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ONTOLOGY REPORT - ANNOTATIONS

Term:lamellipodium assembly
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Accession:GO:0030032 term browser browse the term
Definition:Formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell.
Synonyms:exact_synonym: lamellipodium biosynthesis;   lamellipodium formation
 related_synonym: lamellipodium biogenesis

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lamellipodium assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ablim1 actin binding LIM protein 1 acts_upstream_of_or_within ISO (PMID:22684256) MGI PMID:22684256 NCBI chrNW_004936486:4,720,643...4,906,460 JBrowse link
G Ablim3 actin binding LIM protein family member 3 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:22684256) MGI
Ensembl		 PMID:22684256 GO_REF:0000107 NCBI chrNW_004936504:5,598,186...5,709,505 JBrowse link
G Ajuba ajuba LIM protein acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:3577694|PMID:15728191) MGI
Ensembl		 PMID:15728191 GO_REF:0000107 MGI:3577694 NCBI chrNW_004936722:1,331,568...1,341,854 JBrowse link
G Arhgef4 Rho guanine nucleotide exchange factor 4 involved_in ISO (PMID:17599059) UniProt PMID:17599059 NCBI chrNW_004936469:41,352,361...41,467,466 JBrowse link
G Arhgef6 Rac/Cdc42 guanine nucleotide exchange factor 6 involved_in ISO (MGI:5447607|PMID:18325335) UniProt PMID:18325335 MGI:5447607 NCBI chrNW_004936513:10,488,525...10,598,366 JBrowse link
G Arhgef7 Rho guanine nucleotide exchange factor 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936472:1,784,215...1,857,296 JBrowse link
G Capzb capping actin protein of muscle Z-line subunit beta acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:3051184|PMID:15294161), (MGI:4397629|PMID:19806181) MGI
Ensembl		 PMID:15294161 PMID:19806181 GO_REF:0000107 MGI:3051184 MGI:4397629 NCBI chrNW_004936474:5,594,193...5,656,665 JBrowse link
G Carmil1 capping protein regulator and myosin 1 linker 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936671:1,404,595...1,632,916 JBrowse link
G Ccdc88a coiled-coil domain containing 88A involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936491:1,670,192...1,804,056 JBrowse link
G Cdh13 cadherin 13 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936641:3,925,185...4,223,421 JBrowse link
G Cyfip1 cytoplasmic FMR1 interacting protein 1 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:3033285|PMID:14765121) MGI
Ensembl		 PMID:14765121 GO_REF:0000107 MGI:3033285 NCBI chrNW_004936471:38,264,455...38,331,995 JBrowse link
G Fgd4 FYVE, RhoGEF and PH domain containing 4 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:2179874|PMID:11527409) MGI
Ensembl		 PMID:11527409 GO_REF:0000107 MGI:2179874 NCBI chrNW_004936607:3,675,217...3,796,329 JBrowse link
G Golph3 golgi phosphoprotein 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936518:8,602,367...8,635,665 JBrowse link
G Itgb1 integrin subunit beta 1 involved_in ISO PMID:20091784 ARUK-UCL PMID:20091784 RGD:6480646 NCBI chrNW_004936574:1,465,981...1,495,717 JBrowse link
G Kit KIT proto-oncogene, receptor tyrosine kinase involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936482:17,162,854...17,238,319 JBrowse link
G LOC101965678 beta-parvin involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936718:1,721,452...1,757,423 JBrowse link
G Nck1 NCK adaptor protein 1 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:2664446|PMID:12808099) MGI
Ensembl		 PMID:12808099 GO_REF:0000107 MGI:2664446 NCBI chrNW_004936529:9,647,161...9,718,512 JBrowse link
G Nck2 NCK adaptor protein 2 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:2664446|PMID:12808099) MGI
Ensembl		 PMID:12808099 GO_REF:0000107 MGI:2664446 NCBI chrNW_004936764:141,159...185,482 JBrowse link
G Nckap1 NCK associated protein 1 acts_upstream_of_or_within ISO (MGI:3701029|PMID:16831833)
(MGI:3033285|PMID:14765121)		 MGI PMID:14765121 PMID:16831833 MGI:3033285 MGI:3701029 NCBI chrNW_004936509:11,525,764...11,624,833 JBrowse link
G Nup85 nucleoporin 85 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:3588593|PMID:15995708) MGI
Ensembl		 PMID:15995708 GO_REF:0000107 MGI:3588593 NCBI chrNW_004936594:503,698...531,851 JBrowse link
G P2ry12 purinergic receptor P2Y12 involved_in ISO PMID:20091784 ARUK-UCL PMID:20091784 RGD:6480646 NCBI chrNW_004936758:1,581,828...1,624,332 JBrowse link
G Pmp22 peripheral myelin protein 22 acts_upstream_of_or_within ISO (MGI:5616959|PMID:25429154) MGI PMID:25429154 MGI:5616959 NCBI chrNW_004936724:1,747,015...1,780,298 JBrowse link
G Ptpro protein tyrosine phosphatase receptor type O involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936587:1,967,079...2,188,651 JBrowse link
