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ONTOLOGY REPORT - ANNOTATIONS


Term:regulation of mitotic metaphase/anaphase transition
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Accession:GO:0030071 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of the cell cycle process in which a cell progresses from metaphase to anaphase during mitosis, triggered by the activation of the anaphase promoting complex by Cdc20/Sleepy homolog which results in the degradation of Securin.


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regulation of mitotic metaphase/anaphase transition term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdc23 cell division cycle 23 involved_in ISO (PMID:9790767) UniProt PMID:9790767 NCBI chrNW_004955418:2,194,937...2,221,928
Ensembl chrNW_004955418:2,194,689...2,221,928
JBrowse link
G Cdc6 cell division cycle 6 involved_in ISO (PMID:21041660) BHF-UCL PMID:21041660 NCBI chrNW_004955451:14,857,174...14,871,324
Ensembl chrNW_004955451:14,860,309...14,871,494
JBrowse link
G Cenpe centromere protein E involved_in ISO (PMID:2022189) UniProt PMID:2022189 NCBI chrNW_004955496:5,468,759...5,514,915
Ensembl chrNW_004955496:5,469,239...5,513,574
JBrowse link
G Hecw2 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 involved_in ISO (PMID:24163370) UniProt PMID:24163370 NCBI chrNW_004955403:3,902,881...4,096,189
Ensembl chrNW_004955403:3,752,461...4,090,041
JBrowse link
G Nek6 NIMA related kinase 6 involved_in ISO (PMID:14563848) UniProt PMID:14563848 NCBI chrNW_004955419:3,762,643...3,833,000
Ensembl chrNW_004955419:3,762,643...3,820,979
JBrowse link
G Plk1 polo like kinase 1 involved_in ISO (PMID:23509069)
(PMID:21041660)
UniProt
BHF-UCL
PMID:21041660 PMID:23509069 NCBI chrNW_004955493:2,206,353...2,217,231
Ensembl chrNW_004955493:2,206,353...2,217,231
JBrowse link
G Riok2 RIO kinase 2 involved_in ISO (PMID:21880710) UniProt PMID:21880710 NCBI chrNW_004955418:15,487,248...15,509,490
Ensembl chrNW_004955418:15,487,248...15,513,831
JBrowse link
deactivation of mitotic spindle assembly checkpoint term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdt1 chromatin licensing and DNA replication factor 1 involved_in ISO (PMID:22581055) CAFA PMID:22581055 NCBI chrNW_004955541:2,683,030...2,687,883
Ensembl chrNW_004955541:2,683,408...2,687,102
JBrowse link
G Mad1l1 mitotic arrest deficient 1 like 1 involved_in ISO (PMID:19010891) UniProt PMID:19010891 NCBI chrNW_004955460:9,340,728...9,672,478
Ensembl chrNW_004955460:9,340,681...9,672,134
JBrowse link
G Mad2l1bp MAD2L1 binding protein involved_in ISO (PMID:18022368) UniProt PMID:18022368 NCBI chrNW_004955437:9,423,630...9,433,357 JBrowse link
G Prap1 proline rich acidic protein 1 involved_in ISO (PMID:24374861) UniProt PMID:24374861 NCBI chrNW_004955477:10,982,530...11,002,747 JBrowse link
mitotic spindle assembly checkpoint signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apc APC regulator of WNT signaling pathway acts_upstream_of_or_within ISO (PMID:17227893) MGI PMID:17227893 NCBI chrNW_004955418:2,567,804...2,675,062
Ensembl chrNW_004955418:2,566,975...2,674,832
JBrowse link
G Atm ATM serine/threonine kinase involved_in ISO (PMID:11943150) UniProt PMID:11943150 NCBI chrNW_004955412:10,422,753...10,531,406
Ensembl chrNW_004955412:10,426,135...10,530,545
JBrowse link
G Cenpe centromere protein E involved_in ISO (MGI:2673075|PMID:12925705) UniProt PMID:12925705 MGI:2673075 NCBI chrNW_004955496:5,468,759...5,514,915
Ensembl chrNW_004955496:5,469,239...5,513,574
JBrowse link
G Ik IK cytokine involved_in ISO (PMID:22351768) UniProt PMID:22351768 NCBI chrNW_004955418:39,695...52,862
Ensembl chrNW_004955418:39,695...52,862
JBrowse link
G Klhl22 kelch like family member 22 involved_in ISO (PMID:23455478) UniProt PMID:23455478 NCBI chrNW_004955442:19,010,971...19,051,300
Ensembl chrNW_004955442:19,009,155...19,051,393
JBrowse link
G Kntc1 kinetochore associated 1 involved_in ISO (PMID:11146660) UniProt PMID:11146660 NCBI chrNW_004955482:6,040,964...6,119,814
Ensembl chrNW_004955482:6,043,456...6,115,816
JBrowse link
