regulation of proteolysis - Ontology Report

GO_REF:0000107

NCBI chr11:69,085,434...69,244,791

GSAP

gamma-secretase activating protein

involved_in

IEA

GO_REF:0000107

NCBI chr 7:69,231,374...69,340,215
Ensembl chr 7:83,043,730...83,146,026

PARL

presenilin associated rhomboid like

involved_in

IEA

GO_REF:0000107

NCBI chr 3:180,862,434...180,921,197
Ensembl chr 3:189,032,816...189,088,036

PTPN1

protein tyrosine phosphatase non-receptor type 1

ISO

positive regulation of cysteine-type endopeptidase activity

PMID:18278556

RGD:401965430

NCBI chr20:46,854,918...46,929,509
Ensembl chr20:47,983,098...48,057,421

SHH

sonic hedgehog signaling molecule

acts_upstream_of_or_within

IEA

GO_REF:0000107

NCBI chr 7:147,400,112...147,414,036
Ensembl chr 7:159,114,666...159,126,651

TRAF3

TNF receptor associated factor 3

involved_in

IEA

GO_REF:0000107

NCBI chr14:83,392,689...83,530,974
Ensembl chr14:103,263,440...103,340,670

Factor XII activation

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

F12

coagulation factor XII

involved_in

IEA

GO_REF:0000107

NCBI chr 5:172,703,724...172,711,618
Ensembl chr 5:179,766,243...179,773,485

negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

BIN1

bridging integrator 1

involved_in

ISO

(PMID:27179792)

PMID:27179792

NCBI chr2B:33,168,767...33,228,075
Ensembl chr2B:127,716,550...127,775,378

TMED10

transmembrane p24 trafficking protein 10

acts_upstream_of_or_within

ISO

(PMID:16641999)

PMID:16641999

NCBI chr14:55,683,121...55,728,365
Ensembl chr14:74,526,733...74,572,000

negative regulation of endopeptidase activity

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

CRB2

crumbs cell polarity complex component 2

involved_in

ISO

(PMID:20299451)

PMID:20299451

NCBI chr 9:94,473,423...94,511,285
Ensembl chr 9:123,011,968...123,032,855

FETUB

fetuin B

involved_in

ISO

(PMID:23562279)

PMID:23562279

NCBI chr 3:183,675,258...183,687,754
Ensembl chr 3:192,142,702...192,154,920

GAPDH

glyceraldehyde-3-phosphate dehydrogenase

involved_in

ISO

(PMID:22832495)

PMID:22832495

NCBI chr12:6,665,218...6,669,170
Ensembl chr12:6,583,895...6,587,729

LOC100979269

alpha-2-macroglobulin

ISO

PMID:19240864

RGD:7411612

NCBI chr12:9,154,457...9,202,833
Ensembl chr12:9,385,359...9,433,979

RENBP

renin binding protein

ISO

PMID:11926999

RGD:727355

NCBI chr X:143,490,103...143,499,487
Ensembl chr X:153,376,847...153,386,214

SERPINB1

serpin family B member 1

involved_in

ISO

(PMID:30692621)

PMID:30692621

NCBI chr 6:2,655,244...2,664,074
Ensembl chr 6:2,758,173...2,766,650

SERPINB13

serpin family B member 13

involved_in

ISO

(PMID:12504904)

PMID:12504904

NCBI chr18:56,946,828...56,958,702
Ensembl chr18:60,258,085...60,270,607

SERPINB8

serpin family B member 8

involved_in

ISO

(PMID:8530382)

PMID:8530382

NCBI chr18:57,313,562...57,373,502
Ensembl chr18:60,634,206...60,669,118

SERPINB9

serpin family B member 9

involved_in

ISO

(PMID:21795594)

PMID:21795594

NCBI chr 6:2,709,188...2,725,592
Ensembl chr 6:2,812,815...2,827,932

SERPINE1

serpin family E member 1

ISO

PMID:10717410

RGD:8547889

NCBI chr 7:93,267,517...93,279,728
Ensembl chr 7:106,510,130...106,518,450

SPOCK3

SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3

involved_in

ISO

(PMID:11751414)

PMID:11751414

NCBI chr 4:158,941,142...159,437,078
Ensembl chr 4:171,022,442...171,517,005

TIMP1

TIMP metallopeptidase inhibitor 1

involved_in

ISO

(PMID:3903517)

PMID:3903517

NCBI chr X:40,018,190...40,022,636
Ensembl chr X:47,914,906...47,919,419

negative regulation of ERAD pathway

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

AQP11

aquaporin 11

involved_in

IEA

GO_REF:0000107

NCBI chr11:72,653,721...72,673,698
Ensembl chr11:76,295,778...76,315,292

small glutamine rich tetratricopeptide repeat co-chaperone alpha

involved_in

IEA

GO_REF:0000107

NCBI chr19:1,778,728...1,808,199
Ensembl chr19:2,736,565...2,763,440

SVIP

small VCP interacting protein

involved_in

IEA

GO_REF:0000107 GO_REF:0000118

NCBI chr11:22,828,321...22,837,536
Ensembl chr11:22,735,361...22,744,558

UBXN1

UBX domain protein 1

involved_in

IEA

GO_REF:0000107

NCBI chr11:58,033,304...58,035,893
Ensembl chr11:61,386,797...61,389,404

UBXN2A

UBX domain protein 2A

involved_in

IEA

GO_REF:0000107

NCBI chr2A:23,928,207...24,003,550
Ensembl chr2A:24,038,567...24,097,309

USP14

ubiquitin specific peptidase 14

involved_in

IEA

GO_REF:0000107

NCBI chr18:14,104,754...14,158,402
Ensembl chr18:17,745,733...17,797,070

USP25

ubiquitin specific peptidase 25

involved_in

IEA

GO_REF:0000107

NCBI chr21:2,468,993...2,618,200
Ensembl chr21:15,724,729...15,982,182

negative regulation of membrane protein ectodomain proteolysis

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

IL10

interleukin 10

involved_in

IEA

GO_REF:0000107

NCBI chr 1:182,369,234...182,374,207
Ensembl chr 1:186,648,289...186,653,371

LOC117978217

leucine-rich repeats and immunoglobulin-like domains protein 2

acts_upstream_of_or_within

ISO

(PMID:26651291)

PMID:26651291

PTPN3

protein tyrosine phosphatase non-receptor type 3

involved_in

IEA

GO_REF:0000107

NCBI chr 9:80,528,896...80,651,629
Ensembl chr 9:108,699,761...108,787,464

TIMP1

TIMP metallopeptidase inhibitor 1

involved_in

IEA

GO_REF:0000107 GO_REF:0000118

NCBI chr X:40,018,190...40,022,636
Ensembl chr X:47,914,906...47,919,419

TIMP2

TIMP metallopeptidase inhibitor 2

involved_in

IEA

GO_REF:0000118

NCBI chr17:72,928,692...73,001,892
Ensembl chr17:78,476,807...78,495,649

TIMP3

TIMP metallopeptidase inhibitor 3

involved_in

IEA

GO_REF:0000107 GO_REF:0000118

NCBI chr22:13,811,297...13,872,799
Ensembl chr22:31,662,562...31,723,964

TIMP4

TIMP metallopeptidase inhibitor 4

involved_in

IEA

GO_REF:0000118

NCBI chr 3:12,079,195...12,087,485
Ensembl chr 3:12,425,429...12,433,192

negative regulation of metallopeptidase activity

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

TIMP1

TIMP metallopeptidase inhibitor 1

involved_in

ISO

(PMID:9573338)

PMID:9573338

NCBI chr X:40,018,190...40,022,636
Ensembl chr X:47,914,906...47,919,419

TIMP2

TIMP metallopeptidase inhibitor 2

involved_in

ISO

(PMID:9573338)

PMID:9573338

NCBI chr17:72,928,692...73,001,892
Ensembl chr17:78,476,807...78,495,649

negative regulation of peptidase activity

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

CAST

calpastatin

acts_upstream_of_or_within

ISO

(PMID:21849499)

PMID:21849499

NCBI chr 5:91,972,572...92,084,657
Ensembl chr 5:97,527,071...97,636,650

ECM1

extracellular matrix protein 1

involved_in

ISO

(PMID:16512877)

PMID:16512877

NCBI chr 1:125,853,337...125,858,904
Ensembl chr 1:129,502,041...129,507,819

EPPIN

epididymal peptidase inhibitor

involved_in

ISO

(PMID:18331357)

PMID:18331357

NCBI chr20:41,877,561...41,884,375
Ensembl chr20:42,967,885...42,973,479

SERPINB4

serpin family B member 4

involved_in

ISO

(PMID:12949073)

PMID:12949073

NCBI chr18:56,996,437...57,003,489

SERPINE2

serpin family E member 2

acts_upstream_of_or_within

ISO

(PMID:15509762), (PMID:18398001)

PMID:15509762 PMID:18398001

NCBI chr2B:111,221,317...111,285,491
Ensembl chr2B:229,797,655...229,861,040

SPINK1

serine peptidase inhibitor Kazal type 1

acts_upstream_of_or_within

ISO

(PMID:3428272)

PMID:3428272

NCBI chr 5:143,273,137...143,287,745

negative regulation of plasminogen activation

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

CPB2

carboxypeptidase B2

ISO

PMID:23369837

RGD:7243115

NCBI chr13:26,926,788...26,979,767

CTSZ

cathepsin Z

involved_in

IEA

GO_REF:0000107

NCBI chr20:55,346,241...55,358,354
Ensembl chr20:56,706,511...56,718,941

SERPINE1

serpin family E member 1

involved_in

IEA

GO_REF:0000107 GO_REF:0000118

NCBI chr 7:93,267,517...93,279,728
Ensembl chr 7:106,510,130...106,518,450

SERPINE2

serpin family E member 2

involved_in

IEA

GO_REF:0000107 GO_REF:0000118

NCBI chr2B:111,221,317...111,285,491
Ensembl chr2B:229,797,655...229,861,040

SERPINF2

serpin family F member 2

involved_in

IEA

GO_REF:0000107

NCBI chr17:1,725,469...1,738,887
Ensembl chr17:1,618,549...1,631,570

THBS1

thrombospondin 1

involved_in

IEA

GO_REF:0000107

NCBI chr15:18,521,802...18,538,172
Ensembl chr15:36,776,756...36,793,170

negative regulation of proteasomal protein catabolic process

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

ALAD

aminolevulinate dehydratase

involved_in

IEA

GO_REF:0000107

NCBI chr 9:84,488,339...84,503,360
Ensembl chr 9:112,859,171...112,873,784

F8A1

coagulation factor VIII associated 1

involved_in

ISO

(PMID:27815841)

PMID:27815841

NCBI chr X:144,366,123...144,367,842

F8A3

coagulation factor VIII associated 3

involved_in

ISO

(PMID:27815841)

PMID:27815841

NCBI chr X:144,925,422...144,927,166

GABARAPL2

GABA type A receptor associated protein like 2

involved_in

IEA

GO_REF:0000107

NCBI chr16:56,135,482...56,147,046
Ensembl chr16:75,483,459...75,495,019

HSP90AB1

heat shock protein 90 alpha family class B member 1

involved_in

ISO

PMID:17517623
(PMID:17517623)

PMID:17517623

RGD:13514081

NCBI chr 6:43,842,796...43,849,637
Ensembl chr 6:45,125,773...45,133,872

LAMP3

lysosomal associated membrane protein 3

involved_in

IEA

GO_REF:0000107

NCBI chr 3:180,152,363...180,193,223
Ensembl chr 3:188,324,660...188,363,268

LOC100985575

40-kDa huntingtin-associated protein

involved_in

ISO

(PMID:27815841)

PMID:27815841

NCBI chr X:144,851,466...144,853,185

LOC100988585

transmembrane protein 220

acts_upstream_of_or_within

ISO

(PMID:25683716)

PMID:25683716

NCBI chr17:40,923,397...40,973,382
Ensembl chr17:45,703,642...45,720,520
Ensembl chr17:45,703,642...45,720,520

MARCHF7

membrane associated ring-CH-type finger 7

involved_in

IEA

GO_REF:0000107

NCBI chr2B:47,004,211...47,059,901
Ensembl chr2B:164,377,605...164,432,907

OPHN1

oligophrenin 1

involved_in

IEA

GO_REF:0000107 GO_REF:0000118

NCBI chr X:57,288,297...57,674,685
Ensembl chr X:67,359,364...67,739,114

PRKCG

protein kinase C gamma

involved_in

IEA

GO_REF:0000107

NCBI chr19:50,823,372...50,849,003
Ensembl chr19:59,672,097...59,695,977

PSME3IP1

proteasome activator subunit 3 interacting protein 1

involved_in

IEA

GO_REF:0000107

NCBI chr16:37,430,698...37,464,089
Ensembl chr16:56,563,353...56,596,619

PSMF1

proteasome inhibitor subunit 1

involved_in

IEA

GO_REF:0000107

NCBI chr20:1,275,662...1,325,410
Ensembl chr20:1,043,513...1,092,237

USP19

ubiquitin specific peptidase 19

involved_in

ISO

(PMID:25088257)

