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ONTOLOGY REPORT - ANNOTATIONS


Term:proteoglycan biosynthetic process
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Accession:GO:0030166 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans.
Synonyms:exact_synonym: proteoglycan anabolism;   proteoglycan biosynthesis;   proteoglycan formation;   proteoglycan synthesis


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proteoglycan biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acan aggrecan acts_upstream_of_or_within ISO (MGI:2664273|PMID:3070812) MGI PMID:3070812 MGI:2664273 NCBI chrNW_004936483:14,811,152...14,846,305 JBrowse link
G B3galt6 beta-1,3-galactosyltransferase 6 involved_in ISO (PMID:29443383) UniProt PMID:29443383 NCBI chrNW_004936737:1,887,250...1,889,055 JBrowse link
G Cant1 calcium activated nucleotidase 1 involved_in ISO (PMID:22539336) UniProt PMID:22539336 NCBI chrNW_004936594:3,318,460...3,325,677 JBrowse link
G Chst8 carbohydrate sulfotransferase 8 involved_in
acts_upstream_of_or_within
ISO (PMID:10988300)
(MGI:1928003|PMID:10988300)
UniProt
MGI
PMID:10988300 MGI:1928003 NCBI chrNW_004936570:2,125,111...2,242,172 JBrowse link
G Csgalnact2 chondroitin sulfate N-acetylgalactosaminyltransferase 2 involved_in ISO (PMID:11788602) UniProt PMID:11788602 NCBI chrNW_004936617:2,990,040...3,028,392 JBrowse link
G Ext1 exostosin glycosyltransferase 1 acts_upstream_of_or_within ISO (MGI:4946896|PMID:21185280) MGI PMID:21185280 MGI:4946896 NCBI chrNW_004936470:28,303,213...28,566,470 JBrowse link
G Foxl1 forkhead box L1 acts_upstream_of_or_within ISO (MGI:2153304|PMID:11555641) MGI PMID:11555641 MGI:2153304 NCBI chrNW_004936641:2,226,489...2,227,613 JBrowse link
G Igf1 insulin like growth factor 1 involved_in ISO (PMID:9564845)
(PMID:12746903)
AgBase
BHF-UCL
PMID:9564845 PMID:12746903 NCBI chrNW_004936492:11,709,623...11,784,028 JBrowse link
G Xylt1 xylosyltransferase 1 involved_in ISO (PMID:11087729) RGD
UniProt
PMID:11087729 PMID:19001053 RGD:2313142 NCBI chrNW_004936501:4,164,714...4,337,604 JBrowse link
G Xylt2 xylosyltransferase 2 acts_upstream_of_or_within ISO (MGI:3713963|PMID:17517600) MGI PMID:17517600 MGI:3713963 NCBI chrNW_004936490:11,327,654...11,340,417 JBrowse link
chondroitin sulfate biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chpf chondroitin polymerizing factor involved_in
acts_upstream_of_or_within
ISO (PMID:12761225)
(MGI:5462280|PMID:22952873)
(MGI:5462286|PMID:22952769)
FlyBase
MGI
PMID:12761225 PMID:22952769 PMID:22952873 MGI:5462280 MGI:5462286 NCBI chrNW_004936569:1,918,999...1,923,735 JBrowse link
G Chst11 carbohydrate sulfotransferase 11 involved_in
acts_upstream_of_or_within
ISO (PMID:11056388)
(MGI:4941099|PMID:21138417)
(MGI:1354846|PMID:10722746)
UniProt
MGI
PMID:10722746 PMID:11056388 PMID:21138417 MGI:1354846 MGI:4941099 NCBI chrNW_004936492:9,886,269...10,092,725 JBrowse link
G Chst12 carbohydrate sulfotransferase 12 involved_in ISO (PMID:10781601) UniProt PMID:10781601 NCBI chrNW_004936823:187,920...210,818 JBrowse link
G Chst3 carbohydrate sulfotransferase 3 involved_in
acts_upstream_of_or_within
ISO (PMID:9883891)
(MGI:1206144|PMID:9597547)
(MGI:2156294|PMID:11696535)
UniProt
MGI
PMID:9597547 PMID:9883891 PMID:11696535 MGI:1206144 MGI:2156294 NCBI chrNW_004936521:6,864,456...6,900,122 JBrowse link
G Chst7 carbohydrate sulfotransferase 7 involved_in ISO (PMID:10781596) UniProt PMID:10781596 NCBI chrNW_004936502:12,426,821...12,446,127 JBrowse link
