Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

ONTOLOGY REPORT - ANNOTATIONS


Term:chondroitin sulfate metabolic process
go back to main search page
Accession:GO:0030204 term browser browse the term
Definition:The chemical reactions and pathways involving chondroitin sulfate, any member of a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues, the repeat units of which consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate. They usually occur linked to a protein to form proteoglycans. Two subgroups exist, one in which the sulfate is on the 4-position (chondroitin sulfate A) and the second in which it is in the 6-position (chondroitin sulfate C). They often are polydisperse and often differ in the degree of sulfation from tissue to tissue. The chains of repeating disaccharide are covalently linked to the side chains of serine residues in the polypeptide backbone of a protein by a glycosidic attachment through the trisaccharide unit galactosyl-galactosyl-xylosyl. Chondroitin sulfate B is more usually known as dermatan sulfate.
Synonyms:exact_synonym: chondroitin sulfate metabolism;   chondroitin sulphate metabolic process;   chondroitin sulphate metabolism


show annotations for term's descendants           Sort by:
 
chondroitin sulfate metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BPNT2 3'(2'), 5'-bisphosphate nucleotidase 2 acts_upstream_of_or_within ISO (MGI:3809386|PMID:18695242)
(MGI:3799383|PMID:18539921)
MGI PMID:18539921 PMID:18695242 MGI:3799383 MGI:3809386 NCBI chr 8:53,385,837...53,417,019
Ensembl chr 8:50,753,792...50,785,055
JBrowse link
G CHST11 carbohydrate sulfotransferase 11 acts_upstream_of_or_within ISO (MGI:3767479|PMID:16079159) MGI PMID:16079159 MGI:3767479 NCBI chr12:102,035,480...102,340,084
Ensembl chr12:105,431,075...105,731,172
JBrowse link
G CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 acts_upstream_of_or_within ISO (MGI:4849906|PMID:20812917)
(MGI:4946456|PMID:21148564)
MGI PMID:20812917 PMID:21148564 MGI:4849906 MGI:4946456 NCBI chr 8:18,626,998...18,980,416
Ensembl chr 8:15,576,416...15,904,123
JBrowse link
G DSEL dermatan sulfate epimerase like acts_upstream_of_or_within ISO (MGI:5583874|PMID:22496542) MGI PMID:22496542 MGI:5583874 NCBI chr18:60,880,241...60,890,372 JBrowse link
G EXT1 exostosin glycosyltransferase 1 acts_upstream_of_or_within ISO (MGI:6478099|PMID:32201365) MGI PMID:32201365 MGI:6478099 NCBI chr 8:114,489,325...114,803,763
Ensembl chr 8:117,011,919...117,324,851
JBrowse link
chondroitin sulfate biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CHPF chondroitin polymerizing factor involved_in
acts_upstream_of_or_within
ISO (PMID:12761225)
(MGI:5462280|PMID:22952873)
(MGI:5462286|PMID:22952769)
FlyBase
MGI
PMID:12761225 PMID:22952769 PMID:22952873 MGI:5462280 MGI:5462286 NCBI chr2B:106,796,215...106,801,081
Ensembl chr2B:225,386,262...225,390,886
JBrowse link
G CHST11 carbohydrate sulfotransferase 11 involved_in
acts_upstream_of_or_within
ISO (PMID:11056388)
(MGI:4941099|PMID:21138417)
(MGI:1354846|PMID:10722746)
UniProt
MGI
PMID:10722746 PMID:11056388 PMID:21138417 MGI:1354846 MGI:4941099 NCBI chr12:102,035,480...102,340,084
Ensembl chr12:105,431,075...105,731,172
JBrowse link
G CHST12 carbohydrate sulfotransferase 12 involved_in ISO (PMID:10781601) UniProt PMID:10781601 NCBI chr 7:2,666,062...2,697,292
Ensembl chr 7:2,792,210...2,793,454
JBrowse link
G CHST13 carbohydrate sulfotransferase 13 involved_in ISO (PMID:12080076) UniProt PMID:12080076 NCBI chr 3:123,569,493...123,592,816
Ensembl chr 3:130,889,157...130,907,762
JBrowse link
G CHST3 carbohydrate sulfotransferase 3 involved_in
acts_upstream_of_or_within
ISO (PMID:9883891)
(MGI:2156294|PMID:11696535)
(MGI:1206144|PMID:9597547)
UniProt
MGI
PMID:9597547 PMID:9883891 PMID:11696535 MGI:1206144 MGI:2156294 NCBI chr10:68,427,305...68,476,512
Ensembl chr10:70,951,190...70,994,936
JBrowse link
G CHST7 carbohydrate sulfotransferase 7 involved_in ISO (PMID:10781596) UniProt PMID:10781596 NCBI chr  X:39,012,011...39,036,655
