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ONTOLOGY REPORT - ANNOTATIONS


Term:regulation of mitotic metaphase/anaphase transition
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Accession:GO:0030071 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of the cell cycle process in which a cell progresses from metaphase to anaphase during mitosis, triggered by the activation of the anaphase promoting complex by Cdc20/Sleepy homolog which results in the degradation of Securin.


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regulation of mitotic metaphase/anaphase transition term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdc23 cell division cycle 23 involved_in ISO (PMID:9790767) RGD PMID:9790767 NCBI chr18:26,236,891...26,260,611
Ensembl chr18:26,236,890...26,291,163
JBrowse link
G Cdc26 cell division cycle 26 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 5:75,844,852...75,859,837 JBrowse link
G Cdc6 cell division cycle 6 involved_in ISO (PMID:21041660) RGD PMID:21041660 NCBI chr10:83,864,189...83,878,011
Ensembl chr10:83,864,638...83,878,011
JBrowse link
G Cenpe centromere protein E involved_in ISO (PMID:2022189) RGD PMID:2022189 NCBI chr 2:223,637,035...223,695,692
Ensembl chr 2:223,636,998...223,695,669
JBrowse link
G Hecw2 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 involved_in ISO (PMID:24163370) RGD PMID:24163370 NCBI chr 9:55,359,462...55,753,106
Ensembl chr 9:55,365,203...55,580,327
JBrowse link
G Nek6 NIMA-related kinase 6 involved_in ISS
ISO
GO_REF:0000024
(PMID:14563848)
UniProt
RGD
PMID:14563848 GO_REF:0000024 NCBI chr 3:22,284,269...22,356,302
Ensembl chr 3:22,284,279...22,395,990
JBrowse link
G Plk1 polo-like kinase 1 involved_in ISO (PMID:21041660), (PMID:23509069) RGD PMID:21041660 PMID:23509069 NCBI chr 1:176,716,420...176,726,400
Ensembl chr 1:176,716,420...176,726,400
JBrowse link
G Riok2 RIO kinase 2 involved_in ISO (PMID:21880710) RGD PMID:21880710 NCBI chr 1:58,103,132...58,119,397
Ensembl chr 1:58,103,084...58,120,512
JBrowse link
G Ube2c ubiquitin-conjugating enzyme E2C involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:153,506,636...153,509,036
Ensembl chr 3:153,506,636...153,513,339
JBrowse link
deactivation of mitotic spindle assembly checkpoint term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdt1 chromatin licensing and DNA replication factor 1 involved_in ISO (PMID:22581055) RGD PMID:22581055 NCBI chr19:50,620,713...50,625,659
Ensembl chr19:50,620,713...50,625,659
JBrowse link
G Mad1l1 mitotic arrest deficient 1 like 1 involved_in ISO (PMID:19010891) RGD PMID:19010891 NCBI chr12:14,320,892...14,630,750
Ensembl chr12:14,320,892...14,630,703
JBrowse link
G Mad2l1bp MAD2L1 binding protein involved_in ISO (PMID:18022368) RGD PMID:18022368 NCBI chr 9:14,832,133...14,836,458
Ensembl chr 9:14,832,132...14,837,447
JBrowse link
G Prap1 proline-rich acidic protein 1 involved_in ISS
ISO
GO_REF:0000024
(PMID:24374861)
UniProt
RGD
PMID:24374861 GO_REF:0000024 NCBI chr 1:194,883,078...194,886,874
Ensembl chr 1:194,883,078...194,886,872
JBrowse link
mitotic spindle assembly checkpoint signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apc APC regulator of WNT signaling pathway acts_upstream_of_or_within
involved_in
ISO
IEA
(PMID:17227893)
GO_REF:0000107
RGD
Ensembl
PMID:17227893 GO_REF:0000107 NCBI chr18:25,828,558...25,925,511
Ensembl chr18:25,864,222...25,922,696
JBrowse link
G Atm ATM serine/threonine kinase involved_in ISO (PMID:11943150) RGD PMID:11943150 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437
JBrowse link
G Aurkb aurora kinase B involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr10:53,744,290...53,750,831
Ensembl chr10:53,745,142...53,750,837
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 involved_in ISO
ISS
(PMID:12805209)
GO_REF:0000024
RGD
UniProt
PMID:12805209 GO_REF:0000024 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
JBrowse link
G Bub1 BUB1 mitotic checkpoint serine/threonine kinase involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:115,020,254...115,051,650
