Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

ONTOLOGY REPORT - ANNOTATIONS


Term:chondroitin sulfate metabolic process
go back to main search page
Accession:GO:0030204 term browser browse the term
Definition:The chemical reactions and pathways involving chondroitin sulfate, any member of a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues, the repeat units of which consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate. They usually occur linked to a protein to form proteoglycans. Two subgroups exist, one in which the sulfate is on the 4-position (chondroitin sulfate A) and the second in which it is in the 6-position (chondroitin sulfate C). They often are polydisperse and often differ in the degree of sulfation from tissue to tissue. The chains of repeating disaccharide are covalently linked to the side chains of serine residues in the polypeptide backbone of a protein by a glycosidic attachment through the trisaccharide unit galactosyl-galactosyl-xylosyl. Chondroitin sulfate B is more usually known as dermatan sulfate.
Synonyms:exact_synonym: chondroitin sulfate metabolism;   chondroitin sulphate metabolic process;   chondroitin sulphate metabolism


show annotations for term's descendants           Sort by:
 
chondroitin sulfate metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BPNT2 3'(2'), 5'-bisphosphate nucleotidase 2 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3799383|PMID:18539921)
(MGI:3809386|PMID:18695242)
Ensembl
MGI
PMID:18539921 PMID:18695242 GO_REF:0000107 MGI:3799383 MGI:3809386 NCBI chr 8:56,957,931...56,993,874
Ensembl chr 8:56,957,931...56,993,867
JBrowse link
G CHST11 carbohydrate sulfotransferase 11 acts_upstream_of_or_within ISO (MGI:3767479|PMID:16079159) MGI PMID:16079159 MGI:3767479 NCBI chr12:104,456,948...104,762,014
Ensembl chr12:104,455,295...104,762,014
JBrowse link
G CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 acts_upstream_of_or_within ISO (MGI:4849906|PMID:20812917)
(MGI:4946456|PMID:21148564)
MGI PMID:20812917 PMID:21148564 MGI:4849906 MGI:4946456 NCBI chr 8:19,404,161...19,757,908
Ensembl chr 8:19,404,161...19,758,029
JBrowse link
G DSE dermatan sulfate epimerase involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 6:116,254,171...116,444,861
Ensembl chr 6:116,254,173...116,444,861
Ensembl chr 6:116,254,173...116,444,861
JBrowse link
G DSEL dermatan sulfate epimerase like involved_in
acts_upstream_of_or_within
IBA
ISO
(PMID:21873635)
(MGI:5583874|PMID:22496542)
GO_Central
MGI
PMID:21873635 PMID:22496542 MGI:5583874 NCBI chr18:67,506,587...67,516,720
Ensembl chr18:67,506,587...67,516,720
JBrowse link
G EXT1 exostosin glycosyltransferase 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:6478099|PMID:32201365) Ensembl
MGI
PMID:32201365 GO_REF:0000107 MGI:6478099 NCBI chr 8:117,794,490...118,111,826
Ensembl chr 8:117,794,490...118,111,853
Ensembl chr 8:117,794,490...118,111,853
JBrowse link
G Z84488.1 novel protein involved_in IBA (PMID:21873635) GO_Central PMID:21873635 Ensembl chr 6:116,399,395...116,463,696 JBrowse link
chondroitin sulfate biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G B3GALT6 beta-1,3-galactosyltransferase 6 involved_in IEA UniProt GO_REF:0000041 NCBI chr 1:1,232,237...1,235,041
Ensembl chr 1:1,232,237...1,235,041
JBrowse link
G BCAN brevican involved_in TAS Reactome Reactome:R-HSA-2022870 NCBI chr 1:156,642,117...156,659,528
Ensembl chr 1:156,641,390...156,659,532
JBrowse link
G BGN biglycan involved_in TAS Reactome Reactome:R-HSA-2022870 NCBI chr  X:153,494,980...153,509,546
Ensembl chr  X:153,494,980...153,509,546
JBrowse link
G CHPF chondroitin polymerizing factor involved_in
