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ONTOLOGY REPORT - ANNOTATIONS


Term:chondroitin sulfate metabolic process
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Accession:GO:0030204 term browser browse the term
Definition:The chemical reactions and pathways involving chondroitin sulfate, any member of a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues, the repeat units of which consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate. They usually occur linked to a protein to form proteoglycans. Two subgroups exist, one in which the sulfate is on the 4-position (chondroitin sulfate A) and the second in which it is in the 6-position (chondroitin sulfate C). They often are polydisperse and often differ in the degree of sulfation from tissue to tissue. The chains of repeating disaccharide are covalently linked to the side chains of serine residues in the polypeptide backbone of a protein by a glycosidic attachment through the trisaccharide unit galactosyl-galactosyl-xylosyl. Chondroitin sulfate B is more usually known as dermatan sulfate.
Synonyms:exact_synonym: chondroitin sulfate metabolism;   chondroitin sulphate metabolic process;   chondroitin sulphate metabolism


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chondroitin sulfate metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bpnt2 3'(2'), 5'-bisphosphate nucleotidase 2 acts_upstream_of_or_within IMP (MGI:3809386|PMID:18695242)
(MGI:3799383|PMID:18539921)
MGI PMID:18539921 PMID:18695242 MGI:3799383 MGI:3809386 NCBI chr 4:4,762,484...4,793,306
Ensembl chr 4:4,762,484...4,793,355
JBrowse link
G Chst11 carbohydrate sulfotransferase 11 acts_upstream_of_or_within IMP (MGI:3767479|PMID:16079159) MGI PMID:16079159 MGI:3767479 NCBI chr10:82,984,440...83,195,904
Ensembl chr10:82,985,498...83,195,900
JBrowse link
G Csgalnact1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 acts_upstream_of_or_within IMP (MGI:4946456|PMID:21148564)
(MGI:4849906|PMID:20812917)
MGI PMID:20812917 PMID:21148564 MGI:4849906 MGI:4946456 NCBI chr 8:68,356,781...68,735,621
Ensembl chr 8:68,356,781...68,735,146
JBrowse link
G Dse dermatan sulfate epimerase involved_in IBA (MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:6201960 NCBI chr10:34,151,389...34,208,282
Ensembl chr10:34,151,393...34,207,715
JBrowse link
G Dsel dermatan sulfate epimerase-like acts_upstream_of_or_within
involved_in
IMP
IBA
(MGI:5583874|PMID:22496542)
(MGI:6201960|PMID:21873635)
MGI
GO_Central
PMID:21873635 PMID:22496542 MGI:5583874 MGI:6201960 NCBI chr 1:111,858,701...111,865,052
Ensembl chr 1:111,858,702...111,864,918
JBrowse link
G Ext1 exostosin glycosyltransferase 1 acts_upstream_of_or_within IMP (MGI:6478099|PMID:32201365) MGI PMID:32201365 MGI:6478099 NCBI chr15:53,068,261...53,346,183
Ensembl chr15:53,064,038...53,346,159
JBrowse link
chondroitin sulfate biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chpf chondroitin polymerizing factor involved_in
acts_upstream_of_or_within
ISO
IMP
IBA
IGI
(MGI:5462286|PMID:22952769)
(MGI:6201960|PMID:21873635)
(MGI:5462280|PMID:22952873)
MGI
GO_Central
PMID:21873635 PMID:22952769 PMID:22952873 GO_REF:0000096 MGI:4834177 MGI:5462280 MGI:5462286 MGI:6201960 NCBI chr 1:75,474,569...75,479,471
Ensembl chr 1:75,474,569...75,479,307
JBrowse link
