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ONTOLOGY REPORT - ANNOTATIONS


Term:sphingolipid catabolic process
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Accession:GO:0030149 term browser browse the term
Definition:The chemical reactions and pathways resulting in the breakdown of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid).
Synonyms:exact_synonym: sphingolipid breakdown;   sphingolipid catabolism;   sphingolipid degradation



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sphingolipid catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2 involved_in ISO (PMID:14500380) UniProt PMID:14500380 NCBI chr13:18,586,886...18,697,339
Ensembl chr13:18,587,129...18,697,324
JBrowse link
G SGPL1 sphingosine-1-phosphate lyase 1 involved_in ISO (PMID:28165339)
(PMID:24809814)
UniProt PMID:24809814 PMID:28165339 NCBI chr 4:21,666,264...21,717,476
Ensembl chr 4:21,660,939...21,715,155
JBrowse link
ceramide catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACER1 alkaline ceramidase 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:2670497|PMID:12783875) Ensembl
MGI
PMID:12783875 GO_REF:0000107 MGI:2670497 NCBI chr20:53,819,224...53,838,183
Ensembl chr20:53,819,074...53,838,438
JBrowse link
G ACER2 alkaline ceramidase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:39,190,873...39,223,590
Ensembl chr11:39,190,115...39,219,776
JBrowse link
G ACER3 alkaline ceramidase 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr21:21,711,315...21,863,409
Ensembl chr21:21,714,156...21,863,320
JBrowse link
G ASAH1 N-acylsphingosine amidohydrolase 1 involved_in ISO (MGI:1267186|PMID:9653654)
(PMID:12815059)
(MGI:5505361|PMID:23770692)
(PMID:10610716)
UniProt PMID:9653654 PMID:10610716 PMID:12815059 PMID:23770692 MGI:1267186 MGI:5505361 NCBI chr16:41,297,215...41,335,521
Ensembl chr16:41,297,809...41,323,078
JBrowse link
G ASAH2 N-acylsphingosine amidohydrolase 2 involved_in ISO PMID:10488143
(MGI:6275120|PMID:10652340)
(MGI:3608219|PMID:16126722), (MGI:3640407|PMID:16380386)
(PMID:16229686), (PMID:17475390)
PMID:15123644
PMID:15217782
(PMID:10781606), (PMID:15946935), (PMID:19345744), (PMID:30154232)
UniProt PMID:10488143 PMID:10652340 PMID:10781606 PMID:15123644 PMID:15217782 More... MGI:3608219 MGI:3640407 MGI:6275120 RGD:13838793 RGD:13838794 RGD:13838800 NCBI chr26:37,136,601...37,228,215
Ensembl chr26:37,136,897...37,218,783
JBrowse link
G CEL carboxyl ester lipase acts_upstream_of_or_within ISO (MGI:2158596|PMID:11733511) MGI PMID:11733511 MGI:2158596 NCBI chr 9:51,337,205...51,345,284
Ensembl chr 9:51,337,187...51,362,422
JBrowse link
galactosylceramide catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GALC galactosylceramidase involved_in
acts_upstream_of_or_within
IBA
ISO
ISS
(PMID:21873635)
(MGI:2183819|PMID:11371512)
GO_Central
MGI
UniProt
PMID:11371512 PMID:21873635 GO_REF:0000024 MGI:2183819 NCBI chr 8:59,266,693...59,324,825
Ensembl chr 8:59,267,818...59,324,967
JBrowse link
G GBA3 glucosylceramidase beta 3 involved_in ISO (PMID:17595169) UniProt PMID:17595169 NCBI chr 3:87,080,351...87,190,931
Ensembl chr 3:87,081,134...87,190,987
JBrowse link
G PSAP prosaposin acts_upstream_of_or_within ISO (MGI:2183819|PMID:11371512) MGI PMID:11371512 MGI:2183819 NCBI chr 4:22,571,095...22,603,880
Ensembl chr 4:22,572,153...22,603,848
JBrowse link
ganglioside catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GM2A GM2 ganglioside activator involved_in
acts_upstream_of_or_within
IBA
ISO
(PMID:21873635)
