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ONTOLOGY REPORT - ANNOTATIONS


Term:hyaluronan metabolic process
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Accession:GO:0030212 term browser browse the term
Definition:The chemical reactions and pathways involving hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine.
Synonyms:exact_synonym: hyaluronan metabolism



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hyaluronan metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cemip cell migration inducing hyaluronidase 1 involved_in ISO (PMID:28189611), (PMID:28284715) RGD PMID:28189611 PMID:28284715 NCBI chr 1:137,906,921...138,062,430
Ensembl chr 1:137,908,920...138,062,415
JBrowse link
G Has2 hyaluronan synthase 2 acts_upstream_of_or_within ISO MGI:2176070|MGI:4360705 (PMID:21246657) RGD PMID:21246657 NCBI chr 7:88,113,326...88,139,337
Ensembl chr 7:88,113,326...88,128,933
JBrowse link
G Hyal1 hyaluronidase 1 involved_in ISS
ISO
GO_REF:0000024
(PMID:19478093)
UniProt
RGD
PMID:19478093 GO_REF:0000024 NCBI chr 8:108,250,668...108,254,519
Ensembl chr 8:108,250,667...108,260,210
JBrowse link
G Il15 interleukin 15 IDA RGD PMID:17667861 RGD:5013835 NCBI chr19:25,640,025...25,706,818
Ensembl chr19:25,640,251...25,706,820
JBrowse link
G Itih1 inter-alpha trypsin inhibitor, heavy chain 1 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr16:6,122,246...6,136,363
Ensembl chr16:6,122,248...6,136,363
JBrowse link
G Itih2 inter-alpha-trypsin inhibitor heavy chain 2 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr17:68,375,574...68,411,849
Ensembl chr17:68,375,567...68,411,841
JBrowse link
G Itih3 inter-alpha trypsin inhibitor, heavy chain 3 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr16:6,101,922...6,117,154
Ensembl chr16:6,101,930...6,116,924
JBrowse link
G Itih5 inter-alpha-trypsin inhibitor heavy chain 5 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr17:68,248,115...68,352,216
Ensembl chr17:68,252,128...68,352,207
JBrowse link
G Itih6 inter-alpha-trypsin inhibitor heavy chain family member 6 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr  X:19,753,322...19,790,381
Ensembl chr  X:19,753,625...19,789,500
JBrowse link
G Tnfaip6 TNF alpha induced protein 6 involved_in ISO (PMID:20463016), (PMID:26468290) RGD PMID:20463016 PMID:26468290 NCBI chr 3:36,502,250...36,521,652
Ensembl chr 3:36,502,188...36,521,649
JBrowse link
hyaluronan biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc5 ATP binding cassette subfamily C member 5 involved_in IEA
ISO
GO_REF:0000107
(PMID:17540771)
Ensembl
RGD
PMID:17540771 GO_REF:0000107 NCBI chr11:80,473,809...80,567,257
Ensembl chr11:80,473,872...80,567,253
JBrowse link
G Ccnd3 cyclin D3 IMP RGD PMID:19276076 RGD:2316018 NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371
JBrowse link
G Has1 hyaluronan synthase 1 involved_in
acts_upstream_of_or_within
IBA
ISO
GO_REF:0000033
(PMID:10455188), (PMID:8626618)
(PMID:10617644)
GO_Central
RGD
PMID:8626618 PMID:10455188 PMID:10617644 GO_REF:0000033 NCBI chr 1:58,693,411...58,705,653
Ensembl chr 1:58,693,411...58,705,397
JBrowse link
G Has2 hyaluronan synthase 2 involved_in IEP
ISO
IBA
IEA
PMID:19635555
(MGI:1861536|PMID:10930438), (PMID:10455188), (PMID:8798545)
GO_REF:0000033
(PMID:17324121), (PMID:20507985), (PMID:22016393), (PMID:30394292)
GO_REF:0000041
RGD
GO_Central
UniProt
PMID:8798545 PMID:10455188 PMID:10930438 PMID:17324121 PMID:20507985 More... GO_REF:0000033 GO_REF:0000041 MGI:1861536, RGD:8553259 NCBI chr 7:88,113,326...88,139,337
Ensembl chr 7:88,113,326...88,128,933
JBrowse link
G Has3 hyaluronan synthase 3 involved_in
acts_upstream_of_or_within
ISO
IBA
(PMID:16900089)
(PMID:9060470)
(PMID:10455188)
GO_REF:0000033
RGD
GO_Central
PMID:9060470 PMID:10455188 PMID:16900089 GO_REF:0000033 NCBI chr19:34,768,421...34,782,170