Ensembl chr 3:115,020,254...115,051,650
JBrowse link
G Bub1b BUB1 mitotic checkpoint serine/threonine kinase B involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:105,563,089...105,615,547
Ensembl chr 3:105,563,138...105,615,547
JBrowse link
G Bub3 BUB3 mitotic checkpoint protein involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:186,330,358...186,340,969
Ensembl chr 1:186,327,931...186,395,036
JBrowse link
G Cenpe centromere protein E involved_in ISO (MGI:2673075|PMID:12925705) RGD PMID:12925705 MGI:2673075 NCBI chr 2:223,637,035...223,695,692
Ensembl chr 2:223,636,998...223,695,669
JBrowse link
G Ik IK cytokine involved_in ISS
ISO
GO_REF:0000024
(PMID:22351768)
UniProt
RGD
PMID:22351768 GO_REF:0000024 NCBI chr18:28,358,004...28,372,809
Ensembl chr18:28,357,977...28,378,832
JBrowse link
G Khdc3 KH domain containing 3, subcortical maternal complex member acts_upstream_of_or_within ISO MGI:3844604 (MGI:3844372|PMID:19376971) RGD PMID:19376971 MGI:3844372 NCBI chr 8:73,842,344...73,844,248
Ensembl chr 8:73,842,344...73,844,248
JBrowse link
G Klhl22 kelch-like family member 22 involved_in IBA
IEA
ISO
ISS
PMID:21873635
GO_REF:0000107
(PMID:23455478)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:23455478 PMID:21873635 GO_REF:0000024 GO_REF:0000107, RGD:13792537 NCBI chr11:83,190,891...83,231,746
Ensembl chr11:83,190,891...83,231,770
JBrowse link
G Kntc1 kinetochore associated 1 involved_in ISO (PMID:11146660) RGD PMID:11146660 NCBI chr12:32,769,020...32,839,617
Ensembl chr12:32,769,020...32,839,561
JBrowse link
G Mad1l1 mitotic arrest deficient 1 like 1 involved_in IBA
ISO
PMID:21873635
(PMID:18981471)
RGD PMID:18981471 PMID:21873635 RGD:13792537 NCBI chr12:14,320,892...14,630,750
Ensembl chr12:14,320,892...14,630,703
JBrowse link
G Mad2l1 mitotic arrest deficient 2 like 1 involved_in
acts_upstream_of_or_within
ISO
IBA
(PMID:18981471)
MGI:2178781 (MGI:1930685|PMID:11201745)
PMID:21873635
RGD PMID:11201745 PMID:18981471 PMID:21873635 MGI:1930685, RGD:13792537 NCBI chr 4:95,906,692...95,918,885
Ensembl chr 4:95,906,817...95,913,470
JBrowse link
G Plk1 polo-like kinase 1 involved_in IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(PMID:23455478)
Ensembl
UniProt
RGD
PMID:23455478 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:176,716,420...176,726,400
Ensembl chr 1:176,716,420...176,726,400
JBrowse link
G Psmg2 proteasome assembly chaperone 2 acts_upstream_of_or_within ISO (MGI:2388532|PMID:12147697) RGD PMID:12147697 MGI:2388532 NCBI chr18:61,208,669...61,227,671
Ensembl chr18:61,208,678...61,259,816
JBrowse link
G Spdl1 spindle apparatus coiled-coil protein 1 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr10:19,269,125...19,294,213
Ensembl chr10:19,269,127...19,294,127
JBrowse link
G Tex14 testis expressed 14, intercellular bridge forming factor involved_in IEA
ISO
IBA
ISS
GO_REF:0000107
(MGI:5318128|PMID:22405274)
PMID:21873635
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:22405274 PMID:21873635 GO_REF:0000024 GO_REF:0000107 MGI:5318128, RGD:13792537 NCBI chr10:72,231,766...72,356,938
Ensembl chr10:72,231,801...72,355,805
JBrowse link
G Tpr translocated promoter region, nuclear basket protein involved_in ISO
ISS
(PMID:20133940)
GO_REF:0000024
RGD
UniProt
PMID:20133940 GO_REF:0000024 NCBI chr13:62,424,312...62,487,502
Ensembl chr13:62,424,312...62,487,496
JBrowse link
G Trip13 thyroid hormone receptor interactor 13 involved_in ISO
ISS
(PMID:28553959)
GO_REF:0000024
RGD
UniProt
PMID:28553959 GO_REF:0000024 NCBI chr 1:29,357,093...29,402,078
Ensembl chr 1:29,357,130...29,402,074
JBrowse link
G Ttk Ttk protein kinase involved_in IBA
ISO
PMID:21873635
MGI:5056148 (MGI:5608719|PMID:25197064)
RGD PMID:25197064 PMID:21873635 MGI:5608719, RGD:13792537 NCBI chr 8:84,754,329...84,792,653
Ensembl chr 8:84,754,315...84,792,651
JBrowse link
G Zfp207 zinc finger protein 207 involved_in IBA
ISO
PMID:21873635
(PMID:24462186), (PMID:24462187)