(MGI:894862|PMID:9223328)
GO_Central
MGI
PMID:9223328 PMID:21873635 MGI:894862 NCBI chr 4:58,002,438...58,016,003
Ensembl chr 4:58,003,946...58,015,753
JBrowse link
G HEXA hexosaminidase subunit alpha acts_upstream_of_or_within
involved_in
ISO
IBA
(MGI:1271008|PMID:9645704), (MGI:78473|PMID:8789434)
(PMID:21873635)
(MGI:69059|PMID:7937929), (MGI:894862|PMID:9223328)
MGI
GO_Central
PMID:7937929 PMID:8789434 PMID:9223328 PMID:9645704 PMID:21873635 MGI:1271008 MGI:69059 MGI:78473 MGI:894862 NCBI chr30:35,836,788...35,862,525 JBrowse link
G HEXB hexosaminidase subunit beta involved_in
acts_upstream_of_or_within
ISO (PMID:8123671), (PMID:8672428)
(MGI:1271008|PMID:9645704), (MGI:78473|PMID:8789434)
(MGI:76816|PMID:8566348)
(MGI:1331265|PMID:10021458), (MGI:2670850|PMID:12756243), (MGI:3041658|PMID:12657883), (MGI:3573807|PMID:15748167), (MGI:894862|PMID:9223328)
UniProt
MGI
PMID:8123671 PMID:8566348 PMID:8672428 PMID:8789434 PMID:9223328 More... MGI:1271008 MGI:1331265 MGI:2670850 MGI:3041658 MGI:3573807 MGI:76816 MGI:78473 MGI:894862 NCBI chr 2:57,221,809...57,248,432
Ensembl chr 2:57,222,186...57,248,417
JBrowse link
G NEU1 neuraminidase 1 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr12:1,323,659...1,327,989
Ensembl chr12:1,323,877...1,328,520
JBrowse link
G NEU2 neuraminidase 2 involved_in ISO (PMID:14613940), (PMID:22228546)
(MGI:1354405|PMID:10713120)
UniProt PMID:10713120 PMID:14613940 PMID:22228546 MGI:1354405 NCBI chr25:44,563,664...44,596,837
Ensembl chr25:44,563,411...44,595,653
JBrowse link
G NEU3 neuraminidase 3 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr21:23,456,424...23,484,872 JBrowse link
G NEU4 neuraminidase 4 involved_in ISO (PMID:15213228), (PMID:15847605)
(MGI:4361102|PMID:19506080)
UniProt PMID:15213228 PMID:15847605 PMID:19506080 MGI:4361102 NCBI chr25:51,594,865...51,602,500 JBrowse link
glucosylceramide catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GBA glucosylceramidase beta involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 7:42,317,704...42,322,285
Ensembl chr 7:42,317,862...42,322,864
JBrowse link
G GBA2 glucosylceramidase beta 2 involved_in ISO (PMID:17080196)
(MGI:5484792|PMID:23250757)
(MGI:3690511|PMID:17080196)
(PMID:30308956)
UniProt PMID:17080196 PMID:23250757 PMID:30308956 MGI:3690511 MGI:5484792 NCBI chr11:52,264,959...52,277,298
Ensembl chr11:52,265,070...52,277,213
JBrowse link
G GBA3 glucosylceramidase beta 3 involved_in
NOT|involved_in
ISO (PMID:26724485)
(PMID:20728381)
(PMID:17595169)
UniProt PMID:17595169 PMID:20728381 PMID:26724485 NCBI chr 3:87,080,351...87,190,931
Ensembl chr 3:87,081,134...87,190,987
JBrowse link
glycosphingolipid catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GLA galactosidase alpha involved_in ISO (PMID:10838196)
(PMID:8804427)
UniProt PMID:8804427 PMID:10838196 NCBI chr  X:75,311,536...75,320,391
Ensembl chr  X:75,311,536...75,320,249
JBrowse link
glycosylceramide catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GLA galactosidase alpha acts_upstream_of_or_within ISO (MGI:1859538|PMID:10841515), (MGI:2155538|PMID:11752062), (MGI:86774|PMID:9122231)
(MGI:1860035|PMID:10840053), (MGI:3525994|PMID:15629890)
MGI PMID:9122231 PMID:10840053 PMID:10841515 PMID:11752062 PMID:15629890 MGI:1859538 MGI:1860035 MGI:2155538 MGI:3525994 MGI:86774 NCBI chr  X:75,311,536...75,320,391
Ensembl chr  X:75,311,536...75,320,249
JBrowse link
G NAGA alpha-N-acetylgalactosaminidase involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr10:23,303,950...23,312,409
