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ONTOLOGY REPORT - ANNOTATIONS


Term:glycosaminoglycan metabolic process
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Accession:GO:0030203 term browser browse the term
Definition:The chemical reactions and pathways involving glycosaminoglycans, any one of a group of polysaccharides that contain amino sugars. Formerly known as mucopolysaccharides, they include hyaluronic acid and chondroitin, which provide lubrication in joints and form part of the matrix of cartilage. The three-dimensional structure of these molecules enables them to trap water, which forms a gel and gives glycosaminoglycans their elastic properties.
Synonyms:exact_synonym: glycosaminoglycan metabolism


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glycosaminoglycan metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cln6 CLN6, transmembrane ER protein involved_in ISO (PMID:16857350) RGD PMID:16857350 NCBI chr 8:67,733,215...67,748,170
Ensembl chr 8:67,733,215...67,748,172
JBrowse link
G Foxc1 forkhead box C1 ISO MGI:1856705 (MGI:53846|PMID:4269479) RGD PMID:4269479 MGI:53846 NCBI chr17:33,947,501...33,951,484
Ensembl chr17:33,947,506...33,951,484
JBrowse link
G Hexa hexosaminidase subunit alpha ISO MGI:96074 (MGI:83770|PMID:8896570) RGD PMID:8896570 MGI:83770 NCBI chr 8:64,325,435...64,350,775
Ensembl chr 8:64,325,435...64,350,773
JBrowse link
G Hexb hexosaminidase subunit beta involved_in IEA
ISO
GO_REF:0000107
MGI:96073 (MGI:83770|PMID:8896570)
Ensembl
RGD
PMID:8896570 GO_REF:0000107 MGI:83770 NCBI chr 2:27,983,925...28,003,260
Ensembl chr 2:27,984,117...28,003,186
JBrowse link
G Ndst1 N-deacetylase and N-sulfotransferase 1 ISO MGI:3589383 (MGI:3588476|PMID:16020517) RGD PMID:16020517 MGI:3588476 NCBI chr18:55,951,497...56,014,107
Ensembl chr18:55,955,389...55,992,885
JBrowse link
chondroitin sulfate biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07032202.1 involved_in IBA PMID:21873635 GO_Central PMID:21873635, PMID:21873635 RGD:13792537, RGD:13792537 Ensembl chr18:54,206,651...54,207,523 JBrowse link
G Chpf chondroitin polymerizing factor involved_in ISO
IBA
(PMID:12761225)
PMID:21873635
MGI:2681120|MGI:5464019 (MGI:5462280|PMID:22952873), (MGI:5462286|PMID:22952769)
RGD PMID:12761225 PMID:22952769 PMID:22952873, PMID:21873635, PMID:21873635 MGI:5462280 MGI:5462286, RGD:13792537, RGD:13792537 NCBI chr 9:82,669,199...82,673,898
Ensembl chr 9:82,669,204...82,673,898
JBrowse link
G Chpf2 chondroitin polymerizing factor 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635, PMID:21873635 RGD:13792537, RGD:13792537 NCBI chr 4:7,108,461...7,113,940
Ensembl chr 4:7,108,462...7,113,919
JBrowse link
G Chst11 carbohydrate sulfotransferase 11 involved_in ISO (PMID:11056388)
MGI:1926002 (MGI:1354846|PMID:10722746), (MGI:4941099|PMID:21138417)
RGD PMID:10722746 PMID:11056388 PMID:21138417 MGI:1354846 MGI:4941099 NCBI chr 7:26,641,856...26,890,503
Ensembl chr 7:26,645,422...26,859,716
JBrowse link
G Chst12 carbohydrate sulfotransferase 12 involved_in ISO (PMID:10781601) RGD PMID:10781601 NCBI chr12:16,199,975...16,218,404
Ensembl chr12:16,200,019...16,201,632
JBrowse link
G Chst13 carbohydrate sulfotransferase 13 involved_in ISO (PMID:12080076) RGD PMID:12080076 NCBI chr 4:122,223,846...122,244,848
Ensembl chr 4:122,224,535...122,237,754
JBrowse link
G Chst3 carbohydrate sulfotransferase 3 involved_in IEA
ISO
IBA
GO_REF:0000107
(PMID:9883891)
PMID:21873635
MGI:2176247 (MGI:1206144|PMID:9597547), (MGI:2156294|PMID:11696535)
Ensembl
RGD
PMID:9597547 PMID:9883891 PMID:11696535, PMID:21873635, PMID:21873635 GO_REF:0000107 MGI:1206144 MGI:2156294, RGD:13792537, RGD:13792537 NCBI chr20:29,731,828...29,768,656
Ensembl chr20:29,731,816...29,738,506
JBrowse link
G Chst7 carbohydrate sulfotransferase 7 involved_in ISO
IBA
(PMID:10781596)
PMID:21873635