acts_upstream_of_or_within
IBA
ISO
IDA
TAS
(PMID:21873635)
(MGI:5462280|PMID:22952873)
(MGI:5462286|PMID:22952769)
(PMID:12761225)
GO_Central
MGI
FlyBase
Reactome
PMID:12761225 PMID:21873635 PMID:22952769 PMID:22952873 MGI:5462280 MGI:5462286 Reactome:R-HSA-2022870 NCBI chr 2:219,538,949...219,543,809
Ensembl chr 2:219,538,948...219,543,809
JBrowse link
G CHPF2 chondroitin polymerizing factor 2 involved_in IBA
TAS
(PMID:21873635) GO_Central
Reactome
PMID:21873635 Reactome:R-HSA-2022870 NCBI chr 7:151,232,483...151,238,822
Ensembl chr 7:151,232,489...151,238,827
JBrowse link
G CHST11 carbohydrate sulfotransferase 11 involved_in
acts_upstream_of_or_within
IDA
ISO
TAS
(PMID:11056388)
(MGI:4941099|PMID:21138417)
(MGI:1354846|PMID:10722746)
UniProt
MGI
Reactome
PMID:10722746 PMID:11056388 PMID:21138417 MGI:1354846 MGI:4941099 Reactome:R-HSA-2022870 NCBI chr12:104,456,948...104,762,014
Ensembl chr12:104,455,295...104,762,014
JBrowse link
G CHST12 carbohydrate sulfotransferase 12 involved_in IDA
TAS
(PMID:10781601) UniProt
Reactome
PMID:10781601 Reactome:R-HSA-2022870 NCBI chr 7:2,403,489...2,448,484
Ensembl chr 7:2,403,588...2,448,484
JBrowse link
G CHST13 carbohydrate sulfotransferase 13 involved_in TAS
IDA
(PMID:12080076) Reactome
UniProt
PMID:12080076 Reactome:R-HSA-2022870 NCBI chr 3:126,524,155...126,543,291
Ensembl chr 3:126,524,155...126,543,291
JBrowse link
G CHST15 carbohydrate sulfotransferase 15 involved_in TAS Reactome Reactome:R-HSA-2022870 NCBI chr10:124,006,059...124,093,684
Ensembl chr10:124,007,668...124,093,598
JBrowse link
G CHST3 carbohydrate sulfotransferase 3 involved_in
acts_upstream_of_or_within
IDA
ISO
IBA
TAS
(PMID:9883891)
(MGI:1206144|PMID:9597547)
(MGI:2156294|PMID:11696535)
(PMID:21873635)
UniProt
MGI
GO_Central
Reactome
PMID:9597547 PMID:9883891 PMID:11696535 PMID:21873635 MGI:1206144 MGI:2156294 Reactome:R-HSA-2022870 NCBI chr10:71,964,395...72,013,562
Ensembl chr10:71,964,395...72,013,558
JBrowse link
G CHST7 carbohydrate sulfotransferase 7 involved_in IDA
IBA
TAS
(PMID:10781596)
(PMID:21873635)
UniProt
GO_Central
Reactome
PMID:10781596 PMID:21873635 Reactome:R-HSA-2022870 NCBI chr  X:46,573,765...46,598,496
Ensembl chr  X:46,573,765...46,598,496
JBrowse link
G CHST9 carbohydrate sulfotransferase 9 involved_in TAS Reactome Reactome:R-HSA-2022870 NCBI chr18:26,906,481...27,185,364
Ensembl chr18:26,906,481...27,185,308
JBrowse link
G CHSY1 chondroitin sulfate synthase 1 involved_in
acts_upstream_of_or_within
IBA
ISO
TAS
(PMID:21873635)
(MGI:5462286|PMID:22952769)
GO_Central
MGI
Reactome
PMID:21873635 PMID:22952769 MGI:5462286 Reactome:R-HSA-2022870 NCBI chr15:101,175,727...101,252,048
Ensembl chr15:101,175,727...101,252,048
JBrowse link
G CHSY3 chondroitin sulfate synthase 3 involved_in TAS
IBA
(PMID:21873635) Reactome
GO_Central
PMID:21873635 Reactome:R-HSA-2022870 NCBI chr 5:129,903,384...130,186,637
Ensembl chr 5:129,904,465...130,186,634
JBrowse link
G CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 involved_in IBA
TAS
IDA
(PMID:21873635)
(PMID:11514575), (PMID:12163485)
GO_Central
Reactome
UniProt
PMID:11514575 PMID:12163485 PMID:21873635 Reactome:R-HSA-2022870 NCBI chr 8:19,404,161...19,757,908
Ensembl chr 8:19,404,161...19,758,029
JBrowse link
G CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2 involved_in TAS
IBA
(PMID:21873635) Reactome
GO_Central
PMID:21873635 Reactome:R-HSA-2022870 NCBI chr10:43,138,445...43,185,308
Ensembl chr10:43,138,445...43,185,302
JBrowse link
G CSPG4 chondroitin sulfate proteoglycan 4 involved_in TAS Reactome Reactome:R-HSA-2022870 NCBI chr15:75,674,322...75,712,848
Ensembl chr15:75,674,322...75,712,848
JBrowse link
