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ONTOLOGY REPORT - ANNOTATIONS

Term:actin filament depolymerization
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Accession:GO:0030042 term browser browse the term
Definition:Disassembly of actin filaments by the removal of actin monomers from a filament.
Synonyms:exact_synonym: actin depolymerization
 related_synonym: actin depolymerizing activity

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actin filament depolymerization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AQP2 aquaporin 2 ISO RGD PMID:18678705 RGD:2313131 NCBI chr11:46,179,783...46,188,631
Ensembl chr11:46,180,387...46,188,712 		JBrowse link
G CFL1 cofilin 1 involved_in IEA InterPro GO_REF:0000002 NCBI chr 1:8,408,560...8,410,564 JBrowse link
G CFL2 cofilin 2 involved_in
acts_upstream_of_or_within 		IEA
ISO 		(PMID:24840128) InterPro
Ensembl
MGI		 PMID:24840128 GO_REF:0000002 GO_REF:0000107 NCBI chr24:11,541,226...11,545,690
Ensembl chr24:11,543,638...11,544,335 		JBrowse link
G DSTN destrin, actin depolymerizing factor involved_in IEA InterPro
Ensembl		 GO_REF:0000002 GO_REF:0000107 NCBI chr 2:46,636,111...46,672,771
Ensembl chr 2:46,635,954...46,673,165 		JBrowse link
G GSN gelsolin involved_in ISO
IEA 		RGD
Ensembl		 PMID:11861757 GO_REF:0000107 RGD:1303950 NCBI chr12:18,253,079...18,317,285
Ensembl chr12:18,253,324...18,285,938 		JBrowse link
G LOC103224743 cofilin-1 involved_in IEA InterPro GO_REF:0000002 NCBI chr20:76,654,693...76,655,794 JBrowse link
G LOC103227720 twinfilin-2 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr22:13,581,102...13,598,830
Ensembl chr22:13,589,034...13,598,752
Ensembl chr22:13,589,034...13,598,752 		JBrowse link
G MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1 involved_in IEA UniProt
Ensembl		 GO_REF:0000107 GO_REF:0000117 NCBI chr13:64,400,908...64,424,096
Ensembl chr13:64,400,152...64,427,366 		JBrowse link
G MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 involved_in IEA UniProt
Ensembl		 GO_REF:0000107 GO_REF:0000117 NCBI chr 1:52,481,610...52,723,442
Ensembl chr 1:52,571,224...52,723,371 		JBrowse link
G MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 involved_in IEA UniProt
Ensembl		 GO_REF:0000107 GO_REF:0000117
G PPP1R9B protein phosphatase 1 regulatory subunit 9B ISO RGD PMID:10620493 RGD:10002737 NCBI chr16:43,188,400...43,205,621
Ensembl chr16:43,188,022...43,205,680 		JBrowse link
G TWF1 twinfilin actin binding protein 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr11:40,000,458...40,019,490
Ensembl chr11:39,999,926...40,019,502 		JBrowse link
G VIL1 villin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:104,311,048...104,350,846
Ensembl chr10:104,320,074...104,347,289 		JBrowse link
G WDR1 WD repeat domain 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr27:39,929,749...39,973,892
Ensembl chr27:39,929,787...39,974,012 		JBrowse link
actin filament capping term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AVIL advillin involved_in IEA UniProt GO_REF:0000043 NCBI chr11:53,708,969...53,732,219
Ensembl chr11:53,707,566...53,728,894 		JBrowse link
G CAPZA1 capping actin protein of muscle Z-line subunit alpha 1 involved_in IEA UniProt GO_REF:0000043 NCBI chr20:20,968,348...21,017,256
Ensembl chr20:20,969,828...20,991,971 		JBrowse link
G CAPZA2 capping actin protein of muscle Z-line subunit alpha 2 involved_in IEA UniProt GO_REF:0000043 NCBI chr21:85,543,297...85,598,346
Ensembl chr21:85,543,271...85,601,370 		JBrowse link
G CAPZA3 capping actin protein of muscle Z-line subunit alpha 3 involved_in IEA UniProt GO_REF:0000043 NCBI chr11:18,587,809...18,588,885
