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ONTOLOGY REPORT - ANNOTATIONS


Term:heparin metabolic process
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Accession:GO:0030202 term browser browse the term
Definition:The chemical reactions and pathways involving heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells. They are similar to heparan sulfates but are of somewhat higher average Mr (6000-20000) and contain fewer N-acetyl groups and more N-sulfate and O-sulfate groups; they may be attached in the same manner to protein, forming proteoglycans. They consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues.
Synonyms:exact_synonym: heparin metabolism
 related_synonym: heparan sulfate metabolic process


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heparin metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ext1 exostosin glycosyltransferase 1 acts_upstream_of_or_within ISO (MGI:5704009|PMID:26491162), (MGI:6478099|PMID:32201365) RGD PMID:26491162 PMID:32201365 MGI:5704009 MGI:6478099 NCBI chr 7:92,605,008...92,881,392
Ensembl chr 7:92,605,728...92,882,068
JBrowse link
G Hs2st1 heparan sulfate 2-O-sulfotransferase 1 acts_upstream_of_or_within ISO MGI:1934916 (MGI:2150438|PMID:11457822) RGD PMID:11457822 MGI:2150438 NCBI chr 2:250,467,428...250,600,517
Ensembl chr 2:250,467,429...250,600,517
JBrowse link
heparin biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Angpt1 angiopoietin 1 involved_in ISO
IEA
(PMID:19297368)
GO_REF:0000107
RGD
Ensembl
PMID:19297368 GO_REF:0000107 NCBI chr 7:81,338,327...81,592,459
Ensembl chr 7:81,342,280...81,592,206
JBrowse link
G Ext1 exostosin glycosyltransferase 1 acts_upstream_of_or_within_positive_effect ISO (MGI:1888607|PMID:10926768), (MGI:3050709|PMID:15161920), (MGI:3051956|PMID:15177029), (MGI:4360160|PMID:18480751)
MGI:108050 (MGI:6406739|PMID:21310272), (MGI:6406770|PMID:21148566)
RGD PMID:10926768 PMID:15161920 PMID:15177029 PMID:18480751 PMID:21148566 PMID:21310272 MGI:1888607 MGI:3050709 MGI:3051956 MGI:4360160 MGI:6406739 MGI:6406770 NCBI chr 7:92,605,008...92,881,392
Ensembl chr 7:92,605,728...92,882,068
JBrowse link
G Ext2 exostosin glycosyltransferase 2 acts_upstream_of_or_within ISO MGI:894663 (MGI:6406739|PMID:21310272) RGD PMID:21310272 MGI:6406739 NCBI chr 3:82,602,784...82,734,557
Ensembl chr 3:82,602,785...82,734,533
JBrowse link
G Glce glucuronic acid epimerase involved_in IEA
ISO
GO_REF:0000041
(MGI:2135754|PMID:11279150)
UniProt
RGD
PMID:11279150 GO_REF:0000041 MGI:2135754 NCBI chr 8:67,006,588...67,073,723
Ensembl chr 8:67,006,592...67,040,005
JBrowse link
G Ndst1 N-deacetylase and N-sulfotransferase 1 involved_in IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr18:55,951,497...56,014,107
Ensembl chr18:55,955,389...55,992,885
JBrowse link
G Ndst2 N-deacetylase and N-sulfotransferase 2 involved_in IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr15:3,995,797...4,006,491
Ensembl chr15:3,996,048...4,006,491
Ensembl chr15:3,996,048...4,006,491
JBrowse link
G Ndst3 N-deacetylase and N-sulfotransferase 3 involved_in IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 2:227,736,491...227,903,657
Ensembl chr 2:227,738,650...227,890,077
JBrowse link
G Ndst4 N-deacetylase and N-sulfotransferase 4 involved_in IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 2:229,170,781...229,496,732
Ensembl chr 2:229,196,616...229,496,516
JBrowse link
G Slc10a7 solute carrier family 10, member 7 involved_in ISO (PMID:30082715)
(MGI:6198941|PMID:30082715)
RGD PMID:30082715 MGI:6198941 NCBI chr19:32,857,984...33,081,359
Ensembl chr19:32,855,343...33,080,998
JBrowse link
G Xylt2 xylosyltransferase 2 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:3714171 (MGI:3713963|PMID:17517600)
Ensembl
RGD
PMID:17517600 GO_REF:0000107 MGI:3713963 NCBI chr10:82,386,003...82,399,485
Ensembl chr10:82,386,005...82,399,485
JBrowse link
heparin catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Idua alpha-L-iduronidase acts_upstream_of_or_within ISO MGI:2176236|MGI:4415188 (MGI:4397742|PMID:19834056), (MGI:4414887|PMID:19751987), (MGI:5295514|PMID:21873421)
(PMID:21873421)
RGD PMID:19751987 PMID:19834056 PMID:21873421 MGI:4397742 MGI:4414887 MGI:5295514 NCBI chr14:2,041,828...2,056,762
Ensembl chr14:2,042,411...2,056,762
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19491
    metabolic process 11797
      cellular metabolic process 10755
        sulfur compound metabolic process 325
          heparin metabolic process 12
            heparin biosynthetic process 10
            heparin catabolic process 1
Path 2
Term Annotations click to browse term
  biological_process 19491
    metabolic process 11797
      organic substance metabolic process 11337
        macromolecule metabolic process 9793
          aminoglycan metabolic process 108
            glycosaminoglycan metabolic process 93
              mucopolysaccharide metabolic process 73
                heparin metabolic process 12
                  heparin biosynthetic process 10
                  heparin catabolic process 1
paths to the root