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ONTOLOGY REPORT - ANNOTATIONS


Term:muscle filament sliding
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Accession:GO:0030049 term browser browse the term
Definition:The sliding of actin thin filaments and myosin thick filaments past each other in muscle contraction. This involves a process of interaction of myosin located on a thick filament with actin located on a thin filament. During this process ATP is split and forces are generated.



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muscle filament sliding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Myh6 myosin heavy chain 6 involved_in IEA
IBA
ISO
GO_REF:0000107
PMID:21873635
(PMID:16088376)
Ensembl
RGD
PMID:16088376 PMID:21873635 GO_REF:0000107, RGD:13792537 NCBI chr15:28,418,120...28,442,316
Ensembl chr15:28,417,616...28,441,720
JBrowse link
G Myh7 myosin heavy chain 7 involved_in ISO
IBA
IEA
(PMID:16088376), (PMID:8514894)
PMID:21873635
GO_REF:0000107
RGD
Ensembl
PMID:8514894 PMID:16088376 PMID:21873635 GO_REF:0000107, RGD:13792537 NCBI chr15:28,446,550...28,469,888
Ensembl chr15:28,446,550...28,468,217
JBrowse link
G Myh8 myosin heavy chain 8 involved_in ISO (PMID:17041932) RGD PMID:17041932 NCBI chr10:51,963,510...51,993,103
Ensembl chr10:51,963,510...51,993,232
JBrowse link
G Myl6 myosin light chain 6 involved_in TAS PMID:2304459 HGNC-UCL PMID:2304459 RGD:8554813 NCBI chr 7:910,764...914,062
Ensembl chr 7:910,774...933,791
JBrowse link
G Myl6l myosin, light polypeptide 6, alkali, smooth muscle and non-muscle-like involved_in TAS PMID:2304459 HGNC-UCL PMID:2304459 RGD:8554813
G Tnnt2 troponin T2, cardiac type involved_in ISO
ISS
(PMID:12186860), (PMID:15923195)
GO_REF:0000024
RGD
UniProt
PMID:12186860 PMID:15923195 GO_REF:0000024 NCBI chr13:47,267,325...47,285,390
Ensembl chr13:47,267,204...47,285,388
JBrowse link
G Tpm1 tropomyosin 1 involved_in IDA PMID:11136687 BHF-UCL PMID:11136687 RGD:1556479 NCBI chr 8:67,635,479...67,662,330
Ensembl chr 8:67,635,479...67,662,802
JBrowse link
negative regulation of muscle filament sliding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dbn1 drebrin 1 IDA RGD PMID:17543276 RGD:10398727 NCBI chr17:9,150,608...9,164,982
Ensembl chr17:9,150,659...9,164,984
JBrowse link
regulation of muscle filament sliding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mylk2 myosin light chain kinase 2 involved_in ISO
IEA
(PMID:16448786)
GO_REF:0000107
RGD
Ensembl
PMID:16448786 GO_REF:0000107 NCBI chr 3:141,376,450...141,388,357
Ensembl chr 3:141,376,691...141,387,728
JBrowse link
regulation of muscle filament sliding speed term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tnnc1 troponin C1, slow skeletal and cardiac type involved_in ISO (MGI:3793933|PMID:10747195) RGD PMID:10747195 MGI:3793933 NCBI chr16:6,400,801...6,405,419
Ensembl chr16:6,402,171...6,405,634
JBrowse link
G Tnnt2 troponin T2, cardiac type involved_in IMP PMID:10747195 BHF-UCL PMID:10747195 RGD:8554013 NCBI chr13:47,267,325...47,285,390
Ensembl chr13:47,267,204...47,285,388
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18737
    multicellular organismal process 8865
      system process 3375
        muscle system process 473
          muscle contraction 342
            muscle filament sliding 10
              negative regulation of muscle filament sliding 1
              positive regulation of muscle filament sliding 0
              regulation of muscle filament sliding + 4
Path 2
Term Annotations click to browse term
  biological_process 18737
    cellular process 17432
      actin filament-based process 839
        actin filament-based movement 129
          actin-mediated cell contraction 99
            actin-myosin filament sliding 11
              muscle filament sliding 10
                negative regulation of muscle filament sliding 1
                positive regulation of muscle filament sliding 0
                regulation of muscle filament sliding + 4
paths to the root