Ensembl chr19:34,771,982...34,782,592
JBrowse link
G Hyal1 hyaluronidase 1 involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(PMID:21829529)
UniProt
Ensembl
RGD
PMID:21829529 GO_REF:0000024 GO_REF:0000107 NCBI chr 8:108,250,668...108,254,519
Ensembl chr 8:108,250,667...108,260,210
JBrowse link
G Il1b interleukin 1 beta involved_in ISO (PMID:15100360) RGD PMID:15100360 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
hyaluronan catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd44 CD44 molecule involved_in ISO
IEA
(PMID:17170110)
GO_REF:0000107
(PMID:26528478)
RGD
Ensembl
PMID:17170110 PMID:26528478 GO_REF:0000107 NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620
JBrowse link
G Cemip cell migration inducing hyaluronidase 1 involved_in ISS
ISO
GO_REF:0000024
(MGI:5545862|PMID:24251095)
(PMID:23509262)
UniProt
RGD
PMID:23509262 PMID:24251095 GO_REF:0000024 MGI:5545862 NCBI chr 1:137,906,921...138,062,430
Ensembl chr 1:137,908,920...138,062,415
JBrowse link
G Cemip2 cell migration inducing hyaluronidase 2 involved_in ISO (MGI:6810380|PMID:34624311) RGD PMID:34624311 MGI:6810380 NCBI chr 1:219,330,295...219,407,760
Ensembl chr 1:219,337,985...219,407,760
JBrowse link
G Fgf2 fibroblast growth factor 2 involved_in ISO (PMID:19577615) RGD PMID:19577615 NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221
JBrowse link
G Gusb glucuronidase, beta involved_in ISO (PMID:20385825) RGD PMID:20385825 NCBI chr12:26,701,188...26,714,718
Ensembl chr12:26,697,951...26,726,905
JBrowse link
G Hexa hexosaminidase subunit alpha involved_in ISO MGI:2429698 (PMID:22451654) RGD PMID:22451654 NCBI chr 8:59,936,526...59,961,654
Ensembl chr 8:59,936,660...59,962,013
JBrowse link
G Hexb hexosaminidase subunit beta involved_in IEA
ISO
GO_REF:0000107
MGI:2429701 (PMID:22451654)
Ensembl
RGD
PMID:22451654 GO_REF:0000107 NCBI chr 2:28,483,997...28,504,165
Ensembl chr 2:28,484,012...28,504,223
JBrowse link
G Hmmr hyaluronan-mediated motility receptor involved_in ISO (PMID:26528478) RGD PMID:26528478 NCBI chr10:25,132,933...25,163,029
Ensembl chr10:25,132,977...25,163,060
JBrowse link
G Hyal1 hyaluronidase 1 involved_in ISO
IBA
IEA
(PMID:12084718)
MGI:2658730 (PMID:22451654), (PMID:26887442)
GO_REF:0000033
GO_REF:0000118
GO_REF:0000107
(PMID:11296287), (PMID:17170110), (PMID:20473947), (PMID:21695196), (PMID:21699545), (PMID:21829529)
RGD
GO_Central
TreeGrafter
Ensembl
PMID:11296287 PMID:12084718 PMID:17170110 PMID:20473947 PMID:21695196 More... GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr 8:108,250,668...108,254,519
Ensembl chr 8:108,250,667...108,260,210
JBrowse link
G Hyal2 hyaluronidase 2 involved_in IDA
ISO
IBA
IEA
PMID:19635555
MGI:3836764 (PMID:23172227), (PMID:26887442)
GO_REF:0000033
GO_REF:0000107
(PMID:17170110), (PMID:19443707), (PMID:20554532), (PMID:21699545)
RGD
GO_Central
Ensembl
PMID:17170110 PMID:19443707 PMID:20554532 PMID:21699545 PMID:23172227 More... GO_REF:0000033 GO_REF:0000107, RGD:8553259 NCBI chr 8:108,241,895...108,246,853
Ensembl chr 8:108,243,133...108,246,850
JBrowse link
G Hyal3 hyaluronidase 3 involved_in ISS
IBA
IEA
ISO
GO_REF:0000024
GO_REF:0000033
GO_REF:0000118
GO_REF:0000002
(MGI:4834982|PMID:20586096)
(PMID:21699545)
(PMID:12084718)
UniProt
GO_Central
TreeGrafter
InterPro
RGD
PMID:12084718 PMID:20586096 PMID:21699545 GO_REF:0000002 GO_REF:0000024 GO_REF:0000033 GO_REF:0000118 MGI:4834982 NCBI chr 8:108,254,385...108,260,020
Ensembl chr 8:108,250,667...108,260,647
JBrowse link
G Hyal4 hyaluronidase 4 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 4:53,256,179...53,274,819
Ensembl chr 4:53,256,179...53,274,819
JBrowse link
G Hyal5 hyaluronoglucosaminidase 5 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 4:53,341,105...53,412,280
Ensembl chr 4:53,343,475...53,370,785
