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ONTOLOGY REPORT - ANNOTATIONS


Term:sphingolipid catabolic process
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Accession:GO:0030149 term browser browse the term
Definition:The chemical reactions and pathways resulting in the breakdown of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid).
Synonyms:exact_synonym: sphingolipid breakdown;   sphingolipid catabolism;   sphingolipid degradation



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sphingolipid catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2 involved_in IDA (PMID:14500380) UniProt PMID:14500380 NCBI chr 8:119,557,085...119,673,404
Ensembl chr 8:119,557,086...119,673,453
JBrowse link
G PPT1 palmitoyl-protein thioesterase 1 involved_in TAS (PMID:16542649) UniProt PMID:16542649 NCBI chr 1:40,071,461...40,097,252
Ensembl chr 1:40,072,710...40,097,260
JBrowse link
G SGPL1 sphingosine-1-phosphate lyase 1 involved_in IBA
NAS
IDA
IMP
(PMID:21873635)
(PMID:11018465)
(PMID:24809814)
(PMID:28165339)
GO_Central
UniProt
PMID:11018465 PMID:21873635 PMID:24809814 PMID:28165339 NCBI chr10:70,815,920...70,881,184
Ensembl chr10:70,815,948...70,881,184
JBrowse link
G SMPD2 sphingomyelin phosphodiesterase 2 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 6:109,440,721...109,443,922
Ensembl chr 6:109,440,724...109,443,919
JBrowse link
ceramide catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACER1 alkaline ceramidase 1 involved_in
acts_upstream_of_or_within
ISS
ISO
IMP
(MGI:2670497|PMID:12783875)
(PMID:20207939)
BHF-UCL
MGI
UniProt
PMID:12783875 PMID:20207939 GO_REF:0000024 MGI:2670497 NCBI chr19:6,306,142...6,360,368
Ensembl chr19:6,306,142...6,333,612
JBrowse link
G ACER2 alkaline ceramidase 2 involved_in IMP (PMID:16940153), (PMID:20207939) UniProt PMID:16940153 PMID:20207939 NCBI chr 9:19,408,927...19,455,173
Ensembl chr 9:19,409,009...19,452,505
JBrowse link
G ACER3 alkaline ceramidase 3 involved_in IMP
IDA
(PMID:20207939), (PMID:26792856)
(PMID:30575723)
UniProt PMID:20207939 PMID:26792856 PMID:30575723 NCBI chr11:76,860,888...77,026,797
Ensembl chr11:76,860,859...77,026,797
JBrowse link
G ASAH1 N-acylsphingosine amidohydrolase 1 involved_in IMP
IDA
(PMID:10610716)
(PMID:12815059)
UniProt PMID:10610716 PMID:12815059 NCBI chr 8:18,055,992...18,084,961
Ensembl chr 8:18,055,992...18,084,998
JBrowse link
G ASAH2 N-acylsphingosine amidohydrolase 2 involved_in IMP
IDA
IEA
IBA
(PMID:10781606), (PMID:15946935), (PMID:19345744), (PMID:30154232)
(PMID:16229686), (PMID:17475390)
(PMID:21873635)
UniProt
InterPro
GO_Central
PMID:10781606 PMID:15946935 PMID:16229686 PMID:17475390 PMID:19345744 More... GO_REF:0000002 NCBI chr10:50,184,861...50,251,564
Ensembl chr10:50,182,778...50,279,720
JBrowse link
G ASAH2B N-acylsphingosine amidohydrolase 2B involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr10:50,739,936...50,759,255
Ensembl chr10:50,739,318...50,816,495
JBrowse link
G CEL carboxyl ester lipase involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:2158596|PMID:11733511) Ensembl
MGI
PMID:11733511 GO_REF:0000107 MGI:2158596 NCBI chr 9:133,061,981...133,071,861
Ensembl chr 9:133,061,981...133,071,861
JBrowse link
