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ONTOLOGY REPORT - ANNOTATIONS


Term:chondroitin sulfate metabolic process
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Accession:GO:0030204 term browser browse the term
Definition:The chemical reactions and pathways involving chondroitin sulfate, any member of a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues, the repeat units of which consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate. They usually occur linked to a protein to form proteoglycans. Two subgroups exist, one in which the sulfate is on the 4-position (chondroitin sulfate A) and the second in which it is in the 6-position (chondroitin sulfate C). They often are polydisperse and often differ in the degree of sulfation from tissue to tissue. The chains of repeating disaccharide are covalently linked to the side chains of serine residues in the polypeptide backbone of a protein by a glycosidic attachment through the trisaccharide unit galactosyl-galactosyl-xylosyl. Chondroitin sulfate B is more usually known as dermatan sulfate.
Synonyms:exact_synonym: chondroitin sulfate metabolism;   chondroitin sulphate metabolic process;   chondroitin sulphate metabolism


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chondroitin sulfate metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bpnt2 3'(2'), 5'-bisphosphate nucleotidase 2 acts_upstream_of_or_within ISO MGI:3806990|MGI:3810994 (MGI:3799383|PMID:18539921), (MGI:3809386|PMID:18695242) RGD PMID:18539921 PMID:18695242 MGI:3799383 MGI:3809386 NCBI chr 5:17,775,684...17,802,570
Ensembl chr 5:17,772,608...17,802,570
JBrowse link
G Chst11 carbohydrate sulfotransferase 11 acts_upstream_of_or_within ISO MGI:3768254 (MGI:3767479|PMID:16079159) RGD PMID:16079159 MGI:3767479 NCBI chr 7:20,524,535...20,743,008
Ensembl chr 7:20,528,100...20,743,111
JBrowse link
G Csgalnact1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 acts_upstream_of_or_within ISO MGI:4868209|MGI:4947395 (MGI:4849906|PMID:20812917), (MGI:4946456|PMID:21148564) RGD PMID:20812917 PMID:21148564 MGI:4849906 MGI:4946456 NCBI chr16:20,995,210...21,330,586
Ensembl chr16:21,235,784...21,330,319
JBrowse link
G Dse dermatan sulfate epimerase involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr20:26,118,194...26,196,889
Ensembl chr20:26,118,196...26,196,992
JBrowse link
G Dsel dermatan sulfate epimerase-like involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
MGI:5583872 (MGI:5583874|PMID:22496542)
RGD PMID:22496542 PMID:21873635 MGI:5583874, RGD:13792537 NCBI chr13:186,413...192,592
Ensembl chr13:175,805...192,647
JBrowse link
G Ext1 exostosin glycosyltransferase 1 acts_upstream_of_or_within ISO (MGI:6478099|PMID:32201365) RGD PMID:32201365 MGI:6478099 NCBI chr 7:84,375,769...84,654,625
Ensembl chr 7:84,375,784...84,655,357
JBrowse link
chondroitin sulfate biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07032202.1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537
G Chpf chondroitin polymerizing factor involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
MGI:2681120|MGI:5464019 (MGI:5462280|PMID:22952873), (MGI:5462286|PMID:22952769)
(PMID:12761225)
RGD PMID:12761225 PMID:22952769 PMID:22952873 PMID:21873635 MGI:5462280 MGI:5462286, RGD:13792537 NCBI chr 9:76,963,178...76,967,878
Ensembl chr 9:76,963,184...76,967,878
JBrowse link
G Chpf2 chondroitin polymerizing factor 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 4:10,578,470...10,585,940
Ensembl chr 4:10,580,462...10,585,916
JBrowse link
G Chst11 carbohydrate sulfotransferase 11 involved_in
acts_upstream_of_or_within
ISO (PMID:11056388)
MGI:1926002 (MGI:1354846|PMID:10722746), (MGI:4941099|PMID:21138417)
RGD PMID:10722746 PMID:11056388 PMID:21138417 MGI:1354846 MGI:4941099 NCBI chr 7:20,524,535...20,743,008
Ensembl chr 7:20,528,100...20,743,111
JBrowse link
G Chst12 carbohydrate sulfotransferase 12 involved_in ISO (PMID:10781601) RGD PMID:10781601 NCBI chr12:14,110,631...14,129,099
Ensembl chr12:14,110,393...14,129,057
JBrowse link
G Chst13 carbohydrate sulfotransferase 13 involved_in ISO (PMID:12080076) RGD PMID:12080076 NCBI chr 4:122,824,712...122,837,935
Ensembl chr 4:122,824,022...122,838,019
JBrowse link
G Chst3 carbohydrate sulfotransferase 3 involved_in
acts_upstream_of_or_within
IBA
ISS
ISO
IEA
PMID:21873635
GO_REF:0000024
(PMID:15215498), (PMID:9883891)
MGI:2176247 (MGI:1206144|PMID:9597547), (MGI:2156294|PMID:11696535)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:9597547 PMID:9883891 PMID:11696535 PMID:15215498 PMID:21873635 GO_REF:0000024 GO_REF:0000107 MGI:1206144 MGI:2156294, RGD:13792537 NCBI chr20:28,114,387...28,152,046
Ensembl chr20:28,114,404...28,121,807
JBrowse link
G Chst7 carbohydrate sulfotransferase 7 involved_in IBA
ISO
PMID:21873635
(PMID:10781596)
RGD PMID:10781596 PMID:21873635 RGD:13792537 NCBI chr  X:2,396,260...2,432,828
Ensembl chr  X:2,393,874...2,432,840
JBrowse link
G Chsy1 chondroitin sulfate synthase 1 involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
(PMID:11514575)
MGI:106576 (MGI:5462286|PMID:22952769)
RGD PMID:11514575 PMID:22952769 PMID:21873635 MGI:5462286, RGD:13792537 NCBI chr 1:119,689,626...119,750,711
