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ONTOLOGY REPORT - ANNOTATIONS


Term:sphingolipid catabolic process
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Accession:GO:0030149 term browser browse the term
Definition:The chemical reactions and pathways resulting in the breakdown of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid).
Synonyms:exact_synonym: sphingolipid breakdown;   sphingolipid catabolism;   sphingolipid degradation



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sphingolipid catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Enpp2 ectonucleotide pyrophosphatase/phosphodiesterase 2 involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(PMID:14500380)
UniProt
Ensembl
RGD
PMID:14500380 GO_REF:0000024 GO_REF:0000107 NCBI chr 7:86,202,345...86,325,050
Ensembl chr 7:86,202,350...86,324,827
JBrowse link
G Sgpl1 sphingosine-1-phosphate lyase 1 involved_in ISS
IBA
ISO
GO_REF:0000024
PMID:21873635
(PMID:24809814), (PMID:28165339)
UniProt
RGD
PMID:24809814 PMID:28165339 PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr20:29,047,793...29,094,209
Ensembl chr20:29,047,796...29,094,084
JBrowse link
G Smpd2 sphingomyelin phosphodiesterase 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr20:44,986,229...44,989,343
Ensembl chr20:44,986,231...44,989,441
JBrowse link
ceramide catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acer1 alkaline ceramidase 1 involved_in
acts_upstream_of_or_within
ISO (PMID:20207939)
(MGI:2670497|PMID:12783875)
(MGI:5800647|PMID:27126290)
RGD PMID:12783875 PMID:20207939 PMID:27126290 MGI:2670497 MGI:5800647 NCBI chr 9:1,792,790...1,824,434
Ensembl chr 9:1,793,139...1,824,434
JBrowse link
G Acer2 alkaline ceramidase 2 involved_in ISO (PMID:16940153), (PMID:20207939) RGD PMID:16940153 PMID:20207939 NCBI chr 5:101,391,830...101,442,615
Ensembl chr 5:101,391,885...101,442,614
JBrowse link
G Acer3 alkaline ceramidase 3 involved_in ISO (PMID:20207939), (PMID:26792856), (PMID:30575723)
(MGI:5749603|PMID:26474409)
RGD PMID:20207939 PMID:26474409 PMID:26792856 PMID:30575723 MGI:5749603 NCBI chr 1:152,504,180...152,606,596
Ensembl chr 1:152,504,186...152,606,591
JBrowse link
G Asah1 N-acylsphingosine amidohydrolase 1 involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(MGI:1267186|PMID:9653654), (MGI:5505361|PMID:23770692)
(PMID:10610716), (PMID:12815059)
UniProt
Ensembl
RGD
PMID:9653654 PMID:10610716 PMID:12815059 PMID:23770692 GO_REF:0000024 GO_REF:0000107 MGI:1267186 MGI:5505361 NCBI chr16:50,966,404...50,997,827
Ensembl chr16:50,966,229...51,008,233
JBrowse link
G Asah2 N-acylsphingosine amidohydrolase 2 involved_in IDA
ISO
IBA
PMID:15123644
(MGI:3608219|PMID:16126722), (MGI:3640407|PMID:16380386), (MGI:6275120|PMID:10652340)
PMID:15217782
PMID:21873635
(PMID:10781606), (PMID:15946935), (PMID:16229686), (PMID:17475390), (PMID:19345744), (PMID:30154232)
PMID:10488143
RGD PMID:10652340 PMID:10781606 PMID:15946935 PMID:16126722 PMID:16229686 More... MGI:3608219 MGI:3640407 MGI:6275120, RGD:13838793, RGD:13838794, RGD:13792537, RGD:13838800 NCBI chr 1:229,865,662...229,973,253
Ensembl chr 1:229,865,662...229,939,162
JBrowse link
G Cel carboxyl ester lipase involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:2180867 (MGI:2158596|PMID:11733511)
Ensembl
RGD
PMID:11733511 GO_REF:0000107 MGI:2158596 NCBI chr 3:11,883,532...11,891,035
Ensembl chr 3:11,883,532...11,891,035
