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ONTOLOGY REPORT - ANNOTATIONS


Term:proteoglycan biosynthetic process
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Accession:GO:0030166 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans.
Synonyms:exact_synonym: proteoglycan anabolism;   proteoglycan biosynthesis;   proteoglycan formation;   proteoglycan synthesis


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proteoglycan biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACAN aggrecan acts_upstream_of_or_within ISO (MGI:2664273|PMID:3070812) MGI PMID:3070812 MGI:2664273 NCBI chr15:67,492,494...67,563,265
Ensembl chr15:86,733,853...86,771,420
JBrowse link
G B3GALT6 beta-1,3-galactosyltransferase 6 involved_in ISO (PMID:29443383) UniProt PMID:29443383
G CANT1 calcium activated nucleotidase 1 involved_in ISO (PMID:22539336) UniProt PMID:22539336 NCBI chr17:73,068,196...73,086,900
Ensembl chr17:78,614,244...78,618,317
JBrowse link
G CHST8 carbohydrate sulfotransferase 8 involved_in
acts_upstream_of_or_within
ISO (PMID:10988300)
(MGI:1928003|PMID:10988300)
UniProt
MGI
PMID:10988300 MGI:1928003 NCBI chr19:30,549,667...30,705,452
Ensembl chr19:39,354,974...39,445,592
JBrowse link
G CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2 involved_in ISO (PMID:11788602) UniProt PMID:11788602 NCBI chr10:40,111,714...40,159,683
Ensembl chr10:43,311,054...43,342,855
JBrowse link
G EXT1 exostosin glycosyltransferase 1 acts_upstream_of_or_within ISO (MGI:4946896|PMID:21185280) MGI PMID:21185280 MGI:4946896 NCBI chr 8:114,489,325...114,803,763
Ensembl chr 8:117,011,919...117,324,851
JBrowse link
G FOXL1 forkhead box L1 acts_upstream_of_or_within ISO (MGI:2153304|PMID:11555641) MGI PMID:11555641 MGI:2153304 NCBI chr16:67,249,157...67,252,278 JBrowse link
G IGF1 insulin like growth factor 1 involved_in ISO (PMID:9564845)
(PMID:12746903)
AgBase
BHF-UCL
PMID:9564845 PMID:12746903 NCBI chr12:99,986,887...100,066,773
Ensembl chr12:103,385,911...103,462,177
JBrowse link
G XYLT1 xylosyltransferase 1 involved_in ISO (PMID:11087729) RGD
UniProt
PMID:11087729 PMID:19001053 RGD:2313142 NCBI chr16:20,078,904...20,447,268
Ensembl chr16:17,222,447...17,470,818
JBrowse link
G XYLT2 xylosyltransferase 2 acts_upstream_of_or_within ISO (MGI:3713963|PMID:17517600) MGI PMID:17517600 MGI:3713963 NCBI chr17:44,440,428...44,455,530
Ensembl chr17:49,315,250...49,331,654
JBrowse link
chondroitin sulfate biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CHPF chondroitin polymerizing factor involved_in
acts_upstream_of_or_within
ISO (PMID:12761225)
(MGI:5462280|PMID:22952873)
(MGI:5462286|PMID:22952769)
FlyBase
MGI
PMID:12761225 PMID:22952769 PMID:22952873 MGI:5462280 MGI:5462286 NCBI chr2B:106,796,215...106,801,081
Ensembl chr2B:225,386,262...225,390,886
JBrowse link
G CHST11 carbohydrate sulfotransferase 11 involved_in
acts_upstream_of_or_within
ISO (PMID:11056388)
(MGI:1354846|PMID:10722746)
(MGI:4941099|PMID:21138417)
UniProt
MGI
PMID:10722746 PMID:11056388 PMID:21138417 MGI:1354846 MGI:4941099 NCBI chr12:102,035,480...102,340,084
Ensembl chr12:105,431,075...105,731,172
JBrowse link
