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ONTOLOGY REPORT - ANNOTATIONS

Term:sphingolipid catabolic process
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Accession:GO:0030149 term browser browse the term
Definition:The chemical reactions and pathways resulting in the breakdown of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid).
Synonyms:exact_synonym: sphingolipid breakdown;   sphingolipid catabolism;   sphingolipid degradation


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sphingolipid catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:19,319,815...19,433,492
Ensembl chr 4:19,319,810...19,433,488 		JBrowse link
G SGPL1 sphingosine-1-phosphate lyase 1 involved_in IEA
IBA		 Ensembl
TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr14:73,696,902...73,781,830
Ensembl chr14:73,724,100...73,781,800 		JBrowse link
G SMPD2 sphingomyelin phosphodiesterase 2 involved_in IBA GO_Central GO_REF:0000033 NCBI chr 1:75,508,303...75,511,572
Ensembl chr 1:75,508,350...75,512,153 		JBrowse link
G VPS54 VPS54 subunit of GARP complex involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:77,856,093...77,978,194
Ensembl chr 3:77,856,138...77,975,429 		JBrowse link
ceramide catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACER1 alkaline ceramidase 1 involved_in
acts_upstream_of_or_within		 IEA
ISO
IBA		 (PMID:12783875) Ensembl
MGI
GO_Central
TreeGrafter		 PMID:12783875 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr 2:72,704,603...72,767,474
Ensembl chr 2:72,743,643...72,769,570 		JBrowse link
G ACER2 alkaline ceramidase 2 involved_in IEA
IBA		 Ensembl
TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr 1:203,387,669...203,415,018
Ensembl chr 1:203,386,791...203,414,972 		JBrowse link
G ACER3 alkaline ceramidase 3 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 9:10,985,078...11,167,386
Ensembl chr 9:10,967,857...11,162,502 		JBrowse link
G ASAH1 N-acylsphingosine amidohydrolase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:5,712,048...5,749,811
Ensembl chr17:5,712,058...5,758,821 		JBrowse link
G ASAH2 N-acylsphingosine amidohydrolase 2 involved_in IEA
IBA		 InterPro
Ensembl
TreeGrafter
GO_Central		 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr14:99,018,111...99,141,374
Ensembl chr14:99,025,005...99,129,100 		JBrowse link
G CEL carboxyl ester lipase involved_in
acts_upstream_of_or_within		 IEA
ISO
IBA		 (PMID:11733511) Ensembl
MGI
GO_Central
TreeGrafter		 PMID:11733511 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr 1:272,763,203...272,770,259
Ensembl chr 1:272,763,003...272,770,255 		JBrowse link
galactosylceramide catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GALC galactosylceramidase involved_in
acts_upstream_of_or_within		 IEA
ISO
IBA		 (PMID:11371512) InterPro
MGI
GO_Central
TreeGrafter
Ensembl		 PMID:11371512 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr 7:109,894,576...109,961,407
Ensembl chr 7:109,894,578...109,961,413 		JBrowse link
G GBA3 glucosylceramidase beta 3 involved_in ISO (PMID:17595169) UniProt PMID:17595169 NCBI chr 8:16,897,275...17,012,886
Ensembl chr 8:16,897,288...17,044,570 		JBrowse link
G PSAP prosaposin acts_upstream_of_or_within ISO (PMID:11371512) MGI PMID:11371512 NCBI chr14:74,734,185...74,820,645
Ensembl chr14:74,734,189...74,887,763 		JBrowse link
ganglioside catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GM2A ganglioside GM2 activator involved_in
acts_upstream_of_or_within		 IEA
ISO
IBA		 (PMID:9223328) Ensembl
MGI
TreeGrafter
GO_Central
InterPro		 PMID:9223328 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr16:71,742,090...71,767,872
Ensembl chr16:71,742,090...71,754,884 		JBrowse link
G HEXA hexosaminidase subunit alpha involved_in
acts_upstream_of_or_within		 IEA
ISO
IBA		 (PMID:7937929), (PMID:9223328)
(PMID:8789434), (PMID:9645704)		 Ensembl