Ensembl chr 1:119,686,350...119,750,601
JBrowse link
G Chsy3 chondroitin sulfate synthase 3 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr18:52,644,356...52,901,257
Ensembl chr18:52,644,461...52,898,098
JBrowse link
G Csgalnact1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 involved_in ISO
IBA
(PMID:11514575), (PMID:12163485)
PMID:21873635
RGD PMID:11514575 PMID:12163485 PMID:21873635 RGD:13792537 NCBI chr16:20,995,210...21,330,586
Ensembl chr16:21,235,784...21,330,319
JBrowse link
G Csgalnact2 chondroitin sulfate N-acetylgalactosaminyltransferase 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 4:151,271,774...151,308,856
Ensembl chr 4:151,277,645...151,308,839
JBrowse link
G Slc35d1 solute carrier family 35 member D1 acts_upstream_of_or_within ISO MGI:3774133 (MGI:3771453|PMID:17952091) RGD PMID:17952091 MGI:3771453 NCBI chr 5:117,928,628...117,981,289
Ensembl chr 5:117,934,352...117,981,311
JBrowse link
G Ugdh UDP-glucose 6-dehydrogenase involved_in IEA
ISO
ISS
GO_REF:0000107
(MGI:2675908|PMID:14505572)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:14505572 GO_REF:0000024 GO_REF:0000107 MGI:2675908 NCBI chr14:42,848,704...42,872,351
Ensembl chr14:42,848,854...42,872,354
JBrowse link
G Xylt1 xylosyltransferase 1 involved_in IEA
ISO
GO_REF:0000041
(MGI:5544658|PMID:24161523)
UniProt
RGD
PMID:24161523 GO_REF:0000041 MGI:5544658 NCBI chr 1:171,643,925...171,929,774
Ensembl chr 1:171,643,925...171,926,783
JBrowse link
G Xylt2 xylosyltransferase 2 involved_in IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr10:79,605,910...79,619,482
Ensembl chr10:79,606,007...79,619,391
JBrowse link
chondroitin sulfate catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hyal4 hyaluronidase 4 acts_upstream_of_or_within ISO (MGI:5490850|PMID:23086929) RGD PMID:23086929 MGI:5490850 NCBI chr 4:53,256,179...53,274,819
Ensembl chr 4:53,256,179...53,274,819
JBrowse link
peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07060833.1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 Ensembl chr 4:94,944,360...94,981,873 JBrowse link
G Bgn biglycan acts_upstream_of_or_within ISO (MGI:3807344|PMID:18757743) RGD PMID:18757743 MGI:3807344 NCBI chr  X:151,197,296...151,209,458
Ensembl chr  X:151,197,273...151,209,461
JBrowse link
G Dcn decorin acts_upstream_of_or_within ISO (MGI:3807344|PMID:18757743) RGD PMID:18757743 MGI:3807344 NCBI chr 7:32,281,252...32,321,291
Ensembl chr 7:32,281,252...32,321,270
JBrowse link
G Egflam EGF-like, fibronectin type III and laminin G domains involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(MGI:3807344|PMID:18757743)
Ensembl
RGD
PMID:18757743 GO_REF:0000107 MGI:3807344 NCBI chr 2:56,301,945...56,476,665
Ensembl chr 2:56,302,566...56,476,298
JBrowse link
G Mamdc2 MAM domain containing 2 acts_upstream_of_or_within ISO (MGI:3807344|PMID:18757743) RGD PMID:18757743 MGI:3807344 NCBI chr 1:220,863,959...221,016,493
Ensembl chr 1:220,863,976...221,016,354
JBrowse link
G Ndnf neuron-derived neurotrophic factor acts_upstream_of_or_within ISO (MGI:3807344|PMID:18757743) RGD PMID:18757743 MGI:3807344 NCBI chr 4:94,944,749...94,987,414 JBrowse link
G Prss34 protease, serine, 34 involved_in IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr10:14,315,913...14,317,712
Ensembl chr10:14,315,955...14,317,712
JBrowse link
G Spock2 SPARC/osteonectin, cwcv and kazal like domains proteoglycan 2 acts_upstream_of_or_within ISO (MGI:3807344|PMID:18757743) RGD PMID:18757743 MGI:3807344 NCBI chr20:28,036,909...28,064,272
Ensembl chr20:28,033,475...28,064,272
JBrowse link
G Spock3 SPARC/osteonectin, cwcv and kazal like domains proteoglycan 3 acts_upstream_of_or_within ISO (MGI:3807344|PMID:18757743) RGD PMID:18757743 MGI:3807344 NCBI chr16:26,382,895...26,815,943
Ensembl chr16:26,383,383...26,815,205
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19492
    cellular process 18340
      cellular metabolic process 10717
        sulfur compound metabolic process 328
          chondroitin sulfate metabolic process 30
            chondroitin sulfate biosynthetic process 16
            chondroitin sulfate catabolic process 1
            peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan 9
            protein-chondroitin sulfate linkage via chondroitin sulfate D-glucuronyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine 0
Path 2
Term Annotations click to browse term
  biological_process 19492
    metabolic process 11797
      organic substance metabolic process 11337
        macromolecule metabolic process 9793
          cellular macromolecule metabolic process 8204
            glycoprotein metabolic process 358
              proteoglycan metabolic process 79
                chondroitin sulfate proteoglycan metabolic process 36
                  chondroitin sulfate metabolic process 30
                    chondroitin sulfate biosynthetic process 16
                    chondroitin sulfate catabolic process 1
                    peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan 9
                    protein-chondroitin sulfate linkage via chondroitin sulfate D-glucuronyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine 0
paths to the root