Ensembl chr  X:46,873,942...46,875,436
JBrowse link
G CHSY1 chondroitin sulfate synthase 1 acts_upstream_of_or_within ISO (MGI:5462286|PMID:22952769) MGI PMID:22952769 MGI:5462286 NCBI chr15:79,901,340...79,976,067
Ensembl chr15:99,186,705...99,260,591
JBrowse link
G CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 involved_in ISO (PMID:11514575), (PMID:12163485) UniProt PMID:11514575 PMID:12163485 NCBI chr 8:18,626,998...18,980,416
Ensembl chr 8:15,576,416...15,904,123
JBrowse link
G SLC35D1 solute carrier family 35 member D1 acts_upstream_of_or_within ISO (MGI:3771453|PMID:17952091) MGI PMID:17952091 MGI:3771453 NCBI chr 1:66,248,462...66,303,630
Ensembl chr 1:68,134,617...68,188,694
JBrowse link
G UGDH UDP-glucose 6-dehydrogenase involved_in ISO (MGI:2675908|PMID:14505572) UniProt PMID:14505572 MGI:2675908 NCBI chr 4:33,827,532...33,856,204
Ensembl chr 4:39,681,300...39,708,215
JBrowse link
G XYLT1 xylosyltransferase 1 involved_in ISO (MGI:5544658|PMID:24161523) UniProt PMID:24161523 MGI:5544658 NCBI chr16:20,078,904...20,447,268
Ensembl chr16:17,222,447...17,470,818
JBrowse link
peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BGN biglycan acts_upstream_of_or_within ISO (MGI:3807344|PMID:18757743) MGI PMID:18757743 MGI:3807344 NCBI chr  X:143,045,298...143,059,892
Ensembl chr  X:152,931,608...152,946,292
JBrowse link
G DCN decorin acts_upstream_of_or_within ISO (MGI:3807344|PMID:18757743) MGI PMID:18757743 MGI:3807344 NCBI chr12:88,678,791...88,715,677
Ensembl chr12:91,994,129...92,031,413
JBrowse link
G EGFLAM EGF like, fibronectin type III and laminin G domains acts_upstream_of_or_within ISO (MGI:3807344|PMID:18757743) MGI PMID:18757743 MGI:3807344 NCBI chr 5:71,909,106...72,119,958
Ensembl chr 5:76,944,818...77,073,380
JBrowse link
G MAMDC2 MAM domain containing 2 acts_upstream_of_or_within ISO (MGI:3807344|PMID:18757743) MGI PMID:18757743 MGI:3807344 NCBI chr 9:54,579,265...54,755,474
Ensembl chr 9:68,804,009...68,980,269
JBrowse link
G NDNF neuron derived neurotrophic factor acts_upstream_of_or_within ISO (MGI:3807344|PMID:18757743) MGI PMID:18757743 MGI:3807344 NCBI chr 4:113,242,800...113,283,834
Ensembl chr 4:124,386,606...124,422,793
JBrowse link
G SPOCK2 SPARC (osteonectin), cwcv and kazal like domains proteoglycan 2 acts_upstream_of_or_within ISO (MGI:3807344|PMID:18757743) MGI PMID:18757743 MGI:3807344 NCBI chr10:68,522,002...68,552,001
Ensembl chr10:71,048,773...71,074,203
JBrowse link
G SPOCK3 SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3 acts_upstream_of_or_within ISO (MGI:3807344|PMID:18757743) MGI PMID:18757743 MGI:3807344 NCBI chr 4:158,941,142...159,437,078
Ensembl chr 4:171,022,442...171,517,005
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12543
    cellular process 11661
      cellular metabolic process 7172
        sulfur compound metabolic process 225
          chondroitin sulfate metabolic process 21
            chondroitin sulfate biosynthetic process 11
            chondroitin sulfate catabolic process 0
            peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan 7
            protein-chondroitin sulfate linkage via chondroitin sulfate D-glucuronyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine 0
Path 2
Term Annotations click to browse term
  biological_process 12543
    metabolic process 7835
      organic substance metabolic process 7550
        macromolecule metabolic process 6475
          cellular macromolecule metabolic process 5503
            glycoprotein metabolic process 257
              proteoglycan metabolic process 64
                chondroitin sulfate proteoglycan metabolic process 27
                  chondroitin sulfate metabolic process 21
                    chondroitin sulfate biosynthetic process 11
                    chondroitin sulfate catabolic process 0
                    peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan 7
                    protein-chondroitin sulfate linkage via chondroitin sulfate D-glucuronyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine 0
paths to the root