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ONTOLOGY REPORT - ANNOTATIONS


Term:chondroitin sulfate metabolic process
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Accession:GO:0030204 term browser browse the term
Definition:The chemical reactions and pathways involving chondroitin sulfate, any member of a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues, the repeat units of which consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate. They usually occur linked to a protein to form proteoglycans. Two subgroups exist, one in which the sulfate is on the 4-position (chondroitin sulfate A) and the second in which it is in the 6-position (chondroitin sulfate C). They often are polydisperse and often differ in the degree of sulfation from tissue to tissue. The chains of repeating disaccharide are covalently linked to the side chains of serine residues in the polypeptide backbone of a protein by a glycosidic attachment through the trisaccharide unit galactosyl-galactosyl-xylosyl. Chondroitin sulfate B is more usually known as dermatan sulfate.
Synonyms:exact_synonym: chondroitin sulfate metabolism;   chondroitin sulphate metabolic process;   chondroitin sulphate metabolism


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chondroitin sulfate metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bpnt2 3'(2'), 5'-bisphosphate nucleotidase 2 acts_upstream_of_or_within ISO (MGI:3799383|PMID:18539921)
(MGI:3809386|PMID:18695242)
MGI PMID:18539921 PMID:18695242 MGI:3799383 MGI:3809386 NCBI chrNW_004936496:3,498,534...3,521,939 JBrowse link
G Chst11 carbohydrate sulfotransferase 11 acts_upstream_of_or_within ISO (MGI:3767479|PMID:16079159) MGI PMID:16079159 MGI:3767479 NCBI chrNW_004936492:9,886,269...10,092,725 JBrowse link
G Csgalnact1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 acts_upstream_of_or_within ISO (MGI:4946456|PMID:21148564)
(MGI:4849906|PMID:20812917)
MGI PMID:20812917 PMID:21148564 MGI:4849906 MGI:4946456 NCBI chrNW_004936555:3,639,459...3,807,483 JBrowse link
G Ext1 exostosin glycosyltransferase 1 acts_upstream_of_or_within ISO (MGI:6478099|PMID:32201365) MGI PMID:32201365 MGI:6478099 NCBI chrNW_004936470:28,303,213...28,566,470 JBrowse link
chondroitin sulfate biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chpf chondroitin polymerizing factor involved_in
acts_upstream_of_or_within
ISO (PMID:12761225)
(MGI:5462286|PMID:22952769)
(MGI:5462280|PMID:22952873)
FlyBase
MGI
PMID:12761225 PMID:22952769 PMID:22952873 MGI:5462280 MGI:5462286 NCBI chrNW_004936569:1,918,999...1,923,735 JBrowse link
G Chst11 carbohydrate sulfotransferase 11 involved_in
acts_upstream_of_or_within
ISO (PMID:11056388)
(MGI:4941099|PMID:21138417)
(MGI:1354846|PMID:10722746)
UniProt
MGI
PMID:10722746 PMID:11056388 PMID:21138417 MGI:1354846 MGI:4941099 NCBI chrNW_004936492:9,886,269...10,092,725 JBrowse link
G Chst12 carbohydrate sulfotransferase 12 involved_in ISO (PMID:10781601) UniProt PMID:10781601 NCBI chrNW_004936823:187,920...210,818 JBrowse link
G Chst3 carbohydrate sulfotransferase 3 involved_in
acts_upstream_of_or_within
ISO (PMID:9883891)
(MGI:1206144|PMID:9597547)
(MGI:2156294|PMID:11696535)
UniProt
MGI
PMID:9597547 PMID:9883891 PMID:11696535 MGI:1206144 MGI:2156294 NCBI chrNW_004936521:6,864,456...6,900,122 JBrowse link
G Chst7 carbohydrate sulfotransferase 7 involved_in ISO (PMID:10781596) UniProt PMID:10781596 NCBI chrNW_004936502:12,426,821...12,446,127 JBrowse link
G Chsy1 chondroitin sulfate synthase 1 acts_upstream_of_or_within ISO (MGI:5462286|PMID:22952769) MGI PMID:22952769 MGI:5462286 NCBI chrNW_004936483:2,613,820...2,685,986 JBrowse link
