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ONTOLOGY REPORT - ANNOTATIONS


Term:hyaluronan metabolic process
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Accession:GO:0030212 term browser browse the term
Definition:The chemical reactions and pathways involving hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine.
Synonyms:exact_synonym: hyaluronan metabolism


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hyaluronan metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07028488.1 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 Ensembl chr17:72,036,588...72,046,381 JBrowse link
G Akt1 AKT serine/threonine kinase 1 IEP RGD PMID:20097747 RGD:7243103 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Has2 hyaluronan synthase 2 acts_upstream_of_or_within ISO MGI:2176070|MGI:4360705 (MGI:4880794|PMID:21246657) RGD PMID:21246657 MGI:4880794 NCBI chr 7:96,438,046...96,464,049
Ensembl chr 7:96,438,046...96,464,049
JBrowse link
G Hgf hepatocyte growth factor IEP RGD PMID:20097747 RGD:7243103 NCBI chr 4:15,435,460...15,505,377
Ensembl chr 4:15,433,295...15,505,362
JBrowse link
G Hyal1 hyaluronidase 1 involved_in ISS
ISO
GO_REF:0000024
(PMID:19478093)
UniProt
RGD
PMID:19478093 GO_REF:0000024 NCBI chr 8:116,332,834...116,337,522
Ensembl chr 8:116,332,796...116,335,435
JBrowse link
G Il15 interleukin 15 IDA RGD PMID:17667861 RGD:5013835 NCBI chr19:23,542,606...23,624,366
Ensembl chr19:23,542,889...23,554,594
JBrowse link
G Itih1 inter-alpha trypsin inhibitor, heavy chain 1 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr16:7,012,376...7,026,542
Ensembl chr16:7,012,354...7,026,540
JBrowse link
G Itih2 inter-alpha-trypsin inhibitor heavy chain 2 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr17:72,160,734...72,197,248
Ensembl chr17:72,160,735...72,195,509
JBrowse link
G Itih3 inter-alpha trypsin inhibitor, heavy chain 3 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr16:6,983,779...7,007,288
Ensembl chr16:6,992,062...7,007,287
JBrowse link
G Itih4 inter-alpha-trypsin inhibitor heavy chain 4 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr16:6,970,367...6,985,538
Ensembl chr16:6,970,342...6,985,579
JBrowse link
G Kdr kinase insert domain receptor IEP RGD PMID:20097747 RGD:7243103 NCBI chr14:34,727,677...34,787,127
Ensembl chr14:34,727,623...34,787,183
JBrowse link
G Mki67 marker of proliferation Ki-67 IEP RGD PMID:20097747 RGD:7243103 NCBI chr 1:207,993,895...208,020,454
Ensembl chr 1:207,993,895...208,020,454
JBrowse link
G Pim1 Pim-1 proto-oncogene, serine/threonine kinase IEP RGD PMID:20097747 RGD:7243103 NCBI chr20:8,165,423...8,169,557
Ensembl chr20:8,165,307...8,169,555
JBrowse link
G Vegfa vascular endothelial growth factor A IEP RGD PMID:20097747 RGD:7243103 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
hyaluronan biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccnd3 cyclin D3 IMP RGD PMID:19276076 RGD:2316018 NCBI chr 9:15,404,816...15,410,905
Ensembl chr 9:15,404,822...15,410,943
JBrowse link
G Has1 hyaluronan synthase 1 involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
(MGI:1351415|PMID:10617644)
RGD PMID:10617644, PMID:21873635 MGI:1351415, RGD:13792537 NCBI chr 1:59,720,612...59,732,409
Ensembl chr 1:59,720,612...59,732,409
JBrowse link
G Has2 hyaluronan synthase 2 involved_in IEP
ISO
IEA
IBA
PMID:19635555
(MGI:1861536|PMID:10930438)