JBrowse link
galactosylceramide catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Galc galactosylceramidase involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
(MGI:78941|PMID:8769874)
MGI:1856218 (MGI:2183819|PMID:11371512)
(PMID:8399327)
RGD PMID:8399327 PMID:8769874 PMID:11371512 PMID:21873635 MGI:2183819 MGI:78941, RGD:13792537 NCBI chr 6:117,452,888...117,522,281
Ensembl chr 6:117,452,895...117,515,830
JBrowse link
G Gba3 glucosylceramidase beta 3 involved_in ISO (PMID:17595169) RGD PMID:17595169 NCBI chr14:60,575,368...60,662,952
Ensembl chr14:60,574,976...60,721,653
JBrowse link
G Psap prosaposin acts_upstream_of_or_within ISO MGI:2183897 (MGI:2183819|PMID:11371512) RGD PMID:11371512 MGI:2183819 NCBI chr20:28,214,229...28,240,501
Ensembl chr20:28,214,271...28,240,498
JBrowse link
ganglioside catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gm2a GM2 ganglioside activator involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
MGI:1861930 (MGI:894862|PMID:9223328)
RGD PMID:9223328 PMID:21873635 MGI:894862, RGD:13792537 NCBI chr10:39,219,221...39,231,756
Ensembl chr10:39,219,243...39,231,757
JBrowse link
G Hexa hexosaminidase subunit alpha involved_in
acts_upstream_of_or_within
ISS
ISO
GO_REF:0000024
MGI:1857181|MGI:2429698 (MGI:1271008|PMID:9645704), (MGI:69059|PMID:7937929), (MGI:78473|PMID:8789434), (MGI:894862|PMID:9223328)
(PMID:8123671), (PMID:8672428), (PMID:9694901)
UniProt
RGD
PMID:7937929 PMID:8123671 PMID:8672428 PMID:8789434 PMID:9223328 More... GO_REF:0000024 MGI:1271008 MGI:69059 MGI:78473 MGI:894862 NCBI chr 8:59,936,526...59,961,654
Ensembl chr 8:59,936,660...59,962,013
JBrowse link
G Hexb hexosaminidase subunit beta involved_in
acts_upstream_of_or_within
ISS
ISO
IEA
GO_REF:0000024
MGI:1857438|MGI:2429701 (MGI:1271008|PMID:9645704), (MGI:1331265|PMID:10021458), (MGI:2670850|PMID:12756243), (MGI:3041658|PMID:12657883), (MGI:3573807|PMID:15748167), (MGI:76816|PMID:8566348), (MGI:78473|PMID:8789434), (MGI:894862|PMID:9223328)
(PMID:8123671), (PMID:8672428)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:8123671 PMID:8566348 PMID:8672428 PMID:8789434 PMID:9223328 More... GO_REF:0000024 GO_REF:0000107 MGI:1271008 MGI:1331265 MGI:2670850 MGI:3041658 MGI:3573807 MGI:76816 MGI:78473 MGI:894862 NCBI chr 2:28,483,997...28,504,165
Ensembl chr 2:28,484,012...28,504,223
JBrowse link
G Neu1 neuraminidase 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr20:3,897,480...3,901,745
Ensembl chr20:3,897,480...3,901,745
JBrowse link
G Neu2 neuraminidase 2 involved_in ISS
ISO
IEA
IBA
GO_REF:0000024
(MGI:1354405|PMID:10713120)
(PMID:14613940), (PMID:22228546)
GO_REF:0000107
PMID:21873635
UniProt
RGD
Ensembl
PMID:10713120 PMID:14613940 PMID:22228546 PMID:21873635 GO_REF:0000024 GO_REF:0000107 MGI:1354405, RGD:13792537 NCBI chr 9:88,218,494...88,267,356
Ensembl chr 9:88,249,135...88,267,355
JBrowse link
G Neu3 neuraminidase 3 involved_in IBA
ISO
ISS
PMID:21873635
(MGI:3040535|PMID:14970224), (MGI:3765376|PMID:17708748), (MGI:6478528|PMID:11696012)
GO_REF:0000024
(PMID:10861246), (PMID:11298736), (PMID:15847605), (PMID:17334392)
RGD
UniProt
PMID:10861246 PMID:11298736 PMID:11696012 PMID:14970224 PMID:15847605 More... GO_REF:0000024 MGI:3040535 MGI:3765376 MGI:6478528, RGD:13792537 NCBI chr 1:154,137,732...154,148,879
Ensembl chr 1:154,050,855...154,148,813
JBrowse link
G Neu4 neuraminidase 4 involved_in IBA