galactosylceramide catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GALC galactosylceramidase involved_in
acts_upstream_of_or_within
IBA
ISO
ISS
IEA
IDA
(PMID:21873635)
(MGI:2183819|PMID:11371512)
(PMID:8399327)
GO_Central
MGI
UniProt
InterPro
PMID:8399327 PMID:11371512 PMID:21873635 GO_REF:0000002 GO_REF:0000024 MGI:2183819 NCBI chr14:87,933,014...87,993,665
Ensembl chr14:87,837,820...87,993,665
JBrowse link
G GBA3 glucosylceramidase beta 3 (gene/pseudogene) involved_in IDA (PMID:17595169) UniProt PMID:17595169 NCBI chr 4:22,692,937...22,819,569
Ensembl chr 4:22,692,914...22,819,575
JBrowse link
G PSAP prosaposin acts_upstream_of_or_within ISO (MGI:2183819|PMID:11371512) MGI PMID:11371512 MGI:2183819 NCBI chr10:71,816,298...71,851,251
Ensembl chr10:71,816,298...71,851,325
JBrowse link
ganglioside catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GM2A GM2 ganglioside activator involved_in
acts_upstream_of_or_within
IBA
ISO
IEA
(PMID:21873635)
(MGI:894862|PMID:9223328)
GO_Central
MGI
InterPro
PMID:9223328 PMID:21873635 GO_REF:0000002 MGI:894862 NCBI chr 5:151,253,185...151,270,440
Ensembl chr 5:151,212,150...151,270,440
JBrowse link
G HEXA hexosaminidase subunit alpha involved_in
acts_upstream_of_or_within
IDA
IBA
ISO
(PMID:8123671), (PMID:8672428), (PMID:9694901)
(PMID:21873635)
(MGI:1271008|PMID:9645704), (MGI:78473|PMID:8789434)
(MGI:69059|PMID:7937929), (MGI:894862|PMID:9223328)
UniProt
GO_Central
MGI
PMID:7937929 PMID:8123671 PMID:8672428 PMID:8789434 PMID:9223328 More... MGI:1271008 MGI:69059 MGI:78473 MGI:894862 NCBI chr15:72,340,924...72,376,014
Ensembl chr15:72,340,924...72,376,420
JBrowse link
G HEXB hexosaminidase subunit beta involved_in
acts_upstream_of_or_within
IDA
IBA
ISO
(PMID:8123671), (PMID:8672428)
(PMID:21873635)
(MGI:1331265|PMID:10021458), (MGI:2670850|PMID:12756243), (MGI:3041658|PMID:12657883), (MGI:3573807|PMID:15748167), (MGI:894862|PMID:9223328)
(MGI:76816|PMID:8566348)
(MGI:1271008|PMID:9645704), (MGI:78473|PMID:8789434)
UniProt
GO_Central
MGI
PMID:8123671 PMID:8566348 PMID:8672428 PMID:8789434 PMID:9223328 More... MGI:1271008 MGI:1331265 MGI:2670850 MGI:3041658 MGI:3573807 MGI:76816 MGI:78473 MGI:894862 NCBI chr 5:74,640,023...74,721,288
Ensembl chr 5:74,640,023...74,722,647
JBrowse link
G NEU1 neuraminidase 1 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 6:31,857,659...31,862,821
Ensembl chr 6:31,857,659...31,862,905
JBrowse link
G NEU2 neuraminidase 2 involved_in IBA
IDA
(PMID:21873635)
(PMID:14613940), (PMID:22228546)
GO_Central
UniProt
PMID:14613940 PMID:21873635 PMID:22228546 NCBI chr 2:233,032,672...233,035,057
Ensembl chr 2:233,032,672...233,035,057
JBrowse link
G NEU3 neuraminidase 3 involved_in IDA
IBA
(PMID:10861246), (PMID:11298736), (PMID:15847605), (PMID:17334392)
(PMID:21873635)
UniProt
GO_Central
PMID:10861246 PMID:11298736 PMID:15847605 PMID:17334392 PMID:21873635 NCBI chr11:74,988,644...75,010,907
Ensembl chr11:74,988,279...75,018,893
JBrowse link
G NEU4 neuraminidase 4 involved_in IBA
IDA
(PMID:21873635)
(PMID:15213228), (PMID:15847605)
GO_Central
UniProt
PMID:15213228 PMID:15847605 PMID:21873635 NCBI chr 2:241,809,193...241,817,413
Ensembl chr 2:241,809,065...241,817,413
JBrowse link