GO_REF:0000041
PMID:21873635
(PMID:17324121), (PMID:22016393)
RGD
UniProt
PMID:10930438 PMID:17324121 PMID:22016393, PMID:19635555, PMID:21873635 GO_REF:0000041 MGI:1861536, RGD:8553259, RGD:13792537 NCBI chr 7:96,438,046...96,464,049
Ensembl chr 7:96,438,046...96,464,049
JBrowse link
G Has3 hyaluronan synthase 3 involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
(MGI:86804|PMID:9060470)
(PMID:16900089)
RGD PMID:9060470 PMID:16900089, PMID:21873635 MGI:86804, RGD:13792537 NCBI chr19:39,063,298...39,077,745
Ensembl chr19:39,063,998...39,077,722
JBrowse link
G Hyal1 hyaluronidase 1 involved_in ISS
ISO
IEA
GO_REF:0000024
(PMID:21829529)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:21829529 GO_REF:0000024 GO_REF:0000107 NCBI chr 8:116,332,834...116,337,522
Ensembl chr 8:116,332,796...116,335,435
JBrowse link
G Il1b interleukin 1 beta involved_in ISO
IEA
(PMID:15100360)
GO_REF:0000107
RGD
Ensembl
PMID:15100360 GO_REF:0000107 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
hyaluronan catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd44 CD44 molecule (Indian blood group) involved_in IEA
ISO
GO_REF:0000107
(PMID:17170110)
Ensembl
RGD
PMID:17170110 GO_REF:0000107 NCBI chr 3:92,695,083...92,783,820
Ensembl chr 3:92,696,313...92,783,658
JBrowse link
G Cemip cell migration inducing hyaluronidase involved_in ISS
ISO
GO_REF:0000024
(MGI:5545862|PMID:24251095)
(PMID:23509262)
UniProt
RGD
PMID:23509262 PMID:24251095 GO_REF:0000024 MGI:5545862 NCBI chr 1:146,069,774...146,226,320
Ensembl chr 1:146,069,771...146,226,462
JBrowse link
G Cemip2 cell migration inducing hyaluronidase 2 involved_in ISO (PMID:28246172) RGD PMID:28246172 NCBI chr 1:239,397,322...239,474,931
Ensembl chr 1:239,398,043...239,474,931
JBrowse link
G Fgf2 fibroblast growth factor 2 involved_in ISO (PMID:19577615) RGD PMID:19577615 NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681
JBrowse link
G Hyal1 hyaluronidase 1 involved_in IBA
IEA
ISO
PMID:21873635
GO_REF:0000107
(PMID:11296287), (PMID:17170110), (PMID:20473947), (PMID:21695196), (PMID:21699545), (PMID:21829529)
(PMID:12084718)
Ensembl
RGD
PMID:11296287 PMID:12084718 PMID:17170110 PMID:20473947 PMID:21695196 PMID:21699545 PMID:21829529, PMID:21873635 GO_REF:0000107, RGD:13792537 NCBI chr 8:116,332,834...116,337,522
Ensembl chr 8:116,332,796...116,335,435
JBrowse link
G Hyal2 hyaluronidase 2 involved_in IDA
IBA
IEA
ISO
PMID:19635555
PMID:21873635
GO_REF:0000107
(PMID:17170110), (PMID:19443707), (PMID:20554532), (PMID:21699545)
Ensembl
RGD
PMID:17170110 PMID:19443707 PMID:20554532 PMID:21699545, PMID:19635555, PMID:21873635 GO_REF:0000107, RGD:8553259, RGD:13792537 NCBI chr 8:116,324,062...116,328,978
Ensembl chr 8:116,324,040...116,328,978
JBrowse link
G Hyal3 hyaluronidase 3 involved_in ISS
ISO
IBA
IEA
GO_REF:0000024
(MGI:4834982|PMID:20586096)
PMID:21873635
GO_REF:0000107
(PMID:21699545)
(PMID:12084718)
UniProt
RGD
Ensembl
PMID:12084718 PMID:20586096 PMID:21699545, PMID:21873635 GO_REF:0000024 GO_REF:0000107 MGI:4834982, RGD:13792537 NCBI chr 8:116,336,512...116,342,147
Ensembl chr 8:116,336,512...116,342,146
JBrowse link
G Hyal4 hyaluronidase 4 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 4:52,147,641...52,166,276
Ensembl chr 4:52,147,641...52,167,122
JBrowse link
G Hyal5 hyaluronoglucosaminidase 5 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 4:52,232,565...52,319,777