G CHST12 carbohydrate sulfotransferase 12 involved_in ISO (PMID:10781601) UniProt PMID:10781601 NCBI chr 7:2,666,062...2,697,292
Ensembl chr 7:2,792,210...2,793,454
JBrowse link
G CHST13 carbohydrate sulfotransferase 13 involved_in ISO (PMID:12080076) UniProt PMID:12080076 NCBI chr 3:123,569,493...123,592,816
Ensembl chr 3:130,889,157...130,907,762
JBrowse link
G CHST3 carbohydrate sulfotransferase 3 involved_in
acts_upstream_of_or_within
ISO (PMID:9883891)
(MGI:2156294|PMID:11696535)
(MGI:1206144|PMID:9597547)
UniProt
MGI
PMID:9597547 PMID:9883891 PMID:11696535 MGI:1206144 MGI:2156294 NCBI chr10:68,427,305...68,476,512
Ensembl chr10:70,951,190...70,994,936
JBrowse link
G CHST7 carbohydrate sulfotransferase 7 involved_in ISO (PMID:10781596) UniProt PMID:10781596 NCBI chr  X:39,012,011...39,036,655
Ensembl chr  X:46,873,942...46,875,436
JBrowse link
G CHSY1 chondroitin sulfate synthase 1 acts_upstream_of_or_within ISO (MGI:5462286|PMID:22952769)
(PMID:11514575)
MGI PMID:11514575 PMID:22952769 MGI:5462286 NCBI chr15:79,901,340...79,976,067
Ensembl chr15:99,186,705...99,260,591
JBrowse link
G CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 involved_in ISO (PMID:11514575), (PMID:12163485) UniProt PMID:11514575 PMID:12163485 NCBI chr 8:18,626,998...18,980,416
Ensembl chr 8:15,576,416...15,904,123
JBrowse link
G SLC35D1 solute carrier family 35 member D1 acts_upstream_of_or_within ISO (MGI:3771453|PMID:17952091) MGI PMID:17952091 MGI:3771453 NCBI chr 1:66,248,462...66,303,630
Ensembl chr 1:68,134,617...68,188,694
JBrowse link
G UGDH UDP-glucose 6-dehydrogenase involved_in ISO (MGI:2675908|PMID:14505572) UniProt PMID:14505572 MGI:2675908 NCBI chr 4:33,827,532...33,856,204
Ensembl chr 4:39,681,300...39,708,215
JBrowse link
G XYLT1 xylosyltransferase 1 involved_in ISO (MGI:5544658|PMID:24161523) UniProt PMID:24161523 MGI:5544658 NCBI chr16:20,078,904...20,447,268
Ensembl chr16:17,222,447...17,470,818
JBrowse link
chondroitin sulfate proteoglycan biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G B3GAT3 beta-1,3-glucuronyltransferase 3 involved_in
acts_upstream_of_or_within
ISO (PMID:25893793)
(PMID:21763480)
UniProt
MGI
PMID:21763480 PMID:25893793 NCBI chr11:57,972,509...57,979,702
Ensembl chr11:61,327,454...61,332,323
JBrowse link
G CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2 involved_in
acts_upstream_of_or_within
ISO (PMID:11788602)
(MGI:4941099|PMID:21138417)
UniProt
MGI
PMID:11788602 PMID:21138417 MGI:4941099 NCBI chr10:40,111,714...40,159,683
Ensembl chr10:43,311,054...43,342,855
JBrowse link
G CYTL1 cytokine like 1 acts_upstream_of_or_within ISO (MGI:3758399|PMID:17644814) MGI PMID:17644814 MGI:3758399 Ensembl chr 4:5,092,144...5,098,092 JBrowse link
G IGF1 insulin like growth factor 1 acts_upstream_of_or_within ISO (MGI:3758399|PMID:17644814) MGI PMID:17644814 MGI:3758399 NCBI chr12:99,986,887...100,066,773
Ensembl chr12:103,385,911...103,462,177
JBrowse link
G PXYLP1 2-phosphoxylose phosphatase 1 involved_in ISO (PMID:24425863) UniProt PMID:24425863 NCBI chr 3:138,264,529...138,327,615
Ensembl chr 3:145,864,356...145,925,073
JBrowse link
