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ONTOLOGY REPORT - ANNOTATIONS

Term:sphingolipid catabolic process
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Accession:GO:0030149 term browser browse the term
Definition:The chemical reactions and pathways resulting in the breakdown of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid).
Synonyms:exact_synonym: sphingolipid breakdown;   sphingolipid catabolism;   sphingolipid degradation

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sphingolipid catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Enpp2 ectonucleotide pyrophosphatase/phosphodiesterase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936470:26,994,549...27,099,758
Ensembl chrNW_004936470:26,994,215...27,100,999 		JBrowse link
G Sgpl1 sphingosine-1-phosphate lyase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936521:7,850,370...7,899,998
Ensembl chrNW_004936521:7,848,972...7,900,041 		JBrowse link
G Vps54 VPS54 subunit of GARP complex involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936491:8,835,397...8,922,403
Ensembl chrNW_004936491:8,833,285...8,922,711 		JBrowse link
ceramide catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acer1 alkaline ceramidase 1 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:2670497|PMID:12783875) MGI
Ensembl		 PMID:12783875 GO_REF:0000107 MGI:2670497 NCBI chrNW_004936588:3,688,244...3,705,831
Ensembl chrNW_004936588:3,688,244...3,705,831 		JBrowse link
G Acer2 alkaline ceramidase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936652:1,289,445...1,329,236
Ensembl chrNW_004936652:1,289,382...1,329,409 		JBrowse link
G Acer3 alkaline ceramidase 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936498:5,496,991...5,653,206
Ensembl chrNW_004936498:5,496,991...5,653,206 		JBrowse link
G Asah1 N-acylsphingosine amidohydrolase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936554:104,666...141,761
Ensembl chrNW_004936554:104,229...141,512 		JBrowse link
G Asah2 N-acylsphingosine amidohydrolase 2 involved_in IEA InterPro
Ensembl		 GO_REF:0000002 GO_REF:0000107 NCBI chrNW_004936735:2,004,373...2,092,501
Ensembl chrNW_004936735:2,031,844...2,092,347 		JBrowse link
G Cel carboxyl ester lipase acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:2158596|PMID:11733511) MGI
Ensembl		 PMID:11733511 GO_REF:0000107 MGI:2158596 NCBI chrNW_004936487:19,463,219...19,472,029
Ensembl chrNW_004936487:19,463,182...19,469,900 		JBrowse link
galactosylceramide catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Galc galactosylceramidase acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:2183819|PMID:11371512) MGI
Ensembl
InterPro		 PMID:11371512 GO_REF:0000002 GO_REF:0000107 MGI:2183819 NCBI chrNW_004936488:15,444,184...15,519,395
Ensembl chrNW_004936488:15,444,801...15,518,856 		JBrowse link
G Psap prosaposin acts_upstream_of_or_within ISO (MGI:2183819|PMID:11371512) MGI PMID:11371512 MGI:2183819 NCBI chrNW_004936521:6,975,844...7,009,460
Ensembl chrNW_004936521:6,975,770...7,009,136 		JBrowse link
ganglioside catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gm2a GM2 ganglioside activator acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:894862|PMID:9223328) MGI
InterPro
Ensembl		 PMID:9223328 GO_REF:0000002 GO_REF:0000107 MGI:894862 NCBI chrNW_004936647:4,126,524...4,140,800
Ensembl chrNW_004936647:4,126,577...4,140,786 		JBrowse link
G Hexa hexosaminidase subunit alpha acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:1271008|PMID:9645704), (MGI:78473|PMID:8789434)
(MGI:69059|PMID:7937929), (MGI:894862|PMID:9223328)		 MGI
Ensembl		 PMID:7937929 PMID:8789434 PMID:9223328 PMID:9645704 GO_REF:0000107 MGI:1271008 MGI:69059 MGI:78473 MGI:894862 NCBI chrNW_004936471:31,712,485...31,738,273
Ensembl chrNW_004936471:31,709,491...31,738,245 		JBrowse link
G Hexb hexosaminidase subunit beta acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:1331265|PMID:10021458), (MGI:2670850|PMID:12756243), (MGI:3041658|PMID:12657883), (MGI:3573807|PMID:15748167), (MGI:894862|PMID:9223328)
(MGI:1271008|PMID:9645704), (MGI:78473|PMID:8789434)
(MGI:76816|PMID:8566348)		 MGI
Ensembl		 PMID:8566348 PMID:8789434 PMID:9223328 PMID:9645704 PMID:10021458 More... GO_REF:0000107 MGI:1271008 MGI:1331265 MGI:2670850 MGI:3041658 MGI:3573807 MGI:76816 MGI:78473 MGI:894862 NCBI chrNW_004936549:1,918,482...1,943,665
Ensembl chrNW_004936549:1,917,327...1,943,691 		JBrowse link
G Neu2 neuraminidase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936525:4,177,085...4,179,692
Ensembl chrNW_004936525:4,177,085...4,179,692 		JBrowse link
G Neu3 neuraminidase 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936498:3,897,511...3,915,013
Ensembl chrNW_004936498:3,897,485...3,910,115 		JBrowse link
G Neu4 neuraminidase 4 involved_in ISO (PMID:15213228), (PMID:15847605)
(MGI:4361102|PMID:19506080)		 UniProt PMID:15213228 PMID:15847605 PMID:19506080 MGI:4361102 NCBI chrNW_004936745:172,983...175,470 JBrowse link
