...7,732,468
Ensembl chrNW_004936543:7,721,763...7,731,897 		JBrowse link
G Hexa hexosaminidase subunit alpha involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936471:31,712,485...31,738,273
Ensembl chrNW_004936471:31,709,491...31,738,245 		JBrowse link
G Hexb hexosaminidase subunit beta involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936549:1,918,482...1,943,665
Ensembl chrNW_004936549:1,917,327...1,943,691 		JBrowse link
G Hmmr hyaluronan mediated motility receptor involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936515:570,112...599,400
Ensembl chrNW_004936515:571,139...600,132 		JBrowse link
G Hyal1 hyaluronidase 1 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936529:1,838,212...1,842,399
Ensembl chrNW_004936529:1,838,676...1,841,188 		JBrowse link
G Hyal2 hyaluronidase 2 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936529:1,845,445...1,851,106
Ensembl chrNW_004936529:1,845,763...1,851,252 		JBrowse link
G Hyal3 hyaluronidase 3 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936529:1,831,639...1,837,314
Ensembl chrNW_004936529:1,831,254...1,837,314 		JBrowse link
G Hyal4 hyaluronidase 4 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936605:1,645,204...1,666,510
Ensembl chrNW_004936605:1,645,204...1,666,510 		JBrowse link
G LOC101976844 hyaluronidase-1-like involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936605:1,670,237...1,679,080 JBrowse link
G Lyve1 lymphatic vessel endothelial hyaluronan receptor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936528:7,788,560...7,802,821
Ensembl chrNW_004936528:7,788,352...7,802,902 		JBrowse link
G Spam1 sperm adhesion molecule 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936605:1,595,969...1,602,236
Ensembl chrNW_004936605:1,595,481...1,602,236 		JBrowse link
G Stab2 stabilin 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936492:10,678,074...10,817,870
Ensembl chrNW_004936492:10,678,115...10,833,963 		JBrowse link
G Tgfb1 transforming growth factor beta 1 involved_in ISS
IEA		 AgBase
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chrNW_004936661:3,742,080...3,758,266
Ensembl chrNW_004936661:3,742,066...3,758,272 		JBrowse link
negative regulation of hyaluronan biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ap2a1 adaptor related protein complex 2 subunit alpha 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936664:3,562,800...3,596,983
Ensembl chrNW_004936664:3,562,798...3,599,791 		JBrowse link
G Cltc clathrin heavy chain involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936490:3,659,682...3,726,222
Ensembl chrNW_004936490:3,657,242...3,726,274 		JBrowse link
G Smpd3 sphingomyelin phosphodiesterase 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:22383528) Ensembl
MGI		 PMID:22383528 GO_REF:0000107 NCBI chrNW_004936475:18,667,563...18,755,132
Ensembl chrNW_004936475:18,671,428...18,755,208 		JBrowse link
G Tgfb1 transforming growth factor beta 1 involved_in ISS
IEA		 AgBase
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chrNW_004936661:3,742,080...3,758,266
Ensembl chrNW_004936661:3,742,066...3,758,272 		JBrowse link
positive regulation of hyaluronan biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Egf epidermal growth factor involved_in ISO (PMID:17324121) UniProt PMID:17324121 NCBI chrNW_004936563:1,058,803...1,181,393 JBrowse link
G Has2 hyaluronan synthase 2 ISO RGD PMID:12186949 PMID:17080198 RGD:9588629 RGD:9588632 NCBI chrNW_004936470:25,418,069...25,443,332
Ensembl chrNW_004936470:25,418,063...25,444,634 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936520:733,760...850,563
Ensembl chrNW_004936520:733,668...829,435 		JBrowse link
G Pdgfb platelet derived growth factor subunit B involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936492:2,353,840...2,368,573
Ensembl chrNW_004936492:2,353,841...2,368,573 		JBrowse link
G Ptger4 prostaglandin E receptor 4 ISO RGD PMID:17080198 RGD:9588632 NCBI chrNW_004936518:1,903,636...1,916,746
Ensembl chrNW_004936518:1,903,725...1,916,746 		JBrowse link
regulation of hyaluronan biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Smpd3 sphingomyelin phosphodiesterase 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:22383528) Ensembl
MGI		 PMID:22383528 GO_REF:0000107 NCBI chrNW_004936475:18,667,563...18,755,132
Ensembl chrNW_004936475:18,671,428...18,755,208 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 15969
    metabolic process 9630
      organic substance metabolic process 9204
        macromolecule metabolic process 7677
          aminoglycan metabolic process 109
            glycosaminoglycan metabolic process 99
              mucopolysaccharide metabolic process 80
                hyaluronan metabolic process 38
                  hyaluronan biosynthetic process + 15
                  hyaluronan catabolic process 17
paths to the root