G XYLT1 xylosyltransferase 1 involved_in ISO (PMID:17189265) UniProt PMID:17189265 NCBI chr16:20,078,904...20,447,268
Ensembl chr16:17,222,447...17,470,818
JBrowse link
G XYLT2 xylosyltransferase 2 involved_in ISO (PMID:17189265), (PMID:26027496) UniProt PMID:17189265 PMID:26027496 NCBI chr17:44,440,428...44,455,530
Ensembl chr17:49,315,250...49,331,654
JBrowse link
chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 involved_in ISO (PMID:12163485) UniProt PMID:12163485 NCBI chr 8:18,626,998...18,980,416
Ensembl chr 8:15,576,416...15,904,123
JBrowse link
dermatan sulfate biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CHST12 carbohydrate sulfotransferase 12 involved_in ISO (PMID:10781601) UniProt PMID:10781601 NCBI chr 7:2,666,062...2,697,292
Ensembl chr 7:2,792,210...2,793,454
JBrowse link
G CHST14 carbohydrate sulfotransferase 14 acts_upstream_of_or_within ISO (PMID:11470797) MGI PMID:11470797 NCBI chr15:19,407,477...19,409,645
Ensembl chr15:37,660,621...37,661,622
JBrowse link
G DSE dermatan sulfate epimerase involved_in ISO (PMID:16505484) UniProt PMID:16505484 NCBI chr 6:114,173,641...114,246,129 JBrowse link
dermatan sulfate proteoglycan biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G B3GAT3 beta-1,3-glucuronyltransferase 3 involved_in
acts_upstream_of_or_within
ISO (PMID:25893793)
(PMID:21763480)
UniProt
MGI
PMID:21763480 PMID:25893793 NCBI chr11:57,972,509...57,979,702
Ensembl chr11:61,327,454...61,332,323
JBrowse link
G CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2 involved_in ISO (PMID:11788602) UniProt PMID:11788602 NCBI chr10:40,111,714...40,159,683
Ensembl chr10:43,311,054...43,342,855
JBrowse link
heparan sulfate proteoglycan biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G B3GAT3 beta-1,3-glucuronyltransferase 3 involved_in
acts_upstream_of_or_within
ISO (PMID:25893793)
(PMID:21763480)
UniProt
MGI
PMID:21763480 PMID:25893793 NCBI chr11:57,972,509...57,979,702
Ensembl chr11:61,327,454...61,332,323
JBrowse link
G EXT1 exostosin glycosyltransferase 1 involved_in
acts_upstream_of_or_within
ISO (PMID:10639137), (PMID:9620772)
(MGI:4431165|PMID:20080592)
(MGI:3687782|PMID:10639137)
BHF-UCL
MGI
UniProt
PMID:9620772 PMID:10639137 PMID:20080592 MGI:3687782 MGI:4431165 NCBI chr 8:114,489,325...114,803,763
Ensembl chr 8:117,011,919...117,324,851
JBrowse link
G EXT2 exostosin glycosyltransferase 2 involved_in
acts_upstream_of_or_within
ISO (PMID:17761672)
(MGI:3608483|PMID:16236767)
BHF-UCL
MGI
PMID:16236767 PMID:17761672 MGI:3608483 NCBI chr11:44,055,670...44,204,055
Ensembl chr11:44,522,797...44,699,447
JBrowse link
G EXTL3 exostosin like glycosyltransferase 3 involved_in ISO (PMID:28132690), (PMID:28148688) UniProt PMID:28132690 PMID:28148688 NCBI chr 8:27,983,700...28,035,879
Ensembl chr 8:25,174,414...25,233,599
JBrowse link
G GLCE glucuronic acid epimerase involved_in ISO (PMID:20118238), (PMID:30872481)
(MGI:2135754|PMID:11279150)
UniProt PMID:11279150 PMID:20118238 PMID:30872481 MGI:2135754 NCBI chr15:48,110,725...48,222,251
Ensembl chr15:66,979,271...66,995,646
JBrowse link
G HS6ST1 heparan sulfate 6-O-sulfotransferase 1 acts_upstream_of_or_within ISO (MGI:3715036|PMID:17405882) MGI PMID:17405882 MGI:3715036 NCBI chr2B:31,949,260...32,002,848 JBrowse link