MGI
GO_Central
TreeGrafter		 PMID:7937929 PMID:8789434 PMID:9223328 PMID:9645704 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr 7:60,878,531...60,911,537
Ensembl chr 7:60,878,284...60,913,339 		JBrowse link
G HEXB hexosaminidase subunit beta involved_in
acts_upstream_of_or_within		 IEA
ISO
IBA
ISS		 (PMID:8566348)
(PMID:10021458), (PMID:12657883), (PMID:12756243), (PMID:15748167), (PMID:9223328)
(PMID:8789434), (PMID:9645704)		 Ensembl
MGI
GO_Central
TreeGrafter
UniProt		 PMID:8566348 PMID:8789434 PMID:9223328 PMID:9645704 PMID:10021458 More... GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr 2:83,745,263...83,784,762
Ensembl chr 2:83,744,627...83,784,759 		JBrowse link
G NEU1 neuraminidase 1 involved_in IBA
IEA		 GO_Central
TreeGrafter		 GO_REF:0000033 GO_REF:0000118 NCBI chr 7:23,953,721...23,958,659
Ensembl chr 7:23,947,061...23,958,666 		JBrowse link
G NEU2 neuraminidase 2 involved_in IEA
IBA		 Ensembl
TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr15:133,392,559...133,479,406
Ensembl chr15:133,468,293...133,477,110 		JBrowse link
G NEU3 neuraminidase 3 involved_in IEA
IBA		 Ensembl
GO_Central
TreeGrafter		 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr 9:9,315,263...9,333,878
Ensembl chr 9:9,315,334...9,334,918 		JBrowse link
G NEU4 neuraminidase 4 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr15:140,324,087...140,332,226
Ensembl chr15:140,325,135...140,328,276 		JBrowse link
glucosylceramide catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GBA1 glucosylceramidase beta 1 involved_in IEA
IBA
ISS		 Ensembl
TreeGrafter
GO_Central
UniProt		 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr 4:94,583,905...94,606,689
Ensembl chr 4:94,584,134...94,609,745 		JBrowse link
G GBA2 glucosylceramidase beta 2 involved_in IEA InterPro
Ensembl		 GO_REF:0000002 GO_REF:0000107 NCBI chr 1:236,456,238...236,467,887
Ensembl chr 1:236,455,240...236,468,210 		JBrowse link
G GBA3 glucosylceramidase beta 3 involved_in
NOT|involved_in		 ISO (PMID:17595169)
(PMID:20728381)
(PMID:26724485)		 UniProt PMID:17595169 PMID:20728381 PMID:26724485 NCBI chr 8:16,897,275...17,012,886
Ensembl chr 8:16,897,288...17,044,570 		JBrowse link
glycosphingolipid catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GLA galactosidase alpha involved_in IEA
ISO		 Ensembl
RGD		 PMID:34320241 GO_REF:0000107 RGD:401976418 NCBI chr  X:83,024,582...83,032,273
Ensembl chr  X:83,023,903...83,032,570 		JBrowse link
glycosylceramide catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GBA3 glucosylceramidase beta 3 involved_in IBA
IEA		 GO_Central
TreeGrafter		 GO_REF:0000033 GO_REF:0000118 NCBI chr 8:16,897,275...17,012,886
Ensembl chr 8:16,897,288...17,044,570 		JBrowse link
G GLA galactosidase alpha acts_upstream_of_or_within ISO (PMID:10840053), (PMID:15629890)
(PMID:10841515), (PMID:11752062), (PMID:9122231)		 MGI PMID:9122231 PMID:10840053 PMID:10841515 PMID:11752062 PMID:15629890 NCBI chr  X:83,024,582...83,032,273
Ensembl chr  X:83,023,903...83,032,570 		JBrowse link
G LOC100625897 lactase-phlorizin hydrolase involved_in ISO PMID:4752949 UniProt PMID:4752949 RGD:151356630 NCBI chr15:16,094,277...16,154,467 JBrowse link
positive regulation of glucosylceramide catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PRKCD protein kinase C delta involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:35,290,835...35,323,245
Ensembl chr13:35,290,610...35,323,356 		JBrowse link
positive regulation of sphingomyelin catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ENPP7 ectonucleotide pyrophosphatase/phosphodiesterase 7 involved_in ISO (MGI:4947032|PMID:21177474) UniProt PMID:21177474 MGI:4947032 NCBI chr12:2,612,543...2,619,541
Ensembl chr12:2,612,574...2,619,519 		JBrowse link
G PRKCD protein kinase C delta involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:35,290,835...35,323,245