Ensembl chr11:18,587,966...18,588,865 		JBrowse link
G CAPZB capping actin protein of muscle Z-line subunit beta involved_in IEA UniProt GO_REF:0000043 NCBI chr20:113,062,077...113,207,983
Ensembl chr20:113,062,192...113,210,430 		JBrowse link
G GSN gelsolin involved_in IEA UniProt
Ensembl		 GO_REF:0000043 GO_REF:0000107 NCBI chr12:18,253,079...18,317,285
Ensembl chr12:18,253,324...18,285,938 		JBrowse link
G MYH9 myosin heavy chain 9 NOT|involved_in ISO (PMID:23325791) UniProt PMID:23325791 NCBI chr19:18,985,709...19,093,304
Ensembl chr19:18,986,598...19,052,671 		JBrowse link
G SCIN scinderin involved_in IEA UniProt
Ensembl		 GO_REF:0000043 GO_REF:0000107 NCBI chr21:45,453,034...45,537,733
Ensembl chr21:45,452,659...45,537,323 		JBrowse link
G SPTA1 spectrin alpha, erythrocytic 1 involved_in IEA UniProt GO_REF:0000043 NCBI chr20:5,238,246...5,314,204
Ensembl chr20:5,238,447...5,313,887 		JBrowse link
G SPTAN1 spectrin alpha, non-erythrocytic 1 involved_in IEA UniProt GO_REF:0000043 NCBI chr12:9,503,752...9,585,297
Ensembl chr12:9,503,367...9,585,268 		JBrowse link
G SPTB spectrin beta, erythrocytic involved_in IEA UniProt GO_REF:0000043 GO_REF:0000104 NCBI chr24:41,957,438...42,038,522
Ensembl chr24:41,978,595...42,038,516 		JBrowse link
G SPTBN1 spectrin beta, non-erythrocytic 1 involved_in IEA UniProt GO_REF:0000043 GO_REF:0000104 NCBI chr14:52,266,197...52,487,111
Ensembl chr14:52,262,416...52,487,112 		JBrowse link
G SPTBN2 spectrin beta, non-erythrocytic 2 involved_in IEA UniProt GO_REF:0000043 GO_REF:0000104 NCBI chr 1:7,543,035...7,588,125
Ensembl chr 1:7,556,953...7,590,720 		JBrowse link
G SPTBN4 spectrin beta, non-erythrocytic 4 involved_in IEA UniProt GO_REF:0000043 NCBI chr 6:34,926,413...35,036,611
Ensembl chr 6:34,930,519...35,035,719 		JBrowse link
G SPTBN5 spectrin beta, non-erythrocytic 5 involved_in IEA UniProt GO_REF:0000043 NCBI chr26:41,090,023...41,137,645
Ensembl chr26:41,091,478...41,135,932 		JBrowse link
G TPM1 tropomyosin 1 ISO RGD PMID:15779917 RGD:1600523 NCBI chr26:20,458,287...20,487,387
Ensembl chr26:20,466,037...20,487,135 		JBrowse link
G VIL1 villin 1 involved_in IEA UniProt
Ensembl		 GO_REF:0000043 GO_REF:0000107 NCBI chr10:104,311,048...104,350,846
Ensembl chr10:104,320,074...104,347,289 		JBrowse link
G VILL villin like involved_in IEA UniProt GO_REF:0000043 NCBI chr15:1,395,763...1,412,352
Ensembl chr15:1,395,776...1,409,351 		JBrowse link
actin filament fragmentation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CFL1 cofilin 1 involved_in ISO (PMID:11809832) UniProt PMID:11809832 NCBI chr 1:8,408,560...8,410,564 JBrowse link
G CFL2 cofilin 2 involved_in ISO (PMID:11809832) UniProt PMID:11809832 NCBI chr24:11,541,226...11,545,690
Ensembl chr24:11,543,638...11,544,335 		JBrowse link
G DSTN destrin, actin depolymerizing factor involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:46,636,111...46,672,771
Ensembl chr 2:46,635,954...46,673,165 		JBrowse link
G WDR1 WD repeat domain 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr27:39,929,749...39,973,892
Ensembl chr27:39,929,787...39,974,012 		JBrowse link
actin filament uncapping term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACTN2 actinin alpha 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr25:73,827,900...73,904,516
Ensembl chr25:73,827,874...73,905,146 		JBrowse link
barbed-end actin filament capping term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADD1 adducin 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr27:45,811,611...45,901,277
Ensembl chr27:45,813,496...45,900,778 		JBrowse link
G ADD2 adducin 2 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr14:36,343,978...36,450,685
