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ONTOLOGY REPORT - ANNOTATIONS


Term:regulation of mitotic metaphase/anaphase transition
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Accession:GO:0030071 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of the cell cycle process in which a cell progresses from metaphase to anaphase during mitosis, triggered by the activation of the anaphase promoting complex by Cdc20/Sleepy homolog which results in the degradation of Securin.



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regulation of mitotic metaphase/anaphase transition term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdc23 cell division cycle 23 involved_in ISO (PMID:9790767) UniProt PMID:9790767 NCBI chrNW_004936531:7,371,818...7,392,999 JBrowse link
G Cdc6 cell division cycle 6 involved_in ISO (PMID:21041660) BHF-UCL PMID:21041660 NCBI chrNW_004936490:15,360,477...15,370,519 JBrowse link
G Cenpe centromere protein E involved_in ISO (PMID:2022189) UniProt PMID:2022189 NCBI chrNW_004936520:188,601...265,904 JBrowse link
G Hecw2 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 involved_in ISO (PMID:24163370) UniProt PMID:24163370 NCBI chrNW_004936506:2,704,885...2,913,663 JBrowse link
G Nek6 NIMA related kinase 6 involved_in ISO (PMID:14563848) UniProt PMID:14563848 NCBI chrNW_004936487:12,606,312...12,632,982 JBrowse link
G Plk1 polo like kinase 1 involved_in ISO (PMID:21041660)
(PMID:23509069)
BHF-UCL
UniProt
PMID:21041660 PMID:23509069 NCBI chrNW_004936501:8,321,415...8,332,414 JBrowse link
G Riok2 RIO kinase 2 involved_in ISO (PMID:21880710) UniProt PMID:21880710 NCBI chrNW_004936523:6,293,735...6,313,840 JBrowse link
deactivation of mitotic spindle assembly checkpoint term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdt1 chromatin licensing and DNA replication factor 1 involved_in ISO (PMID:22581055) CAFA PMID:22581055 NCBI chrNW_004936641:916,695...925,411 JBrowse link
G LOC101954960 MAD2L1 binding protein involved_in ISO (PMID:18022368) UniProt PMID:18022368 NCBI chrNW_004936476:16,379,932...16,385,812 JBrowse link
G Mad1l1 mitotic arrest deficient 1 like 1 involved_in ISO (PMID:19010891) UniProt PMID:19010891 NCBI chrNW_004936754:1,842,588...1,957,116 JBrowse link
G Prap1 proline rich acidic protein 1 involved_in ISO (PMID:24374861) UniProt PMID:24374861 NCBI chrNW_004936486:19,477,278...19,480,387 JBrowse link
mitotic spindle assembly checkpoint signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apc APC regulator of WNT signaling pathway acts_upstream_of_or_within ISO (PMID:17227893) MGI PMID:17227893 NCBI chrNW_004936531:6,899,580...7,019,016 JBrowse link
G Atm ATM serine/threonine kinase involved_in ISO (PMID:11943150) UniProt PMID:11943150 NCBI chrNW_004936551:359,134...534,672 JBrowse link
G Birc5 baculoviral IAP repeat containing 5 involved_in ISO (PMID:12805209) UniProt PMID:12805209 NCBI chrNW_004936594:2,812,165...2,820,618 JBrowse link
G Cenpe centromere protein E involved_in ISO (MGI:2673075|PMID:12925705) UniProt PMID:12925705 MGI:2673075 NCBI chrNW_004936520:188,601...265,904 JBrowse link
G Ik IK cytokine involved_in ISO (PMID:22351768) UniProt PMID:22351768 NCBI chrNW_004936531:9,589,035...9,601,266 JBrowse link
G Klhl22 kelch like family member 22 involved_in ISO (PMID:23455478) UniProt PMID:23455478 NCBI chrNW_004936619:2,854,915...2,899,386 JBrowse link
G Kntc1 kinetochore associated 1 involved_in ISO (PMID:11146660) UniProt PMID:11146660 NCBI chrNW_004936558:1,936,946...2,016,474 JBrowse link