PMID:25088257

NCBI chr 3:49,032,373...49,045,238
Ensembl chr 3:50,100,216...50,125,112

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

BAG5

BAG cochaperone 5

involved_in

IEA

GO_REF:0000107

NCBI chr14:84,182,879...84,189,180
Ensembl chr14:103,997,524...103,998,927

BAG6

BAG cochaperone 6

involved_in

IEA

GO_REF:0000107

NCBI chr 6:31,300,126...31,313,829
Ensembl chr 6:32,190,037...32,204,321

CAMLG

calcium modulating ligand

involved_in

IEA

GO_REF:0000107

NCBI chr 5:130,138,644...130,144,540
Ensembl chr 5:136,282,910...136,295,382

CCAR2

cell cycle and apoptosis regulator 2

involved_in

IEA

GO_REF:0000107

NCBI chr 8:21,854,803...21,870,556
Ensembl chr 8:18,794,027...18,808,571

CLEC16A

C-type lectin domain containing 16A

acts_upstream_of_or_within

ISO

(PMID:24949970)

PMID:24949970

NCBI chr16:9,887,877...10,124,500
Ensembl chr16:11,109,869...11,343,512

CSNK2A1

casein kinase 2 alpha 1

involved_in

ISO

(PMID:28031292)

PMID:28031292

NCBI chr20:689,494...752,092
Ensembl chr20:456,629...521,126

CSNK2A2

casein kinase 2 alpha 2

involved_in

IEA

GO_REF:0000107

NCBI chr16:38,426,399...38,466,575
Ensembl chr16:57,557,270...57,596,218

CSNK2B

casein kinase 2 beta

involved_in

ISO

(PMID:28031292)

PMID:28031292

NCBI chr 6:31,327,250...31,331,250

DDRGK domain containing 1

involved_in

IEA

GO_REF:0000107

NCBI chr20:3,276,292...3,290,433
Ensembl chr20:3,038,779...3,052,789

EIF3H

eukaryotic translation initiation factor 3 subunit H

involved_in

IEA

GO_REF:0000107

NCBI chr 8:113,320,059...113,440,769
Ensembl chr 8:115,863,490...115,973,872

FHIT

fragile histidine triad diadenosine triphosphatase

involved_in

ISO

(PMID:15313915)

PMID:15313915

NCBI chr 3:59,670,777...61,177,974

GIPC1

GIPC PDZ domain containing family member 1

involved_in

IEA

GO_REF:0000107

NCBI chr19:14,041,192...14,059,402
Ensembl chr19:14,885,185...14,889,701

HFE

homeostatic iron regulator

involved_in

IEA

GO_REF:0000107

NCBI chr 6:25,921,663...25,930,852
Ensembl chr 6:26,580,358...26,588,591

HSP90AB1

heat shock protein 90 alpha family class B member 1

involved_in

ISO

(PMID:24613385)

PMID:24613385

NCBI chr 6:43,842,796...43,849,637
Ensembl chr 6:45,125,773...45,133,872

KLHL40

kelch like family member 40

acts_upstream_of_or_within
involved_in

ISO
IEA

(PMID:24960163)

MGI
TreeGrafter

PMID:24960163

GO_REF:0000118

NCBI chr 3:42,592,977...42,600,100
Ensembl chr 3:43,657,128...43,664,055

MAP1A

microtubule associated protein 1A

involved_in

ISO

(PMID:26609151)

PMID:26609151

NCBI chr15:22,472,641...22,493,293
Ensembl chr15:40,627,099...40,647,752

MTM1

myotubularin 1

acts_upstream_of_or_within

ISO

(PMID:23695157)

PMID:23695157

NCBI chr X:140,218,742...140,323,495
Ensembl chr X:150,174,758...150,255,381

N4BP1

NEDD4 binding protein 1

involved_in

IEA

GO_REF:0000107 GO_REF:0000118

NCBI chr16:28,809,881...28,881,352
Ensembl chr16:47,698,353...47,769,755

NOP53

NOP53 ribosome biogenesis factor

involved_in

ISO

(PMID:22522597)

PMID:22522597

NCBI chr19:44,739,739...44,751,303

OGT

O-linked N-acetylglucosamine (GlcNAc) transferase

involved_in

IEA

GO_REF:0000107

NCBI chr X:60,798,219...60,840,948
Ensembl chr X:70,852,687...70,894,921

PANO1

proapoptotic nucleolar protein 1

involved_in

ISO

(PMID:22094112)

PMID:22094112

NCBI chr11:814,040...816,633

PARK7

Parkinsonism associated deglycase

acts_upstream_of

IEA

GO_REF:0000107

NCBI chr 1:6,722,260...6,745,915
Ensembl chr 1:7,969,280...7,993,271

PBK

PDZ binding kinase

acts_upstream_of_or_within

IEA

GO_REF:0000107

NCBI chr 8:27,084,789...27,112,986
Ensembl chr 8:24,285,395...24,313,658

PHF20L1

PHD finger protein 20 like 1

involved_in

IEA

GO_REF:0000107

NCBI chr 8:129,427,157...129,500,633
Ensembl chr 8:132,403,053...132,474,452

RGS19

regulator of G protein signaling 19

involved_in

ISO

(PMID:11546783)

PMID:11546783

Ensembl chr20:61,987,428...61,993,936

RPL11

ribosomal protein L11

involved_in

IEA

GO_REF:0000107

NCBI chr 1:22,883,157...22,887,806
Ensembl chr 1:23,868,688...23,873,313

RYBP

RING1 and YY1 binding protein

involved_in

IEA

GO_REF:0000107

NCBI chr 3:72,315,494...72,389,328
Ensembl chr 3:74,247,807...74,318,398

SENP1

SUMO specific peptidase 1

acts_upstream_of_or_within

IEA

GO_REF:0000107

NCBI chr12:40,624,200...40,689,837
Ensembl chr12:41,507,348...41,558,969

SHH

sonic hedgehog signaling molecule

acts_upstream_of_or_within

IEA

GO_REF:0000107

NCBI chr 7:147,400,112...147,414,036
Ensembl chr 7:159,114,666...159,126,651

SMARCC1

SWI/SNF related BAF chromatin remodeling complex subunit C1

acts_upstream_of_or_within

IEA

GO_REF:0000107

NCBI chr 3:47,487,948...47,683,623
Ensembl chr 3:48,590,221...48,781,248

TAF9

TATA-box binding protein associated factor 9

involved_in

ISO

(PMID:11278372)

PMID:11278372

NCBI chr 5:44,630,503...44,635,760

TLK2

tousled like kinase 2

involved_in

IEA

GO_REF:0000107

NCBI chr17:56,542,670...56,678,294
Ensembl chr17:61,689,998...61,830,394

TRIM39

tripartite motif containing 39

involved_in

IEA

GO_REF:0000107

NCBI chr 6:30,104,381...30,121,649
Ensembl chr 6:30,975,260...30,995,764

TTC36

tetratricopeptide repeat domain 36

acts_upstream_of_or_within

IEA

GO_REF:0000107

NCBI chr11:113,364,559...113,368,586
Ensembl chr11:117,295,191...117,298,928

UBXN1

UBX domain protein 1

involved_in

IEA

GO_REF:0000107 GO_REF:0000118

NCBI chr11:58,033,304...58,035,893
Ensembl chr11:61,386,797...61,389,404

UCHL5

ubiquitin C-terminal hydrolase L5

involved_in

IEA

GO_REF:0000107

NCBI chr 1:168,471,501...168,519,366
Ensembl chr 1:172,764,606...172,811,880

USP26

ubiquitin specific peptidase 26

involved_in

IEA

GO_REF:0000107

NCBI chr X:122,155,933...122,160,000
Ensembl chr X:132,463,140...132,465,887

USP38

ubiquitin specific peptidase 38

involved_in

IEA

GO_REF:0000107

NCBI chr 4:135,545,818...135,582,520
Ensembl chr 4:146,844,850...146,881,486

USP5

ubiquitin specific peptidase 5

involved_in

ISO

(PMID:37534934)

PMID:37534934

NCBI chr12:6,983,941...6,998,469
Ensembl chr12:6,895,416...6,909,936

USP7

ubiquitin specific peptidase 7

involved_in

IEA

GO_REF:0000107

NCBI chr16:7,825,332...7,895,095
Ensembl chr16:9,065,858...9,106,146

USP9X

ubiquitin specific peptidase 9 X-linked

involved_in

IEA

GO_REF:0000107

NCBI chr X:33,535,543...33,683,220
Ensembl chr X:41,232,041...41,379,910

WAC

WW domain containing adaptor with coiled-coil

involved_in

IEA

GO_REF:0000107

NCBI chr10:28,685,294...28,777,176
Ensembl chr10:29,042,331...29,130,591

negative regulation of protein processing

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

ACP4

acid phosphatase 4

involved_in

IEA

GO_REF:0000107

NCBI chr19:47,754,780...47,760,294
Ensembl chr19:56,649,018...56,653,909

CDH1

cadherin 1

acts_upstream_of_or_within

ISO

(PMID:17344476)

PMID:17344476

NCBI chr16:49,108,745...49,206,347
Ensembl chr16:68,502,584...68,596,488

CHAC1

ChaC glutathione specific gamma-glutamylcyclotransferase 1

involved_in

IEA

GO_REF:0000107

NCBI chr15:19,895,554...19,898,672
Ensembl chr15:38,145,730...38,148,698

FMR1

fragile X messenger ribonucleoprotein 1

ISO

Casp3

PMID:22817682

RGD:11566024

NCBI chr X:136,937,889...136,976,828
Ensembl chr X:147,365,748...147,405,321

GAS1

growth arrest specific 1

involved_in

IEA

GO_REF:0000107

NCBI chr 9:58,079,700...58,082,849
Ensembl chr 9:86,139,009...86,140,045

GLG1

golgi glycoprotein 1

acts_upstream_of_or_within

ISO

(PMID:20530870)

PMID:20530870

NCBI chr16:55,014,892...55,172,877
Ensembl chr16:74,372,660...74,526,764

IL1R2

interleukin 1 receptor type 2

acts_upstream_of_or_within

IEA

GO_REF:0000107

Ensembl chr2A:103,042,328...103,078,190

LRRK2

leucine rich repeat kinase 2

involved_in

IEA

GO_REF:0000107

NCBI chr12:48,343,621...48,488,337
Ensembl chr12:49,205,930...49,350,462

MDM2

MDM2 proto-oncogene

ISO

caspase-3

PMID:19638633

RGD:2317364

NCBI chr12:66,322,340...66,357,010
Ensembl chr12:69,102,084...69,133,278

NLRP7

NLR family pyrin domain containing 7

involved_in

IEA

GO_REF:0000107

NCBI chr19:51,966,886...51,990,971
Ensembl chr19:60,662,184...60,677,844

PPP1R15A

protein phosphatase 1 regulatory subunit 15A

ISO

Casp3

PMID:21925170

RGD:9999170

NCBI chr19:45,872,596...45,876,376
Ensembl chr19:54,880,141...54,883,003

SNX12

sorting nexin 12

involved_in

IEA

GO_REF:0000107

NCBI chr X:60,327,484...60,336,682
Ensembl chr X:70,384,164...70,395,737

TMEM98

transmembrane protein 98

involved_in

ISO

(PMID:30249802)

PMID:30249802

NCBI chr17:23,844,747...23,858,390
Ensembl chr17:24,133,357...24,146,912

negative regulation of protein processing involved in protein targeting to mitochondrion

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

SIRT4

sirtuin 4

ISO

PMID:24029877

RGD:9586053

NCBI chr12:117,867,453...117,887,968
Ensembl chr12:121,241,112...121,261,777

negative regulation of proteolysis

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

AKT1

AKT serine/threonine kinase 1

involved_in

IEA

GO_REF:0000107

NCBI chr14:85,417,229...85,444,722
Ensembl chr14:105,208,128...105,236,756

BAG6

BAG cochaperone 6

involved_in

IEA

GO_REF:0000107

NCBI chr 6:31,300,126...31,313,829
Ensembl chr 6:32,190,037...32,204,321

CDK5

cyclin dependent kinase 5

involved_in

IEA

GO_REF:0000107

NCBI chr 7:142,640,630...142,644,785
Ensembl chr 7:154,793,344...154,797,499

CST3

cystatin C

involved_in

IEA

GO_REF:0000107

NCBI chr20:23,583,043...23,587,399
Ensembl chr20:23,935,942...23,940,425

CSTA

cystatin A

involved_in

IEA

GO_REF:0000107

NCBI chr 3:119,417,489...119,432,244
Ensembl chr 3:126,323,901...126,338,430

CSTB

cystatin B

involved_in

ISO

(PMID:3488317), (PMID:6203523)

