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ONTOLOGY REPORT - ANNOTATIONS

Term:sphingolipid catabolic process
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Accession:GO:0030149 term browser browse the term
Definition:The chemical reactions and pathways resulting in the breakdown of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid).
Synonyms:exact_synonym: sphingolipid breakdown;   sphingolipid catabolism;   sphingolipid degradation

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sphingolipid catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Enpp2 ectonucleotide pyrophosphatase/phosphodiesterase 2 involved_in ISO (PMID:14500380) UniProt PMID:14500380 NCBI chrNW_004955417:25,308,424...25,384,307
Ensembl chrNW_004955417:25,308,361...25,384,443 		JBrowse link
G Sgpl1 sphingosine-1-phosphate lyase 1 involved_in ISO (PMID:28165339)
(PMID:24809814)		 UniProt PMID:24809814 PMID:28165339 NCBI chrNW_004955437:20,489,641...20,547,105
Ensembl chrNW_004955437:20,488,330...20,547,171 		JBrowse link
G Vps54 VPS54 subunit of GARP complex involved_in ISO (MGI:6430941|PMID:32345721) MGI PMID:32345721 MGI:6430941 NCBI chrNW_004955424:20,329,009...20,443,652
Ensembl chrNW_004955424:20,327,754...20,445,980 		JBrowse link
ceramide catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acer1 alkaline ceramidase 1 involved_in
acts_upstream_of_or_within		 ISO (PMID:20207939)
(MGI:2670497|PMID:12783875)
(MGI:5800647|PMID:27126290)		 UniProt
MGI		 PMID:12783875 PMID:20207939 PMID:27126290 MGI:2670497 MGI:5800647 NCBI chrNW_004955495:3,247,170...3,271,417
Ensembl chrNW_004955495:3,247,083...3,271,720 		JBrowse link
G Acer2 alkaline ceramidase 2 involved_in ISO (PMID:16940153), (PMID:20207939) UniProt PMID:16940153 PMID:20207939 NCBI chrNW_004955434:21,786,857...21,810,648
Ensembl chrNW_004955434:21,786,856...21,810,648 		JBrowse link
G Acer3 alkaline ceramidase 3 involved_in ISO (PMID:20207939), (PMID:26792856)
(MGI:5749603|PMID:26474409)
(PMID:30575723)		 UniProt PMID:20207939 PMID:26474409 PMID:26792856 PMID:30575723 MGI:5749603 NCBI chrNW_004955414:14,741,027...14,846,931
Ensembl chrNW_004955414:14,746,529...14,848,151 		JBrowse link
G Asah1 N-acylsphingosine amidohydrolase 1 involved_in ISO (PMID:10610716)
(MGI:5505361|PMID:23770692)
(MGI:1267186|PMID:9653654)
(PMID:12815059)		 UniProt PMID:9653654 PMID:10610716 PMID:12815059 PMID:23770692 MGI:1267186 MGI:5505361 NCBI chrNW_004955552:1,623,263...1,660,285
Ensembl chrNW_004955552:1,623,738...1,659,086 		JBrowse link
G Asah2 N-acylsphingosine amidohydrolase 2 involved_in ISO (PMID:10781606), (PMID:15946935), (PMID:19345744), (PMID:30154232)
PMID:15123644
(MGI:3608219|PMID:16126722), (MGI:3640407|PMID:16380386)
(MGI:6275120|PMID:10652340)
PMID:15217782
PMID:10488143
(PMID:16229686), (PMID:17475390)		 UniProt PMID:10488143 PMID:10652340 PMID:10781606 PMID:15123644 PMID:15217782 More... MGI:3608219 MGI:3640407 MGI:6275120 RGD:13838793 RGD:13838794 RGD:13838800 NCBI chrNW_004955425:5,840,355...5,931,891
Ensembl chrNW_004955425:5,840,355...5,931,891 		JBrowse link
G Cel carboxyl ester lipase acts_upstream_of_or_within ISO (MGI:2158596|PMID:11733511) MGI PMID:11733511 MGI:2158596 NCBI chrNW_004955513:2,324,025...2,382,877 JBrowse link
galactosylceramide catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Galc galactosylceramidase involved_in
acts_upstream_of_or_within		 ISO (PMID:8399327)
(MGI:78941|PMID:8769874)
(MGI:2183819|PMID:11371512)		 UniProt
MGI		 PMID:8399327 PMID:8769874 PMID:11371512 MGI:2183819 MGI:78941 NCBI chrNW_004955438:10,667,807...10,704,386
Ensembl chrNW_004955438:10,667,807...10,704,384 		JBrowse link
G Psap prosaposin acts_upstream_of_or_within ISO (MGI:2183819|PMID:11371512) MGI PMID:11371512 MGI:2183819 NCBI chrNW_004955437:19,667,252...19,683,669 JBrowse link