Ensembl chr 4:52,235,811...52,275,936
JBrowse link
G Hyal6 hyaluronoglucosaminidase 6 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 4:52,129,576...52,142,241
Ensembl chr 4:52,129,556...52,142,243
JBrowse link
G Spam1 sperm adhesion molecule 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 4:52,194,201...52,204,369
Ensembl chr 4:52,199,416...52,204,425
JBrowse link
G Tgfb1 transforming growth factor, beta 1 involved_in ISO
ISS
(PMID:17324121)
GO_REF:0000024
RGD
UniProt
PMID:17324121 GO_REF:0000024 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
negative regulation of hyaluronan biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ap2a1 adaptor related protein complex 2 subunit alpha 1 involved_in ISO (PMID:23509262), (PMID:24251095) RGD PMID:23509262 PMID:24251095 NCBI chr 1:100,896,582...100,926,443
Ensembl chr 1:100,896,947...100,926,335
JBrowse link
G Cltc clathrin heavy chain involved_in ISO
ISS
(PMID:23509262), (PMID:24251095)
GO_REF:0000024
RGD
UniProt
PMID:23509262 PMID:24251095 GO_REF:0000024 NCBI chr10:74,014,560...74,070,578
Ensembl chr10:74,014,562...74,070,266
JBrowse link
G Smpd3 sphingomyelin phosphodiesterase 3 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:1856877 (MGI:5320806|PMID:22383528)
Ensembl
RGD
PMID:22383528 GO_REF:0000107 MGI:5320806 NCBI chr19:38,237,963...38,321,572
Ensembl chr19:38,237,965...38,321,528
JBrowse link
G Tgfb1 transforming growth factor, beta 1 involved_in ISO
ISS
(PMID:17324121)
GO_REF:0000024
RGD
UniProt
PMID:17324121 GO_REF:0000024 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
positive regulation of hyaluronan biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Egf epidermal growth factor involved_in ISO (PMID:17324121) RGD PMID:17324121 NCBI chr 2:68,820,616...68,895,537 JBrowse link
G Has2 hyaluronan synthase 2 IDA
IMP
RGD PMID:12186949, PMID:17080198 RGD:9588629, RGD:9588632 NCBI chr 7:96,438,046...96,464,049
Ensembl chr 7:96,438,046...96,464,049
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 involved_in ISO
IEA
(PMID:17324121)
GO_REF:0000107
RGD
Ensembl
PMID:17324121 GO_REF:0000107 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Pdgfb platelet derived growth factor subunit B involved_in ISO
ISS
IEA
(PMID:17324121)
GO_REF:0000024
GO_REF:0000107
RGD
UniProt
Ensembl
PMID:17324121 GO_REF:0000024 GO_REF:0000107 NCBI chr 7:121,215,458...121,233,092
Ensembl chr 7:121,214,628...121,232,741
JBrowse link
G Ptger4 prostaglandin E receptor 4 IMP RGD PMID:17080198 RGD:9588632 NCBI chr 2:54,951,625...54,966,470
Ensembl chr 2:54,952,821...54,963,448
JBrowse link
regulation of hyaluronan biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Smpd3 sphingomyelin phosphodiesterase 3 acts_upstream_of_or_within ISO MGI:1856877 (MGI:5320806|PMID:22383528) RGD PMID:22383528 MGI:5320806 NCBI chr19:38,237,963...38,321,572
Ensembl chr19:38,237,965...38,321,528
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19634
    metabolic process 11911
      organic substance metabolic process 11425
        macromolecule metabolic process 9877
          aminoglycan metabolic process 119
            glycosaminoglycan metabolic process 100
              mucopolysaccharide metabolic process 79
                hyaluronan metabolic process 36
                  hyaluronan biosynthetic process + 14
                  hyaluronan catabolic process 12
paths to the root