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ONTOLOGY REPORT - ANNOTATIONS


Term:chondroitin sulfate metabolic process
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Accession:GO:0030204 term browser browse the term
Definition:The chemical reactions and pathways involving chondroitin sulfate, any member of a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues, the repeat units of which consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate. They usually occur linked to a protein to form proteoglycans. Two subgroups exist, one in which the sulfate is on the 4-position (chondroitin sulfate A) and the second in which it is in the 6-position (chondroitin sulfate C). They often are polydisperse and often differ in the degree of sulfation from tissue to tissue. The chains of repeating disaccharide are covalently linked to the side chains of serine residues in the polypeptide backbone of a protein by a glycosidic attachment through the trisaccharide unit galactosyl-galactosyl-xylosyl. Chondroitin sulfate B is more usually known as dermatan sulfate.
Synonyms:exact_synonym: chondroitin sulfate metabolism;   chondroitin sulphate metabolic process;   chondroitin sulphate metabolism


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chondroitin sulfate metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BPNT2 3'(2'), 5'-bisphosphate nucleotidase 2 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3799383|PMID:18539921)
(MGI:3809386|PMID:18695242)
Ensembl
MGI
PMID:18539921 PMID:18695242 GO_REF:0000107 MGI:3799383 MGI:3809386 NCBI chr 4:75,191,256...75,210,988
Ensembl chr 4:75,191,257...75,215,907
JBrowse link
G CHST11 carbohydrate sulfotransferase 11 acts_upstream_of_or_within ISO (MGI:3767479|PMID:16079159) MGI PMID:16079159 MGI:3767479 NCBI chr 5:79,788,558...80,068,903
Ensembl chr 5:79,787,995...80,067,816
JBrowse link
G CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 acts_upstream_of_or_within ISO (MGI:4849906|PMID:20812917)
(MGI:4946456|PMID:21148564)
MGI PMID:20812917 PMID:21148564 MGI:4849906 MGI:4946456 NCBI chr17:12,145,141...12,498,777 JBrowse link
G DSE dermatan sulfate epimerase involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 1:81,996,894...82,063,847 JBrowse link
G DSEL dermatan sulfate epimerase like involved_in
acts_upstream_of_or_within
IBA
ISO
(PMID:21873635)
(MGI:5583874|PMID:22496542)
GO_Central
MGI
PMID:21873635 PMID:22496542 MGI:5583874 NCBI chr 1:154,919,331...154,937,484
Ensembl chr 1:154,919,550...154,935,564
JBrowse link
G EXT1 exostosin glycosyltransferase 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:6478099|PMID:32201365) Ensembl
MGI
PMID:32201365 GO_REF:0000107 MGI:6478099 NCBI chr 4:20,645,002...20,935,769
Ensembl chr 4:20,645,809...20,935,564
JBrowse link
chondroitin sulfate biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CHPF chondroitin polymerizing factor involved_in
acts_upstream_of_or_within
IBA
ISO
(PMID:21873635)
(MGI:5462280|PMID:22952873)
(MGI:5462286|PMID:22952769)
GO_Central
MGI
PMID:21873635 PMID:22952769 PMID:22952873 MGI:5462280 MGI:5462286 NCBI chr15:121,547,666...121,553,590
Ensembl chr15:121,544,230...121,553,288
JBrowse link
G CHPF2 chondroitin polymerizing factor 2 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 Ensembl chr18:5,986,830...5,994,907 JBrowse link
G CHST11 carbohydrate sulfotransferase 11 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:4941099|PMID:21138417)
(MGI:1354846|PMID:10722746)
Ensembl
MGI
PMID:10722746 PMID:21138417 GO_REF:0000107 MGI:1354846 MGI:4941099 NCBI chr 5:79,788,558...80,068,903
Ensembl chr 5:79,787,995...80,067,816
JBrowse link
G CHST12 carbohydrate sulfotransferase 12 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:1,721,047...1,743,080
Ensembl chr 3:1,720,500...1,745,338
JBrowse link
G CHST13 carbohydrate sulfotransferase 13 involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:73,350,670...73,366,374
Ensembl chr13:73,350,671...73,366,086
JBrowse link
G CHST3 carbohydrate sulfotransferase 3 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:2156294|PMID:11696535)
(MGI:1206144|PMID:9597547)
Ensembl
MGI
PMID:9597547 PMID:11696535 GO_REF:0000107 MGI:1206144 MGI:2156294 NCBI chr14:74,850,931...74,891,527
Ensembl chr14:74,850,931...74,891,529
JBrowse link
G CHST7 carbohydrate sulfotransferase 7 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr  X:41,192,993...41,234,654
Ensembl chr  X:41,193,018...41,232,589
JBrowse link
G CHSY1 chondroitin sulfate synthase 1 involved_in
acts_upstream_of_or_within
IBA
ISO
(PMID:21873635)
(MGI:5462286|PMID:22952769)
GO_Central
MGI