G Chsy1 chondroitin sulfate synthase 1 acts_upstream_of_or_within ISO (MGI:5462286|PMID:22952769)
(PMID:11514575)
MGI PMID:11514575 PMID:22952769 MGI:5462286 NCBI chrNW_004936483:2,613,820...2,685,986 JBrowse link
G Csgalnact1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 involved_in ISO (PMID:11514575), (PMID:12163485) UniProt PMID:11514575 PMID:12163485 NCBI chrNW_004936555:3,639,459...3,807,483 JBrowse link
G Slc35d1 solute carrier family 35 member D1 acts_upstream_of_or_within ISO (MGI:3771453|PMID:17952091) MGI PMID:17952091 MGI:3771453 NCBI chrNW_004936591:4,519,136...4,574,925 JBrowse link
G Ugdh UDP-glucose 6-dehydrogenase involved_in ISO (MGI:2675908|PMID:14505572) UniProt PMID:14505572 MGI:2675908 NCBI chrNW_004936482:7,090,241...7,118,315 JBrowse link
G Xylt1 xylosyltransferase 1 involved_in ISO (MGI:5544658|PMID:24161523) UniProt PMID:24161523 MGI:5544658 NCBI chrNW_004936501:4,164,714...4,337,604 JBrowse link
chondroitin sulfate proteoglycan biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G B3gat3 beta-1,3-glucuronyltransferase 3 involved_in
acts_upstream_of_or_within
ISO (PMID:25893793)
(PMID:21763480)
UniProt
MGI
PMID:21763480 PMID:25893793 NCBI chrNW_004936581:636,648...642,138 JBrowse link
G Csgalnact2 chondroitin sulfate N-acetylgalactosaminyltransferase 2 involved_in
acts_upstream_of_or_within
ISO (PMID:11788602)
(MGI:4941099|PMID:21138417)
UniProt
MGI
PMID:11788602 PMID:21138417 MGI:4941099 NCBI chrNW_004936617:2,990,040...3,028,392 JBrowse link
G Cytl1 cytokine like 1 acts_upstream_of_or_within ISO (MGI:3758399|PMID:17644814) MGI PMID:17644814 MGI:3758399 NCBI chrNW_004936477:17,508,833...17,512,608 JBrowse link
G Igf1 insulin like growth factor 1 acts_upstream_of_or_within ISO (MGI:3758399|PMID:17644814) MGI PMID:17644814 MGI:3758399 NCBI chrNW_004936492:11,709,623...11,784,028 JBrowse link
G Pxylp1 2-phosphoxylose phosphatase 1 involved_in ISO (PMID:24425863) UniProt PMID:24425863 NCBI chrNW_004936540:3,075,618...3,133,554 JBrowse link
G Xylt1 xylosyltransferase 1 involved_in ISO (PMID:17189265) UniProt PMID:17189265 NCBI chrNW_004936501:4,164,714...4,337,604 JBrowse link
G Xylt2 xylosyltransferase 2 involved_in ISO (PMID:17189265), (PMID:26027496) UniProt PMID:17189265 PMID:26027496 NCBI chrNW_004936490:11,327,654...11,340,417 JBrowse link
chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Csgalnact1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 involved_in ISO (PMID:12163485) UniProt PMID:12163485 NCBI chrNW_004936555:3,639,459...3,807,483 JBrowse link
dermatan sulfate biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chst12 carbohydrate sulfotransferase 12 involved_in ISO (PMID:10781601) UniProt PMID:10781601 NCBI chrNW_004936823:187,920...210,818 JBrowse link
G Chst14 carbohydrate sulfotransferase 14 acts_upstream_of_or_within ISO (PMID:11470797) MGI PMID:11470797 NCBI chrNW_004936471:3,930,167...3,932,356 JBrowse link
G Dse dermatan sulfate epimerase involved_in ISO (PMID:16505484) UniProt PMID:16505484 NCBI chrNW_004936824:957,783...995,465 JBrowse link
dermatan sulfate proteoglycan biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G B3gat3 beta-1,3-glucuronyltransferase 3 involved_in
acts_upstream_of_or_within
ISO (PMID:25893793)
(PMID:21763480)
UniProt
MGI
PMID:21763480 PMID:25893793 NCBI chrNW_004936581:636,648...642,138 JBrowse link
G Csgalnact2 chondroitin sulfate N-acetylgalactosaminyltransferase 2 involved_in ISO (PMID:11788602) UniProt PMID:11788602 NCBI chrNW_004936617:2,990,040...3,028,392 JBrowse link