G LIPC lipase C, hepatic type ISO RGD PMID:15102889 RGD:1580511 NCBI chr15:37,363,507...37,537,723
Ensembl chr15:55,814,017...55,847,005
JBrowse link
G NDST1 N-deacetylase and N-sulfotransferase 1 involved_in ISO PMID:9915799 UniProt PMID:9915799 RGD:12907548 NCBI chr 5:145,910,993...145,982,933
Ensembl chr 5:151,936,357...151,986,668
JBrowse link
G NDST2 N-deacetylase and N-sulfotransferase 2 acts_upstream_of_or_within ISO (MGI:1343737|PMID:10466727) MGI PMID:10466727 MGI:1343737 NCBI chr10:70,324,842...70,335,169 JBrowse link
G NDST3 N-deacetylase and N-sulfotransferase 3 involved_in ISO (PMID:9915799) UniProt PMID:9915799 NCBI chr 4:110,476,743...110,705,030
Ensembl chr 4:121,031,051...121,259,594
JBrowse link
G UGDH UDP-glucose 6-dehydrogenase involved_in ISO (MGI:2675908|PMID:14505572) UniProt PMID:14505572 MGI:2675908 NCBI chr 4:33,827,532...33,856,204
Ensembl chr 4:39,681,300...39,708,215
JBrowse link
G VANGL2 VANGL planar cell polarity protein 2 acts_upstream_of_or_within ISO (MGI:5498591|PMID:23760952) MGI PMID:23760952 MGI:5498591 NCBI chr 1:135,754,897...135,783,031
Ensembl chr 1:139,683,745...139,704,281
JBrowse link
G XYLT1 xylosyltransferase 1 involved_in ISO (PMID:17189265) UniProt PMID:17189265 NCBI chr16:20,078,904...20,447,268
Ensembl chr16:17,222,447...17,470,818
JBrowse link
G XYLT2 xylosyltransferase 2 involved_in ISO (PMID:17189265), (PMID:26027496) UniProt PMID:17189265 PMID:26027496 NCBI chr17:44,440,428...44,455,530
Ensembl chr17:49,315,250...49,331,654
JBrowse link
heparan sulfate proteoglycan biosynthetic process, enzymatic modification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HS3ST5 heparan sulfate-glucosamine 3-sulfotransferase 5 involved_in ISO (PMID:12138164) UniProt PMID:12138164 NCBI chr 6:111,846,143...112,132,706
Ensembl chr 6:115,917,004...116,089,942
JBrowse link
G HS6ST1 heparan sulfate 6-O-sulfotransferase 1 acts_upstream_of_or_within ISO (MGI:1353793|PMID:10644753) MGI PMID:10644753 MGI:1353793 NCBI chr2B:31,949,260...32,002,848 JBrowse link
G HS6ST2 heparan sulfate 6-O-sulfotransferase 2 acts_upstream_of_or_within ISO (MGI:1353793|PMID:10644753) MGI PMID:10644753 MGI:1353793 NCBI chr  X:121,757,028...122,090,371
Ensembl chr  X:132,065,614...132,395,772
JBrowse link
G HS6ST3 heparan sulfate 6-O-sulfotransferase 3 acts_upstream_of_or_within ISO (MGI:1353793|PMID:10644753) MGI PMID:10644753 MGI:1353793 NCBI chr13:77,256,399...77,998,022
Ensembl chr13:96,414,409...97,148,398
JBrowse link
heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EXT1 exostosin glycosyltransferase 1 involved_in ISO (PMID:17761672) BHF-UCL PMID:17761672 NCBI chr 8:114,489,325...114,803,763
Ensembl chr 8:117,011,919...117,324,851
JBrowse link
G EXT2 exostosin glycosyltransferase 2 involved_in ISO (PMID:17761672) BHF-UCL PMID:17761672 NCBI chr11:44,055,670...44,204,055
Ensembl chr11:44,522,797...44,699,447
JBrowse link
G HS2ST1 heparan sulfate 2-O-sulfotransferase 1 acts_upstream_of_or_within ISO (MGI:2150438|PMID:11457822) MGI PMID:11457822 MGI:2150438 NCBI chr 1:119,432,583...119,630,472