PMID:3488317 PMID:6203523

NCBI chr21:30,030,359...30,032,899

coagulation factor II, thrombin

involved_in

IEA

GO_REF:0000107

NCBI chr11:46,669,925...46,690,391
Ensembl chr11:47,227,891...47,249,157

HDAC6

histone deacetylase 6

involved_in

IEA

GO_REF:0000107

NCBI chr X:41,099,539...41,122,650
Ensembl chr X:48,960,430...48,982,642

IDE

insulin degrading enzyme

ISO

inhibits activity of the multicatalytic proteinase complex (proteasome)

PMID:9000694

RGD:1627643

NCBI chr10:89,196,295...89,320,223
Ensembl chr10:92,716,540...92,833,353

KNG1

kininogen 1

involved_in

IEA

GO_REF:0000107

NCBI chr 3:183,751,598...183,778,655
Ensembl chr 3:192,219,462...192,245,149

LOC100994116

cystatin-S

involved_in

IEA

GO_REF:0000107

NCBI chr20:23,634,895...23,638,284
Ensembl chr20:23,987,931...23,991,674

LOC117978823

battenin

acts_upstream_of_or_within

ISO

(PMID:10527801)

PMID:10527801

NR1H2

nuclear receptor subfamily 1 group H member 2

involved_in

IEA

GO_REF:0000107

NCBI chr19:47,340,077...47,346,737
Ensembl chr19:56,243,124...56,250,024

NR1H3

nuclear receptor subfamily 1 group H member 3

involved_in

IEA

GO_REF:0000107

NCBI chr11:47,195,122...47,215,277
Ensembl chr11:47,748,353...47,768,672

PIK3R1

phosphoinositide-3-kinase regulatory subunit 1

ISO

PMID:15161606

RGD:1625251

NCBI chr 5:45,701,219...45,786,652
Ensembl chr 5:47,267,286...47,350,960

PLAT

plasminogen activator, tissue type

involved_in

IEA

GO_REF:0000107

NCBI chr 8:41,419,415...41,451,951
Ensembl chr 8:38,864,918...38,897,779

RAB23

RAB23, member RAS oncogene family

acts_upstream_of_or_within

ISO

(PMID:16364285)

PMID:16364285

NCBI chr 6:56,744,948...56,780,187
Ensembl chr 6:58,375,559...58,411,107

SERPINA5

serpin family A member 5

ISO

PMID:16088033

RGD:1580291

NCBI chr14:75,205,446...75,217,114
Ensembl chr14:94,537,115...94,548,803

SERPINB10

serpin family B member 10

ISO

PMID:11986314

RGD:634009

NCBI chr18:57,262,514...57,289,744
Ensembl chr18:60,573,580...60,599,697

SERPINE1

serpin family E member 1

involved_in

IEA

GO_REF:0000107

NCBI chr 7:93,267,517...93,279,728
Ensembl chr 7:106,510,130...106,518,450

SERPINE2

serpin family E member 2

involved_in

IEA

GO_REF:0000107

NCBI chr2B:111,221,317...111,285,491
Ensembl chr2B:229,797,655...229,861,040

SPINK5

serine peptidase inhibitor Kazal type 5

acts_upstream_of_or_within

IEA

GO_REF:0000107

NCBI chr 5:143,387,981...143,578,839
Ensembl chr 5:149,506,367...149,590,930

SPINK9

serine peptidase inhibitor Kazal type 9

acts_upstream_of_or_within

ISO

(PMID:16930550)

PMID:16930550

NCBI chr 5:143,746,900...143,766,766

TIMP2

TIMP metallopeptidase inhibitor 2

ISO

PMID:17532789

RGD:2290425

NCBI chr17:72,928,692...73,001,892
Ensembl chr17:78,476,807...78,495,649

TIMP3

TIMP metallopeptidase inhibitor 3

ISO

PMID:17532789

RGD:2290425

NCBI chr22:13,811,297...13,872,799
Ensembl chr22:31,662,562...31,723,964

TM4SF20

transmembrane 4 L six family member 20

involved_in

ISO

(PMID:25310401), (PMID:27499293)

PMID:25310401 PMID:27499293

NCBI chr2B:114,606,488...114,623,569

TP53

tumor protein p53

acts_upstream_of_or_within

IEA

GO_REF:0000107

NCBI chr17:7,699,449...7,717,812
Ensembl chr17:7,684,922...7,706,120

UBXN2A

UBX domain protein 2A

involved_in

IEA

GO_REF:0000107

NCBI chr2A:23,928,207...24,003,550
Ensembl chr2A:24,038,567...24,097,309

VTN

vitronectin

involved_in

IEA

PMID:23277542 PMID:25217637

GO_REF:0000107

NCBI chr17:28,403,813...28,407,202
Ensembl chr17:28,906,508...28,909,583

negative regulation of proteolysis involved in protein catabolic process

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

CDKN2A

cyclin dependent kinase inhibitor 2A

involved_in
acts_upstream_of_or_within

ISO

(PMID:25217637)
(PMID:23277542)

ParkinsonsUK-UCL
MGI

NCBI chr 9:21,803,862...21,831,322

EFNA1

ephrin A1

involved_in

IEA

GO_REF:0000107

NCBI chr 1:130,475,128...130,482,531
Ensembl chr 1:134,083,855...134,091,228

EPHA4

EPH receptor A4

involved_in

IEA

GO_REF:0000107

NCBI chr2B:108,664,475...108,818,802
Ensembl chr2B:227,248,958...227,402,790

UFSP2

UFM1 specific peptidase 2

involved_in

IEA

GO_REF:0000107

NCBI chr 4:177,562,642...177,589,312
Ensembl chr 4:189,779,242...189,805,572

negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

PABPN1L

PABPN1 like, cytoplasmic

acts_upstream_of_or_within

IEA

GO_REF:0000107

NCBI chr16:69,579,421...69,583,803
Ensembl chr16:89,234,156...89,237,595

STYX

serine/threonine/tyrosine interacting protein

involved_in

IEA

GO_REF:0000107 GO_REF:0000118

NCBI chr14:33,326,587...33,371,399
Ensembl chr14:51,610,523...51,651,096

negative regulation of serine-type endopeptidase activity

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

CR1

complement C3b/C4b receptor 1 (Knops blood group)

involved_in

ISO

(PMID:6910481)

PMID:6910481

NCBI chr 1:183,094,601...183,246,957

LOC100985521

serine peptidase inhibitor Kazal type 6

acts_upstream_of_or_within

ISO

(PMID:24352040)

PMID:24352040

NCBI chr 5:143,631,560...143,644,177
Ensembl chr 5:149,639,882...149,652,448

SERPINA1

serpin family A member 1

ISO

PMID:12771515 PMID:20110462 PMID:22228629

PMID:19240864

RGD:7411612

NCBI chr14:75,001,714...75,014,214
Ensembl chr14:94,334,258...94,345,419

SPINK1

serine peptidase inhibitor Kazal type 1

acts_upstream_of_or_within

ISO

(PMID:22228629)
(PMID:20110462)

RGD
MGI

RGD:724699

NCBI chr 5:143,273,137...143,287,745

SPINK2

serine peptidase inhibitor Kazal type 2

acts_upstream_of_or_within

ISO

(PMID:21705336)

PMID:21705336

NCBI chr 4:67,101,686...67,113,671

negative regulation of serine-type peptidase activity

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

SPINK5

serine peptidase inhibitor Kazal type 5

acts_upstream_of_or_within

ISO

(PMID:20179351)

PMID:20179351

NCBI chr 5:143,387,981...143,578,839
Ensembl chr 5:149,506,367...149,590,930

negative regulation of ubiquitin-dependent protein catabolic process

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

ANKS1A

ankyrin repeat and sterile alpha motif domain containing 1A

acts_upstream_of_or_within

ISO

(PMID:20100865)

PMID:16173922 PMID:18560357 PMID:23277542

PMID:20100865

NCBI chr 6:34,450,695...34,653,881
Ensembl chr 6:35,548,124...35,776,185

CDKN2A

cyclin dependent kinase inhibitor 2A

involved_in
acts_upstream_of_or_within

ISO

(PMID:16173922), (PMID:18560357)
(PMID:23277542)

UniProt
MGI

NCBI chr 9:21,803,862...21,831,322

HFE

homeostatic iron regulator

involved_in

IEA

GO_REF:0000107

NCBI chr 6:25,921,663...25,930,852
Ensembl chr 6:26,580,358...26,588,591

HIPK2

homeodomain interacting protein kinase 2

involved_in

ISO

(PMID:21628596)

FlyBase

PMID:21628596

NCBI chr 7:131,506,711...131,722,943

LOC103785569

large ribosomal subunit protein uL18

involved_in

IEA

GO_REF:0000107

NCBI chr 1:160,751,687...160,752,671

PDCL3

phosducin like 3

acts_upstream_of_or_within

ISO

(PMID:23792958)

PMID:23792958

PML

PML nuclear body scaffold

involved_in

IEA

GO_REF:0000107

NCBI chr15:52,903,874...52,955,151
Ensembl chr15:71,658,884...71,710,883

PRMT6

protein arginine methyltransferase 6

involved_in

IEA

GO_REF:0000107

NCBI chr 1:109,582,715...109,586,744
Ensembl chr 1:108,699,098...108,700,225

PSEN1

presenilin 1

involved_in

IEA

GO_REF:0000107

NCBI chr14:53,718,299...53,802,684
Ensembl chr14:72,579,024...72,663,876

PSEN2

presenilin 2

involved_in

ISO

(PMID:20208556)

PMID:20208556

NCBI chr 1:202,328,987...202,354,440
Ensembl chr 1:207,320,937...207,346,295

QRICH2

glutamine rich 2

involved_in

ISO

(PMID:30683861)

PMID:30683861

NCBI chr17:70,222,033...70,256,747
Ensembl chr17:75,774,651...75,807,651

RPL11

ribosomal protein L11

involved_in

IEA

GO_REF:0000107

NCBI chr 1:22,883,157...22,887,806
Ensembl chr 1:23,868,688...23,873,313

RPL23

ribosomal protein L23

involved_in

IEA

GO_REF:0000107

NCBI chr17:18,417,964...18,421,708
Ensembl chr17:18,690,682...18,698,253

RPL5

ribosomal protein L5

involved_in

IEA

GO_REF:0000107

NCBI chr 1:95,497,047...95,507,006
Ensembl chr 1:94,230,451...94,241,522

RPS7

ribosomal protein S7

involved_in

ISO

(PMID:17310983)

CAFA

PMID:17310983

NCBI chr2A:3,593,350...3,599,106
Ensembl chr2A:3,512,079...3,517,785

small glutamine rich tetratricopeptide repeat co-chaperone alpha

involved_in

IEA

GO_REF:0000107

NCBI chr19:1,778,728...1,808,199
Ensembl chr19:2,736,565...2,763,440

SUFU

SUFU negative regulator of hedgehog signaling

acts_upstream_of_or_within

IEA

GO_REF:0000107

NCBI chr10:99,107,516...99,231,761
Ensembl chr10:102,571,886...102,696,472

SVIP

small VCP interacting protein

involved_in

ISO

PMID:17000876

PMID:17000876

RGD:10047192

NCBI chr11:22,828,321...22,837,536
Ensembl chr11:22,735,361...22,744,558

TAF1

TATA-box binding protein associated factor 1

involved_in

IEA

GO_REF:0000107

NCBI chr X:60,630,137...60,729,904
Ensembl chr X:70,684,217...70,782,323

TRIM39

tripartite motif containing 39

involved_in

IEA

GO_REF:0000107

NCBI chr 6:30,104,381...30,121,649
Ensembl chr 6:30,975,260...30,995,764

USP14

ubiquitin specific peptidase 14

involved_in

IEA

GO_REF:0000107

NCBI chr18:14,104,754...14,158,402
Ensembl chr18:17,745,733...17,797,070

USP5

ubiquitin specific peptidase 5

involved_in

IEA

GO_REF:0000107

NCBI chr12:6,983,941...6,998,469
Ensembl chr12:6,895,416...6,909,936

WNT1

Wnt family member 1

acts_upstream_of_or_within

IEA

GO_REF:0000107

NCBI chr12:39,767,839...39,772,460
Ensembl chr12:40,648,413...40,652,583

positive regulation of anaphase-promoting complex-dependent catabolic process

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

CDC20

cell division cycle 20

involved_in

IEA

GO_REF:0000118

NCBI chr 1:42,660,338...42,664,618
Ensembl chr 1:44,039,971...44,044,497

CDC20B

cell division cycle 20B

involved_in

IEA

GO_REF:0000118

NCBI chr 5:58,856,370...58,918,463
Ensembl chr 5:60,478,977...60,538,264

FZR1

fizzy and cell division cycle 20 related 1

involved_in

IEA

GO_REF:0000118

NCBI chr19:2,533,172...2,564,301
Ensembl chr19:3,500,117...3,510,867

positive regulation of aspartic-type peptidase activity

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

GRN

granulin precursor

involved_in

ISO

(PMID:28453791)