RGD PMID:10781596, PMID:21873635, PMID:21873635 RGD:13792537, RGD:13792537 NCBI chr  X:2,623,018...2,657,155
Ensembl chr  X:2,623,024...2,657,155
JBrowse link
G Chsy1 chondroitin sulfate synthase 1 involved_in ISO
IBA
(PMID:11514575)
PMID:21873635
MGI:106576 (MGI:5462286|PMID:22952769)
RGD PMID:11514575 PMID:22952769, PMID:21873635 MGI:5462286, RGD:13792537 NCBI chr 1:127,010,587...127,071,570
Ensembl chr 1:127,010,588...127,071,570
JBrowse link
G Chsy3 chondroitin sulfate synthase 3 involved_in IBA PMID:21873635 GO_Central PMID:21873635, PMID:21873635 RGD:13792537, RGD:13792537 NCBI chr18:54,243,626...54,497,475
Ensembl chr18:54,243,949...54,496,585
JBrowse link
G Csgalnact1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 involved_in ISO
IBA
(PMID:11514575), (PMID:12163485)
PMID:21873635
RGD PMID:11514575 PMID:12163485, PMID:21873635, PMID:21873635 RGD:13792537, RGD:13792537 NCBI chr16:22,704,318...23,075,071
Ensembl chr16:22,979,444...23,074,798
JBrowse link
G Csgalnact2 chondroitin sulfate N-acetylgalactosaminyltransferase 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635, PMID:21873635 RGD:13792537, RGD:13792537 NCBI chr 4:150,148,626...150,185,062
Ensembl chr 4:150,153,844...150,185,044
JBrowse link
G Slc35d1 solute carrier family 35 member D1 ISO MGI:3774133 (MGI:3771453|PMID:17952091) RGD PMID:17952091 MGI:3771453 NCBI chr 5:122,700,396...122,746,815
Ensembl chr 5:122,699,587...122,746,839
JBrowse link
G Ugdh UDP-glucose 6-dehydrogenase involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(MGI:2675908|PMID:14505572)
UniProt
Ensembl
RGD
PMID:14505572 GO_REF:0000024 GO_REF:0000107 MGI:2675908 NCBI chr14:44,479,614...44,502,845
Ensembl chr14:44,479,614...44,502,845
JBrowse link
G Xylt1 xylosyltransferase 1 involved_in IEA
ISO
GO_REF:0000041
(MGI:5544658|PMID:24161523)
UniProt
RGD
PMID:24161523 GO_REF:0000041 MGI:5544658 NCBI chr 1:186,939,698...187,264,758
Ensembl chr 1:187,149,453...187,261,632
JBrowse link
G Xylt2 xylosyltransferase 2 involved_in IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr10:82,386,003...82,399,485
Ensembl chr10:82,386,005...82,399,485
JBrowse link
chondroitin sulfate catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hyal4 hyaluronidase 4 ISO (MGI:5490850|PMID:23086929) RGD PMID:23086929 MGI:5490850 NCBI chr 4:52,147,641...52,166,276
Ensembl chr 4:52,147,641...52,167,122
JBrowse link
chondroitin sulfate metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bpnt2 3'(2'), 5'-bisphosphate nucleotidase 2 ISO MGI:3806990|MGI:3810994 (MGI:3799383|PMID:18539921), (MGI:3809386|PMID:18695242) RGD PMID:18539921 PMID:18695242 MGI:3799383 MGI:3809386 NCBI chr17:90,191,119...90,218,013
Ensembl chr17:90,188,043...90,218,013
Ensembl chr 5:90,188,043...90,218,013
JBrowse link
G Chst11 carbohydrate sulfotransferase 11 ISO MGI:3768254 (MGI:3767479|PMID:16079159) RGD PMID:16079159 MGI:3767479 NCBI chr 7:26,641,856...26,890,503
Ensembl chr 7:26,645,422...26,859,716
JBrowse link
G Csgalnact1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 ISO MGI:4868209|MGI:4947395 (MGI:4849906|PMID:20812917), (MGI:4946456|PMID:21148564) RGD PMID:20812917 PMID:21148564 MGI:4849906 MGI:4946456 NCBI chr16:22,704,318...23,075,071
Ensembl chr16:22,979,444...23,074,798
JBrowse link
G Dse dermatan sulfate epimerase involved_in IBA PMID:21873635 GO_Central PMID:21873635, PMID:21873635 RGD:13792537, RGD:13792537 NCBI chr20:27,703,738...27,784,982
Ensembl chr20:27,703,732...27,782,586
JBrowse link
G Dsel dermatan sulfate epimerase-like involved_in ISO
IBA
MGI:5583872 (MGI:5583874|PMID:22496542)
PMID:21873635
RGD PMID:22496542, PMID:21873635, PMID:21873635 MGI:5583874, RGD:13792537, RGD:13792537 NCBI chr13:1,942,384...1,948,563
Ensembl chr13:1,942,499...1,946,508
JBrowse link
G Ext1 exostosin glycosyltransferase 1 ISO (MGI:6478099|PMID:32201365) RGD PMID:32201365 MGI:6478099 NCBI chr 7:92,605,008...92,881,392
Ensembl chr 7:92,605,728...92,882,068
JBrowse link