Ensembl chr14:36,344,022...36,449,315 		JBrowse link
G ADD3 adducin 3 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 9:102,930,270...103,056,558
Ensembl chr 9:103,010,713...103,057,101 		JBrowse link
G AVIL advillin involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr11:53,708,969...53,732,219
Ensembl chr11:53,707,566...53,728,894 		JBrowse link
G CAPZA1 capping actin protein of muscle Z-line subunit alpha 1 involved_in
acts_upstream_of_or_within 		IEA
ISO 		(PMID:17656356) InterPro
TreeGrafter
MGI
UniProt		 PMID:17656356 GO_REF:0000002 GO_REF:0000104 GO_REF:0000118 NCBI chr20:20,968,348...21,017,256
Ensembl chr20:20,969,828...20,991,971 		JBrowse link
G CAPZA2 capping actin protein of muscle Z-line subunit alpha 2 involved_in IEA InterPro
TreeGrafter
UniProt		 GO_REF:0000002 GO_REF:0000104 GO_REF:0000118 NCBI chr21:85,543,297...85,598,346
Ensembl chr21:85,543,271...85,601,370 		JBrowse link
G CAPZA3 capping actin protein of muscle Z-line subunit alpha 3 involved_in IEA InterPro
TreeGrafter
UniProt		 GO_REF:0000002 GO_REF:0000104 GO_REF:0000118 NCBI chr11:18,587,809...18,588,885
Ensembl chr11:18,587,966...18,588,865 		JBrowse link
G CAPZB capping actin protein of muscle Z-line subunit beta involved_in IEA InterPro
TreeGrafter
UniProt		 GO_REF:0000002 GO_REF:0000104 GO_REF:0000118 NCBI chr20:113,062,077...113,207,983
Ensembl chr20:113,062,192...113,210,430 		JBrowse link
G DBNL drebrin like NOT|acts_upstream_of_or_within ISO (PMID:10637315) MGI PMID:10637315 NCBI chr21:14,610,196...14,627,363
Ensembl chr21:14,608,571...14,627,321 		JBrowse link
G EPS8 EGFR pathway substrate 8, signaling adaptor involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:15,522,761...15,691,343
Ensembl chr11:15,522,616...15,691,133 		JBrowse link
G FLII FLII actin remodeling protein involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr16:17,285,400...17,300,210
Ensembl chr16:17,285,724...17,300,041 		JBrowse link
G GSN gelsolin involved_in IEA UniProt
TreeGrafter		 GO_REF:0000104 GO_REF:0000118 NCBI chr12:18,253,079...18,317,285
Ensembl chr12:18,253,324...18,285,938 		JBrowse link
G LOC103219957 macrophage-capping protein involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr14:21,742,163...21,761,462
Ensembl chr14:21,746,044...21,761,322 		JBrowse link
G LOC103227720 twinfilin-2 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr22:13,581,102...13,598,830
Ensembl chr22:13,589,034...13,598,752
Ensembl chr22:13,589,034...13,598,752 		JBrowse link
G RDX radixin ISO RGD PMID:2500445 RGD:8693627 NCBI chr 1:101,554,640...101,647,765
Ensembl chr 1:101,554,334...101,623,093 		JBrowse link
G SCIN scinderin involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr21:45,453,034...45,537,733
Ensembl chr21:45,452,659...45,537,323 		JBrowse link
G SVIL supervillin involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 9:29,072,613...29,256,563
Ensembl chr 9:29,072,322...29,164,759 		JBrowse link
G TWF1 twinfilin actin binding protein 1 involved_in IEA TreeGrafter
Ensembl		 GO_REF:0000107 GO_REF:0000118 NCBI chr11:40,000,458...40,019,490
Ensembl chr11:39,999,926...40,019,502 		JBrowse link
G VIL1 villin 1 involved_in IEA TreeGrafter
Ensembl		 GO_REF:0000107 GO_REF:0000118 NCBI chr10:104,311,048...104,350,846
Ensembl chr10:104,320,074...104,347,289 		JBrowse link
G VILL villin like involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr15:1,395,763...1,412,352
Ensembl chr15:1,395,776...1,409,351 		JBrowse link
barbed-end actin filament uncapping term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CARMIL1 capping protein regulator and myosin 1 linker 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:46,637,416...46,979,061