PMID:28453791

NCBI chr17:13,046,329...13,054,236
Ensembl chr17:13,211,784...13,219,609

positive regulation of endopeptidase activity

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

AKIRIN2

akirin 2

ISO

MMP-9

PMID:18460465

RGD:2306009

NCBI chr 6:85,549,728...85,577,114

PRELID1

PRELI domain containing 1

involved_in

ISO

(PMID:18945965)

PMID:18945965

NCBI chr 5:172,605,767...172,608,901
Ensembl chr 5:179,669,885...179,672,965

PSENEN

presenilin enhancer, gamma-secretase subunit

involved_in

ISO

(PMID:12660785)

PMID:12660785

NCBI chr19:32,675,331...32,677,285
Ensembl chr19:41,409,662...41,411,089

SFRP2

secreted frizzled related protein 2

acts_upstream_of_or_within

ISO

(PMID:19079247)

PMID:19079247

NCBI chr 4:146,123,075...146,131,543
Ensembl chr 4:157,944,733...157,953,258

VSIR

V-set immunoregulatory receptor

involved_in

ISO

(PMID:20666777)

PMID:20666777

NCBI chr10:68,218,230...68,243,687
Ensembl chr10:70,742,062...70,767,613

positive regulation of ERAD pathway

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

ATXN3

ataxin 3

involved_in

ISO

(PMID:17000876)

PMID:17000876

NCBI chr14:72,693,446...72,741,772

BAG6

BAG cochaperone 6

involved_in

IEA

GO_REF:0000107

NCBI chr 6:31,300,126...31,313,829
Ensembl chr 6:32,190,037...32,204,321

BCAP31

B cell receptor associated protein 31

involved_in

IEA

GO_REF:0000107

NCBI chr X:143,265,920...143,274,956
Ensembl chr X:153,137,992...153,161,628

CAV1

caveolin 1

involved_in

IEA

GO_REF:0000107

NCBI chr 7:108,497,125...108,533,090
Ensembl chr 7:121,193,424...121,229,655

HERPUD1

homocysteine inducible ER protein with ubiquitin like domain 1

involved_in

IEA

GO_REF:0000107

NCBI chr16:37,210,170...37,221,961
Ensembl chr16:56,343,025...56,355,164

LOC100976022

B cell receptor associated protein 31

involved_in

ISO

(PMID:18555783)

PMID:18555783

Ensembl chr X:153,137,992...153,161,628

RNF185

ring finger protein 185

involved_in

IEA

Ensembl
TreeGrafter
InterPro

GO_REF:0000107

NCBI chr22:12,183,591...12,230,371
Ensembl chr22:30,020,353...30,066,266

RNFT1

ring finger protein, transmembrane 1

involved_in

IEA

GO_REF:0000002 GO_REF:0000107 GO_REF:0000118

NCBI chr17:54,016,689...54,029,100
Ensembl chr17:58,858,416...58,869,908

RNFT2

ring finger protein, transmembrane 2

involved_in

IEA

InterPro

GO_REF:0000002

NCBI chr12:114,315,117...114,430,273
Ensembl chr12:117,691,632...117,804,833

small glutamine rich tetratricopeptide repeat co-chaperone alpha

involved_in

IEA

GO_REF:0000107

NCBI chr19:1,778,728...1,808,199
Ensembl chr19:2,736,565...2,763,440

STUB1

STIP1 homology and U-box containing protein 1

involved_in

IEA

GO_REF:0000107

Ensembl chr16:694,414...696,682

TMEM259

transmembrane protein 259

involved_in

IEA

GO_REF:0000107 GO_REF:0000118

Ensembl chr19:983,507...994,212

TMEM67

transmembrane protein 67

ISO

PMID:19815549

RGD:8554391

NCBI chr 8:90,378,623...90,442,904
Ensembl chr 8:92,324,402...92,387,437

TMX1

thioredoxin related transmembrane protein 1

involved_in

IEA

GO_REF:0000107

NCBI chr14:31,844,418...31,861,911
Ensembl chr14:50,129,568...50,147,057

UBQLN1

ubiquilin 1

involved_in

IEA

GO_REF:0000107

NCBI chr 9:41,170,416...41,218,656
Ensembl chr 9:82,597,507...82,645,587

UBQLN2

ubiquilin 2

involved_in

IEA

GO_REF:0000107

NCBI chr X:48,829,844...48,835,040
Ensembl chr X:56,981,985...56,983,859

USP13

ubiquitin specific peptidase 13

involved_in

IEA

GO_REF:0000107

NCBI chr 3:176,685,541...176,818,360
Ensembl chr 3:184,855,388...184,983,158

WFS1

wolframin ER transmembrane glycoprotein

involved_in

IEA

GO_REF:0000107

Ensembl chr 4:6,345,864...6,379,287

XBP1

X-box binding protein 1

acts_upstream_of_or_within

ISO

(PMID:19911006)

PMID:19911006

NCBI chr22:9,863,479...9,869,491
Ensembl chr22:27,567,041...27,571,943

positive regulation of membrane protein ectodomain proteolysis

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

ADAM8

ADAM metallopeptidase domain 8

involved_in

IEA

GO_REF:0000107 GO_REF:0000118

Ensembl chr10:134,172,724...134,186,227

ADAM9

ADAM metallopeptidase domain 9

involved_in

ISO

(PMID:9857183)

PMID:9857183

NCBI chr 8:38,298,194...38,406,706
Ensembl chr 8:35,473,278...35,581,192

ADRA2A

adrenoceptor alpha 2A

involved_in

ISO

(PMID:17655843)

PMID:17655843

NCBI chr10:107,669,860...107,673,685

APOE

apolipoprotein E

involved_in

IEA

GO_REF:0000107

NCBI chr19:41,853,669...41,857,252
Ensembl chr19:50,459,906...50,463,490

APP

amyloid beta precursor protein

involved_in

ISO

(PMID:25015123)

PMID:25015123

NCBI chr21:12,324,455...12,608,594
Ensembl chr21:25,684,355...25,995,072

GPLD1

glycosylphosphatidylinositol specific phospholipase D1

involved_in

IEA

GO_REF:0000107

NCBI chr 6:24,257,923...24,332,171
Ensembl chr 6:24,588,672...24,665,229

IFNG

interferon gamma

involved_in

IEA

GO_REF:0000107

NCBI chr12:65,663,764...65,668,732
Ensembl chr12:68,448,861...68,453,829

IL1B

interleukin 1 beta

involved_in

IEA

GO_REF:0000107

NCBI chr2A:89,216,313...89,223,358
Ensembl chr2A:113,846,306...113,853,424

NRDC

nardilysin convertase

involved_in

IEA

GO_REF:0000107

NCBI chr 1:51,038,711...51,130,404
Ensembl chr 1:52,535,603...52,625,998

PACSIN3

protein kinase C and casein kinase substrate in neurons 3

involved_in

IEA

GO_REF:0000107

NCBI chr11:47,122,620...47,131,559
Ensembl chr11:47,676,432...47,684,485

RGMA

repulsive guidance molecule BMP co-receptor a

acts_upstream_of_or_within

IEA

GO_REF:0000107

NCBI chr15:71,728,669...71,774,447
Ensembl chr15:90,922,199...90,956,179

SH3D19

SH3 domain containing 19

involved_in

ISO

(PMID:15280379)

PMID:15280379

NCBI chr 4:143,460,618...143,664,796
Ensembl chr 4:155,115,280...155,217,392

SNX33

sorting nexin 33

involved_in

IEA

GO_REF:0000107

NCBI chr15:54,556,304...54,570,683
Ensembl chr15:74,151,053...74,159,584

SNX9

sorting nexin 9

involved_in

IEA

GO_REF:0000107

NCBI chr 6:155,724,026...155,844,553
Ensembl chr 6:157,824,918...157,903,357

TNF

tumor necrosis factor

involved_in

IEA

GO_REF:0000107

NCBI chr 6:31,236,650...31,239,423
Ensembl chr 6:32,126,618...32,129,381

TNFRSF1B

TNF receptor superfamily member 1B

involved_in

IEA

GO_REF:0000107 GO_REF:0000118

NCBI chr 1:10,915,743...10,957,765
Ensembl chr 1:12,130,663...12,172,646

positive regulation of metalloendopeptidase activity

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

ARHGEF2

Rho/Rac guanine nucleotide exchange factor 2

involved_in

ISO

(PMID:23389627)

AgBase

PMID:23389627

NCBI chr 1:131,282,514...131,326,535
Ensembl chr 1:135,112,040...135,159,299

MBP

myelin basic protein

involved_in

ISO

(PMID:22524708)

CAFA

PMID:22524708

NCBI chr18:70,369,882...70,526,693
Ensembl chr18:73,629,522...73,755,351

positive regulation of metallopeptidase activity

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

ANTXR1

ANTXR cell adhesion molecule 1

acts_upstream_of_or_within

ISO

(PMID:25572963)

PMID:25572963

NCBI chr2A:69,054,253...69,290,554
Ensembl chr2A:70,175,982...70,412,454

positive regulation of peptidase activity

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

CTSH

cathepsin H

involved_in

ISO

(PMID:20435891)

PMID:20435891

NCBI chr15:57,893,379...57,917,194
Ensembl chr15:76,852,668...76,876,976

PRSS22

serine protease 22

involved_in

ISO

(PMID:15701722)

PMID:15701722

NCBI chr16:1,790,787...1,797,025

RCN3

reticulocalbin 3

involved_in

ISO

(PMID:28939891)

PMID:28939891

NCBI chr19:46,540,352...46,556,508
Ensembl chr19:55,463,535...55,477,478

positive regulation of plasminogen activation

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

ANXA2

annexin A2

involved_in

IEA

GO_REF:0000107

NCBI chr15:39,322,303...39,371,565
Ensembl chr15:57,625,425...57,674,250

CLEC3B

C-type lectin domain family 3 member B

involved_in

ISO

(PMID:12694198)

PMID:12694198

NCBI chr 3:44,927,098...44,936,847
Ensembl chr 3:46,038,115...46,047,927

ENO1

enolase 1

involved_in

IEA

GO_REF:0000107

NCBI chr 1:7,619,490...7,637,558
Ensembl chr 1:8,855,074...8,873,215

F12

coagulation factor XII

involved_in

IEA

GO_REF:0000107

NCBI chr 5:172,703,724...172,711,618
Ensembl chr 5:179,766,243...179,773,485

HPN

hepsin

involved_in

IEA

GO_REF:0000107

NCBI chr19:31,985,761...32,012,841
Ensembl chr19:40,725,319...40,750,628

MELTF

melanotransferrin

involved_in

IEA

InterPro
Ensembl
TreeGrafter

GO_REF:0000107

NCBI chr 3:194,345,474...194,373,690
Ensembl chr 3:204,262,182...204,310,710

PLGRKT

plasminogen receptor with a C-terminal lysine

involved_in
acts_upstream_of_or_within

IEA

GO_REF:0000002 GO_REF:0000107 GO_REF:0000118

NCBI chr 9:5,196,843...5,257,138
Ensembl chr 9:5,382,302...5,441,993

RUVBL1

RuvB like AAA ATPase 1

ISO

PMID:11027681

RGD:67924

NCBI chr 3:125,120,524...125,200,859
Ensembl chr 3:132,486,229...132,528,918

S100A10

S100 calcium binding protein A10

involved_in

IEA

GO_REF:0000107

NCBI chr 1:127,341,974...127,353,054
Ensembl chr 1:130,985,312...130,995,130

positive regulation of proteasomal protein catabolic process

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

BAG2

BAG cochaperone 2

involved_in

IEA

GO_REF:0000107

NCBI chr 6:56,730,297...56,743,123
Ensembl chr 6:58,360,889...58,373,733

DAB2IP

DAB2 interacting protein

involved_in

IEA

GO_REF:0000107

NCBI chr 9:92,696,798...92,912,425
Ensembl chr 9:121,143,457...121,254,336

DDRGK domain containing 1

involved_in

IEA

GO_REF:0000107

NCBI chr20:3,276,292...3,290,433
Ensembl chr20:3,038,779...3,052,789

ECSCR

endothelial cell surface expressed chemotaxis and apoptosis regulator

involved_in
acts_upstream_of_or_within

IEA

GO_REF:0000107 GO_REF:0000118

NCBI chr 5:134,819,568...134,833,508
Ensembl chr 5:140,940,578...140,955,140

FBXW7

F-box and WD repeat domain containing 7

involved_in

IEA

GO_REF:0000107

NCBI chr 4:144,660,676...144,874,404
Ensembl chr 4:156,312,274...156,402,351

FMR1

fragile X messenger ribonucleoprotein 1

involved_in

ISO

(PMID:24709664)