Ensembl chr 1:88,283,872...88,475,198
JBrowse link
G NDST3 N-deacetylase and N-sulfotransferase 3 involved_in ISO (PMID:9915799) UniProt PMID:9915799 NCBI chr 4:110,476,743...110,705,030
Ensembl chr 4:121,031,051...121,259,594
JBrowse link
negative regulation of proteoglycan biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLC2A10 solute carrier family 2 member 10 acts_upstream_of_or_within ISO (PMID:16550171) ARUK-UCL PMID:16550171 NCBI chr20:43,043,801...43,068,304
Ensembl chr20:44,128,837...44,153,148
JBrowse link
positive regulation of heparan sulfate proteoglycan biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CTNNB1 catenin beta 1 involved_in ISO (PMID:15853773) BHF-UCL PMID:15853773 NCBI chr 3:41,104,940...41,145,934
Ensembl chr 3:41,373,726...41,414,030
JBrowse link
G PXYLP1 2-phosphoxylose phosphatase 1 involved_in ISO (PMID:24425863) UniProt PMID:24425863 NCBI chr 3:138,264,529...138,327,615
Ensembl chr 3:145,864,356...145,925,073
JBrowse link
G TCF7L2 transcription factor 7 like 2 involved_in ISO (PMID:15853773) BHF-UCL PMID:15853773 NCBI chr10:109,541,524...109,759,499
Ensembl chr10:112,978,167...113,192,281
JBrowse link
positive regulation of proteoglycan biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MUSTN1 musculoskeletal, embryonic nuclear protein 1 acts_upstream_of_or_within ISO (MGI:5703727|PMID:19410023) MGI PMID:19410023 MGI:5703727 NCBI chr 3:52,774,843...52,778,280
Ensembl chr 3:54,000,547...54,004,099
JBrowse link
G SLC2A10 solute carrier family 2 member 10 acts_upstream_of_or_within ISO (PMID:16550171) ARUK-UCL PMID:16550171 NCBI chr20:43,043,801...43,068,304
Ensembl chr20:44,128,837...44,153,148
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12613
    metabolic process 7908
      primary metabolic process 6973
        protein metabolic process 3866
          glycoprotein metabolic process 260
            proteoglycan metabolic process 64
              proteoglycan biosynthetic process 42
                chondroitin sulfate proteoglycan biosynthetic process + 17
                dermatan sulfate proteoglycan biosynthetic process + 5
                heparan sulfate proteoglycan biosynthetic process + 21
                negative regulation of proteoglycan biosynthetic process 1
                positive regulation of proteoglycan biosynthetic process + 5
Path 2
Term Annotations click to browse term
  biological_process 12613
    metabolic process 7908
      organic substance metabolic process 7622
        organic substance biosynthetic process 3991
          macromolecule biosynthetic process 3280
            cellular macromolecule biosynthetic process 3237
              glycoprotein biosynthetic process 203
                proteoglycan biosynthetic process 42
                  chondroitin sulfate proteoglycan biosynthetic process + 17
                  dermatan sulfate proteoglycan biosynthetic process + 5
                  heparan sulfate proteoglycan biosynthetic process + 21
                  negative regulation of proteoglycan biosynthetic process 1
                  positive regulation of proteoglycan biosynthetic process + 5
paths to the root