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ONTOLOGY REPORT - ANNOTATIONS

Term:chondroitin sulfate metabolic process
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Accession:GO:0030204 term browser browse the term
Definition:The chemical reactions and pathways involving chondroitin sulfate, any member of a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues, the repeat units of which consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate. They usually occur linked to a protein to form proteoglycans. Two subgroups exist, one in which the sulfate is on the 4-position (chondroitin sulfate A) and the second in which it is in the 6-position (chondroitin sulfate C). They often are polydisperse and often differ in the degree of sulfation from tissue to tissue. The chains of repeating disaccharide are covalently linked to the side chains of serine residues in the polypeptide backbone of a protein by a glycosidic attachment through the trisaccharide unit galactosyl-galactosyl-xylosyl. Chondroitin sulfate B is more usually known as dermatan sulfate.
Synonyms:exact_synonym: chondroitin sulfate metabolism;   chondroitin sulphate metabolic process;   chondroitin sulphate metabolism

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chondroitin sulfate metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bpnt2 3'(2'), 5'-bisphosphate nucleotidase 2 acts_upstream_of_or_within ISO (MGI:3799383|PMID:18539921)
(MGI:3809386|PMID:18695242)		 MGI PMID:18539921 PMID:18695242 MGI:3799383 MGI:3809386 NCBI chrNW_004955454:15,899,820...15,918,222 JBrowse link
G Chst11 carbohydrate sulfotransferase 11 acts_upstream_of_or_within ISO (MGI:3767479|PMID:16079159) MGI PMID:16079159 MGI:3767479 NCBI chrNW_004955405:38,985,046...39,134,130
Ensembl chrNW_004955405:38,985,046...39,139,021 		JBrowse link
G Csgalnact1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 acts_upstream_of_or_within ISO (MGI:4946456|PMID:21148564)
(MGI:4849906|PMID:20812917)		 MGI PMID:20812917 PMID:21148564 MGI:4849906 MGI:4946456 NCBI chrNW_004955403:43,178,520...43,347,121
Ensembl chrNW_004955403:43,178,520...43,478,885 		JBrowse link
G Dsel dermatan sulfate epimerase like acts_upstream_of_or_within ISO (MGI:5583874|PMID:22496542) MGI PMID:22496542 MGI:5583874 NCBI chrNW_004955402:51,017,963...51,023,508
Ensembl chrNW_004955402:51,017,963...51,023,508 		JBrowse link
G Ext1 exostosin glycosyltransferase 1 acts_upstream_of_or_within ISO (MGI:6478099|PMID:32201365) MGI PMID:32201365 MGI:6478099 NCBI chrNW_004955417:23,798,044...24,067,759
Ensembl chrNW_004955417:23,798,393...24,067,100 		JBrowse link
chondroitin sulfate biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chpf chondroitin polymerizing factor involved_in
acts_upstream_of_or_within		 ISO (PMID:12761225)
(MGI:5462280|PMID:22952873)
(MGI:5462286|PMID:22952769)		 FlyBase
MGI		 PMID:12761225 PMID:22952769 PMID:22952873 MGI:5462280 MGI:5462286 NCBI chrNW_004955453:13,932,822...13,937,587
Ensembl chrNW_004955453:13,932,822...13,939,350 		JBrowse link
G Chst11 carbohydrate sulfotransferase 11 involved_in
acts_upstream_of_or_within		 ISO (PMID:11056388)
(MGI:1354846|PMID:10722746)
(MGI:4941099|PMID:21138417)		 UniProt
MGI		 PMID:10722746 PMID:11056388 PMID:21138417 MGI:1354846 MGI:4941099 NCBI chrNW_004955405:38,985,046...39,134,130
Ensembl chrNW_004955405:38,985,046...39,139,021 		JBrowse link
G Chst12 carbohydrate sulfotransferase 12 involved_in ISO (PMID:10781601) UniProt PMID:10781601 NCBI chrNW_004955460:12,847,440...12,875,614
Ensembl chrNW_004955460:12,847,440...12,875,614 		JBrowse link
G Chst13 carbohydrate sulfotransferase 13 involved_in ISO (PMID:12080076) UniProt PMID:12080076 NCBI chrNW_004955421:21,770,083...21,787,563 JBrowse link
G Chst3 carbohydrate sulfotransferase 3 involved_in
acts_upstream_of_or_within		 ISO (PMID:9883891)
(MGI:2156294|PMID:11696535)
(MGI:1206144|PMID:9597547)		 UniProt
MGI		 PMID:9597547 PMID:9883891 PMID:11696535 MGI:1206144 MGI:2156294 NCBI chrNW_004955437:19,563,645...19,605,747
Ensembl chrNW_004955437:19,563,088...19,569,889 		JBrowse link
G Chst7 carbohydrate sulfotransferase 7 involved_in ISO (PMID:10781596) UniProt PMID:10781596 NCBI chrNW_004955516:1,435,972...1,466,249
Ensembl chrNW_004955516:1,461,789...1,466,249 		JBrowse link
G Chsy1 chondroitin sulfate synthase 1 involved_in
acts_upstream_of_or_within		 ISO (PMID:11514575)