PMID:24709664

NCBI chr X:136,937,889...136,976,828
Ensembl chr X:147,365,748...147,405,321

KCNE2

potassium voltage-gated channel subfamily E regulatory subunit 2

involved_in

IEA

GO_REF:0000107

LOC106634235

uncharacterized LOC106634235

involved_in

IEA

GO_REF:0000107

NCBI chr21:20,548,631...20,739,999
Ensembl chr21:34,107,443...34,107,814
Ensembl chr21:34,107,443...34,107,814

NEURL3

neuralized E3 ubiquitin protein ligase 3

involved_in

IEA

GO_REF:0000107

NCBI chr2A:102,805,257...102,817,152
Ensembl chr2A:97,420,865...97,428,628

NUPR1

nuclear protein 1, transcriptional regulator

involved_in

IEA

GO_REF:0000107

Ensembl chr16:29,015,155...29,016,987

OAZ1

ornithine decarboxylase antizyme 1

ISO

PMID:12359729

RGD:7245486

NCBI chr19:1,279,139...1,283,079
Ensembl chr19:2,250,678...2,254,179

OSBPL7

oxysterol binding protein like 7

involved_in

IEA

GO_REF:0000107

NCBI chr17:9,715,464...9,729,950
Ensembl chr17:9,897,768...9,912,065

PRKN

parkin RBR E3 ubiquitin protein ligase

involved_in

IEA

GO_REF:0000107

NCBI chr 6:159,293,016...160,679,106
Ensembl chr 6:164,314,990...165,678,770

PSMC2

proteasome 26S subunit, ATPase 2

involved_in

IEA

GOC

GO_REF:0000108

NCBI chr 7:95,338,743...95,359,353
Ensembl chr 7:108,083,203...108,103,494

RNF40

ring finger protein 40

ISO

PMID:12121982

RGD:633892

NCBI chr16:24,194,293...24,207,460
Ensembl chr16:31,129,352...31,142,280

TMTC3

transmembrane O-mannosyltransferase targeting cadherins 3

involved_in

IEA

GO_REF:0000107

NCBI chr12:85,683,455...85,741,118
Ensembl chr12:88,989,033...89,046,630

TREM2

triggering receptor expressed on myeloid cells 2

involved_in

IEA

GO_REF:0000107

NCBI chr 6:40,735,483...40,740,208
Ensembl chr 6:42,043,900...42,048,578

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

AKT1

AKT serine/threonine kinase 1

acts_upstream_of_or_within
involved_in

IEA

GO_REF:0000107

NCBI chr14:85,417,229...85,444,722
Ensembl chr14:105,208,128...105,236,756

ATG7

autophagy related 7

acts_upstream_of_or_within

ISO

(PMID:23152632)

PMID:23152632

NCBI chr 3:11,208,600...11,488,757
Ensembl chr 3:11,554,100...11,833,398

AURKA

aurora kinase A

acts_upstream_of_or_within

ISO

(PMID:17060449)

PMID:17060449

NCBI chr20:52,707,757...52,730,579
Ensembl chr20:53,994,881...54,017,339

AXIN1

axin 1

involved_in
acts_upstream_of_or_within

IEA

GO_REF:0000107 GO_REF:0000118

Ensembl chr16:278,239...337,891

AXIN2

axin 2

involved_in

IEA

GO_REF:0000118

NCBI chr17:59,476,336...59,509,358
Ensembl chr17:64,688,416...64,720,086

BAG2

BAG cochaperone 2

NOT|involved_in

ISO

(PMID:19228967)

PMID:19228967

NCBI chr 6:56,730,297...56,743,123
Ensembl chr 6:58,360,889...58,373,733

BBS7

Bardet-Biedl syndrome 7

acts_upstream_of_or_within

IEA

GO_REF:0000107

NCBI chr 4:114,024,949...114,072,000
Ensembl chr 4:125,161,804...125,208,350

CBFA2T3

CBFA2/RUNX1 partner transcriptional co-repressor 3

involved_in

IEA

GO_REF:0000107

NCBI chr16:69,592,293...69,662,321
Ensembl chr16:89,246,545...89,347,435

CHFR

checkpoint with forkhead and ring finger domains

acts_upstream_of_or_within

IEA

GO_REF:0000107

NCBI chr12:130,318,971...130,366,282
Ensembl chr12:134,923,458...134,968,832
Ensembl chr12:134,923,458...134,968,832

CLU

clusterin

involved_in

IEA

GO_REF:0000107 GO_REF:0000118

NCBI chr 8:26,867,973...26,884,838
Ensembl chr 8:24,070,053...24,083,523

COP1

COP1 E3 ubiquitin ligase

involved_in

IEA

PMID:11955436 PMID:19364825

GO_REF:0000107

NCBI chr 1:151,459,354...151,727,131
Ensembl chr 1:155,156,185...155,425,156

CSNK1A1

casein kinase 1 alpha 1

involved_in

ISO

(PMID:11955436)
(PMID:19364825)

ParkinsonsUK-UCL
FlyBase

NCBI chr 5:144,919,775...144,977,105
Ensembl chr 5:150,929,420...150,985,912

CSNK1D

casein kinase 1 delta

involved_in

ISO

(PMID:19414593)

PMID:19414593

NCBI chr17:76,648,677...76,683,054
Ensembl chr17:82,462,467...82,494,348

CSNK1E

casein kinase 1 epsilon

involved_in

IEA

GO_REF:0000107

NCBI chr22:19,202,599...19,229,344
Ensembl chr22:37,027,094...37,072,942

DAB2

DAB adaptor protein 2

involved_in

IEA

GO_REF:0000107

NCBI chr 5:70,951,198...71,004,836
Ensembl chr 5:76,022,143...76,041,443

DDA1

DET1 and DDB1 associated 1

involved_in

IEA

GO_REF:0000118

NCBI chr19:16,797,750...16,808,427
Ensembl chr19:17,771,925...17,785,267

DDRGK domain containing 1

involved_in

IEA

GO_REF:0000107

NCBI chr20:3,276,292...3,290,433
Ensembl chr20:3,038,779...3,052,789

DET1

DET1 partner of COP1 E3 ubiquitin ligase

involved_in

IEA

GO_REF:0000107 GO_REF:0000118

NCBI chr15:67,203,101...67,238,185
Ensembl chr15:86,411,937...86,444,789

DNAJB2

DnaJ heat shock protein family (Hsp40) member B2

involved_in

IEA

GO_REF:0000118

NCBI chr2B:106,536,846...106,544,430
Ensembl chr2B:225,127,967...225,135,556

DVL1

dishevelled segment polarity protein 1

involved_in

IEA

GO_REF:0000107

NCBI chr 1:92,469...106,748
Ensembl chr 1:1,292,052...1,301,008

FBXO22

F-box protein 22

acts_upstream_of_or_within
involved_in

ISO
IEA

(PMID:19319192)

MGI
TreeGrafter

PMID:19319192

GO_REF:0000118

NCBI chr15:54,817,076...54,849,271
Ensembl chr15:74,410,213...74,441,609

FBXW8

F-box and WD repeat domain containing 8

involved_in

IEA

GO_REF:0000107

NCBI chr12:114,487,476...114,607,384
Ensembl chr12:117,863,254...117,983,269

GABARAP

GABA type A receptor-associated protein

involved_in

ISO

(PMID:25684205)

PMID:25684205

NCBI chr17:7,270,316...7,272,365
Ensembl chr17:7,257,659...7,260,276

GBA1

glucosylceramidase beta 1

acts_upstream_of_or_within

ISO

(PMID:23707074)

PMID:23707074

NCBI chr 1:130,579,300...130,589,560
Ensembl chr 1:134,185,385...134,194,851

GCLC

glutamate-cysteine ligase catalytic subunit

acts_upstream_of_or_within

IEA

GO_REF:0000107

NCBI chr 6:53,052,145...53,102,794
Ensembl chr 6:54,687,315...54,734,994

GSK3A

glycogen synthase kinase 3 alpha

involved_in

IEA

GO_REF:0000107 GO_REF:0000118

NCBI chr19:39,118,330...39,130,768
Ensembl chr19:47,710,197...47,726,948

GSK3B

glycogen synthase kinase 3 beta

involved_in
acts_upstream_of_or_within

IEA
ISO

(PMID:22660580)

Ensembl
TreeGrafter
MGI

PMID:22660580

GO_REF:0000107 GO_REF:0000118

NCBI chr 3:116,943,205...117,215,001
Ensembl chr 3:123,861,379...124,126,771

HAMP

hepcidin antimicrobial peptide

involved_in

IEA

GO_REF:0000107

NCBI chr19:32,228,701...32,231,494
Ensembl chr19:40,964,445...40,968,861

HSPA1A

heat shock protein family A (Hsp70) member 1A

involved_in

ISO

(PMID:24613385)

PMID:24613385

NCBI chr 6:31,476,710...31,491,411

HSPA1B

heat shock protein family A (Hsp70) member 1B

involved_in

ISO

(PMID:24613385)

PMID:24613385

NCBI chr 6:31,488,882...31,491,412

HSPBP1

HSPA (Hsp70) binding protein 1

involved_in

IEA

GO_REF:0000107

NCBI chr19:52,303,121...52,322,771
Ensembl chr19:60,995,202...61,013,756

IL33

interleukin 33

acts_upstream_of_or_within

IEA

GO_REF:0000107

NCBI chr 9:6,027,014...6,069,540
Ensembl chr 9:6,234,178...6,248,624

KLHL40

kelch like family member 40

involved_in

ISO

(PMID:25940086)

PMID:25940086

NCBI chr 3:42,592,977...42,600,100
Ensembl chr 3:43,657,128...43,664,055

LRRK2

leucine rich repeat kinase 2

involved_in

IEA

GO_REF:0000107

NCBI chr12:48,343,621...48,488,337
Ensembl chr12:49,205,930...49,350,462

MAPK8

mitogen-activated protein kinase 8

involved_in

ISO

(PMID:29153991)

PMID:29153991

NCBI chr10:45,806,748...45,936,362

MAPK9

mitogen-activated protein kinase 9

involved_in

IEA

GO_REF:0000107

NCBI chr 5:175,437,167...175,495,469
Ensembl chr 5:182,748,381...182,795,135

MDM2

MDM2 proto-oncogene

involved_in

IEA

GO_REF:0000107

NCBI chr12:66,322,340...66,357,010
Ensembl chr12:69,102,084...69,133,278

NKD2

NKD inhibitor of WNT signaling pathway 2

involved_in

IEA

GO_REF:0000107

Ensembl chr 5:1,075,172...1,081,664

NOP53

NOP53 ribosome biogenesis factor

involved_in

ISO

(PMID:25818168), (PMID:27323397)
(PMID:21804542)

PMID:21804542 PMID:25818168 PMID:27323397

NCBI chr19:44,739,739...44,751,303

NUB1

negative regulator of ubiquitin like proteins 1

involved_in

IEA

GO_REF:0000107

NCBI chr 7:142,927,730...142,964,475
Ensembl chr 7:155,079,243...155,114,676

PABIR1

PP2A Aalpha (PPP2R1A) and B55A (PPP2R2A) interacting phosphatase regulator 1

involved_in

IEA

GO_REF:0000107

NCBI chr 9:56,007,323...56,011,655
Ensembl chr 9:67,544,489...67,545,352

PAQR3

progestin and adipoQ receptor family member 3

involved_in

IEA

GO_REF:0000107

NCBI chr 4:45,255,403...45,279,319
Ensembl chr 4:51,102,305...51,123,506

PIAS1

protein inhibitor of activated STAT 1

involved_in

IEA

GO_REF:0000107

NCBI chr15:47,006,718...47,141,035
Ensembl chr15:65,276,530...65,410,105

PLK1

polo like kinase 1

involved_in

IEA

GO_REF:0000107

NCBI chr16:14,420,972...14,432,821
Ensembl chr16:23,928,773...23,940,779

PLK2

polo like kinase 2

ISO

PMID:18723513

RGD:7241135

NCBI chr 5:55,543,828...55,550,116
Ensembl chr 5:57,177,836...57,184,793

PLK3

polo like kinase 3

involved_in

IEA

GO_REF:0000107

NCBI chr 1:44,104,564...44,110,162
Ensembl chr 1:45,470,016...45,476,021

PRICKLE1

prickle planar cell polarity protein 1

involved_in

IEA

GO_REF:0000107

NCBI chr12:46,127,673...46,262,333
Ensembl chr12:47,100,393...47,126,102

PRKN

parkin RBR E3 ubiquitin protein ligase

involved_in

IEA

GO_REF:0000107

NCBI chr 6:159,293,016...160,679,106
Ensembl chr 6:164,314,990...165,678,770

PSEN1

presenilin 1

involved_in

IEA

GO_REF:0000107

NCBI chr14:53,718,299...53,802,684
Ensembl chr14:72,579,024...72,663,876

PSEN2

presenilin 2

involved_in

ISO

(PMID:20208556)

