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ONTOLOGY REPORT - ANNOTATIONS


Term:sphingolipid catabolic process
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Accession:GO:0030149 term browser browse the term
Definition:The chemical reactions and pathways resulting in the breakdown of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid).
Synonyms:exact_synonym: sphingolipid breakdown;   sphingolipid catabolism;   sphingolipid degradation


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sphingolipid catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07028989.1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 Ensembl chr10:1,622,573...1,674,701 JBrowse link
G Enpp2 ectonucleotide pyrophosphatase/phosphodiesterase 2 ISO
IEA
ISS
(PMID:14500380)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:14500380 GO_REF:0000024, GO_REF:0000107 NCBI chr 7:94,479,931...94,563,086
Ensembl chr 7:94,480,396...94,563,001
JBrowse link
G Pdxdc1 pyridoxal-dependent decarboxylase domain containing 1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:3,232,794...3,321,438
Ensembl chr10:3,232,794...3,321,412
JBrowse link
G Sgpl1 sphingosine-1-phosphate lyase 1 ISS
IBA
ISO
GO_REF:0000024
PMID:21873635
(PMID:24809814), (PMID:28165339)
UniProt
RGD
PMID:24809814, PMID:28165339, PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr20:30,699,936...30,769,178
Ensembl chr20:30,699,872...30,749,940
JBrowse link
G Smpd2 sphingomyelin phosphodiesterase 2 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr20:46,212,070...46,215,183
Ensembl chr20:46,211,892...46,215,120
JBrowse link
ceramide catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acer1 alkaline ceramidase 1 ISO (PMID:20207939)
(MGI:MGI:2670497|PMID:12783875), (MGI:MGI:5800647|PMID:27126290)
RGD PMID:12783875, PMID:20207939, PMID:27126290 MGI:MGI:2670497, MGI:MGI:5800647 NCBI chr 9:10,061,978...10,093,588
Ensembl chr 9:10,061,978...10,093,588
JBrowse link
G Acer2 alkaline ceramidase 2 ISO (PMID:16940153), (PMID:20207939) RGD PMID:16940153, PMID:20207939 NCBI chr 5:105,230,540...105,279,732
Ensembl chr 5:105,230,580...105,279,731
JBrowse link
G Acer3 alkaline ceramidase 3 ISO (MGI:MGI:5749603|PMID:26474409)
(PMID:20207939), (PMID:26792856), (PMID:30575723)
RGD PMID:20207939, PMID:26474409, PMID:26792856, PMID:30575723 MGI:MGI:5749603 NCBI chr 1:163,160,987...163,263,621
Ensembl chr 1:163,160,979...163,263,606
JBrowse link
G Asah1 N-acylsphingosine amidohydrolase 1 IEA
ISO
ISS
GO_REF:0000107
(MGI:MGI:1267186|PMID:9653654), (MGI:MGI:5505361|PMID:23770692)
(PMID:10610716), (PMID:12815059)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:9653654, PMID:10610716, PMID:12815059, PMID:23770692 GO_REF:0000024, GO_REF:0000107, MGI:MGI:1267186, MGI:MGI:5505361 NCBI chr16:53,998,604...54,030,006
Ensembl chr16:53,998,560...54,040,836
JBrowse link
G Asah2 N-acylsphingosine amidohydrolase 2 IDA
IBA
ISO
PMID:10488143
PMID:21873635
(MGI:MGI:3608219|PMID:16126722), (MGI:MGI:3640407|PMID:16380386), (MGI:MGI:6275120|PMID:10652340)
(PMID:10781606), (PMID:15946935), (PMID:16229686), (PMID:17475390), (PMID:19345744), (PMID:30154232)
PMID:15217782
PMID:15123644
RGD PMID:10652340, PMID:10781606, PMID:15946935, PMID:16126722, PMID:16229686, PMID:16380386, PMID:17475390, PMID:19345744, PMID:30154232, PMID:10488143, PMID:21873635, PMID:15217782, PMID:15123644 MGI:MGI:3608219, MGI:MGI:3640407, MGI:MGI:6275120, RGD:13838800, RGD:13792537, RGD:13838794, RGD:13838793 NCBI chr 1:250,557,042...250,665,083