RGD PMID:24462186 PMID:24462187 PMID:21873635 RGD:13792537 NCBI chr10:65,385,823...65,397,591
Ensembl chr10:65,385,740...65,397,386
JBrowse link
G Zw10 zw10 kinetochore protein involved_in ISS
IBA
ISO
GO_REF:0000024
PMID:21873635
(PMID:11146660)
HGNC-UCL
RGD
PMID:11146660 PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr 8:49,396,541...49,424,743
Ensembl chr 8:49,396,545...49,421,805
JBrowse link
G Zwilch zwilch kinetochore protein involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:64,638,401...64,670,911
Ensembl chr 8:64,637,672...64,675,916
JBrowse link
G Zwint ZW10 interacting kinetochore protein involved_in ISO (PMID:15485811) RGD PMID:15485811 NCBI chr20:15,938,157...15,953,997
Ensembl chr20:15,938,157...15,953,957
JBrowse link
negative regulation of mitotic metaphase/anaphase transition term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fbxo5 F-box protein 5 involved_in ISO (PMID:11988738), (PMID:16921029) RGD PMID:11988738 PMID:16921029 NCBI chr 1:42,196,068...42,202,437
Ensembl chr 1:42,196,068...42,202,437
JBrowse link
G Rad21 RAD21 cohesin complex component involved_in ISO (MGI:1340883|PMID:10375619) RGD PMID:10375619 MGI:1340883 NCBI chr 7:83,287,867...83,314,810
Ensembl chr 7:83,287,870...83,314,817
JBrowse link
positive regulation of mitotic cell cycle spindle assembly checkpoint term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dync1li1 dynein cytoplasmic 1 light intermediate chain 1 involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(PMID:19229290)
UniProt
Ensembl
RGD
PMID:19229290 GO_REF:0000024 GO_REF:0000107 NCBI chr 8:114,376,649...114,410,297
Ensembl chr 8:114,376,662...114,410,934
JBrowse link
G Gen1 GEN1 Holliday junction 5' flap endonuclease involved_in ISO (PMID:23108668) RGD PMID:23108668 NCBI chr 6:33,947,599...33,978,461
Ensembl chr 6:33,948,206...33,978,401
JBrowse link
G Mad2l1 mitotic arrest deficient 2 like 1 involved_in ISO (PMID:20870947), (PMID:8824189)
(MGI:4839685|PMID:20870947)
RGD PMID:8824189 PMID:20870947 MGI:4839685 NCBI chr 4:95,906,692...95,918,885
Ensembl chr 4:95,906,817...95,913,470
JBrowse link
G Ndc80 NDC80 kinetochore complex component involved_in ISO (PMID:25743205) RGD PMID:25743205 NCBI chr 9:111,407,191...111,440,921
Ensembl chr 9:111,407,191...111,440,924
JBrowse link
G Pcid2 PCI domain containing 2 involved_in ISO (PMID:20870947)
(MGI:4839685|PMID:20870947)
RGD PMID:20870947 MGI:4839685 NCBI chr16:76,423,245...76,448,712
Ensembl chr16:76,423,245...76,448,712
JBrowse link
G Tpr translocated promoter region, nuclear basket protein involved_in ISS
ISO
GO_REF:0000024
(PMID:18981471), (PMID:19273613)
UniProt
RGD
PMID:18981471 PMID:19273613 GO_REF:0000024 NCBI chr13:62,424,312...62,487,502
Ensembl chr13:62,424,312...62,487,496
JBrowse link
G Xrcc3 X-ray repair cross complementing 3 involved_in ISO (PMID:23108668) RGD PMID:23108668 NCBI chr 6:130,863,405...130,873,765
Ensembl chr 6:130,863,959...130,872,444
JBrowse link
positive regulation of mitotic metaphase/anaphase transition term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anapc11 anaphase promoting complex subunit 11 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:105,875,209...105,886,307 JBrowse link
G Anapc4 anaphase promoting complex subunit 4 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr14:58,125,995...58,159,253
Ensembl chr14:58,125,995...58,157,770
JBrowse link
G Anapc5 anaphase-promoting complex subunit 5 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr12:33,748,714...33,781,709
Ensembl chr12:33,748,735...33,781,781
JBrowse link
G Anapc7 anaphase promoting complex subunit 7 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr12:34,131,214...34,160,819
Ensembl chr12:34,133,429...34,160,005
JBrowse link
G Cdc16 cell division cycle 16 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr16:75,773,026...75,796,586
Ensembl chr16:75,773,028...75,796,550
JBrowse link
G Cdc23 cell division cycle 23 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr18:26,236,891...26,260,611
Ensembl chr18:26,236,890...26,291,163