Ensembl chr17:46,635,199...46,978,932 		JBrowse link
negative regulation of actin filament depolymerization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CFL1 cofilin 1 ISO RGD PMID:15252126 RGD:2306210 NCBI chr 1:8,408,560...8,410,564 JBrowse link
G LIMA1 LIM domain and actin binding 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:46,403,808...46,508,278
Ensembl chr11:46,403,826...46,508,249 		JBrowse link
G PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:10,218,034...10,304,874
Ensembl chr15:10,218,805...10,294,316 		JBrowse link
G PLEKHH2 pleckstrin homology, MyTH4 and FERM domain containing H2 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr14:63,488,305...63,617,146
Ensembl chr14:63,488,773...63,609,021 		JBrowse link
G SHROOM2 shroom family member 2 acts_upstream_of_or_within ISO (PMID:17666436) MGI PMID:17666436 NCBI chr  X:8,242,714...8,405,051
Ensembl chr  X:8,345,056...8,405,552 		JBrowse link
G SPECC1L sperm antigen with calponin homology and coiled-coil domains 1 like acts_upstream_of_or_within ISO (PMID:21703590) MGI PMID:21703590 NCBI chr19:7,488,821...7,539,961
Ensembl chr19:7,488,832...7,539,952 		JBrowse link
G SWAP70 switching B cell complex subunit SWAP70 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:55,074,255...55,156,632
Ensembl chr 1:55,074,209...55,156,599 		JBrowse link
negative regulation of barbed-end actin filament capping term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CARMIL1 capping protein regulator and myosin 1 linker 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:46,637,416...46,979,061
Ensembl chr17:46,635,199...46,978,932 		JBrowse link
G CARMIL2 capping protein regulator and myosin 1 linker 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:59,787,069...59,801,615
Ensembl chr 5:59,787,120...59,801,122 		JBrowse link
G CRACD capping protein inhibiting regulator of actin dynamics involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 7:12,293,366...12,570,793
Ensembl chr 7:12,296,214...12,325,965 		JBrowse link
pointed-end actin filament capping term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LMOD1 leiomodin 1 involved_in IEA InterPro GO_REF:0000002 NCBI chr25:27,460,230...27,511,667
Ensembl chr25:27,460,460...27,511,024 		JBrowse link
G LMOD2 leiomodin 2 involved_in IEA InterPro GO_REF:0000002 NCBI chr21:92,454,067...92,462,904
Ensembl chr21:92,454,438...92,462,958 		JBrowse link
G LMOD3 leiomodin 3 involved_in IEA InterPro GO_REF:0000002 NCBI chr22:30,132,993...30,149,769
Ensembl chr22:30,135,153...30,148,740 		JBrowse link
G TMOD1 tropomodulin 1 involved_in IEA InterPro GO_REF:0000002 NCBI chr12:41,808,594...41,899,713
Ensembl chr12:41,811,036...41,877,357 		JBrowse link
G TMOD2 tropomodulin 2 involved_in IEA InterPro GO_REF:0000002 NCBI chr26:31,560,112...31,624,967
Ensembl chr26:31,568,024...31,624,905 		JBrowse link
G TMOD3 tropomodulin 3 involved_in IEA InterPro GO_REF:0000002 NCBI chr26:31,470,138...31,549,615
Ensembl chr26:31,471,362...31,549,571 		JBrowse link
G TMOD4 tropomodulin 4 involved_in IEA InterPro GO_REF:0000002 NCBI chr20:12,513,935...12,519,497
Ensembl chr20:12,515,429...12,519,402 		JBrowse link
positive regulation of actin filament depolymerization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CFL1 cofilin 1 acts_upstream_of_or_within
involved_in 		ISO (PMID:15548599)
(PMID:23921380) 		MGI
CACAO		 PMID:15548599 PMID:23921380 NCBI chr 1:8,408,560...8,410,564 JBrowse link
G CFL2 cofilin 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr24:11,541,226...11,545,690
Ensembl chr24:11,543,638...11,544,335 		JBrowse link