Ensembl chr 1:250,557,044...250,630,677
JBrowse link
G Cel carboxyl ester lipase ISO
IEA
MGI:MGI:2180867 (MGI:MGI:2158596|PMID:11733511)
GO_REF:0000107
RGD
Ensembl
PMID:11733511 GO_REF:0000107, MGI:MGI:2158596 NCBI chr 3:7,134,021...7,141,522
Ensembl chr 3:7,134,021...7,141,522
JBrowse link
galactosylceramide catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Galc galactosylceramidase ISO
IBA
MGI:MGI:1856218 (MGI:MGI:2183819|PMID:11371512), (MGI:MGI:78941|PMID:8769874)
(PMID:8399327)
PMID:21873635
RGD PMID:8399327, PMID:8769874, PMID:11371512, PMID:21873635 MGI:MGI:2183819, MGI:MGI:78941, RGD:13792537 NCBI chr 6:122,177,195...122,239,411
Ensembl chr 6:122,178,602...122,239,614
JBrowse link
G Gba3 glucosylceramidase beta 3 ISO (PMID:17595169) RGD PMID:17595169 NCBI chr14:64,390,793...64,535,213
Ensembl chr14:64,390,793...64,535,170
JBrowse link
G Psap prosaposin IEA
ISO
GO_REF:0000107
MGI:MGI:2183897 (MGI:MGI:2183819|PMID:11371512)
Ensembl
RGD
PMID:11371512 GO_REF:0000107, MGI:MGI:2183819 NCBI chr20:29,831,302...29,856,876
Ensembl chr20:29,831,314...29,856,875
JBrowse link
ganglioside catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gm2a GM2 ganglioside activator ISO
IBA
MGI:MGI:1861930 (MGI:MGI:894862|PMID:9223328)
PMID:21873635
RGD PMID:9223328, PMID:21873635 MGI:MGI:894862, RGD:13792537 NCBI chr10:40,438,394...40,450,927
Ensembl chr10:40,438,356...40,450,930
JBrowse link
G Hexa hexosaminidase subunit alpha ISO
ISS
MGI:MGI:1857181|MGI:MGI:2429698 (MGI:MGI:1271008|PMID:9645704), (MGI:MGI:69059|PMID:7937929), (MGI:MGI:78473|PMID:8789434), (MGI:MGI:894862|PMID:9223328)
GO_REF:0000024
(PMID:8123671), (PMID:8672428), (PMID:9694901)
RGD
UniProt
PMID:7937929, PMID:8123671, PMID:8672428, PMID:8789434, PMID:9223328, PMID:9645704, PMID:9694901 GO_REF:0000024, MGI:MGI:1271008, MGI:MGI:69059, MGI:MGI:78473, MGI:MGI:894862 NCBI chr 8:64,325,435...64,350,775
Ensembl chr 8:64,325,435...64,350,773
JBrowse link
G Hexb hexosaminidase subunit beta ISO
IEA
ISS
MGI:MGI:1857438|MGI:MGI:2429701 (MGI:MGI:1271008|PMID:9645704), (MGI:MGI:1331265|PMID:10021458), (MGI:MGI:2670850|PMID:12756243), (MGI:MGI:3041658|PMID:12657883), (MGI:MGI:3573807|PMID:15748167), (MGI:MGI:76816|PMID:8566348), (MGI:MGI:78473|PMID:8789434), (MGI:MGI:894862|PMID:9223328)
GO_REF:0000107
GO_REF:0000024
(PMID:8123671), (PMID:8672428)
RGD
Ensembl
UniProt
PMID:8123671, PMID:8566348, PMID:8672428, PMID:8789434, PMID:9223328, PMID:9645704, PMID:10021458, PMID:12657883, PMID:12756243, PMID:15748167 GO_REF:0000024, GO_REF:0000107, MGI:MGI:1271008, MGI:MGI:1331265, MGI:MGI:2670850, MGI:MGI:3041658, MGI:MGI:3573807, MGI:MGI:76816, MGI:MGI:78473, MGI:MGI:894862 NCBI chr 2:27,983,925...28,003,260
Ensembl chr 2:27,984,117...28,003,186
JBrowse link
G Neu1 neuraminidase 1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr20:4,610,995...4,615,258
Ensembl chr20:4,610,995...4,615,247
JBrowse link
G Neu2 neuraminidase 2 IEA
ISO
IBA
ISS
GO_REF:0000107
(MGI:MGI:1354405|PMID:10713120)
(PMID:14613940), (PMID:22228546)
PMID:21873635
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:10713120, PMID:14613940, PMID:22228546, PMID:21873635 GO_REF:0000024, GO_REF:0000107, MGI:MGI:1354405, RGD:13792537 NCBI chr 9:94,702,095...94,724,903
Ensembl chr 9:94,702,129...94,724,902
JBrowse link
G Neu3 neuraminidase 3 ISS
ISO
IBA
GO_REF:0000024
(MGI:MGI:3765376|PMID:17708748)
(PMID:10861246), (PMID:11298736), (PMID:15847605), (PMID:17334392)
PMID:21873635
UniProt
RGD