JBrowse link
G Cdc27 cell division cycle 27 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:89,400,931...89,449,823
Ensembl chr10:89,400,940...89,449,736
JBrowse link
G Cenpe centromere protein E involved_in ISO (MGI:2673075|PMID:12925705) RGD PMID:12925705 MGI:2673075 NCBI chr 2:223,637,035...223,695,692
Ensembl chr 2:223,636,998...223,695,669
JBrowse link
G Cul3 cullin 3 involved_in ISO
IEA
(PMID:17543862)
GO_REF:0000107
RGD
Ensembl
PMID:17543862 GO_REF:0000107 NCBI chr 9:81,592,641...81,670,428
Ensembl chr 9:81,592,641...81,670,462
JBrowse link
G Nsmce2 NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase involved_in ISO
ISS
(PMID:19502785)
GO_REF:0000024
RGD
UniProt
PMID:19502785 GO_REF:0000024 NCBI chr 7:90,936,112...91,173,435
Ensembl chr 7:90,936,112...91,164,899
JBrowse link
G Rb1 RB transcriptional corepressor 1 involved_in ISO
IEA
(PMID:20551165)
GO_REF:0000107
RGD
Ensembl
PMID:20551165 GO_REF:0000107 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302
JBrowse link
regulation of mitotic cell cycle spindle assembly checkpoint term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anapc15 anaphase promoting complex subunit 15 involved_in IBA
ISS
ISO
PMID:21873635
GO_REF:0000024
(PMID:21926987)
UniProt
RGD
PMID:21926987 PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr 1:156,238,640...156,266,005
Ensembl chr 1:156,262,841...156,268,145
JBrowse link
G Ccnb1 cyclin B1 involved_in ISO (PMID:18195732) RGD PMID:18195732 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
JBrowse link
G Cdk5rap2 CDK5 regulatory subunit associated protein 2 involved_in ISS
ISO
IEA
GO_REF:0000024
(PMID:19282672)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:19282672 GO_REF:0000024 GO_REF:0000107 NCBI chr 5:83,792,282...83,961,129
Ensembl chr 5:83,792,284...83,960,782
JBrowse link
G Dusp1 dual specificity phosphatase 1 involved_in ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr10:16,680,489...16,683,276 JBrowse link
G Lcmt1 leucine carboxyl methyltransferase 1 acts_upstream_of_or_within
involved_in
ISO
IEA
(PMID:17724024)
GO_REF:0000107
RGD
Ensembl
PMID:17724024 GO_REF:0000107 NCBI chr 1:177,904,119...177,960,111
Ensembl chr 1:177,904,139...177,960,112
JBrowse link
G Usp44 ubiquitin specific peptidase 44 involved_in ISO (MGI:5448515|PMID:21853124) RGD PMID:21853124 MGI:5448515 NCBI chr 7:28,364,169...28,412,039
Ensembl chr 7:28,364,033...28,410,053
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19492
    cellular process 18340
      cell cycle process 1175
        cell cycle phase transition 494
          mitotic cell cycle phase transition 406
            metaphase/anaphase transition of mitotic cell cycle 60
              regulation of mitotic metaphase/anaphase transition 57
                negative regulation of mitotic metaphase/anaphase transition + 41
                positive regulation of mitotic metaphase/anaphase transition + 15
                regulation of mitotic cell cycle spindle assembly checkpoint + 17
Path 2
Term Annotations click to browse term
  biological_process 19492
    cellular process 18340
      cellular component organization or biogenesis 6481
        cellular component organization 6235
          organelle organization 3752
            organelle fission 508
              nuclear division 456
                mitotic nuclear division 289
                  mitotic sister chromatid segregation 161
                    mitotic sister chromatid separation 64
                      regulation of mitotic sister chromatid separation 61
                        metaphase/anaphase transition of mitotic cell cycle 60
                          regulation of mitotic metaphase/anaphase transition 57
                            negative regulation of mitotic metaphase/anaphase transition + 41
                            positive regulation of mitotic metaphase/anaphase transition + 15
                            regulation of mitotic cell cycle spindle assembly checkpoint + 17
paths to the root