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ONTOLOGY REPORT - ANNOTATIONS

Term:chondroitin sulfate metabolic process
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Accession:GO:0030204 term browser browse the term
Definition:The chemical reactions and pathways involving chondroitin sulfate, any member of a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues, the repeat units of which consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate. They usually occur linked to a protein to form proteoglycans. Two subgroups exist, one in which the sulfate is on the 4-position (chondroitin sulfate A) and the second in which it is in the 6-position (chondroitin sulfate C). They often are polydisperse and often differ in the degree of sulfation from tissue to tissue. The chains of repeating disaccharide are covalently linked to the side chains of serine residues in the polypeptide backbone of a protein by a glycosidic attachment through the trisaccharide unit galactosyl-galactosyl-xylosyl. Chondroitin sulfate B is more usually known as dermatan sulfate.
Synonyms:exact_synonym: chondroitin sulfate metabolism;   chondroitin sulphate metabolic process;   chondroitin sulphate metabolism

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chondroitin sulfate metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BPNT2 3'(2'), 5'-bisphosphate nucleotidase 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (MGI:3809386|PMID:18695242)
(MGI:3799383|PMID:18539921)		 Ensembl
MGI		 PMID:18539921 PMID:18695242 GO_REF:0000107 MGI:3799383 MGI:3809386 NCBI chr29:8,176,977...8,215,561
Ensembl chr29:8,182,508...8,215,868 		JBrowse link
G CHST11 carbohydrate sulfotransferase 11 acts_upstream_of_or_within ISO (MGI:3767479|PMID:16079159) MGI PMID:16079159 MGI:3767479 NCBI chr10:33,555,629...33,810,808
Ensembl chr10:33,555,628...33,810,558 		JBrowse link
G CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 acts_upstream_of_or_within ISO (MGI:4946456|PMID:21148564)
(MGI:4849906|PMID:20812917)		 MGI PMID:20812917 PMID:21148564 MGI:4849906 MGI:4946456 NCBI chr16:22,219,324...22,546,501
Ensembl chr16:22,219,861...22,392,937 		JBrowse link
G DSE dermatan sulfate epimerase involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 1:56,787,809...56,868,037
Ensembl chr 1:56,787,256...56,867,716 		JBrowse link
G DSEL dermatan sulfate epimerase like acts_upstream_of_or_within ISO (MGI:5583874|PMID:22496542) MGI PMID:22496542 MGI:5583874 NCBI chr 1:10,344,468...10,366,936 JBrowse link
G EXT1 exostosin glycosyltransferase 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (MGI:6478099|PMID:32201365) Ensembl
MGI		 PMID:32201365 GO_REF:0000107 MGI:6478099 NCBI chr13:17,172,497...17,457,084
Ensembl chr13:17,172,705...17,456,469 		JBrowse link
chondroitin sulfate biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CHPF chondroitin polymerizing factor involved_in
acts_upstream_of_or_within		 IEA
ISO		 (MGI:5462286|PMID:22952769)
(MGI:5462280|PMID:22952873)		 Ensembl
MGI		 PMID:22952769 PMID:22952873 GO_REF:0000107 MGI:5462280 MGI:5462286 NCBI chr37:26,048,236...26,052,871
Ensembl chr37:26,025,993...26,052,806 		JBrowse link
G CHPF2 chondroitin polymerizing factor 2 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 Ensembl chr16:15,271,805...15,280,024 JBrowse link
G CHST11 carbohydrate sulfotransferase 11 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (MGI:1354846|PMID:10722746)
(MGI:4941099|PMID:21138417)		 Ensembl
MGI		 PMID:10722746 PMID:21138417 GO_REF:0000107 MGI:1354846 MGI:4941099 NCBI chr10:33,555,629...33,810,808
Ensembl chr10:33,555,628...33,810,558 		JBrowse link
G CHST12 carbohydrate sulfotransferase 12 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:14,702,493...14,713,440
Ensembl chr 6:14,705,427...14,706,686 		JBrowse link
G CHST13 carbohydrate sulfotransferase 13 involved_in ISO (PMID:12080076) UniProt PMID:12080076 NCBI chr20:723,380...746,935 JBrowse link
G CHST3 carbohydrate sulfotransferase 3 involved_in
acts_upstream_of_or_within		 IBA
ISO		 (PMID:21873635)
(MGI:2156294|PMID:11696535)
(MGI:1206144|PMID:9597547)		 GO_Central
MGI		 PMID:9597547 PMID:11696535 PMID:21873635 MGI:1206144 MGI:2156294 NCBI chr 4:22,668,430...22,699,157
Ensembl chr 4:22,691,336...22,694,254 		JBrowse link
G CHST7 carbohydrate sulfotransferase 7 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr  X:40,209,884...40,239,077
Ensembl chr  X:40,210,096...40,211,556 		JBrowse link
G CHSY1 chondroitin sulfate synthase 1 involved_in
acts_upstream_of_or_within		 IBA
ISO		 (PMID:21873635)
(MGI:5462286|PMID:22952769)		 GO_Central
MGI		 PMID:21873635 PMID:22952769 MGI:5462286 NCBI chr 3:39,844,227...39,916,484
Ensembl chr 3:39,844,195...40,021,573 		JBrowse link