G Mad1l1 mitotic arrest deficient 1 like 1 involved_in ISO (PMID:18981471) UniProt PMID:18981471 NCBI chrNW_004955460:9,340,728...9,672,478
Ensembl chrNW_004955460:9,340,681...9,672,134
JBrowse link
G Mad2l1 mitotic arrest deficient 2 like 1 involved_in
acts_upstream_of_or_within
ISO (PMID:18981471)
(MGI:1930685|PMID:11201745)
UniProt
MGI
PMID:11201745 PMID:18981471 MGI:1930685 NCBI chrNW_004955428:20,421,718...20,443,394
Ensembl chrNW_004955428:20,421,723...20,430,307
JBrowse link
G Plk1 polo like kinase 1 involved_in ISO (PMID:23455478) UniProt PMID:23455478 NCBI chrNW_004955493:2,206,353...2,217,231
Ensembl chrNW_004955493:2,206,353...2,217,231
JBrowse link
G Psmg2 proteasome assembly chaperone 2 acts_upstream_of_or_within ISO (MGI:2388532|PMID:12147697) MGI PMID:12147697 MGI:2388532 NCBI chrNW_004955402:857,228...870,940
Ensembl chrNW_004955402:857,432...869,983
JBrowse link
G Tex14 testis expressed 14, intercellular bridge forming factor involved_in ISO (MGI:5318128|PMID:22405274) UniProt PMID:22405274 MGI:5318128 NCBI chrNW_004955451:4,206,114...4,296,969
Ensembl chrNW_004955451:4,179,591...4,297,024
JBrowse link
G Tpr translocated promoter region, nuclear basket protein involved_in ISO (PMID:20133940) UniProt PMID:20133940 NCBI chrNW_004955406:24,742,525...24,805,989
Ensembl chrNW_004955406:24,742,525...24,805,989
JBrowse link
G Trip13 thyroid hormone receptor interactor 13 involved_in ISO (PMID:28553959) UniProt PMID:28553959 NCBI chrNW_004955504:434,187...452,636
Ensembl chrNW_004955504:434,159...452,671
JBrowse link
G Ttk TTK protein kinase involved_in ISO (MGI:5608719|PMID:25197064) MGI PMID:25197064 MGI:5608719 NCBI chrNW_004955502:7,824,194...7,866,879 JBrowse link
G Znf207 zinc finger protein 207 involved_in ISO (PMID:24462186), (PMID:24462187) UniProt PMID:24462186 PMID:24462187 NCBI chrNW_004955481:7,307,520...7,325,591
Ensembl chrNW_004955481:7,307,521...7,328,198
JBrowse link
G Zw10 zw10 kinetochore protein involved_in ISO (PMID:11146660) UniProt PMID:11146660 NCBI chrNW_004955412:15,354,918...15,391,233
Ensembl chrNW_004955412:15,350,285...15,391,996
JBrowse link
G Zwint ZW10 interacting kinetochore protein involved_in ISO (PMID:15485811) HGNC-UCL PMID:15485811 NCBI chrNW_004955425:10,477,224...10,486,372
Ensembl chrNW_004955425:10,477,331...10,486,288
JBrowse link
negative regulation of mitotic metaphase/anaphase transition term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fbxo5 F-box protein 5 involved_in ISO (PMID:11988738), (PMID:16921029) UniProt PMID:11988738 PMID:16921029 NCBI chrNW_004955439:8,830,658...8,843,653
Ensembl chrNW_004955439:8,830,975...8,843,828
JBrowse link
G Rad21 RAD21 cohesin complex component involved_in ISO (MGI:1340883|PMID:10375619) CAFA PMID:10375619 MGI:1340883 NCBI chrNW_004955417:22,941,549...22,966,395
Ensembl chrNW_004955417:22,941,479...22,966,837
JBrowse link
positive regulation of mitotic cell cycle spindle assembly checkpoint term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dync1li1 dynein cytoplasmic 1 light intermediate chain 1 involved_in ISO (PMID:19229290) UniProt PMID:19229290 NCBI chrNW_004955620:46,535...82,595
Ensembl chrNW_004955620:46,556...82,595
JBrowse link
G Gen1 GEN1 Holliday junction 5' flap endonuclease involved_in ISO (PMID:23108668) UniProt PMID:23108668 NCBI chrNW_004955469:552,850...590,792
Ensembl chrNW_004955469:552,677...592,137
JBrowse link
G Mad2l1 mitotic arrest deficient 2 like 1 involved_in ISO (PMID:20870947)
(MGI:4839685|PMID:20870947)
(PMID:8824189)
UniProt PMID:8824189 PMID:20870947 MGI:4839685 NCBI chrNW_004955428:20,421,718...20,443,394
Ensembl chrNW_004955428:20,421,723...20,430,307
JBrowse link
G Ndc80 NDC80 kinetochore complex component involved_in ISO (PMID:25743205) UniProt PMID:25743205 NCBI chrNW_004955402:7,692,009...7,728,876
Ensembl chrNW_004955402:7,691,937...7,729,690
JBrowse link
G Pcid2 PCI domain containing 2 involved_in ISO (PMID:20870947)
(MGI:4839685|PMID:20870947)
UniProt PMID:20870947 MGI:4839685 NCBI chrNW_004955404:618,092...639,424
Ensembl chrNW_004955404:618,092...639,704