dermatan sulfate biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chst12 carbohydrate sulfotransferase 12 involved_in ISO (PMID:10781601) RGD PMID:10781601 NCBI chr12:16,199,975...16,218,404
Ensembl chr12:16,200,019...16,201,632
JBrowse link
G Chst14 carbohydrate sulfotransferase 14 involved_in ISO (PMID:11470797) RGD PMID:11470797 NCBI chr 3:110,734,105...110,736,162
Ensembl chr 3:110,734,105...110,736,162
JBrowse link
G Dse dermatan sulfate epimerase involved_in ISO (PMID:16505484) RGD PMID:16505484 NCBI chr20:27,703,738...27,784,982
Ensembl chr20:27,703,732...27,782,586
JBrowse link
dermatan sulfate catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Idua alpha-L-iduronidase involved_in ISO (PMID:24036510)
MGI:2176236|MGI:4415188 (MGI:4397742|PMID:19834056), (MGI:4414887|PMID:19751987)
RGD PMID:19751987 PMID:19834056 PMID:24036510 MGI:4397742 MGI:4414887 NCBI chr14:2,041,828...2,056,762
Ensembl chr14:2,042,411...2,056,762
JBrowse link
dermatan sulfate metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dse dermatan sulfate epimerase involved_in IBA PMID:21873635 GO_Central PMID:21873635, PMID:21873635 RGD:13792537, RGD:13792537 NCBI chr20:27,703,738...27,784,982
Ensembl chr20:27,703,732...27,782,586
JBrowse link
G Dsel dermatan sulfate epimerase-like involved_in ISO
IBA
MGI:5583872 (MGI:5583874|PMID:22496542)
PMID:21873635
RGD PMID:22496542, PMID:21873635, PMID:21873635 MGI:5583874, RGD:13792537, RGD:13792537 NCBI chr13:1,942,384...1,948,563
Ensembl chr13:1,942,499...1,946,508
JBrowse link
glycosaminoglycan biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G B3galt6 Beta-1,3-galactosyltransferase 6 involved_in ISO
IBA
(PMID:11551958)
PMID:21873635
(MGI:2152770|PMID:11551958)
RGD PMID:11551958, PMID:21873635 MGI:2152770, RGD:13792537 NCBI chr 5:173,423,475...173,425,611
Ensembl chr 5:173,423,475...173,425,611
JBrowse link
G B3gat3 beta-1,3-glucuronyltransferase 3 involved_in ISO (PMID:24425863), (PMID:25893793) RGD PMID:24425863 PMID:25893793 NCBI chr 1:225,120,061...225,126,579
Ensembl chr 1:225,120,061...225,126,579
JBrowse link
G B4galt7 beta-1,4-galactosyltransferase 7 involved_in ISO
ISS
(PMID:10438455)
GO_REF:0000024
RGD
UniProt
PMID:10438455 GO_REF:0000024 NCBI chr17:9,549,605...9,558,672
Ensembl chr17:9,550,028...9,558,634
JBrowse link
G Ext1 exostosin glycosyltransferase 1 involved_in ISO (PMID:12907669) RGD PMID:12907669 NCBI chr 7:92,605,008...92,881,392
Ensembl chr 7:92,605,728...92,882,068
JBrowse link
G Ext2 exostosin glycosyltransferase 2 involved_in ISO (PMID:12907669) RGD PMID:12907669 NCBI chr 3:82,602,784...82,734,557
Ensembl chr 3:82,602,785...82,734,533
JBrowse link
G Hexa hexosaminidase subunit alpha involved_in ISO (PMID:25645918) RGD PMID:25645918 NCBI chr 8:64,325,435...64,350,775
Ensembl chr 8:64,325,435...64,350,773
JBrowse link
G Pdgfrb platelet derived growth factor receptor beta IMP RGD PMID:11903042 RGD:1581762 NCBI chr18:56,364,586...56,406,381
Ensembl chr18:56,364,620...56,406,381
JBrowse link
G Pxylp1 2-phosphoxylose phosphatase 1 involved_in ISO
IBA
ISS
(PMID:24425863)
PMID:21873635
GO_REF:0000024
RGD
UniProt
PMID:24425863, PMID:21873635, PMID:21873635 GO_REF:0000024, RGD:13792537, RGD:13792537 NCBI chr 8:104,724,728...104,790,639
Ensembl chr 8:104,724,743...104,790,639
JBrowse link
G Ugdh UDP-glucose 6-dehydrogenase involved_in IBA PMID:21873635 GO_Central PMID:21873635, PMID:21873635 RGD:13792537, RGD:13792537 NCBI chr14:44,479,614...44,502,845
Ensembl chr14:44,479,614...44,502,845
JBrowse link
G Xylt1 xylosyltransferase 1 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 1:186,939,698...187,264,758
Ensembl chr 1:187,149,453...187,261,632
JBrowse link
G Xylt2 xylosyltransferase 2 ISO MGI:3714171 (MGI:3713963|PMID:17517600) RGD PMID:17517600 MGI:3713963 NCBI chr10:82,386,003...82,399,485
Ensembl chr10:82,386,005...82,399,485
JBrowse link