PMID:21873635 PMID:22952769 MGI:5462286 NCBI chr 1:139,730,703...139,804,458
Ensembl chr 1:139,730,721...139,804,583
JBrowse link
G CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr17:12,145,141...12,498,777 JBrowse link
G CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr14:61,372,289...61,415,563
Ensembl chr14:61,372,317...61,415,621
JBrowse link
G PSAP prosaposin involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr14:74,734,185...74,820,645
Ensembl chr14:74,734,189...74,887,763
JBrowse link
G SLC35D1 solute carrier family 35 member D1 acts_upstream_of_or_within ISO (MGI:3771453|PMID:17952091) MGI PMID:17952091 MGI:3771453 NCBI chr 6:145,532,600...145,596,069
Ensembl chr 6:145,533,537...145,596,066
JBrowse link
G UGDH UDP-glucose 6-dehydrogenase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:30,725,281...30,759,359
Ensembl chr 8:30,725,288...30,759,326
JBrowse link
G XYLT1 xylosyltransferase 1 involved_in ISO (MGI:5544658|PMID:24161523) UniProt PMID:24161523 MGI:5544658 NCBI chr 3:27,158,438...27,492,629
Ensembl chr 3:27,158,874...27,492,892
JBrowse link
chondroitin sulfate catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HYAL4 hyaluronidase 4 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:5490850|PMID:23086929) Ensembl
MGI
PMID:23086929 GO_REF:0000107 MGI:5490850 NCBI chr18:23,623,379...23,662,528
Ensembl chr18:23,624,226...23,722,045
JBrowse link
peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BGN biglycan acts_upstream_of_or_within ISO (MGI:3807344|PMID:18757743) MGI PMID:18757743 MGI:3807344 NCBI chr  X:124,282,048...124,295,450
Ensembl chr  X:124,282,224...124,295,448
JBrowse link
G DCN decorin acts_upstream_of_or_within ISO (MGI:3807344|PMID:18757743) MGI PMID:18757743 MGI:3807344 NCBI chr 5:91,678,601...91,713,925
Ensembl chr 5:91,678,608...91,714,235
JBrowse link
G EGFLAM EGF like, fibronectin type III and laminin G domains involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3807344|PMID:18757743) Ensembl
MGI
PMID:18757743 GO_REF:0000107 MGI:3807344 NCBI chr16:23,402,937...23,606,234
Ensembl chr16:23,403,357...23,606,925
JBrowse link
G LOC396700 tryptase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:40,596,408...40,598,426 JBrowse link
G MAMDC2 MAM domain containing 2 acts_upstream_of_or_within ISO (MGI:3807344|PMID:18757743) MGI PMID:18757743 MGI:3807344 NCBI chr 1:223,541,491...223,547,723
Ensembl chr 1:223,385,097...223,549,757
JBrowse link
G NDNF neuron derived neurotrophic factor involved_in
acts_upstream_of_or_within
IBA
ISO
(PMID:21873635)
(MGI:3807344|PMID:18757743)
GO_Central
MGI
PMID:18757743 PMID:21873635 MGI:3807344 NCBI chr 8:103,047,783...103,094,800
Ensembl chr 8:102,996,281...103,088,268
JBrowse link
G SPOCK2 SPARC (osteonectin), cwcv and kazal like domains proteoglycan 2 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3807344|PMID:18757743) Ensembl
MGI
PMID:18757743 GO_REF:0000107 MGI:3807344 NCBI chr14:74,938,164...74,968,126
Ensembl chr14:74,938,179...74,968,388
JBrowse link
G SPOCK3 SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3 acts_upstream_of_or_within ISO (MGI:3807344|PMID:18757743) MGI PMID:18757743 MGI:3807344 NCBI chr14:21,754,419...22,121,051
Ensembl chr14:21,754,463...22,121,051
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16538
    cellular process 15825
      cellular metabolic process 9520
        sulfur compound metabolic process 295
          chondroitin sulfate metabolic process 27
            chondroitin sulfate biosynthetic process 14
            chondroitin sulfate catabolic process 1
            peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan 8
            protein-chondroitin sulfate linkage via chondroitin sulfate D-glucuronyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine 0
Path 2
Term Annotations click to browse term
  biological_process 16538
    metabolic process 10436
      organic substance metabolic process 9988
        macromolecule metabolic process 8649
          cellular macromolecule metabolic process 7325
            glycoprotein metabolic process 354
              proteoglycan metabolic process 75
                chondroitin sulfate proteoglycan metabolic process 34
                  chondroitin sulfate metabolic process 27
                    chondroitin sulfate biosynthetic process 14
                    chondroitin sulfate catabolic process 1
                    peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan 8
                    protein-chondroitin sulfate linkage via chondroitin sulfate D-glucuronyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine 0
paths to the root