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ONTOLOGY REPORT - ANNOTATIONS

Term:heparin metabolic process
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Accession:GO:0030202 term browser browse the term
Definition:The chemical reactions and pathways involving heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells. They are similar to heparan sulfates but are of somewhat higher average Mr (6000-20000) and contain fewer N-acetyl groups and more N-sulfate and O-sulfate groups; they may be attached in the same manner to protein, forming proteoglycans. They consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues.
Synonyms:exact_synonym: heparin metabolism
 related_synonym: heparan sulfate metabolic process

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heparin metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ednra endothelin receptor type A involved_in ISO (PMID:27026367) MGI PMID:27026367 NCBI chrNW_004955428:3,062,303...3,114,761
Ensembl chrNW_004955428:3,062,303...3,114,761 		JBrowse link
G Ednrb endothelin receptor type B involved_in ISO (PMID:27026367) MGI PMID:27026367 NCBI chrNW_004955404:29,394,253...29,425,358
Ensembl chrNW_004955404:29,394,164...29,425,358 		JBrowse link
G Ext1 exostosin glycosyltransferase 1 acts_upstream_of_or_within ISO (PMID:26491162), (PMID:32201365) MGI PMID:26491162 PMID:32201365 NCBI chrNW_004955417:23,798,044...24,067,759
Ensembl chrNW_004955417:23,798,393...24,067,100 		JBrowse link
G Hpse heparanase involved_in ISO (PMID:27026367) MGI PMID:27026367 NCBI chrNW_004955474:6,367,467...6,394,395
Ensembl chrNW_004955474:6,367,467...6,394,395 		JBrowse link
G Hs2st1 heparan sulfate 2-O-sulfotransferase 1 acts_upstream_of_or_within ISO (PMID:11457822) MGI PMID:11457822 NCBI chrNW_004955423:7,090,246...7,253,608
Ensembl chrNW_004955423:7,091,765...7,253,339 		JBrowse link
G Naglu N-acetyl-alpha-glucosaminidase acts_upstream_of_or_within ISO (PMID:12111813), (PMID:25267636), (PMID:29624734) MGI PMID:12111813 PMID:25267636 PMID:29624734 NCBI chrNW_004955451:16,445,338...16,449,243
Ensembl chrNW_004955451:16,445,338...16,450,062 		JBrowse link
heparin biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Angpt1 angiopoietin 1 involved_in ISO (PMID:19297368) UniProt PMID:19297368 NCBI chrNW_004955417:30,199,508...30,386,695
Ensembl chrNW_004955417:30,198,842...30,386,266 		JBrowse link
G Ext1 exostosin glycosyltransferase 1 acts_upstream_of_or_within
acts_upstream_of_or_within_positive_effect		 ISO (PMID:21310272)
(PMID:21148566)
(PMID:10926768), (PMID:15161920), (PMID:15177029), (PMID:18480751)		 MGI PMID:10926768 PMID:15161920 PMID:15177029 PMID:18480751 PMID:21148566 More... NCBI chrNW_004955417:23,798,044...24,067,759
Ensembl chrNW_004955417:23,798,393...24,067,100 		JBrowse link
G Ext2 exostosin glycosyltransferase 2 acts_upstream_of_or_within ISO (PMID:21310272) MGI PMID:21310272 NCBI chrNW_004955422:3,303,948...3,438,381
Ensembl chrNW_004955422:3,304,842...3,447,908 		JBrowse link
G Glce glucuronic acid epimerase involved_in ISO (MGI:2135754|PMID:11279150) UniProt PMID:11279150 MGI:2135754 NCBI chrNW_004955450:7,149,721...7,226,835
Ensembl chrNW_004955450:7,149,721...7,227,524 		JBrowse link
G Slc10a7 solute carrier family 10 member 7 involved_in ISO (PMID:30082715)
(MGI:6198941|PMID:30082715)		 UniProt PMID:30082715 MGI:6198941 NCBI chrNW_004955428:1,999,341...2,250,201
Ensembl chrNW_004955428:1,999,280...2,250,234 		JBrowse link
G Xylt2 xylosyltransferase 2 acts_upstream_of_or_within ISO (PMID:17517600) MGI PMID:17517600 NCBI chrNW_004955451:11,347,254...11,354,489
Ensembl chrNW_004955451:11,344,780...11,354,489 		JBrowse link
heparin catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Idua alpha-L-iduronidase acts_upstream_of_or_within ISO (PMID:21873421)
(PMID:19834056)
(PMID:19751987)		 MGI PMID:19751987 PMID:19834056 PMID:21873421 NCBI chrNW_004955514:474,830...488,007
Ensembl chrNW_004955514:475,731...488,007 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12346
    cellular process 11480
      cellular metabolic process 6295
        sulfur compound metabolic process 230
          heparin metabolic process 12
            heparin biosynthetic process 6
            heparin catabolic process 1
Path 2
Term Annotations click to browse term
  biological_process 12346
    metabolic process 7467
      organic substance metabolic process 7146
        macromolecule metabolic process 6003
          aminoglycan metabolic process 85
            glycosaminoglycan metabolic process 77
              mucopolysaccharide metabolic process 66
                heparin metabolic process 12
                  heparin biosynthetic process 6
                  heparin catabolic process 1
paths to the root