ISO
PMID:21873635
(MGI:4361102|PMID:19506080)
(PMID:15213228), (PMID:15847605)
RGD PMID:15213228 PMID:15847605 PMID:19506080 PMID:21873635 MGI:4361102, RGD:13792537 NCBI chr 9:94,396,920...94,402,576
Ensembl chr 9:94,396,920...94,402,576
JBrowse link
glucosylceramide catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gba glucosylceramidase beta involved_in IBA
ISO
PMID:21873635
(MGI:5141165|PMID:21700325), (MGI:5501380|PMID:23707074), (MGI:6271235|PMID:24211208)
(PMID:16293621), (PMID:19279011), (PMID:21700325), (PMID:24022302), (PMID:24211208), (PMID:9201993)
RGD PMID:9201993 PMID:16293621 PMID:19279011 PMID:21700325 PMID:23707074 More... MGI:5141165 MGI:5501380 MGI:6271235, RGD:13792537 NCBI chr 2:174,609,437...174,615,457
Ensembl chr 2:174,609,403...174,618,263
JBrowse link
G Gba2 glucosylceramidase beta 2 involved_in ISO
ISS
IEA
(PMID:17080196), (PMID:30308956)
(MGI:3690511|PMID:17080196), (MGI:5484792|PMID:23250757)
GO_REF:0000024
GO_REF:0000002
RGD
UniProt
InterPro
PMID:17080196 PMID:23250757 PMID:30308956 GO_REF:0000002 GO_REF:0000024 MGI:3690511 MGI:5484792 NCBI chr 5:57,822,389...57,834,522
Ensembl chr 5:57,822,389...57,834,072
JBrowse link
G Gba3 glucosylceramidase beta 3 involved_in
NOT|involved_in
ISO (PMID:17595169), (PMID:26724485)
(PMID:20728381)
RGD PMID:17595169 PMID:20728381 PMID:26724485 NCBI chr14:60,575,368...60,662,952
Ensembl chr14:60,574,976...60,721,653
JBrowse link
glycosphingolipid catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gla galactosidase, alpha involved_in ISO (PMID:10838196), (PMID:8804427) RGD PMID:8804427 PMID:10838196 NCBI chr  X:97,769,227...97,780,646
Ensembl chr  X:97,768,996...97,780,664
JBrowse link
glycosylceramide catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gba3 glucosylceramidase beta 3 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr14:60,575,368...60,662,952
Ensembl chr14:60,574,976...60,721,653
JBrowse link
G Gla galactosidase, alpha involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
MGI:1861794 (MGI:1859538|PMID:10841515), (MGI:1860035|PMID:10840053), (MGI:2155538|PMID:11752062), (MGI:3525994|PMID:15629890), (MGI:86774|PMID:9122231)
RGD PMID:9122231 PMID:10840053 PMID:10841515 PMID:11752062 PMID:15629890 More... MGI:1859538 MGI:1860035 MGI:2155538 MGI:3525994 MGI:86774, RGD:13792537 NCBI chr  X:97,769,227...97,780,646
Ensembl chr  X:97,768,996...97,780,664
JBrowse link
G Naga alpha-N-acetylgalactosaminidase involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 7:113,846,358...113,855,430
Ensembl chr 7:113,846,374...113,855,315
JBrowse link
positive regulation of glucosylceramide catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Prkcd protein kinase C, delta involved_in IEA
ISO
GO_REF:0000107
(PMID:19279011)
Ensembl
RGD
PMID:19279011 GO_REF:0000107 NCBI chr16:5,769,226...5,807,214
Ensembl chr16:5,769,215...5,799,352
JBrowse link
positive regulation of sphingomyelin catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Enpp7 ectonucleotide pyrophosphatase/phosphodiesterase 7 involved_in ISS
ISO
GO_REF:0000024
(MGI:4947032|PMID:21177474)
UniProt
RGD
PMID:21177474 GO_REF:0000024 MGI:4947032 NCBI chr10:104,242,223...104,246,589
Ensembl chr10:104,242,223...104,246,589
JBrowse link
G Prkcd protein kinase C, delta involved_in IEA
ISO
GO_REF:0000107
(PMID:19279011)
Ensembl
RGD
PMID:19279011 GO_REF:0000107 NCBI chr16:5,769,226...5,807,214