G CSPG5 chondroitin sulfate proteoglycan 5 involved_in TAS Reactome Reactome:R-HSA-2022870 NCBI chr 3:47,562,238...47,580,240
Ensembl chr 3:47,562,238...47,580,792
JBrowse link
G DCN decorin involved_in TAS Reactome Reactome:R-HSA-2022870 NCBI chr12:91,140,484...91,182,817
Ensembl chr12:91,140,484...91,183,217
Ensembl chr12:91,140,484...91,183,217
JBrowse link
G DSE dermatan sulfate epimerase involved_in IEA UniProt GO_REF:0000041 NCBI chr 6:116,254,171...116,444,861
Ensembl chr 6:116,254,173...116,444,861
Ensembl chr 6:116,254,173...116,444,861
JBrowse link
G NCAN neurocan involved_in TAS Reactome Reactome:R-HSA-2022870 NCBI chr19:19,211,958...19,252,233
Ensembl chr19:19,211,958...19,252,233
JBrowse link
G SLC35D1 solute carrier family 35 member D1 acts_upstream_of_or_within ISO (MGI:3771453|PMID:17952091) MGI PMID:17952091 MGI:3771453 NCBI chr 1:66,999,350...67,054,423
Ensembl chr 1:66,999,350...67,054,148
JBrowse link
G UGDH UDP-glucose 6-dehydrogenase involved_in ISS UniProt GO_REF:0000024 NCBI chr 4:39,498,755...39,527,439
Ensembl chr 4:39,498,755...39,528,311
JBrowse link
G VCAN versican involved_in TAS Reactome Reactome:R-HSA-2022870 NCBI chr 5:83,471,744...83,582,302
Ensembl chr 5:83,471,618...83,582,303
JBrowse link
G XYLT1 xylosyltransferase 1 involved_in IEA UniProt GO_REF:0000041 NCBI chr16:17,101,769...17,470,960
Ensembl chr16:17,101,769...17,470,960
JBrowse link
G XYLT2 xylosyltransferase 2 involved_in IEA UniProt GO_REF:0000041 NCBI chr17:50,346,126...50,361,185
Ensembl chr17:50,346,126...50,363,138
JBrowse link
chondroitin sulfate catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ARSB arylsulfatase B involved_in TAS Reactome Reactome:R-HSA-2024101 NCBI chr 5:78,777,209...78,986,087
Ensembl chr 5:78,777,209...78,986,087
JBrowse link
G BCAN brevican involved_in TAS Reactome Reactome:R-HSA-2024101 NCBI chr 1:156,642,117...156,659,528
Ensembl chr 1:156,641,390...156,659,532
JBrowse link
G BGN biglycan involved_in TAS Reactome Reactome:R-HSA-2024101 NCBI chr  X:153,494,980...153,509,546
Ensembl chr  X:153,494,980...153,509,546
JBrowse link
G CSPG4 chondroitin sulfate proteoglycan 4 involved_in TAS Reactome Reactome:R-HSA-2024101 NCBI chr15:75,674,322...75,712,848
Ensembl chr15:75,674,322...75,712,848
JBrowse link
G CSPG5 chondroitin sulfate proteoglycan 5 involved_in TAS Reactome Reactome:R-HSA-2024101 NCBI chr 3:47,562,238...47,580,240
Ensembl chr 3:47,562,238...47,580,792
JBrowse link
G DCN decorin involved_in TAS Reactome Reactome:R-HSA-2024101 NCBI chr12:91,140,484...91,182,817
Ensembl chr12:91,140,484...91,183,217
Ensembl chr12:91,140,484...91,183,217
JBrowse link
G HEXA hexosaminidase subunit alpha involved_in TAS Reactome Reactome:R-HSA-2024101 NCBI chr15:72,340,924...72,376,014
Ensembl chr15:72,340,919...72,376,476
Ensembl chr15:72,340,919...72,376,476
JBrowse link
G HEXB hexosaminidase subunit beta involved_in TAS Reactome Reactome:R-HSA-2024101 NCBI chr 5:74,640,023...74,721,288
Ensembl chr 5:74,640,023...74,722,647
JBrowse link
G HYAL1 hyaluronidase 1 involved_in TAS Reactome Reactome:R-HSA-2024101 NCBI chr 3:50,299,889...50,312,951
Ensembl chr 3:50,299,890...50,312,381
JBrowse link
G HYAL4 hyaluronidase 4 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:5490850|PMID:23086929) Ensembl
MGI
PMID:23086929 GO_REF:0000107 MGI:5490850 NCBI chr 7:123,763,708...123,877,481
Ensembl chr 7:123,828,983...123,877,481
JBrowse link
G IDS iduronate 2-sulfatase involved_in TAS Reactome Reactome:R-HSA-2024101 NCBI chr  X:149,476,988...149,505,306
Ensembl chr  X:149,477,104...149,540,926
Ensembl chr  X:149,477,104...149,540,926
JBrowse link