ganglioside catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gm2a GM2 ganglioside activator acts_upstream_of_or_within ISO (MGI:894862|PMID:9223328) MGI PMID:9223328 MGI:894862 NCBI chrNW_004955408:2,442,406...2,449,426
Ensembl chrNW_004955408:2,442,406...2,449,426 		JBrowse link
G Hexa hexosaminidase subunit alpha involved_in
acts_upstream_of_or_within		 ISO (PMID:8123671), (PMID:8672428), (PMID:9694901)
(MGI:69059|PMID:7937929), (MGI:894862|PMID:9223328)
(MGI:1271008|PMID:9645704), (MGI:78473|PMID:8789434)		 UniProt
MGI		 PMID:7937929 PMID:8123671 PMID:8672428 PMID:8789434 PMID:9223328 More... MGI:1271008 MGI:69059 MGI:78473 MGI:894862 NCBI chrNW_004955450:4,790,342...4,806,862
Ensembl chrNW_004955450:4,790,268...4,806,734 		JBrowse link
G Hexb hexosaminidase subunit beta involved_in
acts_upstream_of_or_within		 ISO (PMID:8123671), (PMID:8672428)
(MGI:1331265|PMID:10021458), (MGI:2670850|PMID:12756243), (MGI:3041658|PMID:12657883), (MGI:3573807|PMID:15748167), (MGI:894862|PMID:9223328)
(MGI:76816|PMID:8566348)
(MGI:1271008|PMID:9645704), (MGI:78473|PMID:8789434)		 UniProt
MGI		 PMID:8123671 PMID:8566348 PMID:8672428 PMID:8789434 PMID:9223328 More... MGI:1271008 MGI:1331265 MGI:2670850 MGI:3041658 MGI:3573807 MGI:76816 MGI:78473 MGI:894862 NCBI chrNW_004955425:25,942,341...25,961,312
Ensembl chrNW_004955425:25,942,278...25,961,312 		JBrowse link
G Neu2 neuraminidase 2 involved_in ISO (PMID:14613940), (PMID:22228546)
(MGI:1354405|PMID:10713120)		 UniProt PMID:10713120 PMID:14613940 PMID:22228546 MGI:1354405 NCBI chrNW_004955453:3,054,626...3,063,070
Ensembl chrNW_004955453:3,052,297...3,061,791 		JBrowse link
G Neu3 neuraminidase 3 involved_in ISO (PMID:10861246), (PMID:11298736), (PMID:15847605), (PMID:17334392)
(MGI:3040535|PMID:14970224), (MGI:3765376|PMID:17708748), (MGI:6478528|PMID:11696012)		 UniProt PMID:10861246 PMID:11298736 PMID:11696012 PMID:14970224 PMID:15847605 More... MGI:3040535 MGI:3765376 MGI:6478528 NCBI chrNW_004955414:16,783,996...16,798,368
Ensembl chrNW_004955414:16,788,171...16,798,535 		JBrowse link
G Neu4 neuraminidase 4 involved_in ISO (PMID:15213228), (PMID:15847605)
(MGI:4361102|PMID:19506080)		 UniProt PMID:15213228 PMID:15847605 PMID:19506080 MGI:4361102 NCBI chrNW_004955542:66,214...70,456
Ensembl chrNW_004955542:66,174...71,058 		JBrowse link
glucosylceramide catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gba1 glucosylceramidase beta 1 involved_in ISO (PMID:16293621), (PMID:24211208), (PMID:9201993)
(MGI:6271235|PMID:24211208)
(MGI:5141165|PMID:21700325), (MGI:5501380|PMID:23707074)
(PMID:19279011), (PMID:21700325), (PMID:24022302)		 UniProt
ParkinsonsUK-UCL		 PMID:9201993 PMID:16293621 PMID:19279011 PMID:21700325 PMID:23707074 More... MGI:5141165 MGI:5501380 MGI:6271235 NCBI chrNW_004955545:1,682,097...1,689,373
Ensembl chrNW_004955545:1,682,097...1,689,376 		JBrowse link
G Gba2 glucosylceramidase beta 2 involved_in ISO (PMID:17080196)
(MGI:5484792|PMID:23250757)
(MGI:3690511|PMID:17080196)
(PMID:30308956)		 UniProt PMID:17080196 PMID:23250757 PMID:30308956 MGI:3690511 MGI:5484792 NCBI chrNW_004955472:553,556...564,411
Ensembl chrNW_004955472:553,556...564,411 		JBrowse link
glycosphingolipid catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gla galactosidase alpha involved_in ISO (PMID:8804427)
(PMID:10838196)		 UniProt PMID:8804427 PMID:10838196 NCBI chrNW_004955503:7,526,077...7,535,817
Ensembl chrNW_004955503:7,521,930...7,535,817 		JBrowse link
glycosylceramide catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gla galactosidase alpha acts_upstream_of_or_within ISO (MGI:1859538|PMID:10841515), (MGI:2155538|PMID:11752062), (MGI:86774|PMID:9122231)
(MGI:1860035|PMID:10840053), (MGI:3525994|PMID:15629890)		 MGI PMID:9122231 PMID:10840053 PMID:10841515 PMID:11752062 PMID:15629890 MGI:1859538 MGI:1860035 MGI:2155538 MGI:3525994 MGI:86774 NCBI chrNW_004955503:7,526,077...7,535,817
Ensembl chrNW_004955503:7,521,930...7,535,817 		JBrowse link