G Pxn paxillin acts_upstream_of_or_within ISO (MGI:2680875|PMID:14636584) MGI PMID:14636584 MGI:2680875 NCBI chrNW_004936668:660,415...709,282 JBrowse link
G Rac1 Rac family small GTPase 1 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:3577694|PMID:15728191) MGI
Ensembl		 PMID:15728191 GO_REF:0000107 MGI:3577694 NCBI chrNW_004936750:107,689...122,679 JBrowse link
G Rhod ras homolog family member D involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936599:2,603,800...2,611,686 JBrowse link
G S1pr1 sphingosine-1-phosphate receptor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936748:1,244,962...1,250,093 JBrowse link
G Sh2b1 SH2B adaptor protein 1 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:2176658|PMID:11786545) MGI
Ensembl		 PMID:11786545 GO_REF:0000107 MGI:2176658 NCBI chrNW_004936501:11,840,227...11,849,742 JBrowse link
G Spata13 spermatogenesis associated 13 involved_in ISO (PMID:17599059) UniProt PMID:17599059 NCBI chrNW_004936688:1,433,231...1,569,954 JBrowse link
G Spef1 sperm flagellar 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936485:14,917,352...14,923,669 JBrowse link
G Vav2 vav guanine nucleotide exchange factor 2 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:3587490|PMID:15728722) MGI
Ensembl		 PMID:15728722 GO_REF:0000107 MGI:3587490 NCBI chrNW_004936669:3,062,538...3,234,167 JBrowse link
G Vav3 vav guanine nucleotide exchange factor 3 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:3587490|PMID:15728722) MGI
Ensembl		 PMID:15728722 GO_REF:0000107 MGI:3587490 NCBI chrNW_004936731:417,610...767,427 JBrowse link
G Vcl vinculin acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:2447097|PMID:12473693) MGI
Ensembl		 PMID:12473693 GO_REF:0000107 MGI:2447097 NCBI chrNW_004936521:5,051,077...5,163,036 JBrowse link
G Wasf2 WASP family member 2 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:2668788|PMID:12879075) MGI
Ensembl		 PMID:12879075 GO_REF:0000107 MGI:2668788 NCBI chrNW_004936474:11,711,582...11,736,154 JBrowse link
G Wasf3 WASP family member 3 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:3625634|PMID:16723544) MGI
Ensembl		 PMID:16723544 GO_REF:0000107 MGI:3625634 NCBI chrNW_004936948:345,942...465,323 JBrowse link
G Whamm WASP homolog associated with actin, golgi membranes and microtubules involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936483:17,469,758...17,492,791 JBrowse link
lamellipodium assembly involved in ameboidal cell migration term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Srgap2 SLIT-ROBO Rho GTPase activating protein 2 involved_in ISO (PMID:20810653) UniProt PMID:20810653 NCBI chrNW_004936557:6,096,258...6,338,024 JBrowse link
negative regulation of lamellipodium assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abi3 ABI family member 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936490:12,280,717...12,290,602 JBrowse link
G Cfl1 cofilin 1 ISO RGD PMID:24093776 RGD:11570550 NCBI chrNW_004936599:3,678,724...3,682,314 JBrowse link
G Hrg histidine rich glycoprotein involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936578:3,285,986...3,295,876 JBrowse link
G Plxnb3 plexin B3 involved_in ISO PMID:20696765 UniProt PMID:20696765 RGD:8554409 NCBI chrNW_004936809:645,569...659,850 JBrowse link
G Slit2 slit guidance ligand 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936477:8,111,212...8,448,567 JBrowse link
positive regulation of lamellipodium assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abi2 abl interactor 2 involved_in ISO (PMID:21107423) ARUK-UCL PMID:21107423 NCBI chrNW_004936631:30,109...101,748 JBrowse link
G Actr2 actin related protein 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936491:9,980,228...10,021,417 JBrowse link
G Actr3 actin related protein 3 involved_in ISO
IEA		 RGD
Ensembl		 PMID:18256280 GO_REF:0000107 RGD:2306202 NCBI chrNW_004936469:55,639,345...55,699,330 JBrowse link
G Akirin1 akirin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936474:20,975,401...20,992,184 JBrowse link
G Aqp1 aquaporin 1 (Colton blood group) ISO RGD PMID:19539607 RGD:2316079 NCBI chrNW_004936478:7,146,997...7,160,369 JBrowse link
G Arpc2 actin related protein 2/3 complex subunit 2 involved_in ISO
IEA		 RGD
Ensembl		 PMID:15252126 GO_REF:0000107 RGD:2306210 NCBI chrNW_004936569:758,358...786,995 JBrowse link
G Atp7a ATPase copper transporting alpha ISO RGD PMID:20671235 RGD:11341707 NCBI chrNW_004936683:2,874,022...2,936,214 JBrowse link
G Auts2 activator of transcription and developmental regulator AUTS2 involved_in ISO (MGI:5908783|PMID:25533347) UniProt PMID:25533347 MGI:5908783 NCBI chrNW_004936543:5,146,961...6,187,634 JBrowse link