glycosaminoglycan catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07030903.1 involved_in IBA PMID:21873635 GO_Central PMID:21873635, PMID:21873635 RGD:13792537, RGD:13792537 Ensembl chr10:108,469,856...108,473,377 JBrowse link
G Hyal2 hyaluronidase 2 involved_in ISO
ISS
(PMID:9712871)
GO_REF:0000024
RGD
UniProt
PMID:9712871 GO_REF:0000024 NCBI chr 8:116,324,062...116,328,978
Ensembl chr 8:116,324,040...116,328,978
JBrowse link
G Hyal4 hyaluronidase 4 TAS RGD PMID:10989127 RGD:1331360 NCBI chr 4:52,147,641...52,166,276
Ensembl chr 4:52,147,641...52,167,122
JBrowse link
G Ids iduronate 2-sulfatase involved_in ISO (PMID:28593992) RGD PMID:28593992 NCBI chr 8:69,447,971...69,466,708
Ensembl chr 8:69,449,801...69,466,618
JBrowse link
G Idua alpha-L-iduronidase IDA
ISO
MGI:2176236|MGI:2651471|MGI:4415188 (MGI:3697540|PMID:16979922), (MGI:4397742|PMID:19834056), (MGI:4414887|PMID:19751987), (MGI:5295514|PMID:21873421), (MGI:5448924|PMID:22580166) RGD PMID:16979922 PMID:19751987 PMID:19834056 PMID:21873421 PMID:22580166, PMID:6138357 MGI:3697540 MGI:4397742 MGI:4414887 MGI:5295514 MGI:5448924, RGD:1599427 NCBI chr14:2,041,828...2,056,762
Ensembl chr14:2,042,411...2,056,762
JBrowse link
G Lyve1 lymphatic vessel endothelial hyaluronan receptor 1 ISO (MGI:2135409|PMID:11278811) RGD PMID:11278811 MGI:2135409 NCBI chr 1:175,663,266...175,676,699
Ensembl chr 1:175,663,266...175,676,699
JBrowse link
G Sgsh N-sulfoglucosamine sulfohydrolase involved_in ISO (PMID:15146460), (PMID:7493035) RGD PMID:7493035 PMID:15146460 NCBI chr10:108,469,312...108,479,094 JBrowse link
heparin biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Angpt1 angiopoietin 1 involved_in IEA
ISO
GO_REF:0000107
(PMID:19297368)
Ensembl
RGD
PMID:19297368 GO_REF:0000107 NCBI chr 7:81,338,327...81,592,459
Ensembl chr 7:81,342,280...81,592,206
JBrowse link
G Ext1 exostosin glycosyltransferase 1 ISO MGI:108050 (MGI:1888607|PMID:10926768), (MGI:3050709|PMID:15161920), (MGI:3051956|PMID:15177029), (MGI:4360160|PMID:18480751), (MGI:6406739|PMID:21310272), (MGI:6406770|PMID:21148566) RGD PMID:10926768 PMID:15161920 PMID:15177029 PMID:18480751 PMID:21148566 PMID:21310272 MGI:1888607 MGI:3050709 MGI:3051956 MGI:4360160 MGI:6406739 MGI:6406770 NCBI chr 7:92,605,008...92,881,392
Ensembl chr 7:92,605,728...92,882,068
JBrowse link
G Ext2 exostosin glycosyltransferase 2 ISO MGI:894663 (MGI:6406739|PMID:21310272) RGD PMID:21310272 MGI:6406739 NCBI chr 3:82,602,784...82,734,557
Ensembl chr 3:82,602,785...82,734,533
JBrowse link
G Glce glucuronic acid epimerase involved_in IEA
ISO
GO_REF:0000041
(MGI:2135754|PMID:11279150)
UniProt
RGD
PMID:11279150 GO_REF:0000041 MGI:2135754 NCBI chr 8:67,006,588...67,073,723
Ensembl chr 8:67,006,592...67,040,005
JBrowse link
G Ndst1 N-deacetylase and N-sulfotransferase 1 involved_in IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr18:55,951,497...56,014,107
Ensembl chr18:55,955,389...55,992,885
JBrowse link
G Ndst2 N-deacetylase and N-sulfotransferase 2 involved_in IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr15:3,995,797...4,006,491
Ensembl chr15:3,996,048...4,006,491
JBrowse link
G Ndst3 N-deacetylase and N-sulfotransferase 3 involved_in IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 2:227,736,491...227,903,657
Ensembl chr 2:227,738,650...227,890,077
JBrowse link
G Ndst4 N-deacetylase and N-sulfotransferase 4 involved_in IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 2:229,170,781...229,496,732
Ensembl chr 2:229,196,616...229,496,516
JBrowse link
G NEWGENE_1304700 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2 involved_in IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr15:3,750,058...3,760,616
Ensembl chr15:3,754,262...3,760,663
JBrowse link
G Slc10a7 solute carrier family 10, member 7 involved_in ISO (PMID:30082715)
(MGI:6198941|PMID:30082715)
RGD PMID:30082715 MGI:6198941 NCBI chr19:32,857,984...33,081,359
Ensembl chr19:32,855,343...33,080,998