glucosylceramide catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gba1 glucosylceramidase beta 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936580:4,715,869...4,720,752
Ensembl chrNW_004936580:4,715,408...4,720,798 		JBrowse link
G Gba2 glucosylceramidase beta 2 involved_in IEA InterPro
Ensembl		 GO_REF:0000002 GO_REF:0000107 NCBI chrNW_004936524:3,730,833...3,742,526
Ensembl chrNW_004936524:3,730,833...3,742,531 		JBrowse link
glycosphingolipid catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gla galactosidase alpha involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936813:474,938...484,753
Ensembl chrNW_004936813:474,949...484,760 		JBrowse link
glycosylceramide catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gla galactosidase alpha acts_upstream_of_or_within ISO (MGI:1859538|PMID:10841515), (MGI:2155538|PMID:11752062), (MGI:86774|PMID:9122231)
(MGI:1860035|PMID:10840053), (MGI:3525994|PMID:15629890)		 MGI PMID:9122231 PMID:10840053 PMID:10841515 PMID:11752062 PMID:15629890 MGI:1859538 MGI:1860035 MGI:2155538 MGI:3525994 MGI:86774 NCBI chrNW_004936813:474,938...484,753
Ensembl chrNW_004936813:474,949...484,760 		JBrowse link
G Lct lactase involved_in ISO PMID:4752949 UniProt PMID:4752949 RGD:151356630 NCBI chrNW_004936469:40,064,822...40,108,423
Ensembl chrNW_004936469:40,064,822...40,107,447 		JBrowse link
positive regulation of glucosylceramide catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Prkcd protein kinase C delta involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936473:3,892,625...3,923,467
Ensembl chrNW_004936473:3,892,366...3,923,515 		JBrowse link
positive regulation of sphingomyelin catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Enpp7 ectonucleotide pyrophosphatase/phosphodiesterase 7 involved_in ISO (MGI:4947032|PMID:21177474) UniProt PMID:21177474 MGI:4947032 NCBI chrNW_004936594:3,855,071...3,864,034
Ensembl chrNW_004936594:3,855,150...3,858,317 		JBrowse link
G Prkcd protein kinase C delta involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936473:3,892,625...3,923,467
Ensembl chrNW_004936473:3,892,366...3,923,515 		JBrowse link
sphingomyelin catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC101955719 sphingomyelin phosphodiesterase 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936470:8,139,207...8,142,061 JBrowse link
G Smpd1 sphingomyelin phosphodiesterase 1 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:5529577|PMID:23973266) MGI
Ensembl
InterPro
UniProt		 PMID:23973266 GO_REF:0000002 GO_REF:0000104 GO_REF:0000107 MGI:5529577 NCBI chrNW_004936842:448,315...452,557
Ensembl chrNW_004936842:447,991...452,630 		JBrowse link
G Smpd2 sphingomyelin phosphodiesterase 2 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:5529577|PMID:23973266) MGI
Ensembl		 PMID:23973266 GO_REF:0000107 MGI:5529577 NCBI chrNW_004936564:5,565,205...5,568,474
Ensembl chrNW_004936564:5,564,784...5,568,956 		JBrowse link
G Smpd3 sphingomyelin phosphodiesterase 3 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:5529577|PMID:23973266) MGI
Ensembl		 PMID:23973266 GO_REF:0000107 MGI:5529577 NCBI chrNW_004936475:18,667,563...18,755,132
Ensembl chrNW_004936475:18,671,428...18,755,208 		JBrowse link
G Smpd4 sphingomyelin phosphodiesterase 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936619:2,647,880...2,676,371
Ensembl chrNW_004936619:2,647,967...2,676,488 		JBrowse link
G Smpdl3a sphingomyelin phosphodiesterase acid like 3A NOT|involved_in ISO
IEA		 (PMID:26783088) UniProt
InterPro		 PMID:26783088 GO_REF:0000002 NCBI chrNW_004936802:1,070,919...1,089,222
Ensembl chrNW_004936802:1,070,683...1,088,614 		JBrowse link
G Smpdl3b sphingomyelin phosphodiesterase acid like 3B involved_in IEA InterPro GO_REF:0000002 NCBI chrNW_004936474:12,158,628...12,179,993
Ensembl chrNW_004936474:12,158,628...12,179,993 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 15029
    metabolic process 9468
      catabolic process 2119
        organic substance catabolic process 1800
          organonitrogen compound catabolic process 1132
            sphingolipid catabolic process 30
              ceramide catabolic process + 19
              ceramide phosphoethanolamine catabolic process 0
              glycosphingolipid catabolic process + 13
              sphinganine-1-phosphate catabolic process 0
              sphingoid catabolic process + 0
              sphingomyelin catabolic process + 9
Path 2
Term Annotations click to browse term
  biological_process 15029
    metabolic process 9468
      primary metabolic process 8522
        lipid metabolic process 1161
          cellular lipid metabolic process 841
            membrane lipid metabolic process 169
              sphingolipid metabolic process 127
                sphingolipid catabolic process 30
                  ceramide catabolic process + 19
                  ceramide phosphoethanolamine catabolic process 0
                  glycosphingolipid catabolic process + 13
                  sphinganine-1-phosphate catabolic process 0
                  sphingoid catabolic process + 0
                  sphingomyelin catabolic process + 9
paths to the root