glucosylceramide catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GBA glucosylceramidase beta involved_in IMP
IDA
IBA
(PMID:19279011), (PMID:21700325), (PMID:24022302)
(PMID:16293621), (PMID:24211208), (PMID:9201993)
(PMID:21873635)
UniProt
GO_Central
PMID:9201993 PMID:16293621 PMID:19279011 PMID:21700325 PMID:21873635 More... NCBI chr 1:155,234,452...155,244,627
Ensembl chr 1:155,234,452...155,244,699
JBrowse link
G GBA2 glucosylceramidase beta 2 involved_in IDA
IMP
(PMID:17080196)
(PMID:30308956)
UniProt PMID:17080196 PMID:30308956 NCBI chr 9:35,736,862...35,749,228
Ensembl chr 9:35,736,866...35,749,228
JBrowse link
G GBA3 glucosylceramidase beta 3 (gene/pseudogene) involved_in
NOT|involved_in
IDA
IMP
(PMID:26724485)
(PMID:17595169)
(PMID:20728381)
UniProt PMID:17595169 PMID:20728381 PMID:26724485 NCBI chr 4:22,692,937...22,819,569
Ensembl chr 4:22,692,914...22,819,575
JBrowse link
glycosphingolipid catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GLA galactosidase alpha involved_in IDA
TAS
IMP
(PMID:8804427)
(PMID:2160973)
(PMID:10838196)
UniProt PMID:2160973 PMID:8804427 PMID:10838196 NCBI chr  X:101,397,803...101,407,925
Ensembl chr  X:101,393,273...101,408,012
JBrowse link
glycosylceramide catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GBA3 glucosylceramidase beta 3 (gene/pseudogene) involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 4:22,692,937...22,819,569
Ensembl chr 4:22,692,914...22,819,575
JBrowse link
G GLA galactosidase alpha involved_in
acts_upstream_of_or_within
IBA
ISO
ISS
(PMID:21873635)
(MGI:1859538|PMID:10841515), (MGI:2155538|PMID:11752062), (MGI:86774|PMID:9122231)
(MGI:1860035|PMID:10840053), (MGI:3525994|PMID:15629890)
GO_Central
MGI
UniProt
PMID:9122231 PMID:10840053 PMID:10841515 PMID:11752062 PMID:15629890 More... GO_REF:0000024 MGI:1859538 MGI:1860035 MGI:2155538 MGI:3525994 MGI:86774 NCBI chr  X:101,397,803...101,407,925
Ensembl chr  X:101,393,273...101,408,012
JBrowse link
G NAGA alpha-N-acetylgalactosaminidase involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr22:42,058,334...42,070,842
Ensembl chr22:42,058,334...42,070,842
JBrowse link
positive regulation of glucosylceramide catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PRKCD protein kinase C delta involved_in IMP (PMID:19279011) BHF-UCL PMID:19279011 NCBI chr 3:53,161,209...53,192,717
Ensembl chr 3:53,156,009...53,192,717
JBrowse link
positive regulation of sphingomyelin catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ENPP7 ectonucleotide pyrophosphatase/phosphodiesterase 7 involved_in ISS UniProt GO_REF:0000024 NCBI chr17:79,730,919...79,742,926
Ensembl chr17:79,730,943...79,742,219
JBrowse link
G PRKCD protein kinase C delta involved_in IMP (PMID:19279011) BHF-UCL PMID:19279011 NCBI chr 3:53,161,209...53,192,717
Ensembl chr 3:53,156,009...53,192,717
JBrowse link
sphingoid catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SPHK1 sphingosine kinase 1 involved_in NAS (PMID:10863092) UniProt PMID:10863092 NCBI chr17:76,383,204...76,387,855
Ensembl chr17:76,376,584...76,387,860
JBrowse link
sphingomyelin catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ENPP7 ectonucleotide pyrophosphatase/phosphodiesterase 7 involved_in IEA InterPro GO_REF:0000002 NCBI chr17:79,730,919...79,742,926
