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ONTOLOGY REPORT - ANNOTATIONS


Term:AP-2 adaptor complex
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Accession:GO:0030122 term browser browse the term
Definition:A heterotetrameric AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits, and links clathrin to the membrane surface of a vesicle, and the cargo receptors during receptor/clathrin mediated endocytosis. Vesicles with AP-2-containing coats are normally found primarily near the plasma membrane, on endocytic vesicles. In at least humans, the AP-2 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different alpha genes (alphaA and alphaC).
Synonyms:exact_synonym: HA2;   HA2 clathrin adaptor


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AP-2 adaptor complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ap2a1 adaptor related protein complex 2 subunit alpha 1 part_of ISO
IBA
(PMID:23676497)
(MGI:5514106|PMID:23676497)
PMID:21873635
RGD PMID:23676497, PMID:21873635 MGI:5514106, RGD:13792537 NCBI chr 1:100,896,582...100,926,443
Ensembl chr 1:100,896,947...100,926,335
JBrowse link
G Ap2a2 adaptor related protein complex 2 subunit alpha 2 part_of IEA
ISO
IMP
IBA
GO_REF:0000002
GO_REF:0000107
(MGI:5514106|PMID:23676497)
PMID:12086608
PMID:21873635
(PMID:23676497)
InterPro
Ensembl
RGD
PMID:23676497, PMID:12086608, PMID:21873635 GO_REF:0000002 GO_REF:0000107 MGI:5514106, RGD:12793054, RGD:13792537 NCBI chr 1:214,534,217...214,607,497
Ensembl chr 1:214,534,284...214,606,169
JBrowse link
G Ap2b1 adaptor related protein complex 2 subunit beta 1 part_of ISO (PMID:12086608), (PMID:23676497)
(MGI:5514106|PMID:23676497)
RGD PMID:12086608 PMID:23676497 MGI:5514106 NCBI chr10:70,516,462...70,621,973
Ensembl chr10:70,520,206...70,621,977
JBrowse link
G Ap2m1 adaptor related protein complex 2 subunit mu 1 part_of IDA
ISO
IBA
PMID:12086608
(MGI:5514106|PMID:23676497)
PMID:21873635
(PMID:23676497)
RGD PMID:23676497, PMID:12086608, PMID:21873635 MGI:5514106, RGD:12793054, RGD:13792537 NCBI chr11:84,041,184...84,047,542
Ensembl chr11:84,041,184...84,047,546
JBrowse link
G Ap2s1 adaptor related protein complex 2 subunit sigma 1 part_of IDA
ISO
(MGI:5882913|PMID:12086608)
PMID:2040623
RGD PMID:12086608, PMID:7593184, PMID:2040623 MGI:5882913, RGD:2306270, RGD:727584 NCBI chr 1:78,671,238...78,682,847
Ensembl chr 1:78,671,121...78,682,871
JBrowse link
G Btbd8 BTB domain containing 8 colocalizes_with
part_of
IDA
ISO
PMID:29262337
(PMID:29262337)
(MGI:6104538|PMID:29262337)
RGD PMID:29262337, PMID:29262337 MGI:6104538, RGD:13601995 NCBI chr14:3,282,422...3,351,740
Ensembl chr14:3,284,089...3,300,200
JBrowse link
G Eps15 epidermal growth factor receptor pathway substrate 15 part_of ISO (MGI:4887327|PMID:17626015) RGD PMID:17626015 MGI:4887327 NCBI chr 5:128,923,809...129,022,268
Ensembl chr 5:128,923,934...129,022,054
JBrowse link
G Picalm phosphatidylinositol binding clathrin assembly protein colocalizes_with
part_of
ISO
IEA
(PMID:16262731)
GO_REF:0000107
RGD
Ensembl
PMID:16262731 GO_REF:0000107 NCBI chr 1:154,377,229...154,458,966
Ensembl chr 1:154,377,247...154,458,425
JBrowse link
G Sgip1 SH3GL interacting endocytic adaptor 1 part_of ISS
ISO
IEA
PMID:17626015
(MGI:4887327|PMID:17626015)
GO_REF:0000107
RGD
Ensembl
PMID:17626015, PMID:17626015 GO_REF:0000107 MGI:4887327, RGD:8554282 NCBI chr 5:122,300,415...122,498,478
Ensembl chr 5:122,390,522...122,491,203
JBrowse link
G Slc18a3 solute carrier family 18 member A3 part_of IDA
IBA
PMID:21873635 RGD
GO_Central
PMID:14724281, PMID:21873635 RGD:2317430, RGD:13792537 NCBI chr16:8,682,668...8,685,529
Ensembl chr16:8,682,669...8,685,529
JBrowse link
G Tbc1d5 TBC1 domain family, member 5 colocalizes_with ISO (PMID:24603492) RGD PMID:24603492 NCBI chr 9:1,144,641...1,747,732
Ensembl chr 9:1,145,700...1,746,397
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 20137
    protein-containing complex 5955
      membrane protein complex 1240
        plasma membrane protein complex 562
          AP-2 adaptor complex 11
Path 2
Term Annotations click to browse term
  cellular_component 20137
    cellular anatomical entity 19833
      organelle 13116
        membrane-bounded organelle 11662
          vesicle 2068
            intracellular vesicle 1908
              cytoplasmic vesicle 1900
                coated vesicle 212
                  coated vesicle membrane 94
                    vesicle coat 56
                      clathrin vesicle coat 27
                        clathrin coat of endocytic vesicle 12
                          AP-2 adaptor complex 11
paths to the root