PMID:10861246, PMID:11298736, PMID:15847605, PMID:17334392, PMID:17708748, PMID:21873635 GO_REF:0000024, MGI:MGI:3765376, RGD:13792537 NCBI chr 1:164,803,574...164,814,777
Ensembl chr 1:164,803,574...164,814,651
JBrowse link
G Neu4 neuraminidase 4 IBA
ISO
PMID:21873635
(MGI:MGI:4361102|PMID:19506080)
(PMID:15213228), (PMID:15847605)
RGD PMID:15213228, PMID:15847605, PMID:19506080, PMID:21873635 MGI:MGI:4361102, RGD:13792537 NCBI chr 9:101,284,902...101,290,558
Ensembl chr 9:101,284,902...101,290,558
JBrowse link
G NEWGENE_1308624 sialidase 4 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 9:101,003,455...101,008,365
Ensembl chr 9:101,005,082...101,008,170
JBrowse link
glucosylceramide catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gba glucosylceramidase beta ISO
IBA
(PMID:16293621), (PMID:19279011), (PMID:21700325), (PMID:24022302), (PMID:24211208), (PMID:9201993)
PMID:21873635
(MGI:MGI:5141165|PMID:21700325), (MGI:MGI:5501380|PMID:23707074), (MGI:MGI:6271235|PMID:24211208)
RGD PMID:9201993, PMID:16293621, PMID:19279011, PMID:21700325, PMID:23707074, PMID:24022302, PMID:24211208, PMID:21873635 MGI:MGI:5141165, MGI:MGI:5501380, MGI:MGI:6271235, RGD:13792537 NCBI chr 2:188,511,781...188,522,602
Ensembl chr 2:188,516,582...188,522,601
JBrowse link
G Gba2 glucosylceramidase beta 2 IEA
ISO
ISS
GO_REF:0000002
(MGI:MGI:3690511|PMID:17080196), (MGI:MGI:5484792|PMID:23250757)
(PMID:17080196), (PMID:30308956)
GO_REF:0000024
InterPro
RGD
UniProt
PMID:17080196, PMID:23250757, PMID:30308956 GO_REF:0000002, GO_REF:0000024, MGI:MGI:3690511, MGI:MGI:5484792 NCBI chr 5:59,068,081...59,079,719
Ensembl chr 5:59,068,081...59,079,719
JBrowse link
G Gba3 glucosylceramidase beta 3 NOT ISO (PMID:20728381)
(PMID:17595169), (PMID:26724485)
RGD PMID:17595169, PMID:20728381, PMID:26724485 NCBI chr14:64,390,793...64,535,213
Ensembl chr14:64,390,793...64,535,170
JBrowse link
glycosphingolipid catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gla galactosidase, alpha ISO (PMID:10838196), (PMID:8804427) RGD PMID:8804427, PMID:10838196 NCBI chr  X:105,405,915...105,417,331
Ensembl chr  X:105,406,792...105,417,323
JBrowse link
glycosylceramide catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gba3 glucosylceramidase beta 3 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr14:64,390,793...64,535,213
Ensembl chr14:64,390,793...64,535,170
JBrowse link
G Gla galactosidase, alpha ISO
IBA
MGI:MGI:1861794 (MGI:MGI:1859538|PMID:10841515), (MGI:MGI:1860035|PMID:10840053), (MGI:MGI:2155538|PMID:11752062), (MGI:MGI:3525994|PMID:15629890), (MGI:MGI:86774|PMID:9122231)
PMID:21873635
RGD PMID:9122231, PMID:10840053, PMID:10841515, PMID:11752062, PMID:15629890, PMID:21873635 MGI:MGI:1859538, MGI:MGI:1860035, MGI:MGI:2155538, MGI:MGI:3525994, MGI:MGI:86774, RGD:13792537 NCBI chr  X:105,405,915...105,417,331
Ensembl chr  X:105,406,792...105,417,323
JBrowse link
G Naga alpha-N-acetylgalactosaminidase IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 7:123,563,047...123,572,074
Ensembl chr 7:123,563,059...123,572,082
JBrowse link
positive regulation of glucosylceramide catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Prkcd protein kinase C, delta ISO
IEA
(PMID:19279011)
GO_REF:0000107
RGD
Ensembl
PMID:19279011 GO_REF:0000107 NCBI chr16:6,655,131...6,675,746
Ensembl chr16:6,655,120...6,675,746
JBrowse link
positive regulation of sphingomyelin catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Enpp7 ectonucleotide pyrophosphatase/phosphodiesterase 7 ISS
ISO
GO_REF:0000024
(MGI:MGI:4947032|PMID:21177474)
UniProt
RGD