G CHSY3 chondroitin sulfate synthase 3 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr11:18,621,196...18,855,018
Ensembl chr11:18,620,781...18,854,177 		JBrowse link
G CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr16:22,219,324...22,546,501
Ensembl chr16:22,219,861...22,392,937 		JBrowse link
G CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr28:3,878,049...3,944,654
Ensembl chr28:3,879,258...3,907,222 		JBrowse link
G SLC35D1 solute carrier family 35 member D1 acts_upstream_of_or_within ISO (MGI:3771453|PMID:17952091) MGI PMID:17952091 MGI:3771453 NCBI chr 5:43,474,641...43,522,237
Ensembl chr 5:43,474,674...43,522,042 		JBrowse link
G SMIM14 small integral membrane protein 14 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:72,839,897...72,934,335
Ensembl chr 3:72,839,920...72,963,208 		JBrowse link
G UGDH UDP-glucose 6-dehydrogenase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:72,935,532...72,964,151
Ensembl chr 3:72,839,920...72,963,208 		JBrowse link
G XYLT1 xylosyltransferase 1 involved_in IEA UniProt GO_REF:0000041 NCBI chr 6:26,742,853...27,041,666
Ensembl chr 6:26,742,853...27,041,666 		JBrowse link
G XYLT2 xylosyltransferase 2 involved_in IEA UniProt GO_REF:0000041 NCBI chr 9:26,316,812...26,329,333
Ensembl chr 9:26,316,774...26,329,511 		JBrowse link
chondroitin sulfate catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HYAL4 hyaluronidase 4 acts_upstream_of_or_within ISO (MGI:5490850|PMID:23086929) MGI PMID:23086929 MGI:5490850 NCBI chr14:11,736,208...11,743,848 JBrowse link
peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BGN biglycan involved_in
acts_upstream_of_or_within		 IEA
ISO		 (MGI:3807344|PMID:18757743) Ensembl
MGI		 PMID:18757743 GO_REF:0000107 MGI:3807344 NCBI chr  X:121,330,371...121,334,634
Ensembl chr  X:121,330,259...121,334,634 		JBrowse link
G DCN decorin involved_in
acts_upstream_of_or_within		 IEA
ISO		 (MGI:3807344|PMID:18757743) Ensembl
MGI		 PMID:18757743 GO_REF:0000107 MGI:3807344 NCBI chr15:31,833,492...31,887,699
Ensembl chr15:31,833,746...31,877,417 		JBrowse link
G EGFLAM EGF like, fibronectin type III and laminin G domains involved_in
acts_upstream_of_or_within		 IEA
ISO		 (MGI:3807344|PMID:18757743) Ensembl
MGI		 PMID:18757743 GO_REF:0000107 MGI:3807344 NCBI chr 4:70,391,657...70,574,629
Ensembl chr 4:70,392,330...70,575,225 		JBrowse link
G MAMDC2 MAM domain containing 2 acts_upstream_of_or_within ISO (MGI:3807344|PMID:18757743) MGI PMID:18757743 MGI:3807344 NCBI chr 1:87,303,230...87,451,197
Ensembl chr 1:87,304,216...87,451,037 		JBrowse link
G NDNF neuron derived neurotrophic factor involved_in
acts_upstream_of_or_within		 IBA
ISO		 (PMID:21873635)
(MGI:3807344|PMID:18757743)		 GO_Central
MGI		 PMID:18757743 PMID:21873635 MGI:3807344 NCBI chr19:19,009,966...19,053,047
Ensembl chr19:19,036,372...19,049,937 		JBrowse link
G SPOCK2 SPARC (osteonectin), cwcv and kazal like domains proteoglycan 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (MGI:3807344|PMID:18757743) Ensembl
MGI		 PMID:18757743 GO_REF:0000107 MGI:3807344 NCBI chr 4:22,744,922...22,771,542
Ensembl chr 4:22,748,458...22,771,239 		JBrowse link
G SPOCK3 SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (MGI:3807344|PMID:18757743) Ensembl
MGI		 PMID:18757743 GO_REF:0000107 MGI:3807344 NCBI chr15:62,395,713...62,661,308
Ensembl chr15:62,395,707...62,661,312 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16205
    cellular process 15514
      cellular metabolic process 9550
        sulfur compound metabolic process 294
          chondroitin sulfate metabolic process 28
            chondroitin sulfate biosynthetic process 16
            chondroitin sulfate catabolic process 1
            peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan 7
            protein-chondroitin sulfate linkage via chondroitin sulfate D-glucuronyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine 0
Path 2
Term Annotations click to browse term
  biological_process 16205
    metabolic process 10484
      organic substance metabolic process 10071
        macromolecule metabolic process 8722
          cellular macromolecule metabolic process 7348
            glycoprotein metabolic process 365
              proteoglycan metabolic process 76
                chondroitin sulfate proteoglycan metabolic process 34
                  chondroitin sulfate metabolic process 28
                    chondroitin sulfate biosynthetic process 16
                    chondroitin sulfate catabolic process 1
                    peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan 7
                    protein-chondroitin sulfate linkage via chondroitin sulfate D-glucuronyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine 0
paths to the root