(MGI:5462286|PMID:22952769)		 MGI PMID:11514575 PMID:22952769 MGI:5462286 NCBI chrNW_004955416:28,070,981...28,136,848
Ensembl chrNW_004955416:28,070,710...28,135,590 		JBrowse link
G Csgalnact1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 involved_in ISO (PMID:11514575), (PMID:12163485) UniProt PMID:11514575 PMID:12163485 NCBI chrNW_004955403:43,178,520...43,347,121
Ensembl chrNW_004955403:43,178,520...43,478,885 		JBrowse link
G Slc35d1 solute carrier family 35 member D1 acts_upstream_of_or_within ISO (MGI:3771453|PMID:17952091) MGI PMID:17952091 MGI:3771453 NCBI chrNW_004955423:23,945,729...23,969,929
Ensembl chrNW_004955423:23,945,572...23,967,295 		JBrowse link
G Ugdh UDP-glucose 6-dehydrogenase involved_in ISO (MGI:2675908|PMID:14505572) UniProt PMID:14505572 MGI:2675908 NCBI chrNW_004955443:7,868,893...7,882,136
Ensembl chrNW_004955443:7,868,893...7,882,129 		JBrowse link
G Xylt1 xylosyltransferase 1 involved_in ISO (MGI:5544658|PMID:24161523) UniProt PMID:24161523 MGI:5544658 NCBI chrNW_004955442:1,787,338...2,042,523
Ensembl chrNW_004955442:1,745,924...2,036,340 		JBrowse link
chondroitin sulfate catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hyal4 hyaluronidase 4 acts_upstream_of_or_within ISO (MGI:5490850|PMID:23086929) MGI PMID:23086929 MGI:5490850 NCBI chrNW_004955479:5,355,667...5,364,092
Ensembl chrNW_004955479:5,355,667...5,364,444 		JBrowse link
peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bgn biglycan acts_upstream_of_or_within ISO (MGI:3807344|PMID:18757743) MGI PMID:18757743 MGI:3807344 NCBI chrNW_004955580:252,183...263,179
Ensembl chrNW_004955580:252,139...263,663 		JBrowse link
G Dcn decorin acts_upstream_of_or_within ISO (MGI:3807344|PMID:18757743) MGI PMID:18757743 MGI:3807344 NCBI chrNW_004955405:28,335,493...28,371,912
Ensembl chrNW_004955405:28,332,545...28,372,323 		JBrowse link
G Egflam EGF like, fibronectin type III and laminin G domains acts_upstream_of_or_within ISO (MGI:3807344|PMID:18757743) MGI PMID:18757743 MGI:3807344 NCBI chrNW_004955426:22,856,515...23,030,517
Ensembl chrNW_004955426:22,856,186...23,031,029 		JBrowse link
G Mamdc2 MAM domain containing 2 acts_upstream_of_or_within ISO (MGI:3807344|PMID:18757743) MGI PMID:18757743 MGI:3807344 NCBI chrNW_004955434:2,884,004...3,064,827
Ensembl chrNW_004955434:2,883,785...3,064,827 		JBrowse link
G Ndnf neuron derived neurotrophic factor acts_upstream_of_or_within ISO (MGI:3807344|PMID:18757743) MGI PMID:18757743 MGI:3807344 NCBI chrNW_004955428:19,552,493...19,587,712
Ensembl chrNW_004955428:19,552,493...19,587,712 		JBrowse link
G Spock2 SPARC (osteonectin), cwcv and kazal like domains proteoglycan 2 acts_upstream_of_or_within ISO (MGI:3807344|PMID:18757743) MGI PMID:18757743 MGI:3807344 NCBI chrNW_004955437:19,494,102...19,519,218
Ensembl chrNW_004955437:19,494,536...19,515,884 		JBrowse link
G Spock3 SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3 acts_upstream_of_or_within ISO (MGI:3807344|PMID:18757743) MGI PMID:18757743 MGI:3807344 NCBI chrNW_004955403:38,476,251...38,870,760
Ensembl chrNW_004955403:38,476,182...38,873,299 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 11952
    cellular process 11169
      cellular metabolic process 6965
        sulfur compound metabolic process 208
          chondroitin sulfate metabolic process 22
            chondroitin sulfate biosynthetic process 11
            chondroitin sulfate catabolic process 1
            peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan 7
            protein-chondroitin sulfate linkage via chondroitin sulfate D-glucuronyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine 0
Path 2
Term Annotations click to browse term
  biological_process 11952
    metabolic process 7564
      organic substance metabolic process 7266
        macromolecule metabolic process 6267
          cellular macromolecule metabolic process 5374
            glycoprotein metabolic process 257
              proteoglycan metabolic process 64
                chondroitin sulfate proteoglycan metabolic process 28
                  chondroitin sulfate metabolic process 22
                    chondroitin sulfate biosynthetic process 11
                    chondroitin sulfate catabolic process 1
                    peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan 7
                    protein-chondroitin sulfate linkage via chondroitin sulfate D-glucuronyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine 0
paths to the root