G Chpf2 chondroitin polymerizing factor 2 involved_in IBA (MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:6201960 NCBI chr 5:24,586,744...24,594,398
Ensembl chr 5:24,586,741...24,594,556
JBrowse link
G Chst11 carbohydrate sulfotransferase 11 acts_upstream_of_or_within
involved_in
IGI
ISO
IDA
(MGI:4941099|PMID:21138417)
(MGI:1354846|PMID:10722746)
MGI PMID:10722746 PMID:21138417 GO_REF:0000096 MGI:1354846 MGI:4834177 MGI:4941099 NCBI chr10:82,984,440...83,195,904
Ensembl chr10:82,985,498...83,195,900
JBrowse link
G Chst12 carbohydrate sulfotransferase 12 involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr 5:140,505,569...140,525,238
Ensembl chr 5:140,505,550...140,525,724
JBrowse link
G Chst13 carbohydrate sulfotransferase 13 involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr 6:90,308,351...90,325,185
Ensembl chr 6:90,308,349...90,325,185
JBrowse link
G Chst3 carbohydrate sulfotransferase 3 acts_upstream_of_or_within
involved_in
IDA
IMP
IBA
ISO
(MGI:1206144|PMID:9597547)
(MGI:2156294|PMID:11696535)
(MGI:6201960|PMID:21873635)
MGI
GO_Central
PMID:9597547 PMID:11696535 PMID:21873635 GO_REF:0000096 MGI:1206144 MGI:2156294 MGI:4834177 MGI:6201960 NCBI chr10:60,181,527...60,222,114
Ensembl chr10:60,181,532...60,219,260
JBrowse link
G Chst7 carbohydrate (N-acetylglucosamino) sulfotransferase 7 involved_in ISO
IBA
(MGI:6201960|PMID:21873635) MGI
GO_Central
PMID:21873635 GO_REF:0000096 MGI:4834177 MGI:6201960 NCBI chr  X:20,058,963...20,099,991
Ensembl chr  X:20,059,560...20,097,521
JBrowse link
G Chsy1 chondroitin sulfate synthase 1 acts_upstream_of_or_within
involved_in
IGI
IBA
ISO
(MGI:5462286|PMID:22952769)
(MGI:6201960|PMID:21873635)
MGI
GO_Central
PMID:21873635 PMID:22952769 GO_REF:0000008 MGI:2154458 MGI:5462286 MGI:6201960 NCBI chr 7:66,109,492...66,173,798
Ensembl chr 7:66,109,515...66,173,798
JBrowse link
G Chsy3 chondroitin sulfate synthase 3 involved_in IBA (MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:6201960 NCBI chr18:59,175,340...59,411,336
Ensembl chr18:59,175,401...59,535,999
JBrowse link
G Csgalnact1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 involved_in ISO
IBA
(MGI:6201960|PMID:21873635) MGI
GO_Central
PMID:21873635 GO_REF:0000096 MGI:4834177 MGI:6201960 NCBI chr 8:68,356,781...68,735,621
Ensembl chr 8:68,356,781...68,735,146
JBrowse link
G Csgalnact2 chondroitin sulfate N-acetylgalactosaminyltransferase 2 involved_in IBA (MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:6201960 NCBI chr 6:118,107,452...118,139,140
Ensembl chr 6:118,107,452...118,139,140
JBrowse link
G Slc35d1 solute carrier family 35 (UDP-glucuronic acid/UDP-N-acetylgalactosamine dual transporter), member D1 acts_upstream_of_or_within IMP (MGI:3771453|PMID:17952091) MGI PMID:17952091 MGI:3771453 NCBI chr 4:103,170,649...103,222,269
Ensembl chr 4:103,170,649...103,215,164
JBrowse link
G Ugdh UDP-glucose dehydrogenase involved_in IMP (MGI:2675908|PMID:14505572) UniProt PMID:14505572 MGI:2675908 NCBI chr 5:65,413,207...65,435,842
Ensembl chr 5:65,413,221...65,435,949
JBrowse link
G Xylt1 xylosyltransferase 1 involved_in IMP (MGI:5544658|PMID:24161523) UniProt PMID:24161523 MGI:5544658 NCBI chr 7:117,380,979...117,667,630
Ensembl chr 7:117,380,979...117,673,580
JBrowse link
chondroitin sulfate catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hyal4 hyaluronoglucosaminidase 4 acts_upstream_of_or_within IDA (MGI:5490850|PMID:23086929) MGI PMID:23086929 MGI:5490850 NCBI chr 6:24,748,367...24,766,519