G IDUA alpha-L-iduronidase involved_in TAS Reactome Reactome:R-HSA-2024101 NCBI chr 4:986,997...1,004,564
Ensembl chr 4:986,997...1,004,564
JBrowse link
G NCAN neurocan involved_in TAS Reactome Reactome:R-HSA-2024101 NCBI chr19:19,211,958...19,252,233
Ensembl chr19:19,211,958...19,252,233
JBrowse link
G VCAN versican involved_in TAS Reactome Reactome:R-HSA-2024101 NCBI chr 5:83,471,744...83,582,302
Ensembl chr 5:83,471,618...83,582,303
JBrowse link
peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BGN biglycan involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3807344|PMID:18757743) Ensembl
MGI
PMID:18757743 GO_REF:0000107 MGI:3807344 NCBI chr  X:153,494,980...153,509,546
Ensembl chr  X:153,494,980...153,509,546
JBrowse link
G DCN decorin involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3807344|PMID:18757743) Ensembl
MGI
PMID:18757743 GO_REF:0000107 MGI:3807344 NCBI chr12:91,140,484...91,182,817
Ensembl chr12:91,140,484...91,183,217
Ensembl chr12:91,140,484...91,183,217
JBrowse link
G EGFLAM EGF like, fibronectin type III and laminin G domains involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3807344|PMID:18757743) Ensembl
MGI
PMID:18757743 GO_REF:0000107 MGI:3807344 NCBI chr 5:38,258,559...38,465,480
Ensembl chr 5:38,258,409...38,465,480
JBrowse link
G MAMDC2 MAM domain containing 2 acts_upstream_of_or_within ISO (MGI:3807344|PMID:18757743) MGI PMID:18757743 MGI:3807344 NCBI chr 9:70,043,581...70,226,972
Ensembl chr 9:70,043,848...70,226,972
JBrowse link
G NDNF neuron derived neurotrophic factor involved_in
acts_upstream_of_or_within
IBA
ISO
ISS
(PMID:21873635)
(MGI:3807344|PMID:18757743)
GO_Central
MGI
UniProt
PMID:18757743 PMID:21873635 GO_REF:0000024 MGI:3807344 NCBI chr 4:121,029,293...121,072,535
Ensembl chr 4:121,035,613...121,073,021
JBrowse link
G SPOCK2 SPARC (osteonectin), cwcv and kazal like domains proteoglycan 2 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3807344|PMID:18757743) Ensembl
MGI
PMID:18757743 GO_REF:0000107 MGI:3807344 NCBI chr10:72,059,034...72,095,313
Ensembl chr10:72,059,034...72,089,032
JBrowse link
G SPOCK3 SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3807344|PMID:18757743) Ensembl
MGI
PMID:18757743 GO_REF:0000107 MGI:3807344 NCBI chr 4:166,733,384...167,234,869
Ensembl chr 4:166,733,384...167,234,796
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18670
    cellular process 17720
      cellular metabolic process 11203
        sulfur compound metabolic process 411
          chondroitin sulfate metabolic process 42
            chondroitin sulfate biosynthetic process 26
            chondroitin sulfate catabolic process 14
            peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan 7
            protein-chondroitin sulfate linkage via chondroitin sulfate D-glucuronyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine 0
Path 2
Term Annotations click to browse term
  biological_process 18670
    metabolic process 12177
      organic substance metabolic process 11697
        macromolecule metabolic process 10120
          cellular macromolecule metabolic process 8644
            glycoprotein metabolic process 432
              proteoglycan metabolic process 94
                chondroitin sulfate proteoglycan metabolic process 48
                  chondroitin sulfate metabolic process 42
                    chondroitin sulfate biosynthetic process 26
                    chondroitin sulfate catabolic process 14
                    peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan 7
                    protein-chondroitin sulfate linkage via chondroitin sulfate D-glucuronyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine 0
paths to the root