JBrowse link
G Tpr translocated promoter region, nuclear basket protein involved_in ISO (PMID:18981471), (PMID:19273613) UniProt PMID:18981471 PMID:19273613 NCBI chrNW_004955406:24,742,525...24,805,989
Ensembl chrNW_004955406:24,742,525...24,805,989
JBrowse link
G Xrcc3 X-ray repair cross complementing 3 involved_in ISO (PMID:23108668) UniProt PMID:23108668 NCBI chrNW_004955538:2,499,297...2,511,898
Ensembl chrNW_004955538:2,501,607...2,509,778
JBrowse link
positive regulation of mitotic metaphase/anaphase transition term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cenpe centromere protein E involved_in ISO (MGI:2673075|PMID:12925705) UniProt PMID:12925705 MGI:2673075 NCBI chrNW_004955496:5,468,759...5,514,915
Ensembl chrNW_004955496:5,469,239...5,513,574
JBrowse link
G Cul3 cullin 3 involved_in ISO (PMID:17543862) UniProt PMID:17543862 NCBI chrNW_004955453:9,546,554...9,629,976
Ensembl chrNW_004955453:9,564,522...9,629,976
JBrowse link
G Nsmce2 NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase involved_in ISO (PMID:19502785) UniProt PMID:19502785 NCBI chrNW_004955461:199,356...451,716
Ensembl chrNW_004955461:201,764...451,776
JBrowse link
G Rb1 RB transcriptional corepressor 1 involved_in ISO (PMID:20551165) BHF-UCL PMID:20551165 NCBI chrNW_004955431:1,960,765...2,124,576
Ensembl chrNW_004955431:1,960,661...2,124,576
JBrowse link
regulation of mitotic cell cycle spindle assembly checkpoint term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anapc15 anaphase promoting complex subunit 15 involved_in ISO (PMID:21926987) UniProt PMID:21926987 NCBI chrNW_004955414:19,218,727...19,222,138
Ensembl chrNW_004955414:19,218,727...19,222,138
JBrowse link
G Ccnb1 cyclin B1 involved_in ISO (PMID:18195732) BHF-UCL PMID:18195732 NCBI chrNW_004955446:140,661...149,500
Ensembl chrNW_004955446:140,093...149,500
JBrowse link
G Cdk5rap2 CDK5 regulatory subunit associated protein 2 involved_in ISO (PMID:19282672) UniProt PMID:19282672 NCBI chrNW_004955419:7,412,177...7,606,883
Ensembl chrNW_004955419:7,412,331...7,610,353
JBrowse link
G Lcmt1 leucine carboxyl methyltransferase 1 acts_upstream_of_or_within ISO (PMID:17724024) MGI PMID:17724024 NCBI chrNW_004955493:3,440,832...3,499,658
Ensembl chrNW_004955493:3,431,578...3,502,066
JBrowse link
G Usp44 ubiquitin specific peptidase 44 involved_in ISO (MGI:5448515|PMID:21853124) UniProt PMID:21853124 MGI:5448515 NCBI chrNW_004955405:31,977,045...32,006,733
Ensembl chrNW_004955405:31,977,602...32,006,810
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 11978
    cellular process 11211
      cell cycle process 950
        cell cycle phase transition 405
          mitotic cell cycle phase transition 330
            metaphase/anaphase transition of mitotic cell cycle 44
              regulation of mitotic metaphase/anaphase transition 40
                negative regulation of mitotic metaphase/anaphase transition + 32
                positive regulation of mitotic metaphase/anaphase transition + 8
                regulation of mitotic cell cycle spindle assembly checkpoint + 16
Path 2
Term Annotations click to browse term
  biological_process 11978
    cellular process 11211
      cellular component organization or biogenesis 4758
        cellular component organization 4673
          organelle organization 2760
            organelle fission 424
              nuclear division 376
                mitotic nuclear division 237
                  mitotic sister chromatid segregation 127
                    mitotic sister chromatid separation 47
                      regulation of mitotic sister chromatid separation 44
                        metaphase/anaphase transition of mitotic cell cycle 44
                          regulation of mitotic metaphase/anaphase transition 40
                            negative regulation of mitotic metaphase/anaphase transition + 32
                            positive regulation of mitotic metaphase/anaphase transition + 8
                            regulation of mitotic cell cycle spindle assembly checkpoint + 16
paths to the root