G DSTN destrin, actin depolymerizing factor acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 2:46,636,111...46,672,771
Ensembl chr 2:46,635,954...46,673,165 		JBrowse link
G F2RL1 F2R like trypsin receptor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:71,095,446...71,109,832
Ensembl chr 4:71,095,500...71,110,005 		JBrowse link
G LOC103223283 chronophin involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:20,340,535...20,357,426
Ensembl chr19:20,360,108...20,368,247
Ensembl chr19:20,360,108...20,368,247 		JBrowse link
G PLEK pleckstrin involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:38,689,387...38,769,090
Ensembl chr14:38,689,393...38,745,893 		JBrowse link
G SEMA5A semaphorin 5A involved_in ISO (PMID:19850054) UniProt PMID:19850054 NCBI chr 4:8,598,680...9,095,346
Ensembl chr 4:8,600,959...9,095,423 		JBrowse link
G VIL1 villin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:104,311,048...104,350,846
Ensembl chr10:104,320,074...104,347,289 		JBrowse link
G WDR1 WD repeat domain 1 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr27:39,929,749...39,973,892
Ensembl chr27:39,929,787...39,974,012 		JBrowse link
positive regulation of barbed-end actin filament capping term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ARPC2 actin related protein 2/3 complex subunit 2 ISO RGD PMID:15252126 RGD:2306210 NCBI chr10:104,098,275...104,144,043
Ensembl chr10:104,098,402...104,135,791 		JBrowse link
G CFL1 cofilin 1 ISO RGD PMID:23704350 RGD:11570555 NCBI chr 1:8,408,560...8,410,564 JBrowse link
regulation of actin filament depolymerization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC103223283 chronophin involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:20,340,535...20,357,426
Ensembl chr19:20,360,108...20,368,247
Ensembl chr19:20,360,108...20,368,247 		JBrowse link
G WDR1 WD repeat domain 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr27:39,929,749...39,973,892
Ensembl chr27:39,929,787...39,974,012 		JBrowse link
regulation of barbed-end actin filament capping term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MTPN myotrophin involved_in IEA Ensembl GO_REF:0000107 NCBI chr21:104,605,924...104,657,664
Ensembl chr21:104,605,592...104,657,866 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19706
    cellular process 19211
      actin filament-based process 826
        actin cytoskeleton organization 730
          actin filament organization 464
            actin polymerization or depolymerization 198
              actin filament depolymerization 62
                actin filament fragmentation 4
                negative regulation of actin filament depolymerization + 48
                positive regulation of actin filament depolymerization + 13
                regulation of actin filament depolymerization + 56
Path 2
Term Annotations click to browse term
  biological_process 19706
    cellular process 19211
      cellular component organization or biogenesis 8786
        cellular component organization 8574
          organelle organization 3611
            cytoskeleton organization 1531
              actin cytoskeleton organization 730
                actin filament organization 464
                  actin polymerization or depolymerization 198
                    actin filament depolymerization 62
                      actin filament fragmentation 4
                      negative regulation of actin filament depolymerization + 48
                      positive regulation of actin filament depolymerization + 13
                      regulation of actin filament depolymerization + 56
paths to the root