JBrowse link
G Xylt2 xylosyltransferase 2 involved_in IEA
ISO
GO_REF:0000107
MGI:3714171 (MGI:3713963|PMID:17517600)
Ensembl
RGD
PMID:17517600 GO_REF:0000107 MGI:3713963 NCBI chr10:82,386,003...82,399,485
Ensembl chr10:82,386,005...82,399,485
JBrowse link
heparin catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Idua alpha-L-iduronidase involved_in ISO (PMID:21873421)
MGI:2176236|MGI:4415188 (MGI:4397742|PMID:19834056), (MGI:4414887|PMID:19751987), (MGI:5295514|PMID:21873421)
RGD PMID:19751987 PMID:19834056 PMID:21873421 MGI:4397742 MGI:4414887 MGI:5295514 NCBI chr14:2,041,828...2,056,762
Ensembl chr14:2,042,411...2,056,762
JBrowse link
heparin metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ext1 exostosin glycosyltransferase 1 ISO (MGI:5704009|PMID:26491162), (MGI:6478099|PMID:32201365) RGD PMID:26491162 PMID:32201365 MGI:5704009 MGI:6478099 NCBI chr 7:92,605,008...92,881,392
Ensembl chr 7:92,605,728...92,882,068
JBrowse link
G Hs2st1 heparan sulfate 2-O-sulfotransferase 1 ISO MGI:1934916 (MGI:2150438|PMID:11457822) RGD PMID:11457822 MGI:2150438 NCBI chr 2:250,467,428...250,600,517
Ensembl chr 2:250,467,429...250,600,517
JBrowse link
hyaluronan biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccnd3 cyclin D3 IMP RGD PMID:19276076 RGD:2316018 NCBI chr 9:15,404,816...15,410,905
Ensembl chr 9:15,404,822...15,410,943
JBrowse link
G Has1 hyaluronan synthase 1 involved_in ISO
IBA
(MGI:1351415|PMID:10617644)
PMID:21873635
RGD PMID:10617644, PMID:21873635, PMID:21873635 MGI:1351415, RGD:13792537, RGD:13792537 NCBI chr 1:59,720,612...59,732,409
Ensembl chr 1:59,720,612...59,732,409
JBrowse link
G Has2 hyaluronan synthase 2 involved_in IEA
ISO
IEP
IBA
GO_REF:0000041
(PMID:17324121), (PMID:22016393)
PMID:19635555
PMID:21873635
(MGI:1861536|PMID:10930438)
UniProt
RGD
PMID:10930438 PMID:17324121 PMID:22016393, PMID:19635555, PMID:21873635, PMID:19635555 GO_REF:0000041 MGI:1861536, RGD:8553259, RGD:13792537, RGD:8553259 NCBI chr 7:96,438,046...96,464,049
Ensembl chr 7:96,438,046...96,464,049
JBrowse link
G Has3 hyaluronan synthase 3 involved_in ISO
IBA
(PMID:16900089)
PMID:21873635
(MGI:86804|PMID:9060470)
RGD PMID:9060470 PMID:16900089, PMID:21873635, PMID:21873635 MGI:86804, RGD:13792537, RGD:13792537 NCBI chr19:39,063,298...39,077,745
Ensembl chr19:39,063,998...39,077,722
JBrowse link
G Hyal1 hyaluronidase 1 involved_in IEA
ISO
ISS
GO_REF:0000107
(PMID:21829529)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:21829529 GO_REF:0000024 GO_REF:0000107 NCBI chr 8:116,332,834...116,337,522
Ensembl chr 8:116,332,796...116,335,435
JBrowse link
G Il1b interleukin 1 beta involved_in IEA
ISO
GO_REF:0000107
(PMID:15100360)
Ensembl
RGD
PMID:15100360 GO_REF:0000107 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
hyaluronan catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd44 CD44 molecule (Indian blood group) involved_in IEA
ISO
GO_REF:0000107
(PMID:17170110)
Ensembl
RGD
PMID:17170110 GO_REF:0000107 NCBI chr 3:92,695,083...92,783,820
Ensembl chr 3:92,696,313...92,783,658
JBrowse link
G Cemip cell migration inducing hyaluronidase involved_in ISO
ISS
(PMID:23509262)
GO_REF:0000024
(MGI:5545862|PMID:24251095)
RGD
UniProt
PMID:23509262 PMID:24251095 GO_REF:0000024 MGI:5545862 NCBI chr 1:146,069,774...146,226,320
Ensembl chr 1:146,069,771...146,226,462
JBrowse link
G Cemip2 cell migration inducing hyaluronidase 2 involved_in ISO (PMID:28246172) RGD PMID:28246172 NCBI chr 1:239,397,322...239,474,931
Ensembl chr 1:239,398,043...239,474,931
JBrowse link
G Fgf2 fibroblast growth factor 2 involved_in ISO (PMID:19577615) RGD PMID:19577615 NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681
JBrowse link
G Hyal1 hyaluronidase 1 involved_in IEA
ISO
IBA
GO_REF:0000107
(PMID:11296287), (PMID:17170110), (PMID:20473947), (PMID:21695196), (PMID:21699545), (PMID:21829529)
(PMID:12084718)
PMID:21873635
Ensembl
RGD