PMID:21177474 GO_REF:0000024, MGI:MGI:4947032 NCBI chr10:108,095,131...108,099,483
Ensembl chr10:108,095,131...108,099,483
JBrowse link
G Prkcd protein kinase C, delta ISO
IEA
(PMID:19279011)
GO_REF:0000107
RGD
Ensembl
PMID:19279011 GO_REF:0000107 NCBI chr16:6,655,131...6,675,746
Ensembl chr16:6,655,120...6,675,746
JBrowse link
sphingomyelin catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Enpp7 ectonucleotide pyrophosphatase/phosphodiesterase 7 IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr10:108,095,131...108,099,483
Ensembl chr10:108,095,131...108,099,483
JBrowse link
G Smpd1 sphingomyelin phosphodiesterase 1 ISO
IBA
(PMID:18815062)
(MGI:MGI:5529577|PMID:23973266)
PMID:21873635
RGD PMID:18815062, PMID:23973266, PMID:21873635 MGI:MGI:5529577, RGD:13792537 NCBI chr 1:170,383,682...170,387,525
Ensembl chr 1:170,383,682...170,387,524
JBrowse link
G Smpd2 sphingomyelin phosphodiesterase 2 ISO (MGI:MGI:5529577|PMID:23973266) RGD PMID:23973266 MGI:MGI:5529577 NCBI chr20:46,212,070...46,215,183
Ensembl chr20:46,211,892...46,215,120
JBrowse link
G Smpd3 sphingomyelin phosphodiesterase 3 ISO
IEA
(MGI:MGI:5529577|PMID:23973266)
GO_REF:0000107
RGD
Ensembl
PMID:23973266 GO_REF:0000107, MGI:MGI:5529577 NCBI chr19:38,237,963...38,321,572
Ensembl chr19:38,237,965...38,321,528
JBrowse link
G Smpd4 sphingomyelin phosphodiesterase 4 IBA
ISO
PMID:21873635
(MGI:MGI:6450503|PMID:25180167)
(PMID:16517606), (PMID:25180167)
RGD PMID:16517606, PMID:25180167, PMID:21873635 MGI:MGI:6450503, RGD:13792537 NCBI chr11:87,522,971...87,546,687
Ensembl chr11:87,522,971...87,546,687
JBrowse link
G Smpd5 sphingomyelin phosphodiesterase 5 ISO (MGI:MGI:6450238|PMID:21183079) RGD PMID:21183079 MGI:MGI:6450238 NCBI chr 7:117,351,694...117,354,241
Ensembl chr 7:117,351,648...117,354,084
JBrowse link
G Smpdl3a sphingomyelin phosphodiesterase, acid-like 3A NOT ISO
ISS
(PMID:26783088)
GO_REF:0000024
RGD
UniProt
PMID:26783088 GO_REF:0000024 NCBI chr20:40,779,022...40,800,842
Ensembl chr20:40,778,927...40,800,868
JBrowse link
G Smpdl3b sphingomyelin phosphodiesterase, acid-like 3B IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 5:150,925,150...150,946,994
Ensembl chr 5:150,925,370...150,949,931
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20027
    metabolic process 12278
      catabolic process 2560
        organic substance catabolic process 2109
          organonitrogen compound catabolic process 1320
            sphingolipid catabolic process 34
              ceramide catabolic process + 22
              ceramide phosphoethanolamine catabolic process 0
              glycosphingolipid catabolic process + 16
              sphinganine-1-phosphate catabolic process 0
              sphingoid catabolic process + 0
              sphingomyelin catabolic process + 9
Path 2
Term Annotations click to browse term
  biological_process 20027
    metabolic process 12278
      primary metabolic process 10941
        lipid metabolic process 1374
          cellular lipid metabolic process 1023
            membrane lipid metabolic process 191
              sphingolipid metabolic process 142
                sphingolipid catabolic process 34
                  ceramide catabolic process + 22
                  ceramide phosphoethanolamine catabolic process 0
                  glycosphingolipid catabolic process + 16
                  sphinganine-1-phosphate catabolic process 0
                  sphingoid catabolic process + 0
                  sphingomyelin catabolic process + 9
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.