Ensembl chr10:23,304,354...23,396,068
JBrowse link
positive regulation of glucosylceramide catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PRKCD protein kinase C delta involved_in ISO (PMID:19279011) BHF-UCL PMID:19279011 NCBI chr20:36,723,491...36,751,982
Ensembl chr20:36,723,809...36,752,191
JBrowse link
positive regulation of sphingomyelin catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ENPP7 ectonucleotide pyrophosphatase/phosphodiesterase 7 involved_in ISO (MGI:4947032|PMID:21177474) UniProt PMID:21177474 MGI:4947032 NCBI chr 9:1,887,093...1,894,728
Ensembl chr 9:1,887,201...1,897,473
JBrowse link
G PRKCD protein kinase C delta involved_in ISO (PMID:19279011) BHF-UCL PMID:19279011 NCBI chr20:36,723,491...36,751,982
Ensembl chr20:36,723,809...36,752,191
JBrowse link
sphingomyelin catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SMPD1 sphingomyelin phosphodiesterase 1 involved_in
acts_upstream_of_or_within
IBA
ISO
(PMID:21873635)
(MGI:5529577|PMID:23973266)
GO_Central
MGI
PMID:21873635 PMID:23973266 MGI:5529577 NCBI chr21:29,714,418...29,719,035
Ensembl chr21:29,714,557...29,719,033
JBrowse link
G SMPD2 sphingomyelin phosphodiesterase 2 acts_upstream_of_or_within ISO (MGI:5529577|PMID:23973266) MGI PMID:23973266 MGI:5529577 NCBI chr12:66,347,628...66,350,322
Ensembl chr12:66,323,022...66,350,322
JBrowse link
G SMPD3 sphingomyelin phosphodiesterase 3 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:5529577|PMID:23973266) Ensembl
MGI
PMID:23973266 GO_REF:0000107 MGI:5529577 NCBI chr 5:81,089,657...81,172,173
Ensembl chr 5:81,142,888...81,172,189
JBrowse link
G SMPD4 sphingomyelin phosphodiesterase 4 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr26:30,397,687...30,419,072
Ensembl chr26:30,398,768...30,418,979
JBrowse link
G SMPDL3A sphingomyelin phosphodiesterase acid like 3A NOT|involved_in ISO (PMID:26783088) UniProt PMID:26783088 NCBI chr 1:62,091,947...62,110,081
Ensembl chr 1:62,092,121...62,109,773
JBrowse link
G SMPDL3B sphingomyelin phosphodiesterase acid like 3B involved_in IEA InterPro GO_REF:0000002 NCBI chr 2:72,427,085...72,450,547
Ensembl chr 2:72,418,872...72,450,737
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 13969
    metabolic process 9103
      catabolic process 2041
        organic substance catabolic process 1699
          organonitrogen compound catabolic process 1089
            sphingolipid catabolic process 30
              ceramide catabolic process + 21
              ceramide phosphoethanolamine catabolic process 0
              glycosphingolipid catabolic process + 15
              sphinganine-1-phosphate catabolic process 0
              sphingoid catabolic process + 0
              sphingomyelin catabolic process + 8
Path 2
Term Annotations click to browse term
  biological_process 13969
    metabolic process 9103
      primary metabolic process 7996
        lipid metabolic process 1113
          cellular lipid metabolic process 832
            membrane lipid metabolic process 170
              sphingolipid metabolic process 132
                sphingolipid catabolic process 30
                  ceramide catabolic process + 21
                  ceramide phosphoethanolamine catabolic process 0
                  glycosphingolipid catabolic process + 15
                  sphinganine-1-phosphate catabolic process 0
                  sphingoid catabolic process + 0
                  sphingomyelin catabolic process + 8
paths to the root