PMID:20208556

NCBI chr 1:202,328,987...202,354,440
Ensembl chr 1:207,320,937...207,346,295

PSMD10

proteasome 26S subunit, non-ATPase 10

involved_in

IEA

GO_REF:0000107

NCBI chr X:97,182,090...97,189,523
Ensembl chr X:107,552,186...107,559,616

RACK1

receptor for activated C kinase 1

involved_in

IEA

GO_REF:0000107

NCBI chr 5:176,462,991...176,470,153
Ensembl chr 5:183,712,665...183,720,128

RAD23A

RAD23 homolog A, nucleotide excision repair protein

involved_in

IEA

GO_REF:0000107

NCBI chr19:12,508,232...12,516,068
Ensembl chr19:13,250,718...13,258,482

RBX1

ring-box 1

involved_in

IEA

GO_REF:0000107

NCBI chr22:21,845,351...21,866,627
Ensembl chr22:39,941,405...39,962,175

RCHY1

ring finger and CHY zinc finger domain containing 1

involved_in

IEA

GO_REF:0000107

NCBI chr 4:48,691,213...48,725,979
Ensembl chr 4:54,526,202...54,561,048

RFPL1

ret finger protein like 1

involved_in

ISO

(PMID:20725088)

PMID:20725088

RNF180

ring finger protein 180

involved_in
acts_upstream_of_or_within

IEA

GO_REF:0000107 GO_REF:0000118

NCBI chr 5:49,624,452...49,841,741
Ensembl chr 5:51,280,064...51,454,750

SH3RF2

SH3 domain containing ring finger 2

involved_in

IEA

GO_REF:0000107 GO_REF:0000118

NCBI chr 5:141,386,060...141,530,993
Ensembl chr 5:147,401,188...147,545,703

SIRT1

sirtuin 1

involved_in

IEA

GO_REF:0000107

NCBI chr10:64,368,878...64,401,684
Ensembl chr10:66,681,598...66,715,069

SIRT2

sirtuin 2

involved_in

IEA

GO_REF:0000107

NCBI chr19:35,984,453...36,005,582
Ensembl chr19:44,533,965...44,554,799

SIRT6

sirtuin 6

involved_in

IEA

GO_REF:0000107

NCBI chr19:3,196,092...3,204,602
Ensembl chr19:4,146,057...4,154,126

SOCS4

suppressor of cytokine signaling 4

involved_in

IEA

InterPro

GO_REF:0000002

NCBI chr14:35,614,238...35,636,531
Ensembl chr14:53,904,783...53,906,105

SOCS5

suppressor of cytokine signaling 5

involved_in

IEA

Ensembl
InterPro

GO_REF:0000002 GO_REF:0000107

NCBI chr2A:46,813,589...46,878,102
Ensembl chr2A:47,804,431...47,806,041

STUB1

STIP1 homology and U-box containing protein 1

involved_in

IEA

GO_REF:0000107

Ensembl chr16:694,414...696,682

SUMO1

small ubiquitin like modifier 1

involved_in

ISO

(PMID:18408734)

PMID:18408734

NCBI chr2B:89,461,773...89,493,879
Ensembl chr2B:207,613,654...207,645,590

SUMO2

small ubiquitin like modifier 2

involved_in

ISO

(PMID:18408734)

PMID:18408734

NCBI chr17:69,115,433...69,130,065

TAF1

TATA-box binding protein associated factor 1

involved_in

IEA

GO_REF:0000107

NCBI chr X:60,630,137...60,729,904
Ensembl chr X:70,684,217...70,782,323

transferrin

involved_in

IEA

GO_REF:0000107

NCBI chr 3:130,799,063...130,830,227
Ensembl chr 3:138,274,159...138,305,476

TRIB1

tribbles pseudokinase 1

involved_in

IEA

GO_REF:0000107 GO_REF:0000118

NCBI chr 8:122,115,194...122,123,319
Ensembl chr 8:124,867,359...124,872,924

TRIB2

tribbles pseudokinase 2

involved_in

IEA

GO_REF:0000107 GO_REF:0000118

NCBI chr2A:12,705,043...12,730,932
Ensembl chr2A:12,847,631...12,873,499

TRIB3

tribbles pseudokinase 3

involved_in

IEA

GO_REF:0000118

NCBI chr20:583,267...605,416
Ensembl chr20:359,879...375,486

UBE2V2

ubiquitin conjugating enzyme E2 V2

ISO

PMID:12750002

RGD:1299567

NCBI chr 8:44,435,496...44,488,517
Ensembl chr 8:41,856,429...41,878,320

USP5

ubiquitin specific peptidase 5

involved_in

IEA

GO_REF:0000107

NCBI chr12:6,983,941...6,998,469
Ensembl chr12:6,895,416...6,909,936

VCP

valosin containing protein

involved_in

IEA

GO_REF:0000107

NCBI chr 9:34,907,147...34,923,227
Ensembl chr 9:35,712,937...35,729,588

ZER1

zyg-11 related cell cycle regulator

involved_in

IEA

GO_REF:0000107

NCBI chr 9:99,853,433...99,895,399
Ensembl chr 9:128,519,972...128,560,098

ZFAND2A

zinc finger AN1-type containing 2A

acts_upstream_of_or_within

ISO

(PMID:16973439)

PMID:16973439

NCBI chr 7:1,392,979...1,401,283
Ensembl chr 7:1,518,912...1,526,107

ZYG11B

zyg-11 family member B, cell cycle regulator

involved_in

ISO

(PMID:31273098)

PMID:31273098

NCBI chr 1:51,987,678...52,087,093

positive regulation of protein processing

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

ANGPTL8

angiopoietin like 8

acts_upstream_of_or_within

IEA

GO_REF:0000107

NCBI chr19:10,787,457...10,790,090
Ensembl chr19:11,498,069...11,500,400

ASTL

astacin like metalloendopeptidase

involved_in

IEA

GO_REF:0000107

NCBI chr2A:103,176,662...103,192,542
Ensembl chr2A:97,049,184...97,063,747

BAG2

BAG cochaperone 2

involved_in

IEA

GO_REF:0000107

NCBI chr 6:56,730,297...56,743,123
Ensembl chr 6:58,360,889...58,373,733

CCBE1

collagen and calcium binding EGF domains 1

involved_in

IEA

GO_REF:0000107

NCBI chr18:52,819,591...53,087,772
Ensembl chr18:56,149,036...56,412,222

CNTN2

contactin 2

acts_upstream_of_or_within

IEA

GO_REF:0000107

NCBI chr 1:180,645,259...180,680,081
Ensembl chr 1:184,931,497...184,966,482

CTNND1

catenin delta 1

acts_upstream_of_or_within

ISO

(PMID:17344476)

PMID:17344476

NCBI chr11:53,000,582...53,058,054
Ensembl chr11:56,470,174...56,527,593

FUZ

fuzzy planar cell polarity protein

acts_upstream_of_or_within

ISO

(PMID:19877275)

PMID:19877275

NCBI chr19:46,819,833...46,826,235
Ensembl chr19:55,736,325...55,742,589

MBL2

mannose binding lectin 2

ISO

Masp2

PMID:20118239

RGD:7242176

NCBI chr10:49,401,364...49,409,328
Ensembl chr10:51,527,758...51,543,432

MMP14

matrix metallopeptidase 14

ISO

PMID:14668206

RGD:1582606

NCBI chr14:3,654,125...3,665,158
Ensembl chr14:21,753,305...21,764,058

NKD2

NKD inhibitor of WNT signaling pathway 2

involved_in

IEA

GO_REF:0000107

Ensembl chr 5:1,075,172...1,081,664

NLRC4

NLR family CARD domain containing 4

involved_in

IEA

GO_REF:0000107

NCBI chr2A:32,241,782...32,284,041
Ensembl chr2A:32,954,185...32,996,465

RHBDD1

rhomboid domain containing 1

involved_in

IEA

GO_REF:0000107

NCBI chr2B:114,041,381...114,245,220
Ensembl chr2B:232,897,487...233,057,578

SPON1

spondin 1

acts_upstream_of_or_within

IEA

GO_REF:0000107

NCBI chr11:14,063,166...14,368,180
Ensembl chr11:13,776,671...14,057,741

SRC

SRC proto-oncogene, non-receptor tyrosine kinase

acts_upstream_of_or_within

IEA

GO_REF:0000107

NCBI chr20:33,667,614...33,727,126
Ensembl chr20:34,822,271...34,839,634

TIMM17A

translocase of inner mitochondrial membrane 17A

ISO

PMID:9756630

RGD:13463485

NCBI chr 1:177,552,399...177,567,148
Ensembl chr 1:181,854,412...181,868,960

TIMM23

translocase of inner mitochondrial membrane 23

ISO

PMID:9756630

RGD:13463485

NCBI chr10:43,123,802...43,157,666

TNP1

transition protein 1

involved_in

IEA

GO_REF:0000107

NCBI chr2B:104,122,748...104,123,349
Ensembl chr2B:222,723,606...222,724,212

TNP2

transition protein 2

involved_in

ISS

GO_REF:0000024

NCBI chr16:10,209,801...10,211,466
Ensembl chr16:11,431,822...11,433,087

positive regulation of protein processing in phagocytic vesicle

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

GSN

gelsolin

involved_in

IEA

GO_REF:0000107

NCBI chr 9:92,413,819...92,460,483
Ensembl chr 9:120,741,148...120,805,831

MYH9

myosin heavy chain 9

involved_in

IEA

GO_REF:0000107

NCBI chr22:17,200,623...17,305,826
Ensembl chr22:35,039,101...35,121,618

positive regulation of proteolysis

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

ASPH

aspartate beta-hydroxylase

involved_in

IEA

GO_REF:0000107

NCBI chr 8:57,921,580...58,134,778
Ensembl chr 8:59,629,707...59,843,658

AURKAIP1

aurora kinase A interacting protein 1

acts_upstream_of_or_within

IEA

GO_REF:0000107

NCBI chr 1:129,234...130,866
Ensembl chr 1:1,329,414...1,331,203

BAD

BCL2 associated agonist of cell death

involved_in

IEA

GO_REF:0000107

NCBI chr11:59,626,981...59,641,824
Ensembl chr11:62,971,808...62,986,257

BAK1

BCL2 antagonist/killer 1

involved_in

IEA

GO_REF:0000107

NCBI chr 6:33,146,998...33,154,755
Ensembl chr 6:34,255,769...34,263,211

BTRC

beta-transducin repeat containing E3 ubiquitin protein ligase

involved_in

IEA

GO_REF:0000107

NCBI chr10:97,958,527...98,159,550
Ensembl chr10:101,431,318...101,632,496

CASP8

caspase 8

involved_in

IEA

GO_REF:0000107

NCBI chr2B:88,490,611...88,542,132
Ensembl chr2B:206,669,544...206,696,468

CD46

CD46 molecule

ISO

PMID:15215199

RGD:2293559

NCBI chr 1:183,330,423...183,373,916
Ensembl chr 1:188,031,758...188,182,046

CFL1

cofilin 1

ISO

PMID:24093776

RGD:11570550

NCBI chr11:61,215,092...61,218,628
Ensembl chr11:64,544,275...64,550,806

CLN6

CLN6 transmembrane ER protein

involved_in

IEA

GO_REF:0000107

NCBI chr15:47,156,583...47,215,805
Ensembl chr15:65,425,472...65,985,242

CYFIP2

cytoplasmic FMR1 interacting protein 2

involved_in

IEA

GO_REF:0000107

NCBI chr 5:152,667,136...152,796,575
Ensembl chr 5:159,292,029...159,418,077

EP300

E1A binding protein p300

ISO

PMID:16973938

RGD:2289912

NCBI chr22:21,986,467...22,076,921
Ensembl chr22:40,079,503...40,168,604

FADD

Fas associated via death domain

involved_in

ISO

(PMID:18387192)

PMID:18387192

NCBI chr11:65,300,889...65,305,020

FBXW11

F-box and WD repeat domain containing 11

involved_in

ISO

(PMID:16885022)

PMID:16885022

NCBI chr 5:167,207,643...167,354,730
Ensembl chr 5:174,124,499...174,271,977

FGFR4

fibroblast growth factor receptor 4

involved_in

IEA

GO_REF:0000107

NCBI chr 5:172,386,443...172,400,271
Ensembl chr 5:179,454,995...179,467,605

HDAC2

histone deacetylase 2

involved_in

IEA

GO_REF:0000107

NCBI chr 6:111,731,139...111,761,826
Ensembl chr 6:115,802,367...115,833,004

HSPA8

heat shock protein family A (Hsp70) member 8

ISO

PMID:9987077

RGD:10059370

NCBI chr11:117,890,545...117,895,262
Ensembl chr11:121,809,800...121,815,773

IST1

IST1 factor associated with ESCRT-III

involved_in

IEA

GO_REF:0000107

NCBI chr16:53,082,530...53,115,965
Ensembl chr16:71,733,302...71,765,969

LOC100984344

calpain-3

involved_in

IEA

GO_REF:0000107

NCBI chr15:21,227,371...21,372,406
Ensembl chr15:39,476,302...39,528,820
Ensembl chr15:39,476,302...39,528,820

OGA

O-GlcNAcase

ISO

Degradation of calmodulin-dependent protein kinase II and alpha fodrin (RGD: 621714).