G Mad1l1 mitotic arrest deficient 1 like 1 involved_in ISO (PMID:18981471) UniProt PMID:18981471 NCBI chrNW_004936754:1,842,588...1,957,116 JBrowse link
G Mad2l1 mitotic arrest deficient 2 like 1 involved_in
acts_upstream_of_or_within
ISO (PMID:18981471)
(MGI:1930685|PMID:11201745)
UniProt
MGI
PMID:11201745 PMID:18981471 MGI:1930685 NCBI chrNW_004936662:92,421...98,531 JBrowse link
G Plk1 polo like kinase 1 involved_in ISO (PMID:23455478) UniProt PMID:23455478 NCBI chrNW_004936501:8,321,415...8,332,414 JBrowse link
G Psmg2 proteasome assembly chaperone 2 acts_upstream_of_or_within ISO (MGI:2388532|PMID:12147697) MGI PMID:12147697 MGI:2388532 NCBI chrNW_004936626:2,328,646...2,344,831 JBrowse link
G Tex14 testis expressed 14, intercellular bridge forming factor involved_in ISO (MGI:5318128|PMID:22405274) UniProt PMID:22405274 MGI:5318128 NCBI chrNW_004936490:4,499,825...4,576,952 JBrowse link
G Tpr translocated promoter region, nuclear basket protein involved_in ISO (PMID:20133940) UniProt PMID:20133940 NCBI chrNW_004936481:4,050,693...4,111,682 JBrowse link
G Trip13 thyroid hormone receptor interactor 13 involved_in ISO (PMID:28553959) UniProt PMID:28553959 NCBI chrNW_004936815:734,029...745,381 JBrowse link
G Ttk TTK protein kinase involved_in ISO (MGI:5608719|PMID:25197064) MGI PMID:25197064 MGI:5608719 NCBI chrNW_004936510:10,176,968...10,213,483 JBrowse link
G Znf207 zinc finger protein 207 involved_in ISO (PMID:24462186), (PMID:24462187) UniProt PMID:24462186 PMID:24462187 NCBI chrNW_004936538:2,514,772...2,541,198 JBrowse link
G Zw10 zw10 kinetochore protein involved_in ISO (PMID:11146660) UniProt PMID:11146660 NCBI chrNW_004936612:825,419...860,971 JBrowse link
G Zwint ZW10 interacting kinetochore protein involved_in ISO (PMID:15485811) HGNC-UCL PMID:15485811 NCBI chrNW_004936693:1,539,987...1,551,685 JBrowse link
negative regulation of mitotic metaphase/anaphase transition term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fbxo5 F-box protein 5 involved_in ISO (PMID:11988738), (PMID:16921029) UniProt PMID:11988738 PMID:16921029 NCBI chrNW_004936489:5,589,621...5,602,221 JBrowse link
G Rad21 RAD21 cohesin complex component involved_in ISO (MGI:1340883|PMID:10375619) CAFA PMID:10375619 MGI:1340883 NCBI chrNW_004936470:29,377,793...29,403,422 JBrowse link
positive regulation of mitotic cell cycle spindle assembly checkpoint term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dync1li1 dynein cytoplasmic 1 light intermediate chain 1 involved_in ISO (PMID:19229290) UniProt PMID:19229290 NCBI chrNW_004936473:23,011,888...23,042,497 JBrowse link
G Gen1 GEN1 Holliday junction 5' flap endonuclease involved_in ISO (PMID:23108668) UniProt PMID:23108668 NCBI chrNW_004936493:13,157,114...13,182,797 JBrowse link
G Mad2l1 mitotic arrest deficient 2 like 1 involved_in ISO (PMID:20870947)
(MGI:4839685|PMID:20870947)
(PMID:8824189)
UniProt PMID:8824189 PMID:20870947 MGI:4839685 NCBI chrNW_004936662:92,421...98,531 JBrowse link
G Ndc80 NDC80 kinetochore complex component involved_in ISO (PMID:25743205) UniProt PMID:25743205 NCBI chrNW_004936672:1,872,205...1,910,956 JBrowse link
G Pcid2 PCI domain containing 2 involved_in ISO (PMID:20870947)
(MGI:4839685|PMID:20870947)
UniProt PMID:20870947 MGI:4839685 NCBI chrNW_004936472:440,440...464,116 JBrowse link