G Csgalnact1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 involved_in ISO (PMID:11514575), (PMID:12163485) UniProt PMID:11514575 PMID:12163485 NCBI chrNW_004936555:3,639,459...3,807,483 JBrowse link
G Slc35d1 solute carrier family 35 member D1 acts_upstream_of_or_within ISO (MGI:3771453|PMID:17952091) MGI PMID:17952091 MGI:3771453 NCBI chrNW_004936591:4,519,136...4,574,925 JBrowse link
G Ugdh UDP-glucose 6-dehydrogenase involved_in ISO (MGI:2675908|PMID:14505572) UniProt PMID:14505572 MGI:2675908 NCBI chrNW_004936482:7,090,241...7,118,315 JBrowse link
G Xylt1 xylosyltransferase 1 involved_in ISO (MGI:5544658|PMID:24161523) UniProt PMID:24161523 MGI:5544658 NCBI chrNW_004936501:4,164,714...4,337,604 JBrowse link
chondroitin sulfate catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hyal4 hyaluronidase 4 acts_upstream_of_or_within ISO (MGI:5490850|PMID:23086929) MGI PMID:23086929 MGI:5490850 NCBI chrNW_004936605:1,645,204...1,666,510 JBrowse link
peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bgn biglycan acts_upstream_of_or_within ISO (MGI:3807344|PMID:18757743) MGI PMID:18757743 MGI:3807344 NCBI chrNW_004936809:375,589...389,718 JBrowse link
G Dcn decorin acts_upstream_of_or_within ISO (MGI:3807344|PMID:18757743) MGI PMID:18757743 MGI:3807344 NCBI chrNW_004936507:7,887,259...7,923,055 JBrowse link
G Egflam EGF like, fibronectin type III and laminin G domains acts_upstream_of_or_within ISO (MGI:3807344|PMID:18757743) MGI PMID:18757743 MGI:3807344 NCBI chrNW_004936518:3,706,818...3,882,308 JBrowse link
G Mamdc2 MAM domain containing 2 acts_upstream_of_or_within ISO (MGI:3807344|PMID:18757743) MGI PMID:18757743 MGI:3807344 NCBI chrNW_004936503:6,212,385...6,374,144 JBrowse link
G Ndnf neuron derived neurotrophic factor acts_upstream_of_or_within ISO (MGI:3807344|PMID:18757743) MGI PMID:18757743 MGI:3807344 NCBI chrNW_004936662:593,848...624,974 JBrowse link
G Spock2 SPARC (osteonectin), cwcv and kazal like domains proteoglycan 2 acts_upstream_of_or_within ISO (MGI:3807344|PMID:18757743) MGI PMID:18757743 MGI:3807344 NCBI chrNW_004936521:6,799,823...6,823,917 JBrowse link
G Spock3 SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3 acts_upstream_of_or_within ISO (MGI:3807344|PMID:18757743) MGI PMID:18757743 MGI:3807344 NCBI chrNW_004936851:316,979...443,444 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12063
    cellular process 11246
      cellular metabolic process 6933
        sulfur compound metabolic process 207
          chondroitin sulfate metabolic process 20
            chondroitin sulfate biosynthetic process 10
            chondroitin sulfate catabolic process 1
            peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan 7
            protein-chondroitin sulfate linkage via chondroitin sulfate D-glucuronyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine 0
Path 2
Term Annotations click to browse term
  biological_process 12063
    metabolic process 7553
      organic substance metabolic process 7281
        macromolecule metabolic process 6267
          cellular macromolecule metabolic process 5354
            glycoprotein metabolic process 253
              proteoglycan metabolic process 63
                chondroitin sulfate proteoglycan metabolic process 26
                  chondroitin sulfate metabolic process 20
                    chondroitin sulfate biosynthetic process 10
                    chondroitin sulfate catabolic process 1
                    peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan 7
                    protein-chondroitin sulfate linkage via chondroitin sulfate D-glucuronyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine 0
paths to the root