PMID:11296287 PMID:12084718 PMID:17170110 PMID:20473947 PMID:21695196 PMID:21699545 PMID:21829529, PMID:21873635, PMID:21873635 GO_REF:0000107, RGD:13792537, RGD:13792537 NCBI chr 8:116,332,834...116,337,522
Ensembl chr 8:116,332,796...116,335,435
JBrowse link
G Hyal2 hyaluronidase 2 involved_in IDA
IBA
IEA
ISO
PMID:19635555
PMID:21873635
GO_REF:0000107
(PMID:17170110), (PMID:19443707), (PMID:20554532), (PMID:21699545)
Ensembl
RGD
PMID:17170110 PMID:19443707 PMID:20554532 PMID:21699545, PMID:19635555, PMID:21873635, PMID:19635555, PMID:21873635 GO_REF:0000107, RGD:8553259, RGD:13792537, RGD:8553259, RGD:13792537 NCBI chr 8:116,324,062...116,328,978
Ensembl chr 8:116,324,040...116,328,978
JBrowse link
G Hyal3 hyaluronidase 3 involved_in IEA
IBA
ISO
ISS
GO_REF:0000107
PMID:21873635
(PMID:21699545)
(PMID:12084718)
GO_REF:0000024
(MGI:4834982|PMID:20586096)
Ensembl
RGD
UniProt
PMID:12084718 PMID:20586096 PMID:21699545, PMID:21873635, PMID:21873635 GO_REF:0000024 GO_REF:0000107 MGI:4834982, RGD:13792537, RGD:13792537 NCBI chr 8:116,336,512...116,342,147
Ensembl chr 8:116,336,512...116,342,146
JBrowse link
G Hyal4 hyaluronidase 4 involved_in IBA PMID:21873635 GO_Central PMID:21873635, PMID:21873635 RGD:13792537, RGD:13792537 NCBI chr 4:52,147,641...52,166,276
Ensembl chr 4:52,147,641...52,167,122
JBrowse link
G Hyal5 hyaluronoglucosaminidase 5 involved_in IBA PMID:21873635 GO_Central PMID:21873635, PMID:21873635 RGD:13792537, RGD:13792537 NCBI chr 4:52,232,565...52,319,777
Ensembl chr 4:52,235,811...52,275,936
JBrowse link
G Hyal6 hyaluronoglucosaminidase 6 involved_in IBA PMID:21873635 GO_Central PMID:21873635, PMID:21873635 RGD:13792537, RGD:13792537 NCBI chr 4:52,129,576...52,142,241
Ensembl chr 4:52,129,556...52,142,243
JBrowse link
G Spam1 sperm adhesion molecule 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635, PMID:21873635 RGD:13792537, RGD:13792537 NCBI chr 4:52,194,201...52,204,369
Ensembl chr 4:52,199,416...52,204,425
JBrowse link
G Tgfb1 transforming growth factor, beta 1 involved_in ISO
ISS
(PMID:17324121)
GO_REF:0000024
RGD
UniProt
PMID:17324121 GO_REF:0000024 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
hyaluronan metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07028488.1 IEA GO_REF:0000002 InterPro GO_REF:0000002 Ensembl chr17:72,036,588...72,046,381 JBrowse link
G Akt1 AKT serine/threonine kinase 1 IEP RGD PMID:20097747 RGD:7243103 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Has2 hyaluronan synthase 2 ISO MGI:2176070|MGI:4360705 (MGI:4880794|PMID:21246657) RGD PMID:21246657 MGI:4880794 NCBI chr 7:96,438,046...96,464,049
Ensembl chr 7:96,438,046...96,464,049
JBrowse link
G Hgf hepatocyte growth factor IEP RGD PMID:20097747 RGD:7243103 NCBI chr 4:15,435,460...15,505,377
Ensembl chr 4:15,433,295...15,505,362
JBrowse link
G Hyal1 hyaluronidase 1 involved_in ISO
ISS
(PMID:19478093)
GO_REF:0000024
RGD
UniProt
PMID:19478093 GO_REF:0000024 NCBI chr 8:116,332,834...116,337,522
Ensembl chr 8:116,332,796...116,335,435
JBrowse link
G Il15 interleukin 15 IDA RGD PMID:17667861 RGD:5013835 NCBI chr19:23,542,606...23,624,366
Ensembl chr19:23,542,889...23,554,594
JBrowse link
G Itih1 inter-alpha trypsin inhibitor, heavy chain 1 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr16:7,012,376...7,026,542
Ensembl chr16:7,012,354...7,026,540
JBrowse link
G Itih2 inter-alpha-trypsin inhibitor heavy chain 2 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr17:72,160,734...72,197,248
Ensembl chr17:72,160,735...72,195,509
JBrowse link
G Itih3 inter-alpha trypsin inhibitor, heavy chain 3 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr16:6,983,779...7,007,288
Ensembl chr16:6,992,062...7,007,287
JBrowse link
G Itih4 inter-alpha-trypsin inhibitor heavy chain 4 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr16:6,970,367...6,985,538
Ensembl chr16:6,970,342...6,985,579
JBrowse link