Ensembl chr16:5,769,215...5,799,352
JBrowse link
sphingomyelin catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Enpp7 ectonucleotide pyrophosphatase/phosphodiesterase 7 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr10:104,242,223...104,246,589
Ensembl chr10:104,242,223...104,246,589
JBrowse link
G Smpd1 sphingomyelin phosphodiesterase 1 involved_in
acts_upstream_of_or_within
ISO
IBA
(PMID:18815062), (PMID:20807762), (PMID:22573858)
(MGI:5529577|PMID:23973266)
PMID:21873635
RGD PMID:18815062 PMID:20807762 PMID:22573858 PMID:23973266 PMID:21873635 MGI:5529577, RGD:13792537 NCBI chr 1:159,892,946...159,896,789
Ensembl chr 1:159,892,859...159,896,794
JBrowse link
G Smpd2 sphingomyelin phosphodiesterase 2 acts_upstream_of_or_within ISO (MGI:5529577|PMID:23973266) RGD PMID:23973266 MGI:5529577 NCBI chr20:44,986,229...44,989,343
Ensembl chr20:44,986,231...44,989,441
JBrowse link
G Smpd3 sphingomyelin phosphodiesterase 3 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(MGI:5529577|PMID:23973266)
Ensembl
RGD
PMID:23973266 GO_REF:0000107 MGI:5529577 NCBI chr19:34,162,337...34,245,786
Ensembl chr19:34,162,341...34,245,749
JBrowse link
G Smpd4 sphingomyelin phosphodiesterase 4 involved_in IBA
ISO
PMID:21873635
(MGI:6450503|PMID:25180167)
(PMID:16517606), (PMID:25180167)
RGD PMID:16517606 PMID:25180167 PMID:21873635 MGI:6450503, RGD:13792537 NCBI chr11:83,362,534...83,386,257
Ensembl chr11:83,362,534...83,386,250
JBrowse link
G Smpd5 sphingomyelin phosphodiesterase 5 involved_in ISO (MGI:6450238|PMID:21183079) RGD PMID:21183079 MGI:6450238 NCBI chr 7:108,009,182...108,011,767
Ensembl chr 7:108,009,173...108,011,763
JBrowse link
G Smpdl3a sphingomyelin phosphodiesterase, acid-like 3A NOT|involved_in ISO
ISS
(PMID:26783088)
GO_REF:0000024
RGD
UniProt
PMID:26783088 GO_REF:0000024 NCBI chr20:37,132,592...37,155,567
Ensembl chr20:37,132,592...37,155,567
JBrowse link
G Smpdl3b sphingomyelin phosphodiesterase, acid-like 3B involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 5:144,944,618...144,966,703
Ensembl chr 5:144,944,636...144,966,720
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19391
    metabolic process 11735
      catabolic process 2535
        organic substance catabolic process 2092
          organonitrogen compound catabolic process 1326
            sphingolipid catabolic process 31
              ceramide catabolic process + 21
              ceramide phosphoethanolamine catabolic process 0
              glycosphingolipid catabolic process + 15
              sphinganine-1-phosphate catabolic process 0
              sphingoid catabolic process + 0
              sphingomyelin catabolic process + 9
Path 2
Term Annotations click to browse term
  biological_process 19391
    metabolic process 11735
      primary metabolic process 10467
        lipid metabolic process 1365
          cellular lipid metabolic process 1021
            membrane lipid metabolic process 187
              sphingolipid metabolic process 141
                sphingolipid catabolic process 31
                  ceramide catabolic process + 21
                  ceramide phosphoethanolamine catabolic process 0
                  glycosphingolipid catabolic process + 15
                  sphinganine-1-phosphate catabolic process 0
                  sphingoid catabolic process + 0
                  sphingomyelin catabolic process + 9
paths to the root