G Tpr translocated promoter region, nuclear basket protein involved_in ISO (PMID:18981471), (PMID:19273613) UniProt PMID:18981471 PMID:19273613 NCBI chrNW_004936481:4,050,693...4,111,682 JBrowse link
G Xrcc3 X-ray repair cross complementing 3 involved_in ISO (PMID:23108668) UniProt PMID:23108668 NCBI chrNW_004936621:1,462,441...1,474,937 JBrowse link
positive regulation of mitotic metaphase/anaphase transition term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cenpe centromere protein E involved_in ISO (MGI:2673075|PMID:12925705) UniProt PMID:12925705 MGI:2673075 NCBI chrNW_004936520:188,601...265,904 JBrowse link
G Cul3 cullin 3 involved_in ISO (PMID:17543862) UniProt PMID:17543862 NCBI chrNW_004936569:6,067,230...6,131,467 JBrowse link
G Nsmce2 NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase involved_in ISO (PMID:19502785) UniProt PMID:19502785 NCBI chrNW_004936470:22,447,278...22,667,302 JBrowse link
G Rb1 RB transcriptional corepressor 1 involved_in ISO (PMID:20551165) BHF-UCL PMID:20551165 NCBI chrNW_004936565:1,596,227...1,746,706 JBrowse link
regulation of mitotic cell cycle spindle assembly checkpoint term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anapc15 anaphase promoting complex subunit 15 involved_in ISO (PMID:21926987) UniProt PMID:21926987 NCBI chrNW_004936498:1,460,795...1,468,363 JBrowse link
G Ccnb1 cyclin B1 involved_in ISO (PMID:18195732) BHF-UCL PMID:18195732 NCBI chrNW_004936480:400,287...407,677 JBrowse link
G Cdk5rap2 CDK5 regulatory subunit associated protein 2 involved_in ISO (PMID:19282672) UniProt PMID:19282672 NCBI chrNW_004936487:8,900,375...9,081,547 JBrowse link
G Lcmt1 leucine carboxyl methyltransferase 1 acts_upstream_of_or_within ISO (PMID:17724024) MGI PMID:17724024 NCBI chrNW_004936501:9,354,607...9,397,675 JBrowse link
G Usp44 ubiquitin specific peptidase 44 involved_in ISO (MGI:5448515|PMID:21853124) UniProt PMID:21853124 MGI:5448515 NCBI chrNW_004936507:11,663,069...11,692,174 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12171
    cellular process 11367
      cell cycle process 960
        cell cycle phase transition 404
          mitotic cell cycle phase transition 330
            metaphase/anaphase transition of mitotic cell cycle 45
              regulation of mitotic metaphase/anaphase transition 41
                negative regulation of mitotic metaphase/anaphase transition + 33
                positive regulation of mitotic metaphase/anaphase transition + 8
                regulation of mitotic cell cycle spindle assembly checkpoint + 16
Path 2
Term Annotations click to browse term
  biological_process 12171
    cellular process 11367
      cellular component organization or biogenesis 4826
        cellular component organization 4743
          organelle organization 2809
            organelle fission 430
              nuclear division 382
                mitotic nuclear division 241
                  mitotic sister chromatid segregation 131
                    mitotic sister chromatid separation 48
                      regulation of mitotic sister chromatid separation 45
                        metaphase/anaphase transition of mitotic cell cycle 45
                          regulation of mitotic metaphase/anaphase transition 41
                            negative regulation of mitotic metaphase/anaphase transition + 33
                            positive regulation of mitotic metaphase/anaphase transition + 8
                            regulation of mitotic cell cycle spindle assembly checkpoint + 16
paths to the root