PMID:17573462

RGD:2305953

NCBI chr10:98,387,144...98,421,105
Ensembl chr10:101,858,879...101,892,479

OGT

O-linked N-acetylglucosamine (GlcNAc) transferase

involved_in

IEA

GO_REF:0000107

NCBI chr X:60,798,219...60,840,948
Ensembl chr X:70,852,687...70,894,921

PERP

p53 apoptosis effector related to PMP22

involved_in

IEA

GO_REF:0000107

NCBI chr 6:135,845,845...135,863,603
Ensembl chr 6:139,931,031...139,947,792

PLK1

polo like kinase 1

involved_in

IEA

GO_REF:0000107

NCBI chr16:14,420,972...14,432,821
Ensembl chr16:23,928,773...23,940,779

STUB1

STIP1 homology and U-box containing protein 1

involved_in

IEA

GO_REF:0000107 GO_REF:0000118

Ensembl chr16:694,414...696,682

TBC1D10A

TBC1 domain family member 10A

involved_in

IEA

GO_REF:0000107

NCBI chr22:11,328,159...11,363,009
Ensembl chr22:29,130,096...29,164,865

TRIM32

tripartite motif containing 32

involved_in

IEA

GO_REF:0000107

NCBI chr 9:87,819,723...87,838,684
Ensembl chr 9:116,183,746...116,185,707

positive regulation of proteolysis involved in protein catabolic process

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

ATP5IF1

ATP synthase inhibitory factor subunit 1

involved_in

IEA

GO_REF:0000107

NCBI chr 1:27,495,250...27,497,255
Ensembl chr 1:28,532,091...28,542,607

CTSC

cathepsin C

involved_in

ISO

PMID:18307834

PMID:18307834

RGD:8661625

NCBI chr11:83,299,827...83,345,383
Ensembl chr11:86,890,010...86,933,847

DDRGK domain containing 1

involved_in

IEA

GO_REF:0000107

NCBI chr20:3,276,292...3,290,433
Ensembl chr20:3,038,779...3,052,789

GBA1

glucosylceramidase beta 1

acts_upstream_of_or_within

ISO

(PMID:21700325)

PMID:21700325

NCBI chr 1:130,579,300...130,589,560
Ensembl chr 1:134,185,385...134,194,851

LAPTM5

lysosomal protein transmembrane 5

involved_in

IEA

GO_REF:0000107

NCBI chr 1:30,005,941...30,031,366
Ensembl chr 1:31,032,963...31,058,385

RGN

regucalcin

ISO

PMID:1513338

RGD:9590188

NCBI chr X:39,513,135...39,530,188
Ensembl chr X:47,371,226...47,388,881

UFL1

UFM1 specific ligase 1

involved_in

IEA

GO_REF:0000107

NCBI chr 6:94,356,440...94,389,920
Ensembl chr 6:98,242,756...98,274,377

positive regulation of serine-type endopeptidase activity

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

CR1

complement C3b/C4b receptor 1 (Knops blood group)

involved_in

ISO

(PMID:2972794)

PMID:2972794

NCBI chr 1:183,094,601...183,246,957

SEMG1

semenogelin 1

involved_in

ISO

(PMID:15563730)

PMID:15563730

NCBI chr20:41,537,773...41,539,964
Ensembl chr20:42,628,856...42,631,405

SEMG2

semenogelin 2

involved_in

ISO

(PMID:15563730)

PMID:15563730

NCBI chr20:41,552,614...41,554,605
Ensembl chr20:42,642,620...42,644,611

positive regulation of ubiquitin-dependent protein catabolic process

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

ATXN3

ataxin 3

involved_in

ISO

(PMID:17000876)

PMID:17000876

NCBI chr14:72,693,446...72,741,772

AXIN1

axin 1

acts_upstream_of_or_within
involved_in

IEA
ISO

PMID:10228155

Ensembl
BHF-UCL

PMID:10228155

GO_REF:0000107 RGD:8553327

Ensembl chr16:278,239...337,891

BCAP31

B cell receptor associated protein 31

involved_in

IEA

GO_REF:0000107

NCBI chr X:143,265,920...143,274,956
Ensembl chr X:153,137,992...153,161,628

CCDC22

CCC complex scaffolding subunit CCDC22

involved_in

IEA

GO_REF:0000107 GO_REF:0000118

NCBI chr X:41,535,439...41,550,547
Ensembl chr X:49,387,980...49,402,742

CDK5RAP3

CDK5 regulatory subunit associated protein 3

NOT|involved_in

ISO

(PMID:16173922)

PMID:16173922

NCBI chr17:9,556,313...9,567,099
Ensembl chr17:9,738,141...9,749,302

CLU

clusterin

involved_in

IEA

GO_REF:0000107

NCBI chr 8:26,867,973...26,884,838
Ensembl chr 8:24,070,053...24,083,523

DISC1

DISC1 scaffold protein

acts_upstream_of_or_within

IEA

GO_REF:0000107

NCBI chr 1:207,180,513...207,594,684
Ensembl chr 1:212,265,520...212,612,079

EGF

epidermal growth factor

involved_in

IEA

GO_REF:0000107

NCBI chr 4:102,410,724...102,509,691
Ensembl chr 4:112,977,565...113,076,460

FBXO22

F-box protein 22

acts_upstream_of_or_within

ISO

(PMID:19319192)

PMID:19319192

NCBI chr15:54,817,076...54,849,271
Ensembl chr15:74,410,213...74,441,609

FBXW7

F-box and WD repeat domain containing 7

involved_in

IEA

GO_REF:0000107

NCBI chr 4:144,660,676...144,874,404
Ensembl chr 4:156,312,274...156,402,351

HERPUD1

homocysteine inducible ER protein with ubiquitin like domain 1

involved_in

IEA

GO_REF:0000107

NCBI chr16:37,210,170...37,221,961
Ensembl chr16:56,343,025...56,355,164

L3MBTL3

L3MBTL histone methyl-lysine binding protein 3

involved_in

IEA

GO_REF:0000107

NCBI chr 6:127,814,847...127,938,220
Ensembl chr 6:131,922,967...132,045,708

LAPTM5

lysosomal protein transmembrane 5

involved_in

IEA

GO_REF:0000107

NCBI chr 1:30,005,941...30,031,366
Ensembl chr 1:31,032,963...31,058,385

LOC100967527

AGBL carboxypeptidase 4

acts_upstream_of_or_within

IEA

GO_REF:0000107

NCBI chr 1:47,807,888...49,264,213
Ensembl chr 1:49,511,379...49,560,314
Ensembl chr 1:49,511,379...49,560,314

LOC100970998

small ubiquitin like modifier 3

acts_upstream_of_or_within

ISO

(PMID:18644859)

PMID:18644859

NCBI chr 1:224,215,377...224,217,052

MTOR

mechanistic target of rapamycin kinase

acts_upstream_of

IEA

GO_REF:0000107

NCBI chr 1:9,871,700...10,028,704
Ensembl chr 1:11,093,765...11,249,841

PTEN

phosphatase and tensin homolog

involved_in

ISO

(PMID:21241890)

PMID:21241890

NCBI chr10:84,587,841...84,689,043
Ensembl chr10:88,093,539...88,194,605

PTK2

protein tyrosine kinase 2

involved_in

ISO

(PMID:18206965)

PMID:18206965

NCBI chr 8:137,330,777...137,677,306
Ensembl chr 8:140,412,773...140,684,898

PTK2B

protein tyrosine kinase 2 beta

involved_in

IEA

GO_REF:0000107

NCBI chr 8:26,580,855...26,729,378
Ensembl chr 8:23,869,825...23,932,474

PYHIN1

pyrin and HIN domain family member 1

involved_in

IEA

GO_REF:0000107

NCBI chr 1:134,283,998...134,329,531
Ensembl chr 1:138,081,611...138,127,115

RNF139

ring finger protein 139

involved_in

IEA

GO_REF:0000107

NCBI chr 8:121,158,715...121,172,069
Ensembl chr 8:123,912,589...123,924,720

small glutamine rich tetratricopeptide repeat co-chaperone alpha

involved_in

IEA

GO_REF:0000107

NCBI chr19:1,778,728...1,808,199
Ensembl chr19:2,736,565...2,763,440

SMURF1

SMAD specific E3 ubiquitin protein ligase 1

involved_in

IEA

GO_REF:0000107

NCBI chr 7:90,995,923...91,112,240
Ensembl chr 7:104,500,965...104,568,046

TGFB1I1

transforming growth factor beta 1 induced transcript 1

involved_in

IEA

GO_REF:0000107

NCBI chr16:23,487,561...23,493,452
Ensembl chr16:31,842,437...31,848,327

TRAF7

TNF receptor associated factor 7

involved_in

IEA

GO_REF:0000107

NCBI chr16:1,013,831...1,036,486
Ensembl chr16:2,266,194...2,279,031

TRIM67

tripartite motif containing 67

acts_upstream_of_or_within

ISO

(PMID:22337885)

PMID:22337885

NCBI chr 1:206,710,490...206,770,111

VCP

valosin containing protein

ISO

PMID:16103111

RGD:1599730

NCBI chr 9:34,907,147...34,923,227
Ensembl chr 9:35,712,937...35,729,588

positive regulation of ubiquitin-specific protease activity

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

TANK

TRAF family member associated NFKB activator

involved_in

ISO

(PMID:25861989)

PMID:25861989

NCBI chr2B:48,426,036...48,525,265
Ensembl chr2B:165,820,833...165,896,438

regulation of endopeptidase activity

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

A2ML1

alpha-2-macroglobulin like 1

involved_in

ISO

(PMID:16298998)

PMID:16298998

NCBI chr12:8,909,111...8,961,857
Ensembl chr12:9,122,447...9,192,371

regulation of ERAD pathway

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

HERPUD1

homocysteine inducible ER protein with ubiquitin like domain 1

involved_in

IEA

GO_REF:0000107 GO_REF:0000118

NCBI chr16:37,210,170...37,221,961
Ensembl chr16:56,343,025...56,355,164

USP19

ubiquitin specific peptidase 19

involved_in

IEA

GO_REF:0000107

NCBI chr 3:49,032,373...49,045,238
Ensembl chr 3:50,100,216...50,125,112

regulation of membrane protein ectodomain proteolysis

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

TSPAN15

tetraspanin 15

involved_in

IEA

GO_REF:0000107

NCBI chr10:65,919,622...65,976,449
Ensembl chr10:68,450,318...68,507,151

TSPAN17

tetraspanin 17

involved_in

IEA

GO_REF:0000107

NCBI chr 5:171,944,792...171,959,797
Ensembl chr 5:179,015,641...179,030,941

TSPAN5

tetraspanin 5

involved_in

IEA

GO_REF:0000107

NCBI chr 4:90,872,988...91,052,345
Ensembl chr 4:101,536,950...101,717,228

regulation of metalloendopeptidase activity

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

RHBDF2

rhomboid 5 homolog 2

acts_upstream_of_or_within

ISO

(PMID:29897333)

PMID:29897333

NCBI chr17:70,418,630...70,449,510
Ensembl chr17:75,968,187...75,987,768

regulation of metallopeptidase activity

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

SVBP

small vasohibin binding protein

involved_in

ISO

(PMID:31171830), (PMID:31235910), (PMID:31235911), (PMID:31270470)

PMID:31171830 PMID:31235910 PMID:31235911 PMID:31270470

NCBI chr 1:42,105,405...42,115,721
Ensembl chr 1:43,482,870...43,492,577

regulation of peptidase activity

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

CAV1

caveolin 1

acts_upstream_of_or_within

ISO

(PMID:17349656)

PMID:17349656

NCBI chr 7:108,497,125...108,533,090
Ensembl chr 7:121,193,424...121,229,655

regulation of proteasomal protein catabolic process

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

APOE

apolipoprotein E

involved_in

IEA

GO_REF:0000107

NCBI chr19:41,853,669...41,857,252
Ensembl chr19:50,459,906...50,463,490

BTRC

beta-transducin repeat containing E3 ubiquitin protein ligase

acts_upstream_of_or_within

IEA

GO_REF:0000107

NCBI chr10:97,958,527...98,159,550
Ensembl chr10:101,431,318...101,632,496

DLGAP1

DLG associated protein 1

involved_in

ISO

PMID:15496675

PMID:15496675

RGD:8553458

NCBI chr18:9,816,171...10,781,490
Ensembl chr18:12,704,306...13,091,118

DNAAF4

dynein axonemal assembly factor 4

involved_in

ISS
IEA

UniProt
Ensembl

GO_REF:0000024 GO_REF:0000107

NCBI chr15:34,382,064...34,469,432
Ensembl chr15:52,711,349...52,791,281

EPM2A

EPM2A glucan phosphatase, laforin

acts_upstream_of_or_within

ISO

(PMID:27107699)