Ensembl chr 6:24,748,329...24,767,662
JBrowse link
peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bgn biglycan acts_upstream_of_or_within IDA (MGI:3807344|PMID:18757743) MGI PMID:18757743 MGI:3807344 NCBI chr  X:73,483,601...73,495,936
Ensembl chr  X:73,483,602...73,495,933
JBrowse link
G Dcn decorin acts_upstream_of_or_within IDA (MGI:3807344|PMID:18757743) MGI PMID:18757743 MGI:3807344 NCBI chr10:97,479,500...97,518,163
Ensembl chr10:97,479,609...97,518,143
JBrowse link
G Egflam EGF-like, fibronectin type III and laminin G domains acts_upstream_of_or_within IDA (MGI:3807344|PMID:18757743) MGI PMID:18757743 MGI:3807344 NCBI chr15:7,206,120...7,398,744
Ensembl chr15:7,206,120...7,398,395
JBrowse link
G Mamdc2 MAM domain containing 2 acts_upstream_of_or_within IDA (MGI:3807344|PMID:18757743) MGI PMID:18757743 MGI:3807344 NCBI chr19:23,302,609...23,448,497
Ensembl chr19:23,302,609...23,448,442
JBrowse link
G Ndnf neuron-derived neurotrophic factor acts_upstream_of_or_within
involved_in
IDA
IBA
(MGI:3807344|PMID:18757743)
(MGI:6201960|PMID:21873635)
MGI
GO_Central
PMID:18757743 PMID:21873635 MGI:3807344 MGI:6201960 NCBI chr 6:65,671,611...65,712,323
Ensembl chr 6:65,671,590...65,712,326
JBrowse link
G Prss34 protease, serine 34 acts_upstream_of_or_within IDA (MGI:3807344|PMID:18757743) MGI PMID:18757743 MGI:3807344 NCBI chr17:25,298,394...25,300,168
Ensembl chr17:25,298,394...25,300,165
JBrowse link
G Spock2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan 2 acts_upstream_of_or_within IDA (MGI:3807344|PMID:18757743) MGI PMID:18757743 MGI:3807344 NCBI chr10:60,106,257...60,135,198
Ensembl chr10:60,106,219...60,135,198
JBrowse link
G Spock3 sparc/osteonectin, cwcv and kazal-like domains proteoglycan 3 acts_upstream_of_or_within IDA (MGI:3807344|PMID:18757743) MGI PMID:18757743 MGI:3807344 NCBI chr 8:62,951,000...63,357,101
Ensembl chr 8:62,951,009...63,357,103
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 23325
    cellular process 17460
      cellular metabolic process 10014
        sulfur compound metabolic process 311
          chondroitin sulfate metabolic process 27
            chondroitin sulfate biosynthetic process 14
            chondroitin sulfate catabolic process 1
            peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan 8
            protein-chondroitin sulfate linkage via chondroitin sulfate D-glucuronyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine 0
Path 2
Term Annotations click to browse term
  biological_process 23325
    metabolic process 11138
      organic substance metabolic process 10698
        macromolecule metabolic process 9198
          cellular macromolecule metabolic process 7617
            glycoprotein metabolic process 346
              proteoglycan metabolic process 76
                chondroitin sulfate proteoglycan metabolic process 34
                  chondroitin sulfate metabolic process 27
                    chondroitin sulfate biosynthetic process 14
                    chondroitin sulfate catabolic process 1
                    peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan 8
                    protein-chondroitin sulfate linkage via chondroitin sulfate D-glucuronyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine 0
paths to the root