G Kdr kinase insert domain receptor IEP RGD PMID:20097747 RGD:7243103 NCBI chr14:34,727,677...34,787,127
Ensembl chr14:34,727,623...34,787,183
JBrowse link
G Mki67 marker of proliferation Ki-67 IEP RGD PMID:20097747 RGD:7243103 NCBI chr 1:207,993,895...208,020,454
Ensembl chr 1:207,993,895...208,020,454
JBrowse link
G Pim1 Pim-1 proto-oncogene, serine/threonine kinase IEP RGD PMID:20097747 RGD:7243103 NCBI chr20:8,165,423...8,169,557
Ensembl chr20:8,165,307...8,169,555
JBrowse link
G Vegfa vascular endothelial growth factor A IEP RGD PMID:20097747 RGD:7243103 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
keratan sulfate biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chst5 carbohydrate sulfotransferase 5 involved_in ISO
IBA
(PMID:11278593)
PMID:21873635
(MGI:1934540|PMID:11278593)
RGD PMID:11278593, PMID:21873635, PMID:21873635 MGI:1934540, RGD:13792537, RGD:13792537 NCBI chr19:44,115,065...44,136,092
Ensembl chr19:44,115,120...44,135,387
JBrowse link
keratan sulfate catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gns glucosamine (N-acetyl)-6-sulfatase IDA RGD PMID:3161730 RGD:1600571 NCBI chr 7:63,467,027...63,501,054
Ensembl chr 7:63,467,216...63,499,353
JBrowse link
keratan sulfate metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chst1 carbohydrate sulfotransferase 1 involved_in ISO
IBA
(PMID:9405439)
PMID:21873635
RGD PMID:9405439, PMID:21873635, PMID:21873635 RGD:13792537, RGD:13792537 NCBI chr 3:81,441,785...81,512,829
Ensembl chr 3:81,498,022...81,512,807
JBrowse link
negative regulation of hyaluronan biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ap2a1 adaptor related protein complex 2 subunit alpha 1 involved_in ISO (PMID:23509262), (PMID:24251095) RGD PMID:23509262 PMID:24251095 NCBI chr 1:100,896,582...100,926,443
Ensembl chr 1:100,896,947...100,926,335
JBrowse link
G Cltc clathrin heavy chain involved_in ISS
ISO
GO_REF:0000024
(PMID:23509262), (PMID:24251095)
UniProt
RGD
PMID:23509262 PMID:24251095 GO_REF:0000024 NCBI chr10:74,014,560...74,070,578
Ensembl chr10:74,014,562...74,070,266
JBrowse link
G Smpd3 sphingomyelin phosphodiesterase 3 involved_in IEA
ISO
GO_REF:0000107
MGI:1856877 (MGI:5320806|PMID:22383528)
Ensembl
RGD
PMID:22383528 GO_REF:0000107 MGI:5320806 NCBI chr19:38,237,963...38,321,572
Ensembl chr19:38,237,965...38,321,528
JBrowse link
G Tgfb1 transforming growth factor, beta 1 involved_in ISO
ISS
(PMID:17324121)
GO_REF:0000024
RGD
UniProt
PMID:17324121 GO_REF:0000024 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07060833.1 involved_in IBA PMID:21873635 GO_Central PMID:21873635, PMID:21873635 RGD:13792537, RGD:13792537 Ensembl chr 4:96,562,725...96,564,611 JBrowse link
G Bgn biglycan ISO (MGI:3807344|PMID:18757743) RGD PMID:18757743 MGI:3807344 NCBI chr  X:157,319,042...157,331,204
Ensembl chr  X:157,319,046...157,331,204
JBrowse link
G Dcn decorin ISO (MGI:3807344|PMID:18757743) RGD PMID:18757743 MGI:3807344 NCBI chr 7:38,742,250...38,782,282
Ensembl chr 7:38,742,051...38,782,323
JBrowse link
G Egflam EGF-like, fibronectin type III and laminin G domains involved_in IEA
ISO
GO_REF:0000107
(MGI:3807344|PMID:18757743)
Ensembl
RGD
PMID:18757743 GO_REF:0000107 MGI:3807344 NCBI chr 2:56,503,002...56,681,334
Ensembl chr 2:56,502,807...56,679,955
JBrowse link
G Mamdc2 MAM domain containing 2 ISO (MGI:3807344|PMID:18757743) RGD PMID:18757743 MGI:3807344 NCBI chr 1:241,071,110...241,223,798
Ensembl chr 1:241,072,072...241,155,537
JBrowse link
G Ndnf neuron-derived neurotrophic factor ISO (MGI:3807344|PMID:18757743) RGD PMID:18757743 MGI:3807344 NCBI chr 4:96,528,830...96,565,780 JBrowse link
G Prss34 protease, serine, 34 involved_in IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr10:14,656,812...14,658,569
Ensembl chr10:14,656,812...14,658,569
JBrowse link
G Spock2 SPARC/osteonectin, cwcv and kazal like domains proteoglycan 2 ISO (MGI:3807344|PMID:18757743) RGD PMID:18757743 MGI:3807344 NCBI chr20:29,654,926...29,679,927