PMID:27107699

NCBI chr 6:143,179,097...143,525,223

GPX1

glutathione peroxidase 1

involved_in

ISO

(PMID:12751788)

PMID:12751788

NCBI chr 3:49,280,038...49,281,455
Ensembl chr 3:50,360,947...50,361,826

LOC100972297

nuclear pore complex-interacting protein family member B6

acts_upstream_of_or_within

ISO

(PMID:23001567)

PMID:23001567

NCBI chr16:604,927...1,697,831

LOC100973071

proteasome activator complex subunit 2-like

involved_in

IEA

GO_REF:0000118

NCBI chr 5:93,520,158...93,520,928

NFE2L1

NFE2 like bZIP transcription factor 1

acts_upstream_of_or_within

IEA

GO_REF:0000107

NCBI chr17:9,476,482...9,489,661
Ensembl chr17:9,657,847...9,671,040

NUDT15

nudix hydrolase 15

involved_in

IEA

GO_REF:0000107

NCBI chr13:29,189,459...29,198,825
Ensembl chr13:47,891,557...47,900,971

PITHD1

PITH domain containing 1

acts_upstream_of_or_within

IEA

GO_REF:0000107

NCBI chr 1:22,970,081...22,979,841
Ensembl chr 1:23,954,980...23,964,085

PKD1

polycystin 1, transient receptor potential channel interacting

acts_upstream_of_or_within

ISO

(PMID:23001567)

PMID:23001567

NCBI chr16:604,366...605,560

PRKACA

protein kinase cAMP-activated catalytic subunit alpha

involved_in

IEA

GO_REF:0000107

NCBI chr19:13,657,344...13,683,864
Ensembl chr19:14,385,191...14,406,205

PSMD14

proteasome 26S subunit, non-ATPase 14

involved_in

IEA

GO_REF:0000107

NCBI chr2B:48,602,395...48,705,229
Ensembl chr2B:165,972,229...166,074,879

PSME1

proteasome activator subunit 1

involved_in

IEA

GO_REF:0000118

NCBI chr14:4,912,390...4,915,219
Ensembl chr14:23,033,548...23,039,405

PSME2

proteasome activator subunit 2

involved_in

IEA

GO_REF:0000118

NCBI chr14:4,919,628...4,922,952
Ensembl chr14:23,043,807...23,047,296

PSME3

proteasome activator subunit 3

involved_in

IEA

GO_REF:0000107 GO_REF:0000118

NCBI chr17:14,474,604...14,484,522
Ensembl chr17:14,700,660...14,711,735

RAD23A

RAD23 homolog A, nucleotide excision repair protein

involved_in

IEA

GO_REF:0000117

NCBI chr19:12,508,232...12,516,068
Ensembl chr19:13,250,718...13,258,482

RAD23B

RAD23 homolog B, nucleotide excision repair protein

involved_in

IEA

GO_REF:0000117

NCBI chr 9:78,433,461...78,482,157
Ensembl chr 9:106,622,377...106,670,317

RHBDF1

rhomboid 5 homolog 1

involved_in

IEA

GO_REF:0000107

Ensembl chr16:49,031...57,222

TMF1

TATA element modulatory factor 1

involved_in

IEA

GO_REF:0000107

NCBI chr 3:68,955,866...68,988,353
Ensembl chr 3:70,322,814...70,355,460

UBB

ubiquitin B

acts_upstream_of_or_within

ISO

(PMID:17571083)

PMID:17571083

NCBI chr17:35,286,699...35,288,429

UBQLN1

ubiquilin 1

involved_in

IEA

GO_REF:0000117

NCBI chr 9:41,170,416...41,218,656
Ensembl chr 9:82,597,507...82,645,587

UBQLN2

ubiquilin 2

involved_in

IEA

GO_REF:0000117

NCBI chr X:48,829,844...48,835,040
Ensembl chr X:56,981,985...56,983,859

UBQLN3

ubiquilin 3

involved_in

IEA

GO_REF:0000117

NCBI chr11:5,651,750...5,654,422
Ensembl chr11:5,334,275...5,336,242

UBQLN4

ubiquilin 4

involved_in

IEA

GO_REF:0000117

NCBI chr 1:131,374,635...131,395,986
Ensembl chr 1:135,209,490...135,225,666

UCHL5

ubiquitin C-terminal hydrolase L5

involved_in

IEA

GO_REF:0000107

NCBI chr 1:168,471,501...168,519,366
Ensembl chr 1:172,764,606...172,811,880

USP14

ubiquitin specific peptidase 14

involved_in

IEA

GO_REF:0000107 GO_REF:0000118

NCBI chr18:14,104,754...14,158,402
Ensembl chr18:17,745,733...17,797,070

USP25

ubiquitin specific peptidase 25

involved_in

IEA

GO_REF:0000118

NCBI chr21:2,468,993...2,618,200
Ensembl chr21:15,724,729...15,982,182

regulation of proteasomal ubiquitin-dependent protein catabolic process

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

ARAF

A-Raf proto-oncogene, serine/threonine kinase

involved_in

IEA

GO_REF:0000107

NCBI chr X:39,997,026...40,007,783
Ensembl chr X:47,893,153...47,904,643

CLEC16A

C-type lectin domain containing 16A

involved_in

ISO

(PMID:36822331)

DisProt

PMID:36822331

NCBI chr16:9,887,877...10,124,500
Ensembl chr16:11,109,869...11,343,512

COMMD1

copper metabolism domain containing 1

involved_in

IEA

GO_REF:0000107 GO_REF:0000118

NCBI chr2A:61,970,830...62,216,677
Ensembl chr2A:63,121,521...63,349,131

DDA1

DET1 and DDB1 associated 1

involved_in

IEA

InterPro

GO_REF:0000002

NCBI chr19:16,797,750...16,808,427
Ensembl chr19:17,771,925...17,785,267

DESI1

desumoylating isopeptidase 1

involved_in

IEA

GO_REF:0000107

NCBI chr22:22,493,114...22,516,191
Ensembl chr22:40,578,968...40,602,094

FOXF2

forkhead box F2

involved_in

ISO

(PMID:29374064)

PMID:29374064

NCBI chr 6:1,209,899...1,215,970

GLMN

glomulin, FKBP associated protein

acts_upstream_of_or_within

IEA

GO_REF:0000107

NCBI chr 1:94,907,342...94,963,052
Ensembl chr 1:93,646,499...93,701,430

GNA12

G protein subunit alpha 12

involved_in

ISO

(PMID:22609986)

PMID:22609986

NCBI chr 7:2,989,832...3,104,848

RAD23A

RAD23 homolog A, nucleotide excision repair protein

involved_in

IEA

GO_REF:0000107

NCBI chr19:12,508,232...12,516,068
Ensembl chr19:13,250,718...13,258,482

RAD23B

RAD23 homolog B, nucleotide excision repair protein

involved_in

IEA

GO_REF:0000107

NCBI chr 9:78,433,461...78,482,157
Ensembl chr 9:106,622,377...106,670,317

UBE2K

ubiquitin conjugating enzyme E2 K

acts_upstream_of_or_within

IEA

GO_REF:0000107

NCBI chr 4:34,026,942...34,111,923
Ensembl chr 4:39,877,966...39,960,397

UBQLN4

ubiquilin 4

involved_in

IEA

GO_REF:0000107

NCBI chr 1:131,374,635...131,395,986
Ensembl chr 1:135,209,490...135,225,666

UFL1

UFM1 specific ligase 1

involved_in
acts_upstream_of_or_within

IEA

GO_REF:0000107 GO_REF:0000118

NCBI chr 6:94,356,440...94,389,920
Ensembl chr 6:98,242,756...98,274,377

WNT10B

Wnt family member 10B

acts_upstream_of_or_within

IEA

GO_REF:0000107

NCBI chr12:39,771,163...39,785,411
Ensembl chr12:40,659,106...40,665,734

XPO1

exportin 1

involved_in

IEA

GO_REF:0000107

NCBI chr2A:61,562,372...61,622,841
Ensembl chr2A:62,698,935...62,757,793

ZNF416

zinc finger protein 416

involved_in

ISO

PMID:33249983
(PMID:33249983)

PMID:33249983

RGD:329955556

NCBI chr19:54,583,428...54,590,792
Ensembl chr19:63,412,869...63,420,231

regulation of protein processing

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

CLN3

CLN3 lysosomal/endosomal transmembrane protein, battenin

involved_in

ISO

(PMID:10924275)

PMID:10924275

CWH43

cell wall biogenesis 43 C-terminal homolog

acts_upstream_of_or_within

IEA

GO_REF:0000107

NCBI chr 4:73,092,093...73,168,001
Ensembl chr 4:83,820,733...83,896,296

IFT52

intraflagellar transport 52

acts_upstream_of_or_within

IEA

GO_REF:0000107

NCBI chr20:39,929,523...39,986,072
Ensembl chr20:41,023,517...41,080,500

IFT88

intraflagellar transport 88

acts_upstream_of_or_within

ISO

(PMID:16254602)
(PMID:15930098)

PMID:15930098 PMID:16254602

NCBI chr13:1,893,102...2,017,771
Ensembl chr13:20,206,471...20,331,204

INPP5B

inositol polyphosphate-5-phosphatase B

acts_upstream_of_or_within

IEA

GO_REF:0000107

NCBI chr 1:37,135,442...37,220,721
Ensembl chr 1:38,485,163...38,567,704

LDLRAD3

low density lipoprotein receptor class A domain containing 3

acts_upstream_of_or_within

IEA

GO_REF:0000107

NCBI chr11:35,917,271...36,204,509
Ensembl chr11:35,791,899...36,076,358

NOTCH4

notch receptor 4

acts_upstream_of_or_within

ISO

(PMID:24667410)

PMID:24667410

NCBI chr 6:31,842,233...31,871,412
Ensembl chr 6:32,722,112...32,750,978

PRKACA

protein kinase cAMP-activated catalytic subunit alpha

acts_upstream_of_or_within

IEA

GO_REF:0000107

NCBI chr19:13,657,344...13,683,864
Ensembl chr19:14,385,191...14,406,205

PRKACB

protein kinase cAMP-activated catalytic subunit beta

acts_upstream_of_or_within

IEA

GO_REF:0000107

NCBI chr 1:116,625,640...116,786,396
Ensembl chr 1:85,487,681...85,644,253

PRSS37

serine protease 37

involved_in

IEA

GO_REF:0000107

NCBI chr 7:133,767,802...133,773,321
Ensembl chr 7:146,236,906...146,242,157

RFX4

regulatory factor X4

acts_upstream_of_or_within

IEA

GO_REF:0000107

NCBI chr12:104,152,816...104,330,383
Ensembl chr12:107,550,254...107,724,623

RNF139

ring finger protein 139

involved_in

IEA

GO_REF:0000107

NCBI chr 8:121,158,715...121,172,069
Ensembl chr 8:123,912,589...123,924,720

RPS6KA2

ribosomal protein S6 kinase A2

acts_upstream_of_or_within

ISO

(PMID:16585392)

PMID:16585392

NCBI chr 6:164,373,829...164,829,195
Ensembl chr 6:169,355,136...169,806,337

regulation of ubiquitin-dependent protein catabolic process

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

L3MBTL3

L3MBTL histone methyl-lysine binding protein 3

involved_in

IEA

GO_REF:0000107

NCBI chr 6:127,814,847...127,938,220
Ensembl chr 6:131,922,967...132,045,708

LOC100991443

katanin p60 ATPase-containing subunit A1

involved_in

IEA

GO_REF:0000107

NCBI chr 6:147,413,892...147,467,587
Ensembl chr 6:152,119,206...152,173,113
Ensembl chr 6:152,119,206...152,173,113

NUB1

negative regulator of ubiquitin like proteins 1

involved_in

IEA

GO_REF:0000118

NCBI chr 7:142,927,730...142,964,475
Ensembl chr 7:155,079,243...155,114,676

PTK2B

protein tyrosine kinase 2 beta

involved_in

IEA

GO_REF:0000107

NCBI chr 8:26,580,855...26,729,378
Ensembl chr 8:23,869,825...23,932,474

TMEM168

transmembrane protein 168

acts_upstream_of_or_within

ISO

(PMID:32175648)

PMID:32175648

NCBI chr 7:104,729,362...104,756,299
Ensembl chr 7:117,433,384...117,458,000

UBE3A

ubiquitin protein ligase E3A

involved_in

IEA

GO_REF:0000107

NCBI chr15:4,494,029...4,595,415
Ensembl chr15:22,747,075...22,825,459

zymogen inhibition

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

FURIN

furin, paired basic amino acid cleaving enzyme

involved_in

ISO

(PMID:11799113), (PMID:9130696)