Ensembl chr13:35,290,610...35,323,356 		JBrowse link
regulation of glucosylceramide catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MIR127 microRNA mir-127 acts_upstream_of ISO (PMID:25584808) ARUK-UCL PMID:25584808 NCBI chr 7:121,709,636...121,709,715
Ensembl chr 7:121,709,640...121,709,720 		JBrowse link
G MIR16-1 microRNA mir-16-1 acts_upstream_of_or_within ISO (PMID:25584808) ARUK-UCL PMID:25584808 NCBI chr13:100,083,329...100,083,405
Ensembl chr13:100,083,329...100,083,405 		JBrowse link
G MIR16-2 microRNA mir-16-2 acts_upstream_of_or_within ISO (PMID:25584808) ARUK-UCL PMID:25584808 NCBI chr11:17,757,606...17,757,684
Ensembl chr11:17,757,601...17,757,687 		JBrowse link
G MIR195 microRNA mir-195 acts_upstream_of_or_within ISO (PMID:25584808) ARUK-UCL PMID:25584808 NCBI chr12:52,422,039...52,422,118
Ensembl chr12:52,422,039...52,422,118 		JBrowse link
sphingomyelin catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SMPD1 sphingomyelin phosphodiesterase 1 involved_in
acts_upstream_of_or_within		 IEA
ISO
IBA		 (PMID:23973266) InterPro
MGI
GO_Central
TreeGrafter
Ensembl
UniProt		 PMID:23973266 GO_REF:0000002 GO_REF:0000033 GO_REF:0000104 GO_REF:0000107 GO_REF:0000118 NCBI chr 9:3,324,091...3,328,493
Ensembl chr 9:3,324,442...3,328,457 		JBrowse link
G SMPD2 sphingomyelin phosphodiesterase 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:23973266) Ensembl
MGI		 PMID:23973266 GO_REF:0000107 NCBI chr 1:75,508,303...75,511,572
Ensembl chr 1:75,508,350...75,512,153 		JBrowse link
G SMPD3 sphingomyelin phosphodiesterase 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:23973266) Ensembl
MGI		 PMID:23973266 GO_REF:0000107 NCBI chr 6:28,938,287...29,025,397
Ensembl chr 6:28,938,290...29,025,357 		JBrowse link
G SMPD4 sphingomyelin phosphodiesterase 4 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr14:50,663,488...50,689,355
Ensembl chr14:50,663,608...50,689,352 		JBrowse link
G SMPD5 sphingomyelin phosphodiesterase 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:639,228...643,057 JBrowse link
G SMPDL3A sphingomyelin phosphodiesterase acid like 3A NOT|involved_in ISO
IEA		 (PMID:26783088) UniProt
InterPro		 PMID:26783088 GO_REF:0000002 NCBI chr 1:39,848,641...39,869,184
Ensembl chr 1:39,848,648...39,868,731 		JBrowse link
G SMPDL3B sphingomyelin phosphodiesterase acid like 3B involved_in IEA InterPro GO_REF:0000002 NCBI chr 6:85,060,639...85,084,483
Ensembl chr 6:85,060,317...85,084,480 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17799
    metabolic process 10358
      organic substance metabolic process 9930
        organic substance catabolic process 2158
          organonitrogen compound catabolic process 1405
            sphingolipid catabolic process 36
              ceramide catabolic process + 25
              ceramide phosphoethanolamine catabolic process 0
              glycosphingolipid catabolic process + 19
              sphinganine-1-phosphate catabolic process 0
              sphingoid catabolic process + 0
              sphingomyelin catabolic process + 9
Path 2
Term Annotations click to browse term
  biological_process 17799
    metabolic process 10358
      primary metabolic process 9009
        lipid metabolic process 1348
          cellular lipid metabolic process 1018
            membrane lipid metabolic process 208
              sphingolipid metabolic process 153
                sphingolipid catabolic process 36
                  ceramide catabolic process + 25
                  ceramide phosphoethanolamine catabolic process 0
                  glycosphingolipid catabolic process + 19
                  sphinganine-1-phosphate catabolic process 0
                  sphingoid catabolic process + 0
                  sphingomyelin catabolic process + 9
paths to the root