Ensembl chr20:29,655,226...29,677,926
JBrowse link
G Spock3 SPARC/osteonectin, cwcv and kazal like domains proteoglycan 3 ISO (MGI:3807344|PMID:18757743) RGD PMID:18757743 MGI:3807344 NCBI chr16:28,372,067...28,716,762
Ensembl chr16:28,372,411...28,716,885
JBrowse link
peptidoglycan catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07067422.1 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 Ensembl chr 9:44,576,918...44,586,358 JBrowse link
G LOC100910070 lysozyme g-like protein 1-like involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 9:44,605,306...44,611,810
Ensembl chr 9:44,605,304...44,617,210
JBrowse link
G LOC103693222 lysozyme g-like protein 2 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 9:44,574,626...44,590,028
Ensembl chr 9:44,499,800...44,509,201
JBrowse link
G Lyg1 lysozyme G1 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 9:44,527,596...44,539,320
Ensembl chr 9:44,527,742...44,534,041
JBrowse link
G Lyg2 lysozyme G2 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 9:44,497,508...44,509,921
Ensembl chr 9:44,499,800...44,509,201
JBrowse link
G Pglyrp1 peptidoglycan recognition protein 1 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 1:79,790,879...79,796,064
Ensembl chr 1:79,790,705...79,796,111
JBrowse link
G Pglyrp2 peptidoglycan recognition protein 2 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 7:14,426,481...14,435,987
Ensembl chr 7:14,429,701...14,435,967
JBrowse link
G Pglyrp3 peptidoglycan recognition protein 3 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 2:191,903,626...192,264,872
Ensembl chr 2:192,253,629...192,264,840
JBrowse link
G Pglyrp3b peptidoglycan recognition protein 3b involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 2:191,900,147...191,916,863
Ensembl chr 2:191,900,317...191,915,563
JBrowse link
G Pglyrp4 peptidoglycan recognition protein 4 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 2:190,125,655...190,204,230
Ensembl chr 2:190,125,693...190,148,265
JBrowse link
positive regulation of hyaluronan biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Egf epidermal growth factor involved_in ISO (PMID:17324121) RGD PMID:17324121 NCBI chr 2:68,820,616...68,895,537 JBrowse link
G Has2 hyaluronan synthase 2 IDA
IMP
RGD PMID:12186949, PMID:17080198 RGD:9588629, RGD:9588632 NCBI chr 7:96,438,046...96,464,049
Ensembl chr 7:96,438,046...96,464,049
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 involved_in IEA
ISO
GO_REF:0000107
(PMID:17324121)
Ensembl
RGD
PMID:17324121 GO_REF:0000107 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Pdgfb platelet derived growth factor subunit B involved_in IEA
ISO
ISS
GO_REF:0000107
(PMID:17324121)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:17324121 GO_REF:0000024 GO_REF:0000107 NCBI chr 7:121,215,458...121,233,092
Ensembl chr 7:121,214,628...121,232,741
JBrowse link
G Ptger4 prostaglandin E receptor 4 IMP RGD PMID:17080198 RGD:9588632 NCBI chr 2:54,951,625...54,966,470
Ensembl chr 2:54,952,821...54,963,448
JBrowse link
regulation of hyaluronan biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Smpd3 sphingomyelin phosphodiesterase 3 ISO MGI:1856877 (MGI:5320806|PMID:22383528) RGD PMID:22383528 MGI:5320806 NCBI chr19:38,237,963...38,321,572
Ensembl chr19:38,237,965...38,321,528
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20078
    metabolic process 12140
      organic substance metabolic process 11646
        macromolecule metabolic process 10055
          aminoglycan metabolic process 122
            glycosaminoglycan metabolic process 103
              galactosaminoglycan metabolic process + 0
              glycosaminoglycan biosynthetic process + 49
              glycosaminoglycan catabolic process + 28
              mucopolysaccharide metabolic process + 80
              peptidoglycan metabolic process + 10
paths to the root