heparan sulfate proteoglycan biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G B3gat3 beta-1,3-glucuronyltransferase 3 involved_in
acts_upstream_of_or_within
ISO (PMID:25893793)
(PMID:21763480)
UniProt
MGI
PMID:21763480 PMID:25893793 NCBI chrNW_004936581:636,648...642,138 JBrowse link
G Ext1 exostosin glycosyltransferase 1 involved_in
acts_upstream_of_or_within
ISO (PMID:10639137), (PMID:9620772)
(MGI:3687782|PMID:10639137)
(MGI:4431165|PMID:20080592)
BHF-UCL
UniProt
MGI
PMID:9620772 PMID:10639137 PMID:20080592 MGI:3687782 MGI:4431165 NCBI chrNW_004936470:28,303,213...28,566,470 JBrowse link
G Ext2 exostosin glycosyltransferase 2 involved_in
acts_upstream_of_or_within
ISO (PMID:17761672)
(MGI:3608483|PMID:16236767)
BHF-UCL
MGI
PMID:16236767 PMID:17761672 MGI:3608483 NCBI chrNW_004936562:4,345,146...4,489,180 JBrowse link
G Extl3 exostosin like glycosyltransferase 3 involved_in ISO (PMID:28132690), (PMID:28148688) UniProt PMID:28132690 PMID:28148688 NCBI chrNW_004936675:1,448,381...1,479,735 JBrowse link
G Glce glucuronic acid epimerase involved_in ISO (PMID:20118238), (PMID:30872481)
(MGI:2135754|PMID:11279150)
UniProt PMID:11279150 PMID:20118238 PMID:30872481 MGI:2135754 NCBI chrNW_004936471:28,984,777...29,035,878 JBrowse link
G Hs6st1 heparan sulfate 6-O-sulfotransferase 1 acts_upstream_of_or_within ISO (MGI:3715036|PMID:17405882) MGI PMID:17405882 MGI:3715036 NCBI chrNW_004936469:43,039,494...43,086,041 JBrowse link
G Lipc lipase C, hepatic type ISO RGD PMID:15102889 RGD:1580511 NCBI chrNW_004936471:19,604,083...19,733,721 JBrowse link
G LOC101971473 N-deacetylase and N-sulfotransferase 3 involved_in ISO (PMID:9915799) UniProt PMID:9915799 NCBI chrNW_004936932:259,847...414,472 JBrowse link
G Ndst1 N-deacetylase and N-sulfotransferase 1 involved_in ISO PMID:9915799 UniProt PMID:9915799 RGD:12907548 NCBI chrNW_004936504:4,413,549...4,495,933 JBrowse link
G Ndst2 N-deacetylase and N-sulfotransferase 2 acts_upstream_of_or_within ISO (MGI:1343737|PMID:10466727) MGI PMID:10466727 MGI:1343737 NCBI chrNW_004936521:5,336,658...5,346,704 JBrowse link
G Ugdh UDP-glucose 6-dehydrogenase involved_in ISO (MGI:2675908|PMID:14505572) UniProt PMID:14505572 MGI:2675908 NCBI chrNW_004936482:7,090,241...7,118,315 JBrowse link
G Vangl2 VANGL planar cell polarity protein 2 acts_upstream_of_or_within ISO (MGI:5498591|PMID:23760952) MGI PMID:23760952 MGI:5498591 NCBI chrNW_004936740:228,377...242,318 JBrowse link
G Xylt1 xylosyltransferase 1 involved_in ISO (PMID:17189265) UniProt PMID:17189265 NCBI chrNW_004936501:4,164,714...4,337,604 JBrowse link
G Xylt2 xylosyltransferase 2 involved_in ISO (PMID:17189265), (PMID:26027496) UniProt PMID:17189265 PMID:26027496 NCBI chrNW_004936490:11,327,654...11,340,417 JBrowse link
heparan sulfate proteoglycan biosynthetic process, enzymatic modification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hs3st5 heparan sulfate-glucosamine 3-sulfotransferase 5 involved_in ISO (PMID:12138164) UniProt PMID:12138164 NCBI chrNW_004936679:2,540,894...2,737,462 JBrowse link
G Hs6st1 heparan sulfate 6-O-sulfotransferase 1 acts_upstream_of_or_within ISO (MGI:1353793|PMID:10644753) MGI PMID:10644753 MGI:1353793 NCBI chrNW_004936469:43,039,494...43,086,041 JBrowse link
G Hs6st2 heparan sulfate 6-O-sulfotransferase 2 acts_upstream_of_or_within ISO (MGI:1353793|PMID:10644753) MGI PMID:10644753 MGI:1353793 NCBI chrNW_004936691:1,976,449...2,257,303 JBrowse link
G Hs6st3 heparan sulfate 6-O-sulfotransferase 3 acts_upstream_of_or_within ISO (MGI:1353793|PMID:10644753) MGI PMID:10644753 MGI:1353793 NCBI chrNW_004936472:13,157,669...13,811,747 JBrowse link
heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ext1 exostosin glycosyltransferase 1 involved_in ISO (PMID:17761672) BHF-UCL PMID:17761672 NCBI chrNW_004936470:28,303,213...28,566,470 JBrowse link
G Ext2 exostosin glycosyltransferase 2 involved_in ISO (PMID:17761672) BHF-UCL PMID:17761672 NCBI chrNW_004936562:4,345,146...4,489,180 JBrowse link
G Hs2st1 heparan sulfate 2-O-sulfotransferase 1 acts_upstream_of_or_within ISO (MGI:2150438|PMID:11457822) MGI PMID:11457822 MGI:2150438 NCBI chrNW_004936732:1,773,043...1,947,081 JBrowse link
G LOC101971473 N-deacetylase and N-sulfotransferase 3 involved_in ISO (PMID:9915799) UniProt PMID:9915799 NCBI chrNW_004936932:259,847...414,472 JBrowse link
negative regulation of proteoglycan biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc2a10 solute carrier family 2 member 10 acts_upstream_of_or_within ISO (PMID:16550171) ARUK-UCL PMID:16550171 NCBI chrNW_004936514:6,490,728...6,504,152 JBrowse link
positive regulation of heparan sulfate proteoglycan biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ctnnb1 catenin beta 1 involved_in ISO (PMID:15853773) BHF-UCL PMID:15853773 NCBI chrNW_004936473:29,999,542...30,034,610 JBrowse link
G Pxylp1 2-phosphoxylose phosphatase 1 involved_in ISO (PMID:24425863) UniProt PMID:24425863 NCBI chrNW_004936540:3,075,618...3,133,554 JBrowse link
G Tcf7l2 transcription factor 7 like 2 involved_in ISO (PMID:15853773) BHF-UCL PMID:15853773 NCBI chrNW_004936486:3,473,877...3,660,565 JBrowse link
positive regulation of proteoglycan biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mustn1 musculoskeletal, embryonic nuclear protein 1 acts_upstream_of_or_within ISO (MGI:5703727|PMID:19410023) MGI PMID:19410023 MGI:5703727 NCBI chrNW_004936473:3,592,259...3,594,717 JBrowse link
G Slc2a10 solute carrier family 2 member 10 acts_upstream_of_or_within ISO (PMID:16550171) ARUK-UCL PMID:16550171 NCBI chrNW_004936514:6,490,728...6,504,152 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12130
    metabolic process 7626
      primary metabolic process 6743
        protein metabolic process 3766
          glycoprotein metabolic process 256
            proteoglycan metabolic process 63
              proteoglycan biosynthetic process 41
                chondroitin sulfate proteoglycan biosynthetic process + 16
                dermatan sulfate proteoglycan biosynthetic process + 5
                heparan sulfate proteoglycan biosynthetic process + 21
                negative regulation of proteoglycan biosynthetic process 1
                positive regulation of proteoglycan biosynthetic process + 5
Path 2
Term Annotations click to browse term
  biological_process 12130
    metabolic process 7626
      organic substance metabolic process 7353
        organic substance biosynthetic process 3894
          macromolecule biosynthetic process 3194
            cellular macromolecule biosynthetic process 3155
              glycoprotein biosynthetic process 200
                proteoglycan biosynthetic process 41
                  chondroitin sulfate proteoglycan biosynthetic process + 16
                  dermatan sulfate proteoglycan biosynthetic process + 5
                  heparan sulfate proteoglycan biosynthetic process + 21
                  negative regulation of proteoglycan biosynthetic process 1
                  positive regulation of proteoglycan biosynthetic process + 5
paths to the root