JBrowse link
G Hyal6 hyaluronoglucosaminidase 6 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 4:53,238,118...53,250,783
Ensembl chr 4:53,237,983...53,250,783
JBrowse link
G Lyve1 lymphatic vessel endothelial hyaluronan receptor 1 involved_in ISO (PMID:11278811) RGD PMID:11278811 NCBI chr 1:164,962,872...164,976,309
Ensembl chr 1:164,962,872...164,976,309
JBrowse link
G Spam1 sperm adhesion molecule 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 4:53,302,745...53,312,913
Ensembl chr 4:53,302,745...53,312,908
JBrowse link
G Stab2 stabilin 2 involved_in IEA
ISO
GO_REF:0000107
MGI:5318244 (PMID:22371575)
Ensembl
RGD
PMID:22371575 GO_REF:0000107 NCBI chr 7:21,249,426...21,433,051
Ensembl chr 7:21,249,391...21,434,042
JBrowse link
G Tgfb1 transforming growth factor, beta 1 involved_in ISO
ISS
(PMID:17324121)
GO_REF:0000024
RGD
UniProt
PMID:17324121 GO_REF:0000024 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
negative regulation of hyaluronan biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ap2a1 adaptor related protein complex 2 subunit alpha 1 involved_in ISO (PMID:23509262), (PMID:24251095) RGD PMID:23509262 PMID:24251095 NCBI chr 1:95,384,306...95,414,170
Ensembl chr 1:95,384,309...95,414,147
JBrowse link
G Cltc clathrin heavy chain involved_in ISO
ISS
IEA
(PMID:23509262), (PMID:24251095)
GO_REF:0000024
GO_REF:0000107
RGD
UniProt
Ensembl
PMID:23509262 PMID:24251095 GO_REF:0000024 GO_REF:0000107 NCBI chr10:71,517,661...71,574,591
Ensembl chr10:71,517,663...71,573,737
JBrowse link
G Smpd3 sphingomyelin phosphodiesterase 3 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:1856877 (PMID:22383528)
Ensembl
RGD
PMID:22383528 GO_REF:0000107 NCBI chr19:34,162,337...34,245,786
Ensembl chr19:34,162,341...34,245,749
JBrowse link
G Tgfb1 transforming growth factor, beta 1 involved_in ISO
ISS
(PMID:17324121)
GO_REF:0000024
RGD
UniProt
PMID:17324121 GO_REF:0000024 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
positive regulation of hyaluronan biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Egf epidermal growth factor involved_in ISO
IEA
(PMID:17324121)
GO_REF:0000107
RGD
Ensembl
PMID:17324121 GO_REF:0000107 NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064
JBrowse link
G Has2 hyaluronan synthase 2 IDA
IMP
RGD PMID:12186949 PMID:17080198 RGD:9588629, RGD:9588632 NCBI chr 7:88,113,326...88,139,337
Ensembl chr 7:88,113,326...88,128,933
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 involved_in ISO
IEA
(PMID:17324121)
GO_REF:0000107
RGD
Ensembl
PMID:17324121 GO_REF:0000107 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Pdgfb platelet derived growth factor subunit B involved_in ISO
IEA
ISS
(PMID:17324121)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:17324121 GO_REF:0000024 GO_REF:0000107 NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984
JBrowse link
G Ptger4 prostaglandin E receptor 4 IMP RGD PMID:17080198 RGD:9588632 NCBI chr 2:54,330,563...54,347,451
Ensembl chr 2:54,335,424...54,346,670
JBrowse link
regulation of hyaluronan biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Smpd3 sphingomyelin phosphodiesterase 3 acts_upstream_of_or_within ISO MGI:1856877 (PMID:22383528) RGD PMID:22383528 NCBI chr19:34,162,337...34,245,786
Ensembl chr19:34,162,341...34,245,749
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  biological_process 20292
    metabolic process 11720
      organic substance metabolic process 11221
        macromolecule metabolic process 9473
          aminoglycan metabolic process 120
            glycosaminoglycan metabolic process 104
              mucopolysaccharide metabolic process 84
                hyaluronan metabolic process 38
                  hyaluronan biosynthetic process + 15
                  hyaluronan catabolic process 18
paths to the root