Ensembl chr17:79,730,943...79,742,219
JBrowse link
G SMPD1 sphingomyelin phosphodiesterase 1 involved_in
acts_upstream_of_or_within
IDA
ISO
IBA
(PMID:18815062), (PMID:20807762), (PMID:22573858)
(MGI:5529577|PMID:23973266)
(PMID:21873635)
UniProt
MGI
GO_Central
PMID:18815062 PMID:20807762 PMID:21873635 PMID:22573858 PMID:23973266 MGI:5529577 NCBI chr11:6,390,474...6,394,998
Ensembl chr11:6,390,440...6,394,998
JBrowse link
G SMPD2 sphingomyelin phosphodiesterase 2 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:5529577|PMID:23973266) Ensembl
MGI
PMID:23973266 GO_REF:0000107 MGI:5529577 NCBI chr 6:109,440,721...109,443,922
Ensembl chr 6:109,440,724...109,443,919
JBrowse link
G SMPD3 sphingomyelin phosphodiesterase 3 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:5529577|PMID:23973266) Ensembl
MGI
PMID:23973266 GO_REF:0000107 MGI:5529577 NCBI chr16:68,358,327...68,448,703
Ensembl chr16:68,358,327...68,448,508
JBrowse link
G SMPD4 sphingomyelin phosphodiesterase 4 involved_in IBA
IDA
(PMID:21873635)
(PMID:16517606), (PMID:25180167)
GO_Central
UniProt
PMID:16517606 PMID:21873635 PMID:25180167 NCBI chr 2:130,151,392...130,181,757
Ensembl chr 2:130,151,392...130,182,750
JBrowse link
G SMPD5 sphingomyelin phosphodiesterase 5 (pseudogene) involved_in ISO (MGI:6450238|PMID:21183079) UniProt PMID:21183079 MGI:6450238 NCBI chr 8:144,049,398...144,050,059
Ensembl chr 8:144,049,079...144,051,522
JBrowse link
G SMPDL3A sphingomyelin phosphodiesterase acid like 3A NOT|involved_in IDA (PMID:26783088) UniProt PMID:26783088 NCBI chr 6:122,788,456...122,809,720
Ensembl chr 6:122,789,049...122,809,720
JBrowse link
G SMPDL3B sphingomyelin phosphodiesterase acid like 3B involved_in IEA InterPro GO_REF:0000002 NCBI chr 1:27,934,955...27,959,152
Ensembl chr 1:27,935,000...27,959,157
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18605
    metabolic process 11952
      catabolic process 2698
        organic substance catabolic process 2223
          organonitrogen compound catabolic process 1424
            sphingolipid catabolic process 34
              ceramide catabolic process + 22
              ceramide phosphoethanolamine catabolic process 0
              glycosphingolipid catabolic process + 15
              sphinganine-1-phosphate catabolic process 0
              sphingoid catabolic process + 1
              sphingomyelin catabolic process + 9
Path 2
Term Annotations click to browse term
  biological_process 18605
    metabolic process 11952
      primary metabolic process 10618
        lipid metabolic process 1485
          cellular lipid metabolic process 1077
            membrane lipid metabolic process 215
              sphingolipid metabolic process 168
                sphingolipid catabolic process 34
                  ceramide catabolic process + 22
                  ceramide phosphoethanolamine catabolic process 0
                  glycosphingolipid catabolic process + 15
                  sphinganine-1-phosphate catabolic process 0
                  sphingoid catabolic process + 1
                  sphingomyelin catabolic process + 9
paths to the root