G Avil advillin involved_in ISO (PMID:29058690) UniProt PMID:29058690 NCBI chrNW_004936646:1,930,447...1,952,069 JBrowse link
G Brk1 BRICK1 subunit of SCAR/WAVE actin nucleating complex involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936602:3,147,773...3,155,739 JBrowse link
G Carmil2 capping protein regulator and myosin 1 linker 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936475:18,036,233...18,049,144 JBrowse link
G Cdc42 cell division cycle 42 involved_in ISO (PMID:8625410) CAFA PMID:8625410 NCBI chrNW_004936474:7,556,765...7,598,687 JBrowse link
G Cfl1 cofilin 1 ISO RGD PMID:15252126 RGD:2306210 NCBI chrNW_004936599:3,678,724...3,682,314 JBrowse link
G Clrn1 clarin 1 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:19423712) MGI
Ensembl		 PMID:19423712 GO_REF:0000107 NCBI chrNW_004936758:1,250,831...1,286,016 JBrowse link
G Cyfip1 cytoplasmic FMR1 interacting protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936471:38,264,455...38,331,995 JBrowse link
G Dnm2 dynamin 2 ISO RGD PMID:14617821 RGD:9685179 NCBI chrNW_004936659:957,408...1,046,393 JBrowse link
G Frmd7 FERM domain containing 7 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:5546532|PMID:23967341) MGI
Ensembl		 PMID:23967341 GO_REF:0000107 MGI:5546532 NCBI chrNW_004936691:2,664,968...2,756,300 JBrowse link
G Fscn1 fascin actin-bundling protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936765:609,894...619,417 JBrowse link
G Hdac4 histone deacetylase 4 ISO RGD PMID:24166750 RGD:9681442 NCBI chrNW_004936745:1,730,743...1,942,071 JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 ISO RGD PMID:15302889 RGD:2316937 NCBI chrNW_004936835:316,767...321,999 JBrowse link
G Mstn myostatin involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936506:7,988,879...7,996,260 JBrowse link
G Mtor mechanistic target of rapamycin kinase acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:3510095|PMID:15467718) MGI
Ensembl		 PMID:15467718 GO_REF:0000107 MGI:3510095 NCBI chrNW_004936474:158,376...282,310 JBrowse link
G Nckap1 NCK associated protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936509:11,525,764...11,624,833 JBrowse link
G Ocln occludin involved_in ISO (PMID:20152177) ARUK-UCL PMID:20152177 NCBI chrNW_004936480:99,516...152,834 JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936480:1,188,408...1,273,210 JBrowse link
G Plce1 phospholipase C epsilon 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936601:817,151...1,105,824 JBrowse link
G Rac1 Rac family small GTPase 1 involved_in
acts_upstream_of_or_within		 ISO
IEA		 (PMID:15467718) RGD
Ensembl
MGI		 PMID:12105187 PMID:15467718 GO_REF:0000107 RGD:1299247 NCBI chrNW_004936750:107,689...122,679 JBrowse link
G Rac2 Rac family small GTPase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936492:3,726,375...3,737,961 JBrowse link
G Wasf2 WASP family member 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936474:11,711,582...11,736,154 JBrowse link
G Wnt1 Wnt family member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936512:6,781,001...6,785,358 JBrowse link
regulation of lamellipodium assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdc42 cell division cycle 42 involved_in ISO (PMID:8625410) CAFA PMID:8625410 NCBI chrNW_004936474:7,556,765...7,598,687 JBrowse link
G Dmtn dematin actin binding protein involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936555:5,884,746...5,911,171 JBrowse link
G Egr3 early growth response 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936555:6,347,446...6,393,784 JBrowse link
G Epha2 EPH receptor A2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936474:3,648,395...3,673,856 JBrowse link
G Fer FER tyrosine kinase involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936531:3,512,976...3,898,885 JBrowse link
G Rac1 Rac family small GTPase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936750:107,689...122,679 JBrowse link
G Was WASP actin nucleation promoting factor involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936721:634,685...641,248 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 14973
    cellular process 13961
      cellular component organization or biogenesis 5494
        cellular component organization 5357
          cell projection organization 1584
            plasma membrane bounded cell projection organization 1564
              lamellipodium organization 92
                lamellipodium assembly 72
                  lamellipodium assembly involved in ameboidal cell migration + 1
                  negative regulation of lamellipodium assembly 5
                  positive regulation of lamellipodium assembly 30
                  regulation of lamellipodium assembly + 39
paths to the root