G Lct lactase involved_in ISO PMID:4752949 UniProt PMID:4752949 RGD:151356630 NCBI chrNW_004955440:3,148,730...3,197,110
Ensembl chrNW_004955440:3,148,730...3,197,110 		JBrowse link
positive regulation of glucosylceramide catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Prkcd protein kinase C delta involved_in ISO (PMID:19279011) BHF-UCL PMID:19279011 NCBI chrNW_004955430:3,125,066...3,151,857
Ensembl chrNW_004955430:3,124,738...3,153,274 		JBrowse link
positive regulation of sphingomyelin catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Enpp7 ectonucleotide pyrophosphatase/phosphodiesterase 7 involved_in ISO (MGI:4947032|PMID:21177474) UniProt PMID:21177474 MGI:4947032 NCBI chrNW_004955506:3,151,133...3,154,613
Ensembl chrNW_004955506:3,151,133...3,154,613 		JBrowse link
G Prkcd protein kinase C delta involved_in ISO (PMID:19279011) BHF-UCL PMID:19279011 NCBI chrNW_004955430:3,125,066...3,151,857
Ensembl chrNW_004955430:3,124,738...3,153,274 		JBrowse link
sphingomyelin catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Smpd1 sphingomyelin phosphodiesterase 1 involved_in
acts_upstream_of_or_within		 ISO (PMID:18815062), (PMID:20807762), (PMID:22573858)
(MGI:5529577|PMID:23973266)		 UniProt
MGI		 PMID:18815062 PMID:20807762 PMID:22573858 PMID:23973266 MGI:5529577 NCBI chrNW_004955414:22,117,929...22,121,744
Ensembl chrNW_004955414:22,117,930...22,121,744 		JBrowse link
G Smpd2 sphingomyelin phosphodiesterase 2 acts_upstream_of_or_within
involved_in		 ISO (MGI:5529577|PMID:23973266)
(MGI:1202145|PMID:9520418)
(PMID:10608884), (PMID:14741383)		 MGI
UniProt		 PMID:9520418 PMID:10608884 PMID:14741383 PMID:23973266 MGI:1202145 MGI:5529577 NCBI chrNW_004955411:34,481,431...34,484,423
Ensembl chrNW_004955411:34,481,823...34,484,406 		JBrowse link
G Smpd3 sphingomyelin phosphodiesterase 3 acts_upstream_of_or_within
involved_in		 ISO (MGI:5529577|PMID:23973266)
(PMID:14741383)		 MGI
UniProt		 PMID:14741383 PMID:23973266 MGI:5529577 NCBI chrNW_004955484:8,207,686...8,298,164
Ensembl chrNW_004955484:8,272,572...8,298,144 		JBrowse link
G Smpd4 sphingomyelin phosphodiesterase 4 involved_in ISO (PMID:16517606), (PMID:25180167)
(MGI:6450503|PMID:25180167)		 UniProt PMID:16517606 PMID:25180167 MGI:6450503 NCBI chrNW_004955442:19,184,794...19,210,999
Ensembl chrNW_004955442:19,184,794...19,210,999 		JBrowse link
G Smpdl3a sphingomyelin phosphodiesterase acid like 3A NOT|involved_in ISO (PMID:26783088) UniProt PMID:26783088 NCBI chrNW_004955436:4,655,730...4,663,993
Ensembl chrNW_004955436:4,655,732...4,663,638 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12288
    metabolic process 7843
      catabolic process 1826
        organic substance catabolic process 1522
          organonitrogen compound catabolic process 976
            sphingolipid catabolic process 28
              ceramide catabolic process + 19
              ceramide phosphoethanolamine catabolic process 0
              glycosphingolipid catabolic process + 13
              sphinganine-1-phosphate catabolic process 0
              sphingoid catabolic process + 0
              sphingomyelin catabolic process + 7
Path 2
Term Annotations click to browse term
  biological_process 12288
    metabolic process 7843
      primary metabolic process 6988
        lipid metabolic process 987
          cellular lipid metabolic process 727
            membrane lipid metabolic process 161
              sphingolipid metabolic process 123
                sphingolipid catabolic process 28
                  ceramide catabolic process + 19
                  ceramide phosphoethanolamine catabolic process 0
                  glycosphingolipid catabolic process + 13
                  sphinganine-1-phosphate catabolic process 0
                  sphingoid catabolic process + 0